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  1. Book ; Online ; E-Book: Pharmacogenomics in Precision Medicine

    Cai, Weimin / Liu, Zhaoqian / Miao, Liyan / Xiang, Xiaoqiang

    From a Perspective of Ethnic Differences

    2020  

    Abstract: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, ... ...

    Author's details edited by Weimin Cai, Zhaoqian Liu, Liyan Miao, Xiaoqiang Xiang
    Abstract This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.
    Keywords Pharmacology ; Laboratory medicine ; Human genetics ; Pharmacology/Toxicology ; Laboratory Medicine ; Human Genetics ; Farmacogenètica
    Subject code 615.7
    Language English
    Size 1 online resource (viii, 289 pages)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-3895-6 ; 981-15-3894-8 ; 978-981-15-3895-7 ; 978-981-15-3894-0
    DOI 10.1007/978-981-15-3895-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Amphiphilic graphene oxide membranes for oil-water separation.

    Tie, Lu / Liu, Weimin

    Science bulletin

    2023  Volume 68, Issue 4, Page(s) 373–375

    Language English
    Publishing date 2023-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Contralateral conjugate eye deviation in hyperacute internal carotid artery occlusion.

    Yin, Juntao / Liu, Xinyue / Li, Xiuli / Zhang, Weimin / Guo, Lixin

    Acta neurologica Belgica

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country Italy
    Document type Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-024-02491-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.57: Show issues Location:
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  4. Article: A novel serum m

    Chen, Yaxin / Xie, Yufang / Bi, Liyun / Ci, Hang / Li, Weimin / Liu, Dan

    Frontiers in genetics

    2024  Volume 15, Page(s) 1270302

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2024.1270302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enhancing the relative abundance of comammox nitrospira in ammonia oxidizer community decreases N

    Ren, Zhichang / Li, Deyong / Zhang, Zhuang / Sun, Weimin / Liu, Guoqiang

    Chemosphere

    2024  Volume 356, Page(s) 141883

    Abstract: Comammox Nitrospira and canonical ammonia-oxidizing bacteria (cAOB) generally coexist in activated sludge. In present study, the effect of comammox Nitrospira on ... ...

    Abstract Comammox Nitrospira and canonical ammonia-oxidizing bacteria (cAOB) generally coexist in activated sludge. In present study, the effect of comammox Nitrospira on N
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Novel Underwater Acoustic Target Recognition Method Based on MFCC and RACNN.

    Liu, Dali / Yang, Hongyuan / Hou, Weimin / Wang, Baozhu

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 1

    Abstract: In ocean remote sensing missions, recognizing an underwater acoustic target is a crucial technology for conducting marine biological surveys, ocean explorations, and other scientific activities that take place in water. The complex acoustic propagation ... ...

    Abstract In ocean remote sensing missions, recognizing an underwater acoustic target is a crucial technology for conducting marine biological surveys, ocean explorations, and other scientific activities that take place in water. The complex acoustic propagation characteristics present significant challenges for the recognition of underwater acoustic targets (UATR). Methods such as extracting the DEMON spectrum of a signal and inputting it into an artificial neural network for recognition, and fusing the multidimensional features of a signal for recognition, have been proposed. However, there is still room for improvement in terms of noise immunity, improved computational performance, and reduced reliance on specialized knowledge. In this article, we propose the Residual Attentional Convolutional Neural Network (RACNN), a convolutional neural network that quickly and accurately recognize the type of ship-radiated noise. This network is capable of extracting internal features of Mel Frequency Cepstral Coefficients (MFCC) of the underwater ship-radiated noise. Experimental results demonstrate that the proposed model achieves an overall accuracy of 99.34% on the ShipsEar dataset, surpassing conventional recognition methods and other deep learning models.
    Language English
    Publishing date 2024-01-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24010273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association of pretreatment neutrophil-to-lymphocyte ratio with clinical outcomes in cancer immunotherapy: An evidence synthesis from 30 meta-analyses.

    Wang, Haoyu / Yang, Ruiyuan / Liu, Dan / Li, Weimin

    International immunopharmacology

    2024  Volume 132, Page(s) 111936

    Abstract: Background: The Neutrophil-to-lymphocyte ratio (NLR) holds relevance in cancer immunotherapy outcomes, yet its validation remains limited. Thus, we conducted an umbrella review to comprehensively assess the association between pretreatment NLR and ... ...

    Abstract Background: The Neutrophil-to-lymphocyte ratio (NLR) holds relevance in cancer immunotherapy outcomes, yet its validation remains limited. Thus, we conducted an umbrella review to comprehensively assess the association between pretreatment NLR and immunotherapy outcomes, along with evaluating their credibility and strength.
    Methods: Electronic databases, including PubMed, Web of Science, Embase, Scopus, and Cochrane, were systematically searched for eligible systematic reviews and meta-analyses. Quality assessment and evidence grading utilized AMSTAR, GRADE, and additional classification criteria, following PRISMA and PRIOR guidelines.
    Results: Thirty unique meta-analyses were included, with 24 associations (80%) exhibiting statistical significance. Notably, associations between pretreatment NLR and the prognosis of renal cell carcinoma, hepatocellular carcinoma, melanoma, and non-small cell lung cancer garnered highly suggestive or convincing evidence grading.
    Conclusions: Elevated pretreatment NLR correlates with poor outcomes in cancer immunotherapy, suggesting its potential as a biomarker for identifying appropriate treatment populations and predicting clinical outcomes. Nevertheless, further validation through prospective cohort studies is warranted.
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5408: Show issues Location:
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  8. Article: Salvia miltiorrhiza

    Tian, Shiyang / Liu, Tianyi / Jiang, Jingwei / Zhao, Xiting / Fan, Yunpeng / Zhang, Weimin / Ma, Wuren / Guo, Tingting / Wang, Weiling / Liu, Yingqiu

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1349139

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1349139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A new phenylspirodrimane derivative from the deep-sea-derived fungus

    Wang, Shuo / Li, Saini / Chen, Yuchan / Wang, Yanlin / Liu, Zhaoming / Zhang, Weimin / Deng, Hong

    Natural product research

    2024  , Page(s) 1–7

    Abstract: A new phenylspirodrimane derivative named stachybotrysin A ( ...

    Abstract A new phenylspirodrimane derivative named stachybotrysin A (
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2305197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pararorine A, isoindolinone alkaloid from the endophytic fungus Paramyrothecium roridum and its anti-tumor activity.

    Chen, Yuchan / Liu, Hongxin / Wang, Nuoyi / Tan, Haibo / Zhang, Weimin

    Fitoterapia

    2024  Volume 175, Page(s) 105931

    Abstract: Pararorine A, a new isoindolinone alkaloid was isolated from Paramyrothecium roridum, an endophytic fungus from the medicinal plant Gynochthodes officinalis (F.C. How) Razafim. & B. Bremer. The structure of this compound was elucidated by extensive ... ...

    Abstract Pararorine A, a new isoindolinone alkaloid was isolated from Paramyrothecium roridum, an endophytic fungus from the medicinal plant Gynochthodes officinalis (F.C. How) Razafim. & B. Bremer. The structure of this compound was elucidated by extensive spectroscopic (UV, IR, MS, and NMR) analyses. In addition, the antitumor activity of pararorine A was evaluated against SF-268, MCF-7, HepG2, and A549 tumor cell lines. The results revealed that pararorine A exhibited potent antitumor activities with the IC
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2024.105931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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