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  1. Article: Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children.

    Kung, Charmaine Jeng Sum / Hon, Kam Lun / Tang, Man Fung / Cheng, Nam Sze / Ng, Gigi Wing Gi / Leung, Christy Wing Man / Leung, Ting Fan

    Translational pediatrics

    2024  Volume 13, Issue 3, Page(s) 436–446

    Abstract: Background: Eczema is associated with multiple genes regulating epidermal barrier functions and immunological pathways. However, their epistatic interactions are not well studied. This cross-sectional study investigated the relationship between ... ...

    Abstract Background: Eczema is associated with multiple genes regulating epidermal barrier functions and immunological pathways. However, their epistatic interactions are not well studied. This cross-sectional study investigated the relationship between childhood eczema phenotypes and single-nucleotide polymorphisms (SNPs) of immune regulatory genes.
    Methods: One thousand three hundred and twenty-nine Chinese eczematous children and 1,179 non-allergic controls were recruited. Nine SNPs of immune regulatory genes signal transducer and activator of transcription 3 (
    Results: TGFB1
    Conclusions: Functional
    Language English
    Publishing date 2024-03-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Potential Interaction between

    Yang, Guangpu Kenneth / Chen, Huanxiong / Cheng, Ka-Lo / Tang, Man-Fung / Wang, Yujia / Hung, Lik-Hang Alec / Cheng, Chun-Yiu Jack / Mak, King-Lun Kingston / Lee, Yuk-Wai Wayne

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that is associated with low bone mineral density (BMD). Vitamin D (Vit-D) supplementation has been suggested to improve BMD in AIS, and its outcomes may be related to genetic ... ...

    Abstract Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that is associated with low bone mineral density (BMD). Vitamin D (Vit-D) supplementation has been suggested to improve BMD in AIS, and its outcomes may be related to genetic factors. The present study aimed to (a) investigate the synergistic effect between a low BMD-related gene (wingless-related integration site 16,
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Facile C-N bond cleavage of primary aliphatic amines by (salen)ruthenium(VI) nitrido complexes.

    Pan, Yunling / Cheng, Lin / Pan, Yi / Man, Wai-Lun / Yiu, Shek-Man / Xie, Jianhui / Lau, Kai-Chung / Lau, Tai-Chu

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 14, Page(s) 5404–5408

    Abstract: We report the first example of oxidative cleavage of the strong C-N bonds of primary amines by a ruthenium(VI) nitrido complex. The driving force for this very fast C-N cleavage reaction comes from the formation of stable NN after the initial coupling ... ...

    Abstract We report the first example of oxidative cleavage of the strong C-N bonds of primary amines by a ruthenium(VI) nitrido complex. The driving force for this very fast C-N cleavage reaction comes from the formation of stable NN after the initial coupling of the amine N and the nitrido ligand.
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt00600f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The

    Smith, L Courtney / Lun, Cheng Man

    Frontiers in immunology

    2017  Volume 8, Page(s) 725

    Abstract: The complex innate immune system of sea urchins is underpinned by several multigene families including ... ...

    Abstract The complex innate immune system of sea urchins is underpinned by several multigene families including the
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.00725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Extending the phenotype of Shashi-Pena syndrome: a case report and review of literature.

    Ho, Stephanie Ka Lun / Cheng, Shirley Sze Wing / Cheng, Timothy Hua Tse / Leung, Lai-Ting / Lam, Emily Kai Yee / Mok, Myth Tsz Shun / Lo, Ivan Fai Man / Luk, Ho-Ming

    Clinical dysmorphology

    2023  Volume 32, Issue 3, Page(s) 139–146

    MeSH term(s) Humans ; Phenotype ; Abnormalities, Multiple/diagnosis ; Abnormalities, Multiple/genetics
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1121482-x
    ISSN 1473-5717 ; 0962-8827
    ISSN (online) 1473-5717
    ISSN 0962-8827
    DOI 10.1097/MCD.0000000000000462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Thermally activated delayed fluorescence tetradentate ligand-containing gold(III) complexes with preferential molecular orientation and their application in organic light-emitting devices.

    Au-Yeung, Cathay Chai / Leung, Ming-Yi / Lai, Shiu-Lun / Cheng, Shun-Cheung / Li, Lok-Kwan / Tang, Man-Chung / Kwok, Wing-Kei / Ko, Chi-Chiu / Chan, Mei-Yee / Yam, Vivian Wing-Wah

    Materials horizons

    2024  Volume 11, Issue 1, Page(s) 151–162

    Abstract: A new class of thermally activated delayed fluorescence (TADF) pyridine-/pyrazine-containing tetradentate C^C^N^N gold(III) complexes have been designed and synthesized. Displaying photoluminescence quantum yields (PLQYs) of up to 0.77 in solid-state ... ...

    Abstract A new class of thermally activated delayed fluorescence (TADF) pyridine-/pyrazine-containing tetradentate C^C^N^N gold(III) complexes have been designed and synthesized. Displaying photoluminescence quantum yields (PLQYs) of up to 0.77 in solid-state thin films, these complexes showed at-least a six-fold increase in the radiative decay rate constant (
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2744250-0
    ISSN 2051-6355 ; 2051-6347
    ISSN (online) 2051-6355
    ISSN 2051-6347
    DOI 10.1039/d3mh00910f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hospital Burden of Chronic Obstructive Pulmonary Disease in Hong Kong - The Trend from 2006 to 2014.

    Chan, Hok Sum / Ko, Fanny Wai San / Chan, Johnny Wai Man / Choo, Kah Lin / So, Loletta Kit Ying / Lam, David Chi Leung / Sin, Kit Man / Wong, Wei Yin / Cheng, Yuk Lun / Wong, Maureen Mo Lin

    International journal of chronic obstructive pulmonary disease

    2023  Volume 18, Page(s) 507–519

    Abstract: Background: Chronic obstructive pulmonary disease (COPD) is a common cause for hospital admission. This study aims to review the hospital burden of COPD in Hong Kong (HK) and the trend from year 2006 to 2014.: Methods: A multi-center, retrospective ... ...

    Abstract Background: Chronic obstructive pulmonary disease (COPD) is a common cause for hospital admission. This study aims to review the hospital burden of COPD in Hong Kong (HK) and the trend from year 2006 to 2014.
    Methods: A multi-center, retrospective study of the characteristics of COPD patients discharged from the public hospitals of HK from year 2006 to 2014. Anonymized data retrieval and analysis were performed. The demographic data of the subjects, use of health-care resources, ventilatory support, medications used and mortality of the subjects were analyzed.
    Results: Total patient headcount (HC) and admission number reduced from 10,425 and 23,362 in year 2006 to 9613 and 19,771, respectively, in 2014. There was a progressive reduction of female COPD HC from 2193 (21%) in year 2006 to 1517 (16%) in 2014. The utilization of non-invasive ventilation (NIV) increased rapidly and peaked in 2010 (29%) and decreased thereafter. There was a rapid increase in the prescription of long-acting bronchodilators (from 15% to 64%). COPD and pneumonia were the top causes of death, but death due to pneumonia was rapidly increasing while death due to COPD was progressively decreasing over the period.
    Conclusion: COPD HC and admission number (particularly in female patients) decreased progressively from year 2006 to 2014. There was also a decreasing trend of severity of disease as reflected by lower NIV use (after year 2010) and lower mortality rate due to COPD. Reduced smoking prevalence and tuberculosis (TB) notification rate in the community in the past might have reduced the incidence and severity of COPD and the hospital burden of disease. We observed an increasing trend of mortality due to pneumonia in COPD patients. Appropriate and timely vaccination programs are recommended for COPD patients as in the general elderly population.
    MeSH term(s) Humans ; Female ; Aged ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Hong Kong/epidemiology ; Retrospective Studies ; Pneumonia/epidemiology ; Hospitals, Public
    Language English
    Publishing date 2023-04-06
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S394698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: How early warning with the Oxygen Reserve Index (ORi™) can improve the detection of desaturation during induction of general anesthesia?

    Cheng, Hung-Wei / Yeh, Chia-Yi / Chang, Man-Yun / Ting, Chien-Kun / Chang, Po-Lun

    Journal of clinical monitoring and computing

    2021  Volume 36, Issue 5, Page(s) 1379–1385

    Abstract: The Oxygen Reserve Index (ORi™) is a dimensionless parameter with a value between 0 and 1. It is related to the real-time oxygenation status in the moderate hyperoxic range. The purpose of this study is to investigate the added warning time provided by ... ...

    Abstract The Oxygen Reserve Index (ORi™) is a dimensionless parameter with a value between 0 and 1. It is related to the real-time oxygenation status in the moderate hyperoxic range. The purpose of this study is to investigate the added warning time provided by different ORi alarm triggers and the continuous trends of ORi, SpO
    MeSH term(s) Anesthesia, General ; Humans ; Hyperoxia ; Monitoring, Physiologic/methods ; Oxygen ; Respiration
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-12-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-021-00776-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2054: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Mechanism of Viral Glycoprotein Targeting by Membrane-associated-RING-CH Proteins.

    Lun, Cheng Man / Waheed, Abdul A / Majadly, Alhlam / Powell, Nicole / Freed, Eric O

    bioRxiv : the preprint server for biology

    2021  

    Abstract: An emerging class of cellular inhibitory proteins has been identified that targets viral glycoproteins. These include the membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases that, among other functions, downregulate cell-surface proteins ... ...

    Abstract An emerging class of cellular inhibitory proteins has been identified that targets viral glycoproteins. These include the membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases that, among other functions, downregulate cell-surface proteins involved in adaptive immunity. The RING-CH domain of MARCH proteins is thought to function by catalyzing the ubiquitination of the cytoplasmic tails (CTs) of target proteins, leading to their degradation. MARCH proteins have recently been reported to target retroviral envelope glycoproteins (Env) and vesicular stomatitis virus G glycoprotein (VSV-G). However, the mechanism of antiviral activity remains poorly defined. Here we show that MARCH8 antagonizes the full-length forms of HIV-1 Env, VSV-G, Ebola virus glycoprotein (EboV-GP), and the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) thereby impairing the infectivity of virions pseudotyped with these viral glycoproteins. This MARCH8-mediated targeting of viral glycoproteins requires the E3 ubiquitin ligase activity of the RING-CH domain. We observe that MARCH8 protein antagonism of VSV-G is CT dependent. In contrast, MARCH8-mediated targeting of HIV-1 Env, EboV-GP and SARS-CoV-2 S protein by MARCH8 does not require the CT, suggesting a novel mechanism of MARCH-mediated antagonism of these viral glycoproteins. Confocal microscopy data demonstrate that MARCH8 traps the viral glycoproteins in an intracellular compartment. We observe that the endogenous expression of
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.01.25.428025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins.

    Lun, Cheng Man / Waheed, Abdul A / Majadly, Ahlam / Powell, Nicole / Freed, Eric O

    mBio

    2021  Volume 12, Issue 2

    Abstract: An emerging class of cellular inhibitory proteins has been identified that targets viral glycoproteins. These include the membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases that, among other functions, downregulate cell surface proteins ... ...

    Abstract An emerging class of cellular inhibitory proteins has been identified that targets viral glycoproteins. These include the membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases that, among other functions, downregulate cell surface proteins involved in adaptive immunity. The RING-CH domain of MARCH proteins is thought to function by catalyzing the ubiquitination of the cytoplasmic tails (CTs) of target proteins, leading to their degradation. MARCH proteins have recently been reported to target retroviral envelope glycoproteins (Env) and vesicular stomatitis virus G glycoprotein (VSV-G). However, the mechanism of antiviral activity remains poorly defined. Here we show that MARCH8 antagonizes the full-length forms of HIV-1 Env, VSV-G, Ebola virus glycoprotein (EboV-GP), and the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thereby impairing the infectivity of virions pseudotyped with these viral glycoproteins. This MARCH8-mediated targeting of viral glycoproteins requires the E3 ubiquitin ligase activity of the RING-CH domain. We observe that MARCH8 protein antagonism of VSV-G is CT dependent. In contrast, MARCH8-mediated targeting of HIV-1 Env, EboV-GP, and SARS-CoV-2 S protein by MARCH8 does not require the CT, suggesting a novel mechanism of MARCH-mediated antagonism of these viral glycoproteins. Confocal microscopy data demonstrate that MARCH8 traps the viral glycoproteins in an intracellular compartment. We observe that the endogenous expression of
    MeSH term(s) Amino Acid Sequence ; Cells, Cultured ; Gene Expression Regulation/drug effects ; HEK293 Cells ; Humans ; Interferons/pharmacology ; Intracellular Space/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mutation ; RNA Viruses/classification ; RNA Viruses/metabolism ; Species Specificity ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Viral Envelope Proteins/chemistry ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Virion/metabolism ; Virus Replication
    Chemical Substances Membrane Proteins ; Viral Envelope Proteins ; Interferons (9008-11-1) ; MARCHF8 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00219-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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