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  1. Book ; Thesis: Siliziumnitrid: ein biokompatibler Werkstoff

    Reske, Thomas Marc

    Ergebnisse der Zellkultur

    2002  

    Author's details vorgelegt von Thomas Marc Reske
    Language German
    Size 65 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Essen, Univ., Diss., 2003
    HBZ-ID HT013666819
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 E 1744 order for loan Magazin

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  2. Book: VT-Fibel

    Reschke, Konrad / Lehmann, Katja / Mende, Thomas

    Verhaltenstherapie in Übersichten

    (Berichte aus der Psychologie)

    2005  

    Author's details Reschke ; Lehmann ; Mende
    Series title Berichte aus der Psychologie
    Keywords Verhaltenstherapie
    Language German
    Size 193 S. : Ill., 21 cm, 291 gr.
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book
    HBZ-ID HT014525973
    ISBN 3-8322-4230-9 ; 978-3-8322-4230-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 5349 order for loan Magazin

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  3. Article ; Online: Post-modification of PLLA nanofiber nonwovens by various solvent treatments

    Götz Andreas / Reske Thomas / Oschatz Stefan / Grabow Niels / Illner Sabine

    Current Directions in Biomedical Engineering, Vol 9, Iss 1, Pp 495-

    2023  Volume 498

    Abstract: Degradable polymeric Biomaterials, such as polylactic acid, are widely used in medical field as bioresorbable implant coatings. More recently, stent covers, implantable tubes or wound dressings made from electrospun nanofibers have been developed. In ... ...

    Abstract Degradable polymeric Biomaterials, such as polylactic acid, are widely used in medical field as bioresorbable implant coatings. More recently, stent covers, implantable tubes or wound dressings made from electrospun nanofibers have been developed. In order to tailor the material for specific applications, dedicated fine-tuning procedures are required. To modify fiber interconnection or porosity, solvents or their dilutions are applicable. In this work, the effect of differently diluted protic and aprotic-polar solvents on electrospun poly-L-lactic acid (PLLA) nonwovens was investigated via immersion or vapor exposure. Fiber adhesion was observed with protic solvents. Fiber destruction and increased polymer crystallinity was observed with aprotic polar solvents. The immersion duration revealed to be far more irrelevant than solvent dilution. None of the tested solvents affected molecular weight. This opens up significant research potential to replace halogenated solvents as a cornerstone of eco-friendly “green” electrospinning processes. The results of this study are suggesting that biomaterials with desired properties can be produced in a targeted manner.
    Keywords fiber interconnection ; solvent influence ; tailored morphology ; Medicine ; R
    Subject code 660
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Automated 3D thorax model generation using handheld video-footage.

    Dussel, Nadine / Fuchs, Reinhard / Reske, Andreas W / Neumuth, Thomas

    International journal of computer assisted radiology and surgery

    2022  Volume 17, Issue 9, Page(s) 1707–1716

    Abstract: Purpose: For the visualization of pulmonary ventilation with Electrical Impedance Tomography (EIT) most devices use standard reconstruction models, featuring common thorax dimensions and predetermined electrode locations. Any discrepancies between the ... ...

    Abstract Purpose: For the visualization of pulmonary ventilation with Electrical Impedance Tomography (EIT) most devices use standard reconstruction models, featuring common thorax dimensions and predetermined electrode locations. Any discrepancies between the available model and the patient in terms of body shape and electrode position lead to incorrectly displayed impedance distributions. This work addresses that problem by presenting and evaluating a method for 3D model generation of the thorax and any affixed electrodes based on handheld video-footage.
    Methods: Therefore, a process was developed, providing users with the ability to capture a patient's chest and the attached electrodes via smartphone. Once data is collected, extracted images are used to generate a 3D model with a structure from motion approach and locate electrodes with ArUco markers. For the evaluation of the developed method, multiple tests were performed in laboratory environments, which were compared with manually created reference models and differences quantified based on mean distance, standard deviation, and maximum distance.
    Results: The implemented workflow allows for automated model reconstruction based on videos or selected images captured with a handheld device. It generates sparse point clouds from which a surface mesh is reconstructed and returns relative coordinates of any identified ArUco marker. The average value for the mean distance error of two model generations was 5.4 mm while the mean standard deviation was 6.0 mm. The average runtime of twelve reconstructions was 5:17 min, with a minimal runtime of 3:22 min and a maximal runtime of 7:29 min.
    Conclusion: The presented methods and results show that model reconstruction of a patient's thorax and applied electrodes at an emergency site is feasible with already available devices. This is a first step toward the automated generation of patient-specific reconstruction models for Electrical Impedance Tomography based on images recorded with handheld devices.
    MeSH term(s) Electric Impedance ; Electrodes ; Humans ; Image Processing, Computer-Assisted/methods ; Thorax ; Tomography/methods ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-03-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2365628-1
    ISSN 1861-6429 ; 1861-6410
    ISSN (online) 1861-6429
    ISSN 1861-6410
    DOI 10.1007/s11548-022-02593-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6615: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Pirfenidone release from ophthalmic implants – perspectives for a drug-eluting microstent for glaucoma therapy

    Reske Thomas / Stahnke Thomas / Bajer Dalibor / Grabow Niels / Khaimov Valeria / Guthoff Rudolf F. / Schmitz Klaus-Peter / Siewert Stefan

    Current Directions in Biomedical Engineering, Vol 9, Iss 1, Pp 399-

    2023  Volume 402

    Abstract: Elevated intraocular pressure is the main risk factor for glaucoma and its adjustment to physiological levels can prevent progression of the disease. If conventional drop-based glaucoma therapy fails, surgical interventions such as trabeculectomy or the ... ...

    Abstract Elevated intraocular pressure is the main risk factor for glaucoma and its adjustment to physiological levels can prevent progression of the disease. If conventional drop-based glaucoma therapy fails, surgical interventions such as trabeculectomy or the application of implants, which drain aqueous humour from the eye and thus reduce intraocular pressure, are used as final therapeutic procedures. These interventions are becoming increasingly minimally invasive and the drainage implants are getting steadily smaller, which is why these interventions are now called microinvasive glaucoma surgery (MIGS). Both, surgery and drainage implant-based glaucoma therapy are limited by wound healing processes and fibrosis that occlude the newly created drainage pathways for the aqueous humour. To suppress unwanted postoperative fibrosis coupled with an increased extracellular matrix production, cytostatics like mitomycin c or 5- fluorouracil are currently used, which are associated with side effects. Therefore, more specific antifibrotic agents are key for a durable functionality of the interventions in glaucoma therapy. In this study a specific active substance (pirfenidone, PFD) was added in a polymer matrix for controlled release. Previous studies have shown that the release of pirfenidone from a thermoplastic silicone polycarbonate elastomer, which could be used as a material for a glaucoma drainage implant, has been relatively fast. To decelerate the release the influence of the alternate polymers Poly-L-Lactide (PLLA) and Poly-D,LLactide (PDLLA) as alternative drug carriers was investigated. Furthermore, a reduction of the pirfenidone content was used to delay the release.
    Keywords glaucoma microstent ; fibrosis ; drug release ; drug eluting system ; pirfenidone ; antifibrotic ; polymer ; Medicine ; R
    Subject code 660
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: DLP 3D printing of Dexamethasoneincorporated PEGDA-based photopolymers

    Mau Robert / Reske Thomas / Eickner Thomas / Grabow Niels / Seitz Hermann

    Current Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 406-

    compressive properties and drug release

    2020  Volume 409

    Abstract: Photopolymerizing, high-resolution 3D printing methods such as Stereolithography (SLA) or Digital Light Processing (DLP) are very promising for the manufacturing of drug-incorporated, patient specific implants. However, a drug-load may be limited by ... ...

    Abstract Photopolymerizing, high-resolution 3D printing methods such as Stereolithography (SLA) or Digital Light Processing (DLP) are very promising for the manufacturing of drug-incorporated, patient specific implants. However, a drug-load may be limited by adequately solubility of the active pharmaceutical ingredient (API) in the photopolymer. Furthermore, a drug-load may affect the mechanical properties of the material negatively. Here, we investigate the DLP 3D printing of drugincorporated photopolymers. Polyethylene glycol diacrylate (PEGDA, Mn = 700 g/mol) is used as matrix polymer and Dexamethasone (DEX) is used for drug-loading (10 g/L and 20 g/L). Compressive properties, drug release and drug stability of 3D printed test samples were analyzed. DEX was found to be sparingly soluble in the PEGDA-based photopolymer. Not all drug particles can be dissolved at a concentration of 20 g/L and a slurry-like suspension is formed. Drug-incorporated photopolymers of 10 g/L (solution) and 20 g/L (suspension) were processed successfully via DLP. The higher the drug-load, the lower the compressive strength. Mechanical properties can be improved via a post-curing in a UV light curing box. Drug-incorporated 3D printed test samples show burst-release of DEX. The post-curing process does not affect drug release. DEX degrades in 3D-printed test samples significantly (~ 30 %) over a several days time period.
    Keywords digital light processing (dlp) ; polyethylene glycol diacrylate (pegda) ; dexamethasone (dex) ; drug delivery ; drug release ; compressive strength ; Medicine ; R
    Subject code 660
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Biological test methods for stents

    Klußmann-Fricke Bastian-Jesper / Stahnke Thomas / Siewert Stefan / Reske Thomas / Bohne Eric / Schmitz Klaus-Peter / Khaimov Valeria

    Current Directions in Biomedical Engineering, Vol 8, Iss 2, Pp 392-

    cellular responses to microstructured biomaterials

    2022  Volume 395

    Abstract: One of the greatest challenges in the development of novel implants is to find materials that optimally interact with the tissue and support the function of the implant over a long period of time. Especially considering the fact that biomaterials are ... ...

    Abstract One of the greatest challenges in the development of novel implants is to find materials that optimally interact with the tissue and support the function of the implant over a long period of time. Especially considering the fact that biomaterials are used in multiple applications in modern implants, a better understanding of the physiology of the tissue in contact with the material becomes more and more important. To better understand the cellular responses to biomaterials, it is furthermore necessary that the models used reflect the physiological conditions at the implant site. However, in most cases, immortalized cell lines instead of tissue-specific primary cells are used to study the biocompatibility of implant materials. When interpreting these results, it is important to consider that cell lines differ significantly from primary cells found in their native environment. In this study, we examined the morphological differences between a cell line and primary cells upon contact with various implant structures resembling implant prototypes. Using a mouse fibroblast cell line in comparison with primary porcine fibroblasts, we discuss the results with respect to the use of cell lines for biocompatibility testing of biomaterials. Our results suggest that to better estimate meaningful results regarding the compatibility of implant structures, key control experiments should always be performed with specific primary cells.
    Keywords primary cells ; cell lines ; biocompatibility ; fibroblasts ; microscopy ; stent-prototypes ; Medicine ; R
    Subject code 612
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Safety evaluation of resveratrol as an active compound for drug-eluting cardiovascular implants

    Khaimov Valeria / Reske Thomas / Matschegewski Claudia / Grabow Niels / Eickner Thomas

    Current Directions in Biomedical Engineering, Vol 5, Iss 1, Pp 331-

    2019  Volume 333

    Abstract: Resveratrol is a member of stilbenoids with promising anti-atherosclerotic properties. This hallmark makes it an extremely interesting candidate for local drug delivery to damaged tissue adjacent to the implant in order to reduce implant-related ... ...

    Abstract Resveratrol is a member of stilbenoids with promising anti-atherosclerotic properties. This hallmark makes it an extremely interesting candidate for local drug delivery to damaged tissue adjacent to the implant in order to reduce implant-related complications. For the regulatory approval drug-eluting medical devices have to be thoroughly tested for safety, efficacy and interactions with the surrounding tissue, including tests for sensitization among others. Studies for sensitization help to estimate the risk for an allergic reaction upon prolonged exposure to a chemical compound. Due to increased social and regulatory demand for replacement of animal experiments by in vitro approaches a number of reliable predictive non-animal tests have been developed. Here, we assessed the skin sensitization potential of resveratrol by the direct peptide reactivity assay (DPRA), one of the first non-animal tests adopted by the OECD.
    Keywords stents ; endothelialization ; resveratrol ; drugeluting ; sensitization ; Medicine ; R
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Accelerated Degradation of polymeric surgical suture materials

    Reske Thomas / Eickner Thomas / Grabow Niels / Schmitz Klaus-Peter / Siewert Stefan

    Current Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 458-

    2020  Volume 460

    Abstract: The degradable polymer Polydioxanone (PDO) is used for medical implants since 1981. Manufacturers state a degradation timeframe of <180 days or an absorption duration of 182-238 days [1, 2]. Aim of this study was to find in vitro-conditions to degrade ... ...

    Abstract The degradable polymer Polydioxanone (PDO) is used for medical implants since 1981. Manufacturers state a degradation timeframe of <180 days or an absorption duration of 182-238 days [1, 2]. Aim of this study was to find in vitro-conditions to degrade PDO films within four weeks. Therefore the degradation of PDO was performed in accelerated conditions in tempered alkaline glycine NaOH buffer. Molecular weight and mass loss were studied. PDO results were compared with poly lactic-co-glycolic acid P(LLA-co-GA).
    Keywords biodegradable polydioxanone ; poly lactic-coglycolic acid ; accelerated degradation ; alkaline ; Medicine ; R
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Quantitative evaluation of cell morphology and material interactions on opaque biomaterials

    Klußmann-Fricke Bastian-J. / Reske Thomas / Schmitz Klaus-Peter / Siewert Stefan / Khaimov Valeria

    Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 664-

    2021  Volume 667

    Abstract: One of the key aspects in the development of novel implants is to find suitable materials and understand the mechanisms that occur when a material is exposed to the tissues of the human body. These mechanisms are commonly referred to as the ... ...

    Abstract One of the key aspects in the development of novel implants is to find suitable materials and understand the mechanisms that occur when a material is exposed to the tissues of the human body. These mechanisms are commonly referred to as the biocompatibility of the material. A better understanding of the tissue-material interactions becomes more urgent as biomaterials are used in wide-ranging applications like modern medical devices. However, most biomaterials used for implants are opaque, resulting in difficulties for the microscopical evaluation during in vitro biocompatibility testing. Particularly, cell morphology and adhesion capabilities of cells can provide insights in the interactions between implant materials and tissues at the implant site. To improve our capabilities in biocompatibility testing of novel biomaterials we applied a new method to quantitatively assess cellular parameters on opaque samples using fluorescence microscopy and bio-image analysis.
    Keywords biocompatibility ; microscopy ; biomaterials ; image analysis ; implant-tissue interactions ; Medicine ; R
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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