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  1. Article: [Pseudoaldosteronism].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2012  Volume 70 Suppl 6, Page(s) 720–724

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Glycyrrhiza/adverse effects ; Humans ; Liddle Syndrome/chemically induced ; Liddle Syndrome/diagnosis ; Male ; Middle Aged
    Language Japanese
    Publishing date 2012-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pregnancy-associated diabetes insipidus in Japan-a review based on quoting from the literatures reported during the period from 1982 to 2019.

    Takeda, Ryoyu / Demura, Masashi / Sugimura, Yoshihisa / Miyamori, Isamu / Konoshita, Tadashi / Yamamoto, Hiroshi

    Endocrine journal

    2021  Volume 68, Issue 4, Page(s) 375–385

    Abstract: This Review Article overviews the literature on diabetes insipidus (DI) associated with pregnancy and labor in Japan published from 1982 to 2019. The total number of patients collected was 361, however, only one-third of these cases had detailed ... ...

    Abstract This Review Article overviews the literature on diabetes insipidus (DI) associated with pregnancy and labor in Japan published from 1982 to 2019. The total number of patients collected was 361, however, only one-third of these cases had detailed pathophysiologic information enabling us to identify the respective etiology and subtype. Pregnancy-associated DI can be divided into 3 etiologies, central (neurogenic) DI, nephrogenic DI, and excess vasopressinase-associated DI. Neurogenic DI has various causes: for example, DI associated with tumoral lesions in the pituitary and neighboring area, DI associated with Sheehan's syndrome and/or pituitary apoplexy, and DI associated with lymphocytic infundibuloneurohypophysitis (LINH, stalkitis). Nephrogenic DI results from defective response of the kidney to normal levels of vasopressin. However, the most interesting causal factor of pregnancy-associated DI is excess vasopressinase, caused either by excess production of vasopressinase by the placenta or defective clearance of vasopressinase by the liver. Hepatic complications resulting in pregnancy-associated DI include acute fatty liver of pregnancy (AFLP) and HELLP syndrome (syndrome of hemolysis, elevated liver enzymes, low platelets), as well as pre-existing or co-incidental hepatic diseases. A possible role of glucose uptake in putative stress-induced DI and the importance of correct diagnosis and treatment of pregnancy-associated DI, including use of 1-deamino 8-D arginine vasopressin, are also discussed.
    MeSH term(s) Adult ; Cystinyl Aminopeptidase/blood ; Diabetes Insipidus/blood ; Diabetes Insipidus/etiology ; Female ; Humans ; Japan ; Pregnancy
    Chemical Substances Cystinyl Aminopeptidase (EC 3.4.11.3)
    Language English
    Publishing date 2021-03-23
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ20-0745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Synthetic mineralocorticoid].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2008  Volume 66, Issue 1, Page(s) 125–129

    Abstract: Fludrocortisone acetate (Florinef) is a synthetic steroid with a potent mineralocorticoid action, and used for treatment of Addison's disease and salt losing form of congenital adrenal hyperplasia. It is also used for severe hypotension to restore ... ...

    Abstract Fludrocortisone acetate (Florinef) is a synthetic steroid with a potent mineralocorticoid action, and used for treatment of Addison's disease and salt losing form of congenital adrenal hyperplasia. It is also used for severe hypotension to restore adequate plasma volume. Caution is necessary for possible side effects of hypernatremia, hypokalemia, hyperglycemia and congestive heart failure when used chronically. A synthetic steroid which selectively binds and activates renal MR-LBD but not GR, or non-epithelial MR, although not found at present, may be a promising mineralocorticoids to be used in the above disorders.
    MeSH term(s) Fludrocortisone/adverse effects ; Fludrocortisone/analogs & derivatives ; Fludrocortisone/therapeutic use ; Humans ; Mineralocorticoids/chemical synthesis ; Mineralocorticoids/pharmacology ; Receptors, Mineralocorticoid/drug effects
    Chemical Substances Mineralocorticoids ; Receptors, Mineralocorticoid ; Fludrocortisone (U0476M545B) ; fludrocortisone acetate (V47IF0PVH4)
    Language Japanese
    Publishing date 2008-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Drug-induced pseudoaldosteronism].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2007  Volume 65 Suppl 8, Page(s) 592–596

    MeSH term(s) 11-beta-Hydroxysteroid Dehydrogenase Type 2/antagonists & inhibitors ; Early Diagnosis ; Glycyrrhiza/adverse effects ; Glycyrrhizic Acid/adverse effects ; Humans ; Hyperaldosteronism/chemically induced ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/physiopathology ; Hyperaldosteronism/therapy ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Spironolactone/therapeutic use
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Spironolactone (27O7W4T232) ; Glycyrrhizic Acid (6FO62043WK) ; 11-beta-Hydroxysteroid Dehydrogenase Type 2 (EC 1.1.1.146)
    Language Japanese
    Publishing date 2007-10-28
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Vascular action of aldosterone].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2005  Volume 63 Suppl 3, Page(s) 263–268

    MeSH term(s) Aldosterone/physiology ; Animals ; Blood Vessels/physiology ; Humans
    Chemical Substances Aldosterone (4964P6T9RB)
    Language Japanese
    Publishing date 2005-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Cellular function of 11beta-HSD1].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2006  Volume Suppl 1, Page(s) 648–650

    MeSH term(s) 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors ; 11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics ; 11-beta-Hydroxysteroid Dehydrogenase Type 1/physiology ; Adipocytes/metabolism ; Animals ; Cortisone/metabolism ; Humans ; Hydrocortisone/biosynthesis ; Hydrocortisone/physiology ; Metabolic Syndrome/etiology ; Obesity/etiology ; Organ Specificity
    Chemical Substances 11-beta-Hydroxysteroid Dehydrogenase Type 1 (EC 1.1.1.146) ; Cortisone (V27W9254FZ) ; Hydrocortisone (WI4X0X7BPJ)
    Language Japanese
    Publishing date 2006-05-28
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Pseudo aldosteronism].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2006  Volume Suppl 1, Page(s) 645–647

    MeSH term(s) 11-beta-Hydroxysteroid Dehydrogenase Type 2/antagonists & inhibitors ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Glycyrrhiza/adverse effects ; Glycyrrhizic Acid/adverse effects ; Humans ; Hydrocortisone/metabolism ; Hyperaldosteronism/etiology ; Hyperaldosteronism/therapy ; Hypertension/complications ; Mineralocorticoid Receptor Antagonists/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Mineralocorticoid Receptor Antagonists ; Glycyrrhizic Acid (6FO62043WK) ; 11-beta-Hydroxysteroid Dehydrogenase Type 2 (EC 1.1.1.146) ; Hydrocortisone (WI4X0X7BPJ)
    Language Japanese
    Publishing date 2006-05-28
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Aldosterone biosynthesis and related enzyme genes].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2005  Volume 63 Suppl 3, Page(s) 213–219

    MeSH term(s) Aldosterone/biosynthesis ; Cytochrome P-450 CYP11B2/genetics ; Humans ; Steroid 11-beta-Hydroxylase/genetics
    Chemical Substances Aldosterone (4964P6T9RB) ; Cytochrome P-450 CYP11B2 (EC 1.14.15.4) ; Steroid 11-beta-Hydroxylase (EC 1.14.15.4)
    Language Japanese
    Publishing date 2005-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Involvement of Aldosterone and mineralocorticoid receptor in pathogenesis of cardiovascular diseases].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2004  Volume 62 Suppl 3, Page(s) 144–146

    MeSH term(s) 11-beta-Hydroxysteroid Dehydrogenase Type 2/physiology ; Aldosterone/pharmacology ; Aldosterone/physiology ; Angiotensin II/metabolism ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Fibrosis ; Humans ; Hydrocortisone/metabolism ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Myocardium/pathology ; Plasminogen Activator Inhibitor 1/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Receptors, Mineralocorticoid/physiology ; Spironolactone/therapeutic use
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Plasminogen Activator Inhibitor 1 ; Receptor, Angiotensin, Type 1 ; Receptors, Mineralocorticoid ; Angiotensin II (11128-99-7) ; Spironolactone (27O7W4T232) ; Aldosterone (4964P6T9RB) ; 11-beta-Hydroxysteroid Dehydrogenase Type 2 (EC 1.1.1.146) ; Hydrocortisone (WI4X0X7BPJ)
    Language Japanese
    Publishing date 2004-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Aldosterone].

    Miyamori, Isamu

    Nihon rinsho. Japanese journal of clinical medicine

    2004  Volume 62, Issue 1, Page(s) 37–42

    Abstract: Nonepithelial effect of aldosterone has been recognized as a cardiovascular risk factor independent of elevation of blood pressure. Pro-inflammatory effect of aldosterone in vasculature appears to be an initiating event for the target organ injuries. ... ...

    Abstract Nonepithelial effect of aldosterone has been recognized as a cardiovascular risk factor independent of elevation of blood pressure. Pro-inflammatory effect of aldosterone in vasculature appears to be an initiating event for the target organ injuries. Recent clinical trials of aldosterone receptor blockers in congestive heart failure indicate the efficacy of aldosterone antagonism to prevent cardiac death. In addition to elevated plasma levels of aldosterone, mineralocorticoid receptor expression in cardiovascular tissues may contribute to the progression of heart failure. In this review, emerging role of aldosterone as a cardiovascular risk is highlighted.
    MeSH term(s) Aldosterone/physiology ; Animals ; Heart Failure/drug therapy ; Humans ; Receptors, Mineralocorticoid/drug effects
    Chemical Substances Receptors, Mineralocorticoid ; Aldosterone (4964P6T9RB)
    Language Japanese
    Publishing date 2004-01
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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