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  1. Article ; Online: Y-Configuration Stenting for Coil Embolization of Complex Intracranial Aneurysms: Distinguishing Between Use of Crossing-Y and Kissing-Y.

    Sato, Kenichi / Matsumoto, Yasushi / Kanoke, Atsushi / Ito, Akira / Fujimura, Miki / Tominaga, Teiji

    World neurosurgery

    2020  Volume 146, Page(s) e1054–e1062

    Abstract: Objective: Coil embolization with Y stenting is recognized as a suitable treatment for complex ... wide-necked aneurysms. Y stenting comprises crossing-Y stenting, in which a stent is passed ... through the interstices of another stent, and kissing-Y stenting, in which 2 stents are arranged in parallel. The purpose ...

    Abstract Objective: Coil embolization with Y stenting is recognized as a suitable treatment for complex wide-necked aneurysms. Y stenting comprises crossing-Y stenting, in which a stent is passed through the interstices of another stent, and kissing-Y stenting, in which 2 stents are arranged in parallel. The purpose of this study was to elucidate how to distinguish between use of the 2 Y-stenting techniques.
    Methods: Clinical and angiographic data of patients who underwent coil embolization with Y stenting at our department from 2015 to 2019 were retrospectively analyzed. Basic characteristics, endovascular procedure, complications, and outcomes were compared between kissing-Y and crossing-Y stenting groups.
    Results: Thirty-eight intracranial aneurysms in 38 consecutive patients were included in this study. Nineteen patients (50%) were treated with coil embolization with kissing-Y stenting and 19 (50%) with crossing-Y. Endovascular procedures were successfully performed in all but 1 patient, in the kissing-Y group, who had stent migration. One hemorrhage (2.6%) recurred 12 months after coiling with kissing-Y stenting. Angiographic follow-up (mean, 15.8 months) was available in 35 patients. Adequate occlusion was shown in 14 patients (77.8%) and 13 patients (76.5%) in the kissing-Y and crossing-Y groups, respectively. Larger, wider-necked, and more proximal aneurysms were treated with kissing-Y stenting than with crossing-Y stenting, although there were no significant differences between the groups in complication rates or clinical outcomes.
    Conclusions: Kissing-Y and crossing-Y stenting of intracranial aneurysms were both feasible and yielded reasonable angiographic and clinical results. The choice between the kissing-Y or crossing-Y-stenting technique should be decided according to the angioarchitecture of targeted aneurysms.
    MeSH term(s) Aged ; Aged, 80 and over ; Aneurysm, Ruptured/surgery ; Asymptomatic Diseases ; Cerebral Angiography ; Embolization, Therapeutic ; Endovascular Procedures/methods ; Female ; Headache/physiopathology ; Humans ; Hydrocephalus/physiopathology ; Intracranial Aneurysm/physiopathology ; Intracranial Aneurysm/surgery ; Male ; Middle Aged ; Ocular Motility Disorders/physiopathology ; Prosthesis Failure ; Retrospective Studies ; Stents ; Subarachnoid Hemorrhage/surgery ; Vision Disorders/physiopathology
    Language English
    Publishing date 2020-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.11.092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Monocaprin Enhances Bioavailability of Fucoxanthin in Diabetic/Obese KK- A y Mice

    Kodai Nagata / Naoki Takatani / Fumiaki Beppu / Aya Abe / Etsuko Tominaga / Tomohisa Fukuhara / Makoto Ozeki / Masashi Hosokawa

    Marine Drugs, Vol 20, Iss 446, p

    2022  Volume 446

    Abstract: ... obese KK- A y mice. After 4 weeks of feeding with the experimental diets, the serum fucoxanthinol ...

    Abstract Fucoxanthin is a marine carotenoid found in brown seaweeds and several microalgae. It has been reported that fucoxanthin has health benefits such as anti-obesity and anti-diabetic effects. To facilitate fucoxanthin applications in the food industry, it is important to improve its low bioavailability. We attempted the combined feeding of fucoxanthin-containing seaweed oil (SO) and monocaprin in a powder diet and analyzed the fucoxanthin metabolite contents in the liver, small intestine and serum of diabetic/obese KK- A y mice. After 4 weeks of feeding with the experimental diets, the serum fucoxanthinol concentrations of the mice fed 0.2% SO and 0.5% monocaprin were higher than those of the 0.2% SO-fed mice. Furthermore, fucoxanthinol accumulation in the liver and small intestine tended to increase in a combination diet of 0.2% SO and 0.125–0.5% monocaprin compared with a diet of 0.2% SO alone, although amarouciaxanthin A accumulation was not different among the 0.2% SO-fed groups. These results suggest that a combination of monocaprin with fucoxanthin-containing SO is an effective treatment for improving the bioavailability of fucoxanthin.
    Keywords fucoxanthin ; monocaprin ; bioavailability ; fucoxanthinol ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Preparation and characterization of concentrated y-Oryzanol nanodispersions by solvent displacement method: Effect of processing conditions on nanoparticles formation

    Taarji, Noamane / Bouhoute, Meryem / Kobayashi, Isao / Tominaga, Kenichi / Isoda, Hiroko / Nakajima, Mitsutoshi

    Food hydrocolloids

    2022  Volume 123, Issue -, Page(s) 107161

    Language English
    Document type Article
    ZDB-ID 742742-6
    ISSN 0268-005X
    Database Current Contents Nutrition, Environment, Agriculture

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  4. Article ; Online: Rapid selection of XO embryonic stem cells using Y chromosome-linked GFP transgenic mice.

    Yamamoto, Satoshi / Nagao, Yasumitsu / Kuroiwa, Kenji / Hakamata, Yoji / Ichida, Masaru / Saito-Ohara, Fumiko / Tominaga, Kaoru / Endo, Hitoshi

    Transgenic research

    2014  Volume 23, Issue 5, Page(s) 757–765

    Abstract: We developed a transgenic mouse line with Y chromosome-linked green fluorescent protein expressing ... transgenes (Y-GFP) by the conventional microinjection into the pronucleus of C57BL/6J fertilized oocytes ... Embryonic stem (ES) cells derived from Y-GFP mice enabled not only sexing but also the identification of 39 ...

    Abstract We developed a transgenic mouse line with Y chromosome-linked green fluorescent protein expressing transgenes (Y-GFP) by the conventional microinjection into the pronucleus of C57BL/6J fertilized oocytes. Embryonic stem (ES) cells derived from Y-GFP mice enabled not only sexing but also the identification of 39, XO karyotype by the lack of Y chromosome. Actually, when fluorescence activated cell sorting (FACS) was applied to Y-GFP ES cells, non-fluorescent ES cells were conveniently collected and showed the lack of Y chromosome by PCR genotyping and Southern blot analysis. FACS analysis revealed Y chromosome loss occurred at 2.9 % of 40, XY ES cells after five passages. These Y-GFP ES cells are potentially applicable to reduce the time, cost and effort needed to generate the gene-targeted mice by the production of male and female mice derived from the same ES cell clone.
    MeSH term(s) Abnormal Karyotype ; Animals ; Blotting, Southern ; DNA Primers/genetics ; Embryonic Stem Cells/cytology ; Female ; Flow Cytometry/methods ; Gene Transfer Techniques ; Genes, Y-Linked/genetics ; Green Fluorescent Proteins/genetics ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Polymerase Chain Reaction ; Transgenes/genetics
    Chemical Substances DNA Primers ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2014-07-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 31620-9
    ISSN 1573-9368 ; 0962-8819
    ISSN (online) 1573-9368
    ISSN 0962-8819
    DOI 10.1007/s11248-014-9813-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Revascularization of the anterior cerebral artery by Y-shaped superficial temporal artery interposition graft for the treatment of a de novo aneurysm arising at the site of A3-A3 bypass: technical case report.

    Endo, Hidenori / Sugiyama, Shin-Ichiro / Endo, Toshiki / Fujimura, Miki / Shimizu, Hiroaki / Tominaga, Teiji

    Journal of neurosurgery

    2018  Volume 129, Issue 5, Page(s) 1120–1124

    Abstract: ... in the front wall of the anastomosis site, where the aneurysm developed. A Y-shaped superficial temporal artery ... an underlying cause of the aneurysm formation. A Y-shaped STA interposition graft is a useful option to treat ...

    Abstract The most frequently used option to reconstruct the anterior cerebral artery (ACA) is an ACA-ACA side-to-side anastomosis. The long-term outcome and complications of this technique are unclear. The authors report a case of a de novo aneurysm arising at the site of A3-A3 anastomosis. A 53-year-old woman underwent A3-A3 side-to-side anastomosis for the treatment of a ruptured right A2 dissecting aneurysm. At 44 months after surgery, a de novo aneurysm developed at the site of anastomosis. The aneurysm developed in the front wall of the anastomosis site, and projected to the anterosuperior direction. A computational fluid dynamics (CFD) study showed the localized region with high wall shear stress coincident with the pulsation in the front wall of the anastomosis site, where the aneurysm developed. A Y-shaped superficial temporal artery (STA) interposition graft was used successfully to reconstruct both ACAs, and then the aneurysm was trapped. To the authors' knowledge, this is the first case of a de novo aneurysm that developed at the site of an ACA-ACA side-to-side anastomosis. A CFD study showed that hemodynamic stress might be an underlying cause of the aneurysm formation. A Y-shaped STA interposition graft is a useful option to treat this aneurysm. Long-term follow-up is necessary to detect this rare complication after ACA-ACA anastomosis.
    MeSH term(s) Anterior Cerebral Artery/diagnostic imaging ; Anterior Cerebral Artery/surgery ; Cerebral Angiography ; Cerebral Revascularization/methods ; Female ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Middle Aged ; Neurosurgical Procedures/methods ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/surgery ; Temporal Arteries/transplantation ; Treatment Outcome
    Language English
    Publishing date 2018-01-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2017.6.JNS17931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Answer to the Letter to the Editor of J. Huang et al. concerning "Risk factors for surgical site infection and urinary tract infection after spine surgery" by Tominaga H, Setoguchi T, Ishidou Y, Nagano S, Yamamoto T, and Komiya S (2016) Eur Spine J; DOI 10.1007/s00586-016-4674-2.

    Tominaga, Hiroyuki

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2016  Volume 25, Issue 11, Page(s) 3772

    Language English
    Publishing date 2016-11
    Publishing country Germany
    Document type Letter
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-016-4775-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Combined leaf gas-exchange system for model assessment.

    Tominaga, Jun / Kawamitsu, Yoshinobu

    Journal of experimental botany

    2024  

    Abstract: Leaf gas-exchange measurements are useful in assessing environmental responses of plants. However, uncertainties in the leaf gas-exchange model potentially limit its application. The main challenge in the model-dependent calculations is to detect ... ...

    Abstract Leaf gas-exchange measurements are useful in assessing environmental responses of plants. However, uncertainties in the leaf gas-exchange model potentially limit its application. The main challenge in the model-dependent calculations is to detect violations of assumptions. Here, we developed a system that integrates the direct measurement of leaf intercellular CO2 concentration and the standard open-flow (OF) and novel open-diffusion (OD) systems for flux measurement into one instrument. In the OD system, a gas-permeable membrane between the leaf ambient and outside air creates CO2 and H2O differentials, rather than the air flow in the OF chamber. We measured hypostomatous and amphistomatous leaves of several species with different photosynthetic capacities. The CO2 and H2O differentials in the OD system strictly depend on the flux measured by the OF system. The lower permeability of the membrane resulted in a larger differential per flux, indicating that the OD system can increase the resolution for a small flux. An analysis of conductance model and observations suggested that cuticle and leaf intercellular conductances and the unsaturation of leaf humidity contributed to discrepancies between the direct measurement and standard calculation. The developed combined system provides an opportunity to address these overlooked concepts in leaf gas exchange.
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erae081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor.

    Kanayama, Hiroyuki / Tominaga, Takashi / Tominaga, Yoko / Kato, Nobuo / Yoshimura, Hiroshi

    The journal of physiological sciences : JPS

    2024  Volume 74, Issue 1, Page(s) 16

    Abstract: The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of ... ...

    Abstract The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABA
    MeSH term(s) Rats ; Animals ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, GABA-B/metabolism ; Somatosensory Cortex/metabolism ; Baclofen
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; Receptors, GABA-B ; Baclofen (H789N3FKE8)
    Language English
    Publishing date 2024-03-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-024-00911-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Stable wide-field voltage imaging for observing neuronal plasticity at the neuronal network level.

    Tominaga, Takashi / Kajiwara, Riichi / Tominaga, Yoko

    Biophysics and physicobiology

    2023  Volume 20, Issue 1, Page(s) e200015

    Abstract: Plasticity is the key feature of our brain function. Specifically, plasticity of hippocampal synapses is critical for learning and memory. The functional properties of the neuronal circuit change as a result of synaptic plasticity. This review summarizes ...

    Abstract Plasticity is the key feature of our brain function. Specifically, plasticity of hippocampal synapses is critical for learning and memory. The functional properties of the neuronal circuit change as a result of synaptic plasticity. This review summarizes the use of voltage-sensitive dyes (VSDs) to examine neuronal circuit plasticity. We will discuss the significance of plastic changes in circuit function as well as the technical issue of using VSDs. Further, we will discuss the neural circuit level plasticity of the hippocampus caused by long-term potentiation and the entorhinal-perirhinal connection. This review article is an extended version of the Japanese article, Membrane Potential Imaging with Voltage-sensitive Dye (VSD) for Long-term Recording, published in SEIBUTSU BUTSURI Vol. 61, p. 404-408 (2021).
    Language English
    Publishing date 2023-03-11
    Publishing country Japan
    Document type Journal Article
    ISSN 2189-4779
    ISSN 2189-4779
    DOI 10.2142/biophysico.bppb-v20.0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Functional Dissection of Ipsilateral and Contralateral Neural Activity Propagation Using Voltage-Sensitive Dye Imaging in Mouse Prefrontal Cortex.

    Gusain, Pooja / Taketoshi, Makiko / Tominaga, Yoko / Tominaga, Takashi

    eNeuro

    2023  Volume 10, Issue 12

    Abstract: Prefrontal cortex (PFC) intrahemispheric activity and the interhemispheric connection have a significant impact on neuropsychiatric disorder pathology. This study aimed to generate a functional map of FC intrahemispheric and interhemispheric connections. ...

    Abstract Prefrontal cortex (PFC) intrahemispheric activity and the interhemispheric connection have a significant impact on neuropsychiatric disorder pathology. This study aimed to generate a functional map of FC intrahemispheric and interhemispheric connections. Functional dissection of mouse PFCs was performed using the voltage-sensitive dye (VSD) imaging method with high speed (1 ms/frame), high resolution (256 × 256 pixels), and a large field of view (∼10 mm). Acute serial 350 μm slices were prepared from the bregma covering the PFC and numbered 1-5 based on their distance from the bregma (i.e., 1.70, 1.34, 0.98, 0.62, and 0.26 mm) with reference to the Mouse Brain Atlas (Paxinos and Franklin, 2008). The neural response to electrical stimulation was measured at nine sites and then averaged, and a functional map of the propagation patterns was created. Intracortical propagation was observed in slices 3-5, encompassing the anterior cingulate cortex (ACC) and corpus callosum (CC). The activity reached area 33 of the ACC. Direct white matter stimulation activated area 33 in both hemispheres. Similar findings were obtained via DiI staining of the CC. Imaging analysis revealed directional biases in neural signals traveling within the ACC, whereby the signal transmission speed and probability varied based on the signal direction. Specifically, the spread of neural signals from cg2 to cg1 was stronger than that from cingulate cortex area 1(cg1) to cingulate cortex area 2(cg2), which has implications for interhemispheric functional connections. These findings highlight the importance of understanding the PFC functional anatomy in evaluating neuromodulators like serotonin and dopamine, as well as other factors related to neuropsychiatric diseases.
    MeSH term(s) Mice ; Animals ; Voltage-Sensitive Dye Imaging ; Corpus Callosum/physiology ; Gyrus Cinguli/physiology ; Prefrontal Cortex/diagnostic imaging ; Serotonin ; Neural Pathways/physiology
    Chemical Substances Serotonin (333DO1RDJY)
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0161-23.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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