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Article ; Online: ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis.

Xiong, Mengneng / Yin, Lisha / Gui, Yiqian / Lv, Chunyu / Ma, Xixiang / Guo, Shuangshuang / Wu, Yanqing / Feng, Shenglei / Fan, Xv / Zhou, Shumin / Wang, Lingjuan / Wen, Yujiao / Wang, Xiaoli / Xie, Qingzhen / Namekawa, Satoshi H / Yuan, Shuiqiao

The Journal of cell biology

2023 Volume 222, Issue 5

Abstract: ... pachytene piRNA biogenesis with regard to the lack of a secondary amplification process known as the Ping ... pong cycle. However, the underlying molecular mechanism and the venue for the suppression of the Ping ... family member protein RNF17 and is associated with P-bodies. Importantly, ADAD2 directs RNF17 to repress Ping ...

Abstract	Pachytene piRNA biogenesis is a hallmark of the germline, distinct from another wave of pre-pachytene piRNA biogenesis with regard to the lack of a secondary amplification process known as the Ping-pong cycle. However, the underlying molecular mechanism and the venue for the suppression of the Ping-pong cycle remain elusive. Here, we showed that a testis-specific protein, ADAD2, interacts with a TDRD family member protein RNF17 and is associated with P-bodies. Importantly, ADAD2 directs RNF17 to repress Ping-pong activity in pachytene piRNA biogenesis. The P-body localization of RNF17 requires the intrinsically disordered domain of ADAD2. Deletion of Adad2 or Rnf17 causes the mislocalization of each other and subsequent Ping-pong activity derepression, secondary piRNAs overproduced, and disruption of P-body integrity at the meiotic stage, thereby leading to spermatogenesis arrested at the round spermatid stage. Collectively, by identifying the ADAD2-dependent mechanism, our study reveals a novel function of P-bodies in suppressing Ping-pong activity in pachytene piRNA biogenesis.
MeSH term(s)	Male ; Meiotic Prophase I ; Piwi-Interacting RNA ; Processing Bodies ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Spermatogenesis/genetics
Chemical Substances	Piwi-Interacting RNA ; RNA, Small Interfering
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202206067
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Erratum: PING WANG (), GUANGLIN XIE () & WENKAI WANG () (2022) Description of a new species of the genus Anoplophora Hope, 1839 (Coleoptera: Cerambycidae, Lamiinae). Zootaxa, 5195 (1): 97-100.

Wang, Ping / Xie, Guanglin / Wang, Wenkai

Zootaxa

2022 Volume 5209, Issue 5, Page(s) 599

Language	English
Publishing date	2022-11-21
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5209.5.8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Erratum: PING WANG (), GUANGLIN XIE () & WENKAI WANG () (2022) Description of a new species of the genus Sinodorcadion Gressitt, 1939 (Coleoptera: Cerambycidae: Lamiinae). Zootaxa, 5195 (4): 385-390.

Wang, Ping / Xie, Guanglin / Wang, Wenkai

Zootaxa

2022 Volume 5209, Issue 5, Page(s) 600

Language	English
Publishing date	2022-11-21
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5209.5.9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise

Wang, Di / Li, Quan / Pan, Chun-Shui / Yan, Li / Sun, Kai / Wang, Xiao-Yi / Anwaier, Gulinigaer / Liao, Qian-Zan / Xie, Ting-Ting / Fan, Jing-Yu / Huo, Xin-Mei / Wang, Yuan / Han, Jing-Yan

Frontiers in pharmacology

2022 Volume 13, Page(s) 891802

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.891802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise via Regulation of Cytoskeleton

Di Wang / Quan Li / Chun-Shui Pan / Li Yan / Kai Sun / Xiao-Yi Wang / Gulinigaer Anwaier / Qian-Zan Liao / Ting-Ting Xie / Jing-Yu Fan / Xin-Mei Huo / Yuan Wang / Jing-Yan Han

Frontiers in Pharmacology, Vol

2022 Volume 13

Abstract: Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used ...

Abstract	Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used in China for respiratory diseases. However, the role of YPF in alveolar-capillary barrier dysfunction remains unknown. This study aimed to explore the effect and potential mechanism of YPF on alveolar-capillary barrier injury induced by exhausted exercise.Methods: Male Sprague–Dawley rats were used to establish an exhausted-exercise model by using a motorized rodent treadmill. YPF at doses of 2.18 g/kg was administrated by gavage before exercise training for 10 consecutive days. Food intake-weight/body weight, blood gas analysis, lung water percent content, BALF protein concentration, morphological observation, quantitative proteomics, real-time PCR, and Western blot were performed. A rat pulmonary microvascular endothelial cell line (PMVEC) subjected to hypoxia was applied for assessing the related mechanism.Results: YPF attenuated the decrease of food intake weight/body weight, improved lung swelling and hemorrhage, alleviated the increase of lung water percent content and BALF protein concentration, and inhibited the impairment of lung morphology. In addition, YPF increased the expression of claudin 3, claudin 18, occludin, VE-cadherin, and β-catenin, attenuated the epithelial and endothelial hyperpermeability in vivo and/or in vitro, and the stress fiber formation in PMVECs after hypoxia. Quantitative proteomics discovered that the effect of YPF implicated the Siah2-ubiquitin-proteasomal pathway, Gng12-PAK1-MLCK, and RhoA/ROCK, which was further confirmed by Western blot. Data are available via ProteomeXchange with identifier PXD032737.Conclusion: YPF ameliorated alveolar-capillary barrier injury induced by exhausted exercise, which is accounted for at least partly by the regulation of cytoskeleton.
Keywords	traditional Chinese medicine ; lung injury ; proteomics ; cell junctions ; stress fiber ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells.

Du, Yingqing / Zheng, Yuzhong / Yu, Ciel Xiaomei / Zhong, Lishan / Li, Yafang / Wu, Baomeng / Hu, Weihui / Zhu, Elsa Wanyi / Xie, Venus Wei / Xu, Qitian / Zhan, Xingri / Huang, Yamiao / Zeng, Liyi / Zhang, Zhenxia / Liu, Xi / Yin, Jiachuan / Zha, Guangcai / Chan, Kelvin / Tsim, Karl Wah Keung

Frontiers in pharmacology

2021 Volume 12, Page(s) 678126

Abstract: ... however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS ...

Abstract	Cisplatin is one of the first line anti-cancer drugs prescribed for treatment of solid tumors; however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS), a well-known ancient Chinese herbal combination formula consisting of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, is prescribed as a herbal decoction to treat immune disorders in clinic. To understand the fast-onset action of YPFS as an anti-cancer drug to fight against the drug resistance of cisplatin, we provided detailed analyses of intracellular cisplatin accumulation, cell viability, and expressions and activities of ATP-binding cassette transporters and glutathione S-transferases (GSTs) in YPFS-treated lung cancer cell lines. In cultured A549 or its cisplatin-resistance A549/DDP cells, application of YPFS increased accumulation of intracellular cisplatin, resulting in lower cell viability. In parallel, the activities and expressions of ATP-binding cassette transporters and GSTs were down-regulated in the presence of YPFS. The expression of p65 subunit of NF-κB complex was reduced by treating the cultures with YPFS, leading to a high ratio of Bax/Bcl-2, i.e. increasing the rate of cell death. Prim-O-glucosylcimifugin, one of the abundant ingredients in YPFS, modulated the activity of GSTs, and then elevated cisplatin accumulation, resulting in increased cell apoptosis. The present result supports the notion of YPFS in reversing drug resistance of cisplatin in lung cancer cells by elevating of intracellular cisplatin, and the underlying mechanism may be down regulating the activities and expressions of ATP-binding cassette transporters and GSTs.
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.678126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze.

Han, Jingzhe / Xie, Yanan / Yan, Haiyan / Cao, Yuecheng / HongmeiWang / Cao, Duanhua

BMC neurology

2019 Volume 19, Issue 1, Page(s) 28

Abstract: Background: Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports ... accompanied by saccadic ping pong gaze. Intravenous immunoglobulin (0.4 g/kg) was given for immunomodulation ...

Abstract	Background: Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b antibody syndrome with Bickerstaff's Encephalitis (BBE) overlapping classic Guillain-Barre Syndrome (GBS) after aortic valve replacement, accompanied by an excessive PPG in the course of diagnosis and treatment, this was indeed rarely. Case presentation: A 55-year-old male patient was admitted to our hospital with intermittent chest tightness for 3 months, and his condition has worsened in the past 10 days. Aortic valve replacement was performed because of the existence of the moderate and severe stenosis of aortic valve. Horizontal movement of the eyeball was involuntarily slow. The eyeball hovered and returned from one side to the other horizontally for 3-4 s per cycle. In combination with the patient's typical clinical and laboratory tests, the final diagnosis was anti GQ1b antibody syndrome BBE combined with GBS, accompanied by saccadic ping pong gaze. Intravenous immunoglobulin (0.4 g/kg) was given for immunomodulation, methylprednisolone (1000 mg) therapy and symptomatic treatment were performed in the patient. Conclusions: The patients were discharged from hospital on the thirtieth day because of economic reasons. After 6 months of follow up, the patients left behind a lack of fluency in speech and limb mobility, but the basic life can be taken care of by himself.
MeSH term(s)	Aortic Valve Stenosis/surgery ; Autoantibodies/immunology ; Cardiovascular Surgical Procedures/adverse effects ; Encephalitis/complications ; Encephalitis/drug therapy ; Encephalitis/immunology ; Gangliosides/immunology ; Guillain-Barre Syndrome/complications ; Guillain-Barre Syndrome/drug therapy ; Guillain-Barre Syndrome/immunology ; Heart Valve Prosthesis ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Middle Aged ; Ocular Motility Disorders/immunology
Chemical Substances	Autoantibodies ; Gangliosides ; Immunoglobulins, Intravenous ; GQ1b ganglioside (68652-37-9)
Language	English
Publishing date	2019-02-19
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1471-2377
ISSN (online)	1471-2377
DOI	10.1186/s12883-019-1258-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bidirectional ventricular tachycardia: ping pong in the His-Purkinje system.

Baher, Alex A / Uy, Matthew / Xie, Fagen / Garfinkel, Alan / Qu, Zhilin / Weiss, James N

Heart rhythm

2010 Volume 8, Issue 4, Page(s) 599–605

Abstract: ... was to evaluate a simple "ping pong" model of reciprocating bigeminy to explain BVT.: Methods ... produced polymorphic VT.: Conclusion: This "ping pong" mechanism of reciprocating bigeminy readily ...

Abstract	Background: Bidirectional ventricular tachycardia (BVT), which is characterized by an alternating beat-to-beat ECG QRS axis, is a rare but intriguing arrhythmia associated with digitalis toxicity, familial catecholaminergic polymorphic ventricular tachycardia (CPVT), and several other conditions that predispose cardiac myocytes to delayed afterdepolarizations (DADs) and triggered activity. Evidence from human and animal studies attributes BVT to alternating ectopic foci originating from the distal His-Purkinje system in the left and/or right ventricle, respectively. Objective: The purpose of this study was to evaluate a simple "ping pong" model of reciprocating bigeminy to explain BVT. Methods: We constructed a two-dimensional anatomic model of the rabbit ventricles with a simplified His-Purkinje system, in which different sites in the His-Purkinje system had different heart rate thresholds for DAD-induced bigeminy. Results: When the heart rate exceeded the threshold for bigeminy at the first site in the His-Purkinje system, ventricular bigeminy developed, causing the heart rate to accelerate and exceed the threshold for bigeminy at the second site. Thus, the triggered beat from the first site induced a triggered beat from the second site. The triggered beat from the second site next reciprocated by inducing a triggered beat from the first site, and so forth. Bigeminy from two sites produced BVT, and that from three or more sites produced polymorphic VT. Conclusion: This "ping pong" mechanism of reciprocating bigeminy readily produces the characteristic ECG pattern of BVT and its degeneration to polymorphic VT if additional sites develop bigeminy.
MeSH term(s)	Action Potentials/physiology ; Animals ; Bundle of His/pathology ; Bundle of His/physiopathology ; Computer Simulation ; Disease Models, Animal ; Electrocardiography ; Heart Rate ; Models, Anatomic ; Purkinje Fibers/pathology ; Purkinje Fibers/physiopathology ; Rabbits ; Tachycardia/pathology ; Tachycardia/physiopathology ; Tachycardia, Ventricular/pathology ; Tachycardia, Ventricular/physiopathology
Language	English
Publishing date	2010-11-29
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2010.11.038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Screening active components from Yu-ping-feng-san for regulating initiative key factors in allergic sensitization.

Shen, Dandan / Xie, Xuejian / Zhu, Zhijie / Yu, Xi / Liu, Hailiang / Wang, Huizhu / Fan, Hongwei / Wang, Dawei / Jiang, Guorong / Hong, Min

PloS one

2014 Volume 9, Issue 9, Page(s) e107279

Abstract: Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases ...

Abstract	Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse. Our previous studies demonstrated that YPFS efficiently inhibited T helper 2 cytokines in allergic inflammation. The underlying mechanisms of action of YPFS and its effective components remain unclear. In this study, it was shown that YPFS significantly inhibited production of thymic stromal lymphopoietin (TSLP), an epithelial cell-derived initiative factor in allergic inflammation, in vitro and in vivo. A method of human bronchial epithelial cell (16HBE) binding combined with HPLC-MS (named 16HBE-HPLC-MS) was established to explore potential active components of YPFS. The following five components bound to 16HBE cells: calycosin-7-glucoside, ononin, claycosin, sec-o-glucosylhamaudol and formononetin. Serum from YPFS-treated mice was analyzed and three major components were detected claycosin, formononetin and cimifugin. Among these, claycosin and formononetin were detected by 16HBE-HPLC-MS and in the serum of YPFS-treated mice. Claycosin and formononetin decreased the level of TSLP markedly at the initial stage of allergic inflammation in vivo. Nuclear factor (NF)-κB, a key transcription factor in TSLP production, was also inhibited by claycosin and formononetin, either in terms of transcriptional activation or its nuclear translocation in vitro. Allergic inflammation was reduced by claycosin and formononetin when they are administered only at the initial stage in a murine model of atopic contact dermatitis. Thus, epithelial cell binding combined with HPLC-MS is a valid method for screening active components from complex mixtures of Chinese medicine. It was demonstrated that the compounds screened from YPFS significantly attenuated allergic inflammation probably by reducing TSLP production via regulating NF-κB activation.
MeSH term(s)	Animals ; Bronchi/cytology ; Cell Line ; Cytokines/biosynthesis ; Cytokines/blood ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Hypersensitivity/blood ; Hypersensitivity/drug therapy ; Hypersensitivity/metabolism ; Isoflavones/analysis ; Isoflavones/metabolism ; Isoflavones/pharmacology ; Mice ; Mice, Inbred BALB C ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Protein Transport/drug effects ; Time Factors ; Transcriptional Activation/drug effects
Chemical Substances	Cytokines ; Drugs, Chinese Herbal ; Isoflavones ; NF-kappa B ; yu ping feng san ; formononetin (295DQC67BJ) ; thymic stromal lymphopoietin (GT0IL38SP4)
Language	English
Publishing date	2014-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0107279
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Zhong yi yao lin chuang ping jia fang fa yan jiu yu shi jian

Xie, Yanming

2014

Author's details	zhu bian Xie Yanming
MeSH term(s)	Materia Medica ; Drug Evaluation ; Medicine, Chinese Traditional
Language	Chinese
Size	19, 571 pages :, illustrations
Edition	Di 1 ban.
Document type	Book
ISBN	9787117200974 ; 7117200979
Database	Catalogue of the US National Library of Medicine (NLM)

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