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Article: Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies.

KrishnaRaju, Alluri Venkata / Somepalli, Venkateswarlu / Thanawala, Shefali / Shah, Rajat

2023 Volume 15, Page(s) 291–305

Abstract: Background: Stress is the psychological, physiological, and behavioral response of an individual's body when they perceive a lack of equilibrium between the demands placed upon them and their ability to meet those demands. Adaptogens are herbs that help ...

Abstract	Background: Stress is the psychological, physiological, and behavioral response of an individual's body when they perceive a lack of equilibrium between the demands placed upon them and their ability to meet those demands. Adaptogens are herbs that help with stress management, and Ashwagandha is one such safe and effective adaptogen. Objective: We evaluated the anti-neuroinflammatory potential of Ashwagandha sustained-release formulation (AshwaSR) by estimating the in vitro expression of pro-inflammatory cytokines, and its efficacy on anxiety and depression in an in vivo study. Methods: Our in vitro study investigated the anti-inflammatory potential of AshwaSR by estimating the expression of tumour necrosis factor [TNF]-α and interleukin [IL]-1β levels in LPS-induced THP-1 human monocytes, and the antioxidant effects by its potential to inhibit the superoxide [SO] generation in PMA-induced HL-60 human monocytic cells. The in vivo study assessed the efficacy of AshwaSR on chronic unpredictable stress (CUS)-induced comorbid anxiety and depression in Results: AshwaSR inhibited TNF-α, IL-1β and superoxide production in a dose-dependent manner in the in vitro study. The in vivo CUS model induced depression-like and anxiety-like behaviour. Treatments with AshwaSR and escitalopram showed improvement in the EPM and MWM models compared to the CUS-group. Conclusion: In vitro study demonstrated that AshwaSR inhibits expressions of pro-inflammatory cytokines, IL-1β and TNF-α, and superoxide production. Further, the in vivo study confirmed its anxiolytic and stress-relieving effects in the CUS model that confirmed AshwaSR's potential in managing stress and stress-related symptoms.
Language	English
Publishing date	2023-07-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2587465-2
ISSN	1179-1454
ISSN	1179-1454
DOI	10.2147/JEP.S407906
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Article ; Online: Unique amino acid substitution in RBD region of SARS-CoV-2 Omicron XAY.2

Salsekar, Lekha / Rahangdale, Shefali / Tamboli, Ekant / Khairnar, Krishna

bioRxiv

Abstract: We attempted to explain the rare mutation at the receptor binding domain of the spike protein in the XAY.2 variant of SARS-CoV-2 from the perspective of hydrophobic interactions. We propose that decreasing hydrophobicity at position 446 and 486 of the ... ...

Abstract	We attempted to explain the rare mutation at the receptor binding domain of the spike protein in the XAY.2 variant of SARS-CoV-2 from the perspective of hydrophobic interactions. We propose that decreasing hydrophobicity at position 446 and 486 of the RBD region of the spike protein might affect the infectivity of SARS-CoV-2. We also estimated the probable mutations at the 446 and 486 position the virus may acquire, leading to a decreased hydrophobicity.
Keywords	covid19
Language	English
Publishing date	2023-01-09
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.01.09.523246
Database	COVID19

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Article ; Online: Giloy: a potential anti-COVID-19 herb with propitious pharmacological attributes: a short review.

Arora, Shefali / Goyal, Anjali / Rawat, Devendra Singh / Samantha, Krishna

Journal of biomolecular structure & dynamics

2022 Volume 41, Issue 14, Page(s) 7001–7008

Abstract: Plant-based medicine actually restores the balance in the body instead of treating the source of the disease. The strain of coronavirus (SAR-CoV-2) going to be more serious due to the lack of a reliable treatment option. Holistic treatment for this ... ...

Abstract	Plant-based medicine actually restores the balance in the body instead of treating the source of the disease. The strain of coronavirus (SAR-CoV-2) going to be more serious due to the lack of a reliable treatment option. Holistic treatment for this disease is in the form of Ayurveda as traditional medicine. As the infection of coronavirus is spreading like a wildfire, so the one way to fight is 'immunity'. Building immunity is the only way to stay safe and healthy and prepared themselves for the ongoing pandemic. In the current scenario, good immunity safeguard us from disease progression and prevention from this deadly virus. Giloy herb came into the limelight after the start of the COVID-19 pandemic due to its immunomodulatory and antiviral activity. The genome sequencing of Giloy is proved to be a breakthrough for controlling the COVID-19.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2022-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2022.2110157
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Article: Statin Induced Rhabdomyolysis.

Kumar, Sampath / Anne, Shefali / B, Hari Krishna

The Journal of the Association of Physicians of India

2021 Volume 69, Issue 10, Page(s) 11–12

Abstract: Statins are group of medicines that lower the level of low-density lipoprotein (LDL) cholesterol. They may exert toxic effects on skeletal muscle ranging from simple muscle pain to life-threatening complications such as rhabdomyolysis. We report a case ... ...

Abstract	Statins are group of medicines that lower the level of low-density lipoprotein (LDL) cholesterol. They may exert toxic effects on skeletal muscle ranging from simple muscle pain to life-threatening complications such as rhabdomyolysis. We report a case of 74-year-old male who was prescribed statins along with other drugs for treatment of coronary artery disease (CAD) and developed rhabdomyolysis which lead to acute renal failure. We report this case as statin induced rhabdomyolysis is very rare.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Aged ; Coronary Artery Disease ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Male ; Muscle, Skeletal ; Rhabdomyolysis/chemically induced
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2021-08-24
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
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Article ; Online: Germ Cells Get by with a Little Cannibalistic Help from Their Friends.

Krishna, Shefali / Overholtzer, Michael

Developmental cell

2016 Volume 39, Issue 6, Page(s) 631–633

Abstract: During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in ... ...

Abstract	During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells.
MeSH term(s)	Cell Communication ; Germ Cells
Language	English
Publishing date	2016--19
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2016.12.003
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

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Article ; Online: Mechanisms and consequences of entosis.

Krishna, Shefali / Overholtzer, Michael

Cellular and molecular life sciences : CMLS

2016 Volume 73, Issue 11-12, Page(s) 2379–2386

Abstract: Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis ... ...

Abstract	Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
MeSH term(s)	Apoptosis/physiology ; Autophagy/physiology ; Carcinogenesis/pathology ; Entosis/physiology ; Humans ; Neoplasms/pathology ; Phagocytosis/physiology
Language	English
Publishing date	2016-04-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-016-2207-0
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Article ; Online: Dynamics of Influenza A and SARS-CoV-2 coinfections during the COVID-19 pandemic in India

Ravikumar, Sandhra / Tamboli, Ekant / Rahangdale, Shefali / Salsekar, Lekha / Tomar, Siddharth Singh / Khairnar, Krishna

medRxiv

Abstract: The SARS-CoV-2 exhibits similar aetiology, mode of transmission and clinical presentation as the H1N1pdm09 (a subtype of Influenza A) and Influenza A (other subtypes), and can exist as a coinfection in the same patient. It is essential to understand the ... ...

Abstract	The SARS-CoV-2 exhibits similar aetiology, mode of transmission and clinical presentation as the H1N1pdm09 (a subtype of Influenza A) and Influenza A (other subtypes), and can exist as a coinfection in the same patient. It is essential to understand the coinfection dynamics of these viruses for effective management of the disease. This study examined 959 SARS-CoV-2 positive samples collected from the six states and three union territories in India from May to December 2022. The clinical data was accessed from the Integrated Health Information Platform (IHIP) and the Indian council of medical research (ICMR) COVID-19 data portal. The samples were tested for SARS-CoV-2, H1N1pdm09 and Influenza A using Reverse Transcriptase Real-Time Polymerase Chain Reaction q(RT-PCR). All 959 samples were subjected to SARS-CoV-2 whole genome sequencing (WGS) using Oxford Nanopore Next Generation Sequencing (NGS). From the 959 SARS-CoV-2 positive samples, 17.5% were co-infected with H1N1pdm09, 8.2% were co-infected with Influenza A, and 74.2% were only positive for SARS-CoV-2. The comparative analysis of viral load among the coinfected cases revealed that Influenza A and H1N1pdm09 had higher viral loads than SARS-CoV-2 in the studied samples. Out of 959 samples subjected to WGS, 815 and 144 were considered quality control (QC) passed, and QC failed, respectively, for SARS-CoV-2 variant calling. SARS-CoV-2 WGS identified 46 different variants belonging to the Omicron lineage. The SARS-CoV-2 and Influenza A coinfection group; and the SARS-CoV-2 and H1N1pdm09 coinfection group showed a higher proportion of symptomatic cases. This work demonstrates the need for coinfection analysis for the H1N1pdm09 virus, Influenza A virus and SARS-CoV-2 while studying the etiological agent in individuals with ILI/SARI symptoms. It is recommended that, in addition to determining the aetiology of ILI/SARI, an examination for H1N1pdm09 and Influenza A be conducted concurrently utilising molecular tools such as WGS and RT-PCR to understand the variant dynamics and the viral load for taking an informed decision during the patient management and treatment discourse.
Keywords	covid19
Language	English
Publishing date	2023-02-22
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2023.02.19.23285730
Database	COVID19

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Article: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain.

Thanawala, Shefali / Shah, Rajat / Somepalli, Venkateswarlu / Alluri, KrishnaRaju Venkata / Desomayanandam, Prabakaran / Bhuvanendran, Arun

Clinical pharmacology : advances and applications

2021 Volume 13, Page(s) 91–100

Abstract: Background: Knee pain causes functional limitations, eventually compromising the quality of life. We evaluated the efficacy of our water-dispersible turmeric formulation (60% natural curcuminoids, TurmXTRA 60N: Methods: In this randomized, double- ... ...

Abstract	Background: Knee pain causes functional limitations, eventually compromising the quality of life. We evaluated the efficacy of our water-dispersible turmeric formulation (60% natural curcuminoids, TurmXTRA 60N Methods: In this randomized, double-blind, placebo-controlled trial, subjects received either 250 mg WDTE60N capsule (150 mg curcuminoids; n = 53) or appearance-matched placebo capsule (n = 53) once daily for 90 days. Primary endpoint was change in pain score on the visual analogue scale (VAS) after 80-m fast-paced walk test. Results: A total of 96 subjects completed the study. WDTE60N reduced VAS score from baseline (5.4 ± 0.9) to day 90 (3.8 ± 0.8) with greater mean reduction than placebo (-1.5 ± 0.7 vs -0.6 ± 0.8, Conclusion: WDTE60N 250 mg administered once daily for 3 months, alleviated knee pain, improved joint function in healthy subjects with chronic knee pain, was well tolerated and safe.
Language	English
Publishing date	2021-05-21
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520726-X
ISSN	1179-1438
ISSN	1179-1438
DOI	10.2147/CPAA.S307464
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Article: Mechanisms and consequences of entosis

Krishna, Shefali / Michael Overholtzer

Cellular and molecular life sciences. 2016 June, v. 73, no. 11-12

2016

Abstract: Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called âcell-in-cellâ structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during ... ...

Abstract	Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called âcell-in-cellâ structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
Keywords	carcinogenesis ; cell death ; hosts
Language	English
Dates of publication	2016-06
Size	p. 2379-2386.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-016-2207-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparative bioavailability of curcuminoids from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study.

Thanawala, Shefali / Shah, Rajat / Alluri, KrishnaRaju Venkata / Somepalli, Venkateswarlu / Vaze, Sanjay / Upadhyay, Vivek

The Journal of pharmacy and pharmacology

2021 Volume 73, Issue 6, Page(s) 816–823

Abstract: Objectives: The therapeutic utility of turmeric (Curcuma longa L., Zingiberaceae) is limited due to low bioavailability of its active principal curcuminoids. This study evaluates the pharmacokinetic characteristics of a natural, water-dispersible ... ...

Abstract	Objectives: The therapeutic utility of turmeric (Curcuma longa L., Zingiberaceae) is limited due to low bioavailability of its active principal curcuminoids. This study evaluates the pharmacokinetic characteristics of a natural, water-dispersible turmeric extract containing 60% curcuminoids (TurmXtra 60N), referred to as WDTE60N, compared to standard turmeric extract 95% (STE95). Methods: This open-label, two-way crossover, single oral dose, comparative pharmacokinetic study, randomized 14 subjects to receive one capsule of WDTE60N (150 mg curcuminoids) or three capsules of STE95 (500 mg curcuminoids each). The resulting dose ratio of actives for WDTE60N:STE95 was 1:10. Key findings: Peak plasma levels of free curcumin, total curcuminoids, tetrahydrocurcumin and demethoxycurcumin were similar (P > 0.05). Cmax of total curcumin was higher (P = 0.0253) for WDTE60N at a 10-fold lower dose compared to STE95 (43.5 ± 28.5 vs. 21.3 ± 10.7 ng/ml). Mean AUC0-t was higher (P < 0.001) for free curcumin and comparable for total curcumin and total curcuminoids with WDTE60N than with STE95. Five adverse events were reported in three subjects (mild in severity) and were unrelated to study products. Conclusion: WDTE60N showed higher absorption and comparable exposure for free curcumin, total curcumin and total curcuminoids at a 10-fold lower dose than STE95.
MeSH term(s)	Administration, Oral ; Adult ; Area Under Curve ; Biological Availability ; Cross-Over Studies ; Curcuma/adverse effects ; Curcuma/chemistry ; Curcumin/pharmacokinetics ; Diarylheptanoids/chemistry ; Diarylheptanoids/pharmacokinetics ; Humans ; Male ; Plant Extracts/adverse effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacokinetics ; Severity of Illness Index ; Young Adult
Chemical Substances	Diarylheptanoids ; Plant Extracts ; turmeric extract (856YO1Z64F) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2021-03-23
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgab028
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