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Article ; Online: The uneven decline of gastric cancer in the USA: epidemiology of a health disparity.

Rabkin, Charles S

Lancet regional health. Americas

2023 Volume 24, Page(s) 100551

Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2023.100551
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Article ; Online: White Blood Cell Count, Neutrophil-to-Lymphocyte Ratio, and Incident Cancer in the UK Biobank.

Song, Minkyo / Graubard, Barry I / Loftfield, Erikka / Rabkin, Charles S / Engels, Eric A

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2024

Abstract: Background: The peripheral white blood cell (WBC) and neutrophil-to-lymphocyte ratio (NLR) reflect levels of inflammation and adaptive immunity. They are associated with cancer prognosis, but their associations with cancer incidence are not established.! ...

Abstract	Background: The peripheral white blood cell (WBC) and neutrophil-to-lymphocyte ratio (NLR) reflect levels of inflammation and adaptive immunity. They are associated with cancer prognosis, but their associations with cancer incidence are not established. Methods: We evaluated 443,540 cancer-free adults in the UK Biobank with data on total WBC and its subsets, follow-up starting one year after baseline. Cox regression was used to estimate hazard ratios (HRs) per quartile of WBC or NLR for incidence of 73 cancer types. Results: 22,747 incident cancers were diagnosed during a median of 6.9 years of follow-up. WBC was associated with risk of cancer overall (HR 1.05, 95%CI 1.03-1.06), chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL: 2.79, 2.45-3.18), lung cancer (1.14, 1.08-1.20), and breast cancer (1.05-1.02-1.08). NLR was positively associated with cancer overall (HR 1.03, 95%CI 1.02-1.04, per quartile) and kidney cancer (1.16, 1.07-1.25), and inversely with CLL/SLL (0.38, 0.33-0.42). Conclusions: High WBC or NLR may reflect excessive inflammatory status, promoting development of some cancers. Conversely, low NLR indicates a relative rise in lymphocytes, which could reflect an increase in circulating premalignant cells before CLL/SLL diagnosis. Peripheral WBC and NLR, in combination with other clinical information or biomarkers, may be useful tools for cancer risk stratification. Impact: Elevated levels of white blood cells or an increased neutrophil-to-lymphocyte ratio may indicate an overly active inflammatory response, potentially contributing to the eventual onset of certain types of cancer.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-23-1145
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Article ; Online: Antibodies Against Epstein-Barr Virus as Disease Markers of Gastric Cancer: A Systematic Review.

Fontes-Lemus, José I / Zhao, Isaac / Rabkin, Charles S / Fuentes-Pananá, Ezequiel M

Technology in cancer research & treatment

2023 Volume 22, Page(s) 15330338231169875

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Herpesvirus 4, Human ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology ; Risk
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/15330338231169875
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Article ; Online: Associations Between Autoimmune Conditions and Gastric Cancer Risk Among Elderly Adults in the United States.

Song, Minkyo / Camargo, M Constanza / Derkach, Andriy / Rabkin, Charles S / Engels, Eric A

The American journal of gastroenterology

2022 Volume 117, Issue 3, Page(s) 486–490

Abstract: Introduction: Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute.: Methods: In a case-control study, we evaluated 47 autoimmune conditions among 39,125 gastric cancers and 200,000 cancer-free ... ...

Abstract	Introduction: Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute. Methods: In a case-control study, we evaluated 47 autoimmune conditions among 39,125 gastric cancers and 200,000 cancer-free controls. Results: Six conditions were associated with increased gastric cancer risk (range of adjusted odds ratios: 1.28-1.93, P < 0.05): PA, membranous nephropathy, primary biliary cirrhosis, pure red cell aplasia, primary sclerosing cholangitis, and Graves disease. PA was associated with 8 other autoimmune conditions (adjusted odds ratios: 1.57-4.54, P < 0.05). Discussion: Autoimmune conditions associated with gastric cancer or PA may reflect effects of autoimmune gastritis or other carcinogenic pathways.
MeSH term(s)	Adult ; Aged ; Anemia, Pernicious/complications ; Anemia, Pernicious/epidemiology ; Autoimmune Diseases/complications ; Autoimmune Diseases/epidemiology ; Case-Control Studies ; Humans ; Stomach Neoplasms/complications ; Stomach Neoplasms/etiology ; United States/epidemiology
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000001622
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Article ; Online: Neutrophil-to-lymphocyte ratio and mortality in the United States general population.

Song, Minkyo / Graubard, Barry I / Rabkin, Charles S / Engels, Eric A

Scientific reports

2021 Volume 11, Issue 1, Page(s) 464

Abstract: The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood reflects the balance between systemic inflammation and immunity and is emerging as a prognostic biomarker in many diseases, but its predictive role for mortality in the general population has ... ...

Abstract	The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood reflects the balance between systemic inflammation and immunity and is emerging as a prognostic biomarker in many diseases, but its predictive role for mortality in the general population has not been investigated. We analyzed 1999-2014 National Health and Nutrition Examination Survey mortality-linked data, followed up until 2015. In participants aged > 30 with measurements of differential white blood cell counts, NLR was calculated and categorized into quartiles. Associations of increased NLR with overall or cause-specific mortality were assessed with Cox proportional hazard regression models, adjusted for potential confounders. Increased NLR was associated with overall mortality (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.10-1.17, per quartile NLR) and mortality due to heart disease (1.17, 1.06-1.29), chronic lower respiratory disease (1.24, 1.04-1.47), influenza/pneumonia (1.26, 1.03-1.54) and kidney disease (1.26, 1.03-1.54). NLR was associated with cancer mortality only in the first follow-up year (HR 1.48, 95% CI 1.11-1.98). The association with chronic lower respiratory disease mortality was stronger in individuals with prevalent lung diseases (HR 1.46, 95% CI 1.14-1.88, P
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cause of Death ; Chronic Disease/mortality ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Immunity ; Inflammation ; Leukocyte Count ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Predictive Value of Tests ; Prognosis ; Time Factors ; United States/epidemiology
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-01-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-79431-7
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Article ; Online: Chronic Hepatitis and Non-Hodgkin Lymphoma Among People With HIV: Implications for Screening, Treatment, and Prevention.

Rabkin, Charles S / Goedert, James J

Annals of internal medicine

2016 Volume 166, Issue 1, Page(s) 69–70

MeSH term(s)	HIV Infections ; Hepatitis, Chronic ; Humans ; Lymphoma, Non-Hodgkin ; Risk Factors
Language	English
Publishing date	2016-10-18
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M16-2340
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Article ; Online: The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes.

Thorell, Kaisa / Muñoz-Ramírez, Zilia Y / Wang, Difei / Sandoval-Motta, Santiago / Boscolo Agostini, Rajiv / Ghirotto, Silvia / Torres, Roberto C / Falush, Daniel / Camargo, M Constanza / Rabkin, Charles S

Nature communications

2023 Volume 14, Issue 1, Page(s) 8184

Abstract: Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with ... ...

Abstract	Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
MeSH term(s)	Humans ; Genome, Bacterial/genetics ; Helicobacter pylori ; Base Sequence ; Genomics ; Population Groups ; Helicobacter Infections/microbiology
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43562-y
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Article: Gastric Cancer: an Evolving Disease.

Song, Minkyo / Rabkin, Charles S / Camargo, M Constanza

Current treatment options in gastroenterology

2018 Volume 16, Issue 4, Page(s) 561–569

Abstract: Purpose of review: Prevalence of Helicobacter pylori, the primary risk factor for gastric cancer, is declining globally. Paralleling this trend, gastric cancer incidence is also decreasing. Historically, the populations most affected by this neoplasia ... ...

Abstract	Purpose of review: Prevalence of Helicobacter pylori, the primary risk factor for gastric cancer, is declining globally. Paralleling this trend, gastric cancer incidence is also decreasing. Historically, the populations most affected by this neoplasia have been males, Asians, and groups with low socioeconomic status. This review provides an update on recently published literature regarding changes in gastric cancer epidemiology. Recent findings: Gastric cancer incidence trends vary by age, sex, race/ethnicity, and tumor anatomical location. Overall incidence appears to be leveling off among young birth cohorts in Western populations, where H. pylori has declined considerably. The changes are more prominent for females and for tumors arising beyond the esophageal-gastric junction. The classical incidence pattern of gastric cancer is evolving. While uncertain, several hypotheses may explain the changing burden of disease. The mix of gastric cancer risk factors appears to be shifting, with H. pylori no longer the sole etiological driver. These changes may eliminate the previous predilection of males and lead to increases in overall gastric cancer rates. Analytical studies addressing known and novel factors related to major societal transitions may provide clues to understanding re-emergence of this serious public health problem.
Language	English
Publishing date	2018-10-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057334-0
ISSN	1534-309X ; 1092-8472
ISSN (online)	1534-309X
ISSN	1092-8472
DOI	10.1007/s11938-018-0203-1
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Article ; Online: Neutrophil-to-lymphocyte ratio and mortality in the United States general population

Minkyo Song / Barry I. Graubard / Charles S. Rabkin / Eric A. Engels

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood reflects the balance between systemic inflammation and immunity and is emerging as a prognostic biomarker in many diseases, but its predictive role for mortality in the general ... ...

Abstract	Abstract The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood reflects the balance between systemic inflammation and immunity and is emerging as a prognostic biomarker in many diseases, but its predictive role for mortality in the general population has not been investigated. We analyzed 1999–2014 National Health and Nutrition Examination Survey mortality-linked data, followed up until 2015. In participants aged > 30 with measurements of differential white blood cell counts, NLR was calculated and categorized into quartiles. Associations of increased NLR with overall or cause-specific mortality were assessed with Cox proportional hazard regression models, adjusted for potential confounders. Increased NLR was associated with overall mortality (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.10–1.17, per quartile NLR) and mortality due to heart disease (1.17, 1.06–1.29), chronic lower respiratory disease (1.24, 1.04–1.47), influenza/pneumonia (1.26, 1.03–1.54) and kidney disease (1.26, 1.03–1.54). NLR was associated with cancer mortality only in the first follow-up year (HR 1.48, 95% CI 1.11–1.98). The association with chronic lower respiratory disease mortality was stronger in individuals with prevalent lung diseases (HR 1.46, 95% CI 1.14–1.88, Pinteraction = 0.01), while NLR showed positive associations with mortality from heart disease (1.21, 1.07–1.38) and cerebrovascular disease (1.30, 1.04–1.63) only among individuals without these conditions at baseline. NLR is associated with mortality overall and due to certain causes in the general population. Associations over short follow-up intervals and among individuals with conditions at baseline suggest effects of disordered inflammation and immunity on progression of those conditions, while other associations may reflect contributions to disease etiology.
Keywords	Medicine ; R ; Science ; Q
Subject code	310
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Tumour virus epidemiology.

Lunn, Ruth M / Jahnke, Gloria D / Rabkin, Charles S

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2017 Volume 372, Issue 1732

Abstract: A viral etiology of cancer was first demonstrated in 1911 by Peyton Rous who injected cell-free filtrate from a chicken sarcoma into healthy chickens and found it induced a tumour. Since the discovery over 50 years ago of the Epstein-Barr virus as the ... ...

Abstract	A viral etiology of cancer was first demonstrated in 1911 by Peyton Rous who injected cell-free filtrate from a chicken sarcoma into healthy chickens and found it induced a tumour. Since the discovery over 50 years ago of the Epstein-Barr virus as the cause of Burkitt lymphoma, seven other human viruses or groups of viruses-hepatitis B virus, hepatitis C virus, human immunodeficiency virus type 1, some human papillomaviruses, human T-cell lymphotropic virus type 1, Kaposi sarcoma-associated herpesvirus and Merkel cell polyomavirus-have been linked to human cancer. Collectively, these eight viruses cause over 20 different types of cancer and contribute to 10-12% of all cancer, with a greater burden in low- and middle-income countries. For many viruses, immunosuppression greatly increases the risks of persistent infection, development of chronic sequelae and cancer. Although several viruses share similar routes of transmission (especially sexual activity, injection drug use and mother-to-child transmission), the predominant route of transmission varies across viruses, and for the same virus can vary by geographical location. In general, vulnerable populations at the greatest risk for viral infections and their associated diseases include people, especially children, living in low- to middle-income countries, men who have sex with men, people who use injection drugs and female sex workers.This article is part of the themed issue 'Human oncogenic viruses'.
MeSH term(s)	Humans ; Oncogenic Viruses/physiology ; Tumor Virus Infections/epidemiology ; Tumor Virus Infections/virology
Language	English
Publishing date	2017-09-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2016.0266
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