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  1. Article ; Online: Antimicrobial Susceptibility Distributions of Clinical Isolates of Nontuberculous Mycobacteria in Israel.

    Hershko, Yizhak / Adler, Amos

    Microbial drug resistance (Larchmont, N.Y.)

    2023  Volume 29, Issue 7, Page(s) 302–308

    Abstract: There is a scarcity of data regarding the antimicrobial susceptibility testing profiles of nontuberculous mycobacterial (NTM) in Israel and other Middle Eastern countries. We aimed to describe the antimicrobial susceptibility profiles of NTM in Israel. A ...

    Abstract There is a scarcity of data regarding the antimicrobial susceptibility testing profiles of nontuberculous mycobacterial (NTM) in Israel and other Middle Eastern countries. We aimed to describe the antimicrobial susceptibility profiles of NTM in Israel. A total of 410 clinical isolates of NTM, identified to the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry or
    MeSH term(s) Humans ; Nontuberculous Mycobacteria/genetics ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology ; Mycobacterium Infections, Nontuberculous/microbiology ; Linezolid/pharmacology ; Linezolid/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Amikacin/therapeutic use ; Clarithromycin/therapeutic use ; Israel/epidemiology ; Microbial Sensitivity Tests
    Chemical Substances Linezolid (ISQ9I6J12J) ; Anti-Bacterial Agents ; Amikacin (84319SGC3C) ; Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1290490-9
    ISSN 1931-8448 ; 1076-6294
    ISSN (online) 1931-8448
    ISSN 1076-6294
    DOI 10.1089/mdr.2023.0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4435: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: WarA, a remote homolog of NpmA and KamB from Nocardia wallacei, confers broad spectrum aminoglycoside resistance in Nocardia and Mycobacteria.

    Hershko, Yizhak / Rannon, Ella / Adler, Amos / Burstein, David / Barkan, Daniel

    International journal of antimicrobial agents

    2024  Volume 63, Issue 2, Page(s) 107089

    Abstract: Objectives: Aminoglycoside resistance in bacteria is typically conferred by specific drug-modifying enzymes. Infrequently, such resistance is achieved through 16S ribosomal RNA methyltransferases, such as NpmA and KamB encoded by Escherichia coli and ... ...

    Abstract Objectives: Aminoglycoside resistance in bacteria is typically conferred by specific drug-modifying enzymes. Infrequently, such resistance is achieved through 16S ribosomal RNA methyltransferases, such as NpmA and KamB encoded by Escherichia coli and Streptoalloteichus tenebrarius, respectively. These enzymes are not widespread and have not been described in Nocardia species to date.
    Methods: We report the genomic mining of 18 Nocardia wallacei isolates that were found to be specifically and substantially resistant to amikacin.
    Results: We identified a gene coding for a protein with very distant homology to NpmA and KamB. However, 3-D modeling revealed that the tertiary structure of these three proteins was highly similar. Cloning and expressing this gene in two susceptible bacteria Nocardia asteroides, and Mycobacterium smegmatis (another Actinobacterium) led to high-level, pan-aminoglycoside resistance in both cases. We named this gene warA (Wallacei Amikacin Resistance A).
    Conclusions: This is the first description and experimental characterization of a gene of this family in Nocardia, and the first demonstration that such activity could lead to pan-aminoglycoside resistance in Mycobacteria as well. The discovery of this novel gene has important biotechnology and clinical implications.
    MeSH term(s) Aminoglycosides/metabolism ; Amikacin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Nocardia/genetics ; Nocardia/metabolism ; Escherichia coli/genetics ; Mycobacterium/genetics ; Mycobacterium/metabolism ; RNA, Ribosomal, 16S/genetics ; Drug Resistance, Bacterial/genetics
    Chemical Substances Aminoglycosides ; Amikacin (84319SGC3C) ; Anti-Bacterial Agents ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 500: Show issues

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  3. Article: Oxycodone-Acetaminophen Abuse by Inhalation.

    Hershkowitz, Isca / Cahn, Avivit / Keidar Haran, Tal / Hershko, Alon Y

    The Israel Medical Association journal : IMAJ

    2024  Volume 26, Issue 1, Page(s) 54–55

    MeSH term(s) Humans ; Acetaminophen/adverse effects ; Oxycodone/adverse effects ; Drug Combinations ; Analgesics, Opioid/adverse effects ; Double-Blind Method ; Analgesics, Non-Narcotic/adverse effects ; Pain, Postoperative
    Chemical Substances oxycodone-acetaminophen ; Acetaminophen (362O9ITL9D) ; Oxycodone (CD35PMG570) ; Drug Combinations ; Analgesics, Opioid ; Analgesics, Non-Narcotic
    Language English
    Publishing date 2024-02-28
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The Nocardial

    Hershko, Yizhak / Adler, Amos / Barkan, Daniel

    Microorganisms

    2023  Volume 11, Issue 7

    Abstract: The current study aimed to evaluate the feasibility of using the aminoglycoside 2″-O- ... ...

    Abstract The current study aimed to evaluate the feasibility of using the aminoglycoside 2″-O-phosphotransferase
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11071697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Glycopeptidolipid Defects Leading to Rough Morphotypes of Mycobacterium abscessus Do Not Confer Clinical Antibiotic Resistance.

    Hershko, Yizhak / Adler, Amos / Barkan, Daniel / Meir, Michal

    Microbiology spectrum

    2023  , Page(s) e0527022

    Abstract: Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections. Within chronically infected patients, M. abscessus isolates undergo molecular changes leading to increased virulence and antibiotic resistance. Specifically, mutations ... ...

    Abstract Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections. Within chronically infected patients, M. abscessus isolates undergo molecular changes leading to increased virulence and antibiotic resistance. Specifically, mutations in glycopeptidolipid (GPL) synthesis genes, leading to the rough phenotype, are associated with invasive, nonremitting infections and a severe clinical course. It has been unclear whether GPL defects confer antibiotic resistance independently of other molecular changes. We used transposon technology to isolate a rough (GPL-defective; Tn
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.05270-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neutrophil-erythrocyte rosette formation: case report and proposed mechanism.

    Hershkowitz, I / Haran, A / Hershko, A Y

    QJM : monthly journal of the Association of Physicians

    2022  Volume 116, Issue 4, Page(s) 303–304

    MeSH term(s) Humans ; Rosette Formation ; Neutrophils ; Erythrocytes
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcac238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Recurrent haemoptysis: a rare diagnosis of kaposiform lymphangiomatosis and review of literature.

    Fedidat, Roukhama / Elia, Anna / Hershko, Alon / Fridlender, Zvi

    BMJ case reports

    2022  Volume 15, Issue 9

    Abstract: Kaposiform lymphangiomatosis (KLA) is a rare clinicopathological entity among lymphatic anomalies. The main involved sites are the mediastinum and the lungs but the disease can also affect multiple extrathoracic organs. Little is known about the ... ...

    Abstract Kaposiform lymphangiomatosis (KLA) is a rare clinicopathological entity among lymphatic anomalies. The main involved sites are the mediastinum and the lungs but the disease can also affect multiple extrathoracic organs. Little is known about the pathophysiology, the natural history, the treatment response and the long-term outcome of this disorder. KLA is typically diagnosed in childhood. We present here the case of an adult man with 13 years recurrent episodes of haemoptysis who was finally found to suffer from KLA. Following this, we present a comprehensive review of the literature.
    MeSH term(s) Adult ; Hemoptysis/etiology ; Humans ; Lung ; Lymphangioleiomyomatosis ; Lymphangioma/complications ; Lymphangioma/diagnosis ; Lymphatic Abnormalities ; Male
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial: The Expansion of Female Fertility.

    Hershko Klement, Anat / Oron, Galia / Bentov, Yaakov

    Frontiers in reproductive health

    2022  Volume 3, Page(s) 781019

    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2021.781019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Luteal phase support in fresh and frozen embryo transfers.

    Greenbaum, Shirley / Athavale, Ahlad / Hershko Klement, Anat / Bentov, Yaakov

    Frontiers in reproductive health

    2022  Volume 4, Page(s) 919948

    Abstract: Context: Luteal phase support (LPS) has become an essential component of IVF protocols following both fresh and frozen embryo transfers, yet there is still controversy with regards to the optimal protocol of LPS to enhance treatment outcome.: Search ... ...

    Abstract Context: Luteal phase support (LPS) has become an essential component of IVF protocols following both fresh and frozen embryo transfers, yet there is still controversy with regards to the optimal protocol of LPS to enhance treatment outcome.
    Search strategy: A search
    Conclusions: We present data that supports the use of Progesterone LPS in fresh and frozen embryo transfers. No benefits were found to the addition of hCG or estradiol to progesterone LPS in fresh transfers, however GnRH agonist may have a role. IM Progesterone was not advantageous over vaginal progesterone in fresh transfers but was superior in frozen transfers. The timing of LPS introduction, the interval to embryo transfer, as well as the serum concentration of progesterone, have significant effects on the success of the treatment.
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2022.919948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Transient Inflammatory Reaction with a B-Cell Lymphoid Infiltrate and Dysplastic Bone Marrow Changes Associated with the BNT162b2 COVID-19 Vaccine.

    Vronsky, Daniella / Hershkowitz, Shimrit / Hershko, Alon / Eliakim-Raz, Noa

    European journal of case reports in internal medicine

    2022  Volume 9, Issue 6, Page(s) 3381

    Abstract: COVID-19 vaccines were introduced soon after the COVID-19 pandemic emerged in 2020. Various side effects were reported worldwide, including several types of common systemic side effects such as fever and general fatigue. Reports of other rare ... ...

    Abstract COVID-19 vaccines were introduced soon after the COVID-19 pandemic emerged in 2020. Various side effects were reported worldwide, including several types of common systemic side effects such as fever and general fatigue. Reports of other rare manifestations also emerged. We report the case of an adult male with a rare systemic syndrome mimicking lymphoma after he had received the first dose of an mRNA-based COVID-19 vaccine. After nearly 6 months of investigation with suspicion for an infection or malignancy, all symptoms resolved, laboratory tests normalized, and imaging showed no sign of active disease.
    Learning points: A lymphoma-like reaction is a possible side effect of COVID-19 vaccination.It is important to rule out other causes of systemic symptoms before diagnosing a reaction to a COVID-19 vaccine.A lymphoma-like reaction following administration of a COVID-19 vaccine has a good prognosis.
    Language English
    Publishing date 2022-06-27
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2022_003381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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