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  1. Article ; Online: Benchmarking pre-clinical heart failure with preserved ejection fraction models: can we do better?

    Kass, David A

    Cardiovascular research

    2024  

    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvae059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  2. Article ; Online: Inhibiting Both Neprilysin and Phosphodiesterase Type 9: Turning on the Faucet While Plugging the Sink.

    Kass, David A

    JACC. Heart failure

    2023  Volume 11, Issue 2, Page(s) 240–242

    MeSH term(s) Humans ; Phosphoric Diester Hydrolases ; Heart Failure/drug therapy ; Neprilysin ; Natriuretic Peptide, Brain ; Atrial Natriuretic Factor
    Chemical Substances Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Neprilysin (EC 3.4.24.11) ; Natriuretic Peptide, Brain (114471-18-0) ; Atrial Natriuretic Factor (85637-73-6)
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2022.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: What's EF Got to Do, Got to Do With It?

    Kass, David A

    Circulation

    2022  Volume 146, Issue 18, Page(s) 1327–1328

    MeSH term(s) Humans ; Stroke Volume ; Ventricular Function, Left ; Heart Failure ; Prognosis
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.062052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding HFpEF With Obesity: Will Pigs Come to the Rescue?

    Kass, David A

    JACC. Basic to translational science

    2021  Volume 6, Issue 2, Page(s) 171–173

    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2020.12.010
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  5. Article ; Online: COVID-19 and Severe Obesity: A Big Problem?

    Kass, David A

    Annals of internal medicine

    2020  Volume 173, Issue 10, Page(s) 840–841

    MeSH term(s) Adipose Tissue/metabolism ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; Body Mass Index ; COVID-19 ; Coronavirus Infections/epidemiology ; Hospitalization ; Humans ; Intubation, Intratracheal ; Obesity, Morbid/complications ; Obesity, Morbid/epidemiology ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Respiration, Artificial ; Respiratory Insufficiency/virology ; Risk Factors ; SARS-CoV-2 ; United States/epidemiology
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-5677
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  6. Article ; Online: Fresh evidence overturns the identification of a factor involved in blood-vessel dilation.

    Kass, David A

    Nature

    2019  Volume 566, Issue 7745, Page(s) 462–464

    MeSH term(s) Blood Pressure ; Dilatation ; Humans ; Inflammation ; Oxygen ; Singlet Oxygen
    Chemical Substances Singlet Oxygen (17778-80-2) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2019-02-25
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-00508-z
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    Zs.MO 244: Show issues

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  7. Article ; Online: Publisher Correction: Cellular and molecular pathobiology of heart failure with preserved ejection fraction.

    Mishra, Sumita / Kass, David A

    Nature reviews. Cardiology

    2021  Volume 18, Issue 10, Page(s) 735

    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-021-00516-5
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  9. Article ; Online: Cellular and molecular pathobiology of heart failure with preserved ejection fraction.

    Mishra, Sumita / Kass, David A

    Nature reviews. Cardiology

    2021  Volume 18, Issue 6, Page(s) 400–423

    Abstract: Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality, and has very few effective treatments. HFpEF is arguably the ... ...

    Abstract Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality, and has very few effective treatments. HFpEF is arguably the greatest unmet medical need in cardiovascular disease. Although HFpEF was initially considered to be a haemodynamic disorder characterized by hypertension, cardiac hypertrophy and diastolic dysfunction, the pandemics of obesity and diabetes mellitus have modified the HFpEF syndrome, which is now recognized to be a multisystem disorder involving the heart, lungs, kidneys, skeletal muscle, adipose tissue, vascular system, and immune and inflammatory signalling. This multiorgan involvement makes HFpEF difficult to model in experimental animals because the condition is not simply cardiac hypertrophy and hypertension with abnormal myocardial relaxation. However, new animal models involving both haemodynamic and metabolic disease, and increasing efforts to examine human pathophysiology, are revealing new signalling pathways and potential therapeutic targets. In this Review, we discuss the cellular and molecular pathobiology of HFpEF, with the major focus being on mechanisms relevant to the heart, because most research has focused on this organ. We also highlight the involvement of other important organ systems, including the lungs, kidneys and skeletal muscle, efforts to characterize patients with the use of systemic biomarkers, and ongoing therapeutic efforts. Our objective is to provide a roadmap of the signalling pathways and mechanisms of HFpEF that are being characterized and which might lead to more patient-specific therapies and improved clinical outcomes.
    MeSH term(s) Heart Failure/physiopathology ; Humans ; Stroke Volume
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-020-00480-6
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  10. Book ; Online: Kultur unterwegs: Relevanz einer Instanz : Reisebilder, Dingwelten, Perspektiven

    Schleper, Thomas / Steinert, Mark / Karabaic, Milena / Veltzke, Veit / Otten, Thomas / Valk, Thorsten / Käss, Alexandra / Mentzel, Jan-David / Mangold, Josef / Hauser, Walter / Hänel, Dagmar / Kleefeld, Klaus-Dieter / Bredenbeck, Martin

    2021  

    Keywords The arts: general issues ; Bildung, Denkmalpflege, Digitalität, Industriekultur, Krise, Kulturarbeit, Kulturlandschaft, Kunst, Museum, Nachhaltigkeit, Popularkultur, Strukturwandel, Tourismus, Wissenschaft
    Size 1 electronic resource (224 pages)
    Publisher Reimer Verlag
    Publishing place Berlin
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT021233084
    ISBN 978-3-98501-066-0 ; 978-3-7861-2880-9 ; 3-98501-066-8 ; 3-7861-2880-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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