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  1. Article ; Online: Biography of Joanne R Lupton (1944-2020).

    Turner, Nancy D / Chapkin, Robert S

    The Journal of nutrition

    2022  Volume 152, Issue 4, Page(s) 914–916

    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/nxac022
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    Uc I Zs.205: Show issues Location:
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  2. Article: Robert Chapkin on Relationships Between the Gut Microbiome, Diet, and Colorectal Cancer.

    Chapkin, Robert S

    Oncology (Williston Park, N.Y.)

    2018  Volume 32, Issue 5, Page(s) 248–249

    MeSH term(s) Biomedical Research/history ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/history ; Colorectal Neoplasms/microbiology ; Diet/adverse effects ; Diet/history ; Gastrointestinal Microbiome ; History, 20th Century ; History, 21st Century ; Humans ; Intestines/microbiology ; Risk Factors
    Language English
    Publishing date 2018-05-26
    Publishing country United States
    Document type Biography ; Historical Article ; Interview
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
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    Zs.A 3168: Show issues Location:
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    Zs.MO 372: Show issues

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  3. Article ; Online: Human Microbiome in Health and Disease: The Good, the Bad, and the Bugly.

    Bresalier, Robert S / Chapkin, Robert S

    Digestive diseases and sciences

    2020  Volume 65, Issue 3, Page(s) 671–673

    MeSH term(s) Gastrointestinal Diseases/metabolism ; Gastrointestinal Diseases/microbiology ; Gastrointestinal Diseases/pathology ; Health Status ; Humans ; Microbiota/physiology
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06059-y
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  4. Article ; Online: Extinction scenarios in evolutionary processes: a multinomial Wright-Fisher approach.

    Roitershtein, Alexander / Rastegar, Reza / Chapkin, Robert S / Ivanov, Ivan

    Journal of mathematical biology

    2023  Volume 87, Issue 4, Page(s) 63

    Abstract: We study a discrete-time multi-type Wright-Fisher population process. The mean-field dynamics of the stochastic process is induced by a general replicator difference equation. We prove several results regarding the asymptotic behavior of the model, ... ...

    Abstract We study a discrete-time multi-type Wright-Fisher population process. The mean-field dynamics of the stochastic process is induced by a general replicator difference equation. We prove several results regarding the asymptotic behavior of the model, focusing on the impact of the mean-field dynamics on it. One of the results is a limit theorem that describes sufficient conditions for an almost certain path to extinction, first eliminating the type which is the least fit at the mean-field equilibrium. The effect is explained by the metastability of the stochastic system, which under the conditions of the theorem spends almost all time before the extinction event in a neighborhood of the equilibrium. In addition to the limit theorems, we propose a maximization principle for a general deterministic replicator dynamics and study its implications for the stochastic model.
    MeSH term(s) Population Dynamics ; Biological Evolution ; Stochastic Processes
    Language English
    Publishing date 2023-09-26
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187101-8
    ISSN 1432-1416 ; 0303-6812
    ISSN (online) 1432-1416
    ISSN 0303-6812
    DOI 10.1007/s00285-023-01993-7
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  5. Article ; Online: Aryl Hydrocarbon Receptor Activity in Intestinal Epithelial Cells in the Formation of Colonic Tertiary Lymphoid Tissues.

    Garcia-Villatoro, Erika Leonor / Ufondu, Arinzechukwu / Callaway, Evelyn S / Allred, Kimberly / Safe, Stephen H / Chapkin, Robert S / Jayaraman, Arul / Allred, Clinton D

    American journal of physiology. Gastrointestinal and liver physiology

    2024  

    Abstract: After birth, the development of secondary lymphoid tissues (SLTs) in the colon is dependent on the expression of the Aryl Hydrocarbon Receptor (AhR) in immune cells as a response to the availability of AhR ligands. However, little is known about how AhR ... ...

    Abstract After birth, the development of secondary lymphoid tissues (SLTs) in the colon is dependent on the expression of the Aryl Hydrocarbon Receptor (AhR) in immune cells as a response to the availability of AhR ligands. However, little is known about how AhR activity from intestinal epithelial cells (IECs) may influence the development of tertiary lymphoid tissues (TLTs). As organized structures that develop at sites of inflammation or infection during adulthood, TLTs serve as localized centers of adaptive immune responses, and their presence has been associated with the resolution of inflammation and tumorigenesis in the colon. Here, we investigated the effect of the conditional loss of AhR activity in IECs in the formation and immune cell composition of TLTs in a model of acute inflammation. In females, loss of AhR activity in IECs reduced the formation of TLTs without significantly changing disease outcomes nor immune cell composition within TLTs. In males lacking AhR expression in IECs, increased disease activity index, lower expression of functional-IEC genes, increased number of TLTs, increased T-cell density, and lower B- to T-cell ratio was observed. These findings may represent an unfavorable prognosis when exposed to DSS-induced epithelial damage compared to females. Sex and loss of IEC AhR also resulted in changes in microbial populations in the gut. Collectively, these data suggest that the formation of TLTs in the colon is influenced by sex and AhR expression in IECs.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00274.2023
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  6. Article ; Online: Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action.

    Safe, Stephen / Kothari, Jainish / Hailemariam, Amanuel / Upadhyay, Srijana / Davidson, Laurie A / Chapkin, Robert S

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates of mortality and decreased rates of neurological and metabolic diseases, including Parkinson's disease and ... ...

    Abstract Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates of mortality and decreased rates of neurological and metabolic diseases, including Parkinson's disease and type 2 diabetes. In addition, there is also evidence that higher coffee consumption is associated with lower rates of colon and rectal cancer, as well as breast, endometrial, and other cancers, although for some of these cancers, the results are conflicting. These studies reflect the chemopreventive effects of coffee; there is also evidence that coffee consumption may be therapeutic for some forms of breast and colon cancer, and this needs to be further investigated. The mechanisms associated with the chemopreventive or chemotherapeutic effects of over 1000 individual compounds in roasted coffee are complex and may vary with different diseases. Some of these mechanisms may be related to nuclear factor erythroid 2 (Nrf2)-regulated pathways that target oxidative stress or pathways that induce reactive oxygen species to kill diseased cells (primarily therapeutic). There is evidence for the involvement of receptors which include the aryl hydrocarbon receptor (AhR) and orphan nuclear receptor 4A1 (NR4A1), as well as contributions from epigenetic pathways and the gut microbiome. Further elucidation of the mechanisms will facilitate the potential future clinical applications of coffee extracts for treating cancer and other inflammatory diseases.
    MeSH term(s) Humans ; Anticarcinogenic Agents ; Diabetes Mellitus, Type 2/prevention & control ; Neoplasms/drug therapy ; Neoplasms/prevention & control ; Oxidative Stress ; Reactive Oxygen Species ; Coffee
    Chemical Substances Anticarcinogenic Agents ; Reactive Oxygen Species ; Coffee
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032706
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  7. Article: Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine.

    Han, Huajun / Jayaraman, Arul / Safe, Stephen / Chapkin, Robert S

    Current stem cell reports

    2021  Volume 6, Issue 4, Page(s) 109–118

    Abstract: Purpose of review: Intestinal stem cells, the most rapidly proliferating adult stem cells, are exquisitely sensitive to extrinsic dietary factors. Uncontrolled regulation of intestinal stem cells is closely linked to colon tumorigenesis. This review ... ...

    Abstract Purpose of review: Intestinal stem cells, the most rapidly proliferating adult stem cells, are exquisitely sensitive to extrinsic dietary factors. Uncontrolled regulation of intestinal stem cells is closely linked to colon tumorigenesis. This review focuses on how dietary and microbial derived cues regulate intestinal stem cell functionality and colon tumorigenesis in mouse models by targeting the aryl hydrocarbon receptor (AhR).
    Recent findings: AhR, a ligand activated transcription factor, can integrate environmental, dietary and microbial cues to modulate intestinal stem cell proliferation, differentiation and their microenvironment, affecting colon cancer risk. Modulation of AhR activity is associated with many chronic diseases, including inflammatory bowel diseases where AhR expression is protective.
    Summary: AhR signaling controls the maintenance and differentiation of intestinal stem cells, influences local niche factors, and plays a protective role in colon tumorigenesis. Mounting evidence suggests that extrinsic nutritional/dietary cues which modulate AhR signaling may be a promising approach to colon cancer chemoprevention.
    Language English
    Publishing date 2021-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2808623-5
    ISSN 2198-7866
    ISSN 2198-7866
    DOI 10.1007/s40778-020-00184-0
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  8. Article ; Online: Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis.

    Han, Huajun / Safe, Stephen / Jayaraman, Arul / Chapkin, Robert S

    Annual review of nutrition

    2021  Volume 41, Page(s) 455–478

    Abstract: The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds structurally diverse ligands and senses cues from environmental toxicants and physiologically relevant dietary/microbiota-derived ligands. ... ...

    Abstract The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds structurally diverse ligands and senses cues from environmental toxicants and physiologically relevant dietary/microbiota-derived ligands. The AhR is an ancient conserved protein and is widely expressed across different tissues in vertebrates and invertebrates. AhR signaling mediates a wide range of cellular functions in a ligand-, cell type-, species-, and context-specific manner. Dysregulation of AhR signaling is linked to many developmental defects and chronic diseases. In this review, we discuss the emerging role of AhR signaling in mediating bidirectional host-microbiome interactions. We also consider evidence showing the potential for the dietary/microbial enhancement ofhealth-promoting AhR ligands to improve clinical pathway management in the context of inflammatory bowel diseases and colon tumorigenesis.
    MeSH term(s) Animals ; Diet ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; Ligands ; Microbiota ; Receptors, Aryl Hydrocarbon/metabolism
    Chemical Substances Ligands ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2021-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev-nutr-043020-090050
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    Zs.A 1786: Show issues Location:
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  9. Article ; Online: Fate and distribution of orally-ingested CeO

    Ma, Xingmao / Wang, Xiaoxuan / Xu, Lei / Shi, Honglan / Yang, Hu / Landrock, Kerstin K / Sharma, Virender K / Chapkin, Robert S

    Soil & Environmental Health

    2023  Volume 1, Issue 2

    Abstract: The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following ... ...

    Abstract The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following oral intake. Cerium oxide nanoparticle (CeO
    Language English
    Publishing date 2023-04-17
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2949-9194
    ISSN (online) 2949-9194
    DOI 10.1016/j.seh.2023.100017
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  10. Article ; Online: Ah receptor ligands and their impacts on gut resilience: structure-activity effects.

    Safe, Stephen / Jayaraman, Arul / Chapkin, Robert S

    Critical reviews in toxicology

    2020  Volume 50, Issue 6, Page(s) 463–473

    Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and structurally related halogenated aromatics modulate gene expression and induce biochemical and toxic responses that are mediated by initial binding to the aryl hydrocarbon receptor (AhR). The AhR ... ...

    Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and structurally related halogenated aromatics modulate gene expression and induce biochemical and toxic responses that are mediated by initial binding to the aryl hydrocarbon receptor (AhR). The AhR also binds structurally diverse compound including pharmaceuticals, endogenous biochemicals, health-promoting phytochemicals, and microbial metabolites. Many of these AhR ligands do not induce TCDD-like toxic responses and some AhR ligands such as microbial metabolites of tryptophan play a role in maintaining gut health and protecting against intestinal inflammation and cancer. Many AhR ligands exhibit tissue- and response-specific AhR agonist or antagonist activities, and act as selective AhR modulators (SAhRMs) and this SAhRM-like activity has also been observed in AhR-ligand-mediated effects in the intestine. This review summarizes studies showing that several AhR ligands including phytochemicals and TCDD protect against dextran sodium sulfate-induced intestinal inflammation. In contrast, AhR ligands such as oxazole compounds enhance intestinal inflammation suggesting that AhR-mediated gut health can be enhanced or decreased by selective AhR modulators and this needs to be considered in development of AhR ligands for therapeutic applications in treating intestinal inflammation.
    MeSH term(s) Gastrointestinal Microbiome ; Humans ; Ligands ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon
    Chemical Substances Ligands ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1097071-x
    ISSN 1547-6898 ; 1040-8444
    ISSN (online) 1547-6898
    ISSN 1040-8444
    DOI 10.1080/10408444.2020.1773759
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