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Article ; Online: Distribution of Pb, Sr, and U isotopic signature and multielement composition of sediment in Lake Balaton (Hungary) at a sediment trap deep dredged 40 years ago near Balatongyörök-search for routes of recent pollution.

Beyer, Dániel Ernő / Varga, Mária / Fazekas, Péter / Pánczél, János K

Environmental science and pollution research international

2023 Volume 30, Issue 14, Page(s) 42311–42326

Abstract: We studied the Pb, Sr, and U isotopic composition and the concentration of toxic metal elements in sediment core samples collected in Lake Balaton at a sediment trap that was deep dredged in 1979, to analyze their changes in the last 40 years. Pb ... ...

Abstract	We studied the Pb, Sr, and U isotopic composition and the concentration of toxic metal elements in sediment core samples collected in Lake Balaton at a sediment trap that was deep dredged in 1979, to analyze their changes in the last 40 years. Pb isotopic composition profiles of cores taken from the sediment trap showed different
MeSH term(s)	Lakes ; Lead ; Hungary ; Geologic Sediments ; Environmental Monitoring ; Poland ; Metals, Heavy/analysis
Chemical Substances	Lead (2P299V784P) ; Metals, Heavy
Language	English
Publishing date	2023-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-25120-z
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Article ; Online: Mechanisms of Antiviral Immune Evasion of SARS-CoV-2.

Beyer, Daniel K / Forero, Adriana

Journal of molecular biology

2021 Volume 434, Issue 6, Page(s) 167265

Abstract: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response and high levels of proinflammatory cytokine expression. Type I and III IFNs serve as a ... ...

Abstract	Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response and high levels of proinflammatory cytokine expression. Type I and III IFNs serve as a first line of defense during acute viral infections and are readily antagonized by viruses to establish productive infection. A rapidly growing body of work has interrogated the mechanisms by which SARS-CoV-2 antagonizes both IFN induction and IFN signaling to establish productive infection. Here, we summarize these findings and discuss the molecular interactions that prevent viral RNA recognition, inhibit the induction of IFN gene expression, and block the response to IFN treatment. We also describe the mechanisms by which SARS-CoV-2 viral proteins promote host shutoff. A detailed understanding of the host-pathogen interactions that unbalance the IFN response is critical for the design and deployment of host-targeted therapeutics to manage COVID-19.
MeSH term(s)	COVID-19/genetics ; COVID-19/immunology ; Gene Expression ; Humans ; Immune Evasion ; Immunity, Innate ; Interferons/genetics ; RNA, Viral/immunology ; SARS-CoV-2/immunology
Chemical Substances	RNA, Viral ; Interferons (9008-11-1)
Language	English
Publishing date	2021-09-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2021.167265
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Article: Mechanisms of Antiviral Immune Evasion of SARS-CoV-2

Beyer, Daniel K. / Forero, Adriana

Journal of molecular biology. 2021 Sept. 14,

2021

Abstract	Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response and high levels of proinflammatory cytokine expression. Type I and III IFNs serve as a first line of defense during acute viral infections and are readily antagonized by viruses to establish productive infection. A rapidly growing body of work has interrogated the mechanisms by which SARS-CoV-2 antagonizes both IFN induction and IFN signaling to establish productive infection. Here, we summarize these findings and discuss the molecular interactions that prevent viral RNA recognition, inhibit the induction of IFN gene expression, and block the response to IFN treatment. We also describe the mechanisms by which SARS-CoV-2 viral proteins promote host shutoff. A detailed understanding of the host-pathogen interactions that unbalance the IFN response is critical for the design and deployment of host-targeted therapeutics to manage COVID-19.
Keywords	COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; cytokines ; gene expression ; immune evasion ; interferons ; molecular biology ; therapeutics
Language	English
Dates of publication	2021-0914
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2021.167265
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Distribution of Pb, Sr, and U isotopic signature and multielement composition of sediment in Lake Balaton (Hungary) at a sediment trap deep dredged 40 years ago near Balatongyörök—search for routes of recent pollution

Beyer, Dániel Ernő / Varga, Mária / Fazekas, Peter / Pánczél, János K.

Environ Sci Pollut Res. 2023 Mar., v. 30, no. 14 p.42311-42326

2023

Abstract	We studied the Pb, Sr, and U isotopic composition and the concentration of toxic metal elements in sediment core samples collected in Lake Balaton at a sediment trap that was deep dredged in 1979, to analyze their changes in the last 40 years. Pb isotopic composition profiles of cores taken from the sediment trap showed different ²⁰⁶Pb/²⁰⁷Pb ratios ranging from 1.206 ± 0.002 at the bottom of the core (phase 1) compared to 1.185 ± 0.002 at the top of the core (phase 2). Phase 2 is the fraction reflecting isotopic signatures of the latest 40 years. At 80–100-cm depth, a transition zone was observed. Pb concentration together with Zn, Sb, Cu, Cd, and Fe showed elevated, 2–4 times higher values in the top phase of the sediment. The calculated Pb isotopic composition of pollutant Pb fraction was 1.177 ± 0.005 in the case of the ²⁰⁶Pb/²⁰⁷Pb and 2.456 ± 0.004 for ²⁰⁸Pb/²⁰⁷Pb, which shows good agreement with literature data for lead ores in Poland and Germany, but it is distinct from literature data for leaded fuel concerning Middle and Eastern Europe. The marked difference in the Pb signatures of phases enabled the construction of a sediment deposition rate map. U and Mo showed a characteristic concentration peak positioned exactly at the depth of the Pb signature transition. The isotopic signature of U based on ²³⁴U and ²³⁵U also showed a similar pattern. We suggest that the deposition of U and Mo can be related to cyanobacterial blooms in Lake Balaton in the late 1970s and early1980s.
Keywords	fuels ; lakes ; lead ; pollutants ; pollution ; sediment deposition ; sediment traps ; sediments ; toxicity ; Eastern European region ; Germany ; Hungary ; Poland
Language	English
Dates of publication	2023-03
Size	p. 42311-42326.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-25120-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Scanning transmission helium ion microscopy on carbon nanomembranes.

Emmrich, Daniel / Wolff, Annalena / Meyerbröker, Nikolaus / Lindner, Jörg K N / Beyer, André / Gölzhäuser, Armin

Beilstein journal of nanotechnology

2021 Volume 12, Page(s) 222–231

Abstract: A dark-field scanning transmission ion microscopy detector was designed for the helium ion microscope. The detection principle is based on a secondary electron conversion holder with an exchangeable aperture strip allowing its acceptance angle to be ... ...

Abstract	A dark-field scanning transmission ion microscopy detector was designed for the helium ion microscope. The detection principle is based on a secondary electron conversion holder with an exchangeable aperture strip allowing its acceptance angle to be tuned from 3 to 98 mrad. The contrast mechanism and performance were investigated using freestanding nanometer-thin carbon membranes. The results demonstrate that the detector can be optimized either for most efficient signal collection or for maximum image contrast. The designed setup allows for the imaging of thin low-density materials that otherwise provide little signal or contrast and for a clear end-point detection in the fabrication of nanopores. In addition, the detector is able to determine the thickness of membranes with sub-nanometer precision by quantitatively evaluating the image signal and comparing the results with Monte Carlo simulations. The thickness determined by the dark-field transmission detector is compared to X-ray photoelectron spectroscopy and energy-filtered transmission electron microscopy measurements.
Language	English
Publishing date	2021-02-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2583584-1
ISSN	2190-4286
ISSN	2190-4286
DOI	10.3762/bjnano.12.18
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Article: Impact of Coronavirus Disease 2019 (COVID-19) Pandemic on Surgical Site Infection in Patients with Inflammatory Bowel Disease-A Monocentric, Retrospective Cohort Study.

Strobel, Rahel Maria / Baehr, Amelie / Hammerich, Ralf / Schulze, Daniel / Lehmann, Kai Siegfried / Lauscher, Johannes Christian / Beyer, Katharina / Otto, Susanne Dorothea / Seifarth, Claudia

Journal of clinical medicine

2024 Volume 13, Issue 3

Abstract: 1) ...

Abstract	(1)
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030650
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Article ; Online: Scanning transmission helium ion microscopy on carbon nanomembranes

Daniel Emmrich / Annalena Wolff / Nikolaus Meyerbröker / Jörg K. N. Lindner / André Beyer / Armin Gölzhäuser

Beilstein Journal of Nanotechnology, Vol 12, Iss 1, Pp 222-

2021 Volume 231

Abstract	A dark-field scanning transmission ion microscopy detector was designed for the helium ion microscope. The detection principle is based on a secondary electron conversion holder with an exchangeable aperture strip allowing its acceptance angle to be tuned from 3 to 98 mrad. The contrast mechanism and performance were investigated using freestanding nanometer-thin carbon membranes. The results demonstrate that the detector can be optimized either for most efficient signal collection or for maximum image contrast. The designed setup allows for the imaging of thin low-density materials that otherwise provide little signal or contrast and for a clear end-point detection in the fabrication of nanopores. In addition, the detector is able to determine the thickness of membranes with sub-nanometer precision by quantitatively evaluating the image signal and comparing the results with Monte Carlo simulations. The thickness determined by the dark-field transmission detector is compared to X-ray photoelectron spectroscopy and energy-filtered transmission electron microscopy measurements.
Keywords	carbon nanomembranes ; dark field ; helium ion microscopy (him) ; scanning transmission ion microscopy (stim) ; srim simulations ; Technology ; T ; Chemical technology ; TP1-1185 ; Science ; Q ; Physics ; QC1-999
Subject code	530
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Beilstein-Institut
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Überbau : Produktionsverhältnisse der Architektur im Anthropozän

2021

Keywords	History of architecture ; Conservation of the environment ; architecture
Size	1 electronic resource (133 pages)
Publishing place	Berlin
Document type	Book ; Online
Note	German ; Open Access
HBZ-ID	HT021233282
ISBN	9783798332140 ; 3798332142
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A laboratory-based multifunctional near ambient pressure X-ray photoelectron spectroscopy system for electrochemical, catalytic, and cryogenic studies.

Haug, Leander / Griesser, Christoph / Thurner, Christoph W / Winkler, Daniel / Moser, Toni / Thaler, Marco / Bartl, Pit / Rainer, Manuel / Portenkirchner, Engelbert / Schumacher, David / Dierschke, Karsten / Köpfle, Norbert / Penner, Simon / Beyer, Martin K / Loerting, Thomas / Kunze-Liebhäuser, Julia / Klötzer, Bernhard

The Review of scientific instruments

2023 Volume 94, Issue 6

Abstract: A versatile multifunctional laboratory-based near ambient pressure x-ray photoelectron spectroscopy (XPS) instrument is presented. The entire device is highly customized regarding geometry, exchangeable manipulators and sample stages for liquid- and ... ...

Abstract	A versatile multifunctional laboratory-based near ambient pressure x-ray photoelectron spectroscopy (XPS) instrument is presented. The entire device is highly customized regarding geometry, exchangeable manipulators and sample stages for liquid- and solid-state electrochemistry, cryochemistry, and heterogeneous catalysis. It therefore delivers novel and unique access to a variety of experimental approaches toward a broad choice of functional materials and their specific surface processes. The high-temperature (electro)catalysis manipulator is designed for probing solid state/gas phase interactions for heterogeneous catalysts including solid electrolyzer/fuel cell electrocatalysts at pressures up to 15 mbar and temperatures from room temperature to 1000 °C. The liquid electrochemistry manipulator is specifically designed for in situ spectroscopic investigations of polarized solid/liquid interfaces using aqueous electrolytes and the third one for experiments for ice and ice-like materials at cryogenic temperatures to approximately -190 °C. The flexible and modular combination of these setups provides the opportunity to address a broad spectrum of in situ and operando XPS experiments on a laboratory-based system, circumventing the limited accessibility of experiments at synchrotron facilities.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0151755
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Article: Advancing Beyond the Hippocampus to Preserve Cognition for Patients With Brain Metastases: Dosimetric Results From a Phase 2 Trial of Memory-Avoidance Whole Brain Radiation Therapy.

Perlow, Haley K / Nalin, Ansel P / Ritter, Alex R / Addington, Mark / Ward, Aubrie / Liu, Michal / Nappi, Collin / Blakaj, Dukagjin M / Beyer, Sasha J / Thomas, Evan M / Grecula, John C / Raval, Raju R / Kotecha, Rupesh / Boulter, Daniel / Dawson, Erica L / Zoller, Wesley / Palmer, Joshua D

Advances in radiation oncology

2023 Volume 9, Issue 2, Page(s) 101337

Abstract: Purpose: Recent advances to preserve neurocognitive function in patients treated for brain metastases include stereotactic radiosurgery, hippocampal avoidance whole brain radiation therapy (WBRT), and memantine administration. The hippocampus, corpus ... ...

Abstract	Purpose: Recent advances to preserve neurocognitive function in patients treated for brain metastases include stereotactic radiosurgery, hippocampal avoidance whole brain radiation therapy (WBRT), and memantine administration. The hippocampus, corpus callosum, fornix, and amygdala are key neurocognitive substructures with a low propensity for brain metastases. Herein, we report our preliminary experience using a "memory-avoidance" WBRT (MA-WBRT) approach that spares these substructures for patients with >15 brain metastases. Methods and materials: Ten consecutive patients treated with MA-WBRT on a phase 2 clinical trial were reviewed. In each patient, the hippocampi, amygdalae, corpus callosum, and fornix were contoured. Patients were not eligible for MA-WBRT if they had metastases in these substructures. A memory-avoidance region was created using a 5-mm volumetric expansion around these substructures. Hotspots were avoided in the hypothalamus and pituitary gland. Coverage of brain metastases was prioritized over memory avoidance dose constraints. Dose constraints for these avoidance structures included a D100% ≤ 9 Gy and D0.03 cm Results: On average, the memory avoidance structure volume was 37.1 cm Conclusions: Modern volumetric modulated arc therapy techniques allow for sparing of the hippocampus, amygdala, corpus callosum, and fornix with good target coverage and homogeneity. After enrollment is completed, quality of life and cognitive data will be evaluated to assess the efficacy of MA-WBRT to mitigate declines in quality of life and cognition after whole brain radiation.
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2023.101337
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