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Article ; Online: NAD

Yaku, Keisuke / Nakagawa, Takashi

2023 Volume 39, Issue 16-18, Page(s) 1133–1149

Abstract: Significance: ...

Abstract	Significance:
MeSH term(s)	Humans ; NAD/metabolism ; Nucleotides
Chemical Substances	NAD (0U46U6E8UK) ; Nucleotides
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2023.0354
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Zs.A 5488: Show issues

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Article ; Online: Efficacy of BAY 60-2770, a soluble guanylate cyclase activator, for coronary spasm in animal models.

Tawa, Masashi / Nakagawa, Keisuke / Ohkita, Mamoru

The Journal of pharmacology and experimental therapeutics

2024

Abstract: Ischemia with non-obstructive coronary arteries (INOCA), caused by coronary artery spasm, has gained increasing attention owing to the poor quality of life of impacted patients. Therapeutic options to address INOCA remain limited, and developing new ... ...

Abstract	Ischemia with non-obstructive coronary arteries (INOCA), caused by coronary artery spasm, has gained increasing attention owing to the poor quality of life of impacted patients. Therapeutic options to address INOCA remain limited, and developing new therapeutic agents is desirable. Herein, we examined whether soluble guanylate cyclase (sGC) activators could be beneficial in preventing coronary spasms. In organ chamber experiments with isolated canine coronary arteries, prostaglandin F
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.123.001918
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Article ; Online: Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice.

Tawa, Masashi / Nakagawa, Keisuke / Ohkita, Mamoru

Physiological reports

2023 Volume 11, Issue 12, Page(s) e15755

Abstract: This study investigated whether beetroot juice (BRJ) ingestion ameliorates aging-induced functional and structural changes in vasculature. Aged mice (98-100 weeks old) were supplemented with BRJ (nitrate: 3.5 mmol/L) or drinking water for 4 weeks and ... ...

Abstract	This study investigated whether beetroot juice (BRJ) ingestion ameliorates aging-induced functional and structural changes in vasculature. Aged mice (98-100 weeks old) were supplemented with BRJ (nitrate: 3.5 mmol/L) or drinking water for 4 weeks and compared with young mice (12-15 weeks old). The vasorelaxant response of isolated aortas to acetylcholine was markedly weaker in aged mice than in young mice, but the attenuated relaxation was significantly improved in BRJ-supplemented aged mice. The acetylcholine-induced relaxation was completely abolished by N
MeSH term(s)	Mice ; Animals ; Nitrates ; Acetylcholine ; Antioxidants ; Dietary Supplements ; Vascular Diseases
Chemical Substances	Nitrates ; Acetylcholine (N9YNS0M02X) ; Antioxidants
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15755
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Article ; Online: Increased psoas tendon running angle in patients with Legg-Calvé-Perthes disease: a new theory for the aetiology of children with avascular femoral head necrosis.

Nakagawa, Keisuke / Kitano, Toshio

Journal of pediatric orthopedics. Part B

2022 Volume 31, Issue 2, Page(s) e160–e166

Abstract: The cause of Legg-Calvé-Perthes disease (LCPD) remains unknown. We propose a new hypothesis that the iliopsoas muscle and/or tendon affects the progression of ischemic necrosis of the femoral head as an anatomical factor. The purpose of this study was to ...

Abstract	The cause of Legg-Calvé-Perthes disease (LCPD) remains unknown. We propose a new hypothesis that the iliopsoas muscle and/or tendon affects the progression of ischemic necrosis of the femoral head as an anatomical factor. The purpose of this study was to test this hypothesis by measuring the psoas major tendon angle (PMTA) and cross-sectional area (CSA) of the iliopsoas muscle on MRI. We selected three predetermined axial MRI scans at the level of the psoas major tendon origin, the femoral head, and the lesser trochanter. We calculated the proximal, distal, and combined PMTA and compared these angles between the LCPD group and the transient synovitis (TS) group as a control. Our results revealed that the proximal PMTAs of the LCPD-affected sides were significantly greater than in the TS controls (P < 0.05), while there were no significant differences in the proximal PMTA, combined PMTA, and CSA. This result indicates that the psoas major tendon of the patient with LCPD curves sharply on the anterior capsule of the hip joint more than in the control group patients. This sudden curve of the psoas major tendon may be involved in the development of LCPD. We measured PMTAs in patients with LCPD. Our findings suggested that the running curve of the psoas major tendon is an anatomical factor that influences the development of mechanically-induced ischemia in LCPD.
MeSH term(s)	Child ; Femur Head ; Femur Head Necrosis/diagnostic imaging ; Femur Head Necrosis/etiology ; Hip Joint/diagnostic imaging ; Humans ; Legg-Calve-Perthes Disease/diagnostic imaging ; Tendons
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article
ISSN	1473-5865
ISSN (online)	1473-5865
DOI	10.1097/BPB.0000000000000936
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Article ; Online: Diagnostic imaging for elbow TRASH lesions in children and usefulness of ultrasonography using standard planes.

Shintani, Kosuke / Hosomi, Ryo / Suzuki, Keisuke / Hidaka, Noriaki / Nakagawa, Keisuke / Kitano, Toshio

Journal of pediatric orthopedics. Part B

2023 Volume 32, Issue 6, Page(s) 557–564

Abstract: Fractures around the elbow in children should be carefully evaluated because the main portion is cartilaginous, and radiographs are not completely reliable. This study aimed to assess the diagnostic imaging for pediatric elbow fractures that require ... ...

Abstract	Fractures around the elbow in children should be carefully evaluated because the main portion is cartilaginous, and radiographs are not completely reliable. This study aimed to assess the diagnostic imaging for pediatric elbow fractures that require special attention and consider the usefulness of ultrasonography with seven standard planes for the diagnosis. Patients diagnosed with elbow fractures wherein TRASH (The Radiographic Appearance Seemed Harmless) lesions were evaluated retrospectively. The diagnoses on initial radiographs, final diagnoses, additional imaging excluding radiographs, and the treatments were investigated. The standard planes for ultrasonography to detect elbow fractures included an anterior transverse scan at the level of the capitellum and proximal radioulnar joint, an anterior longitudinal scan at the level of the humeroradial and humeroulnar joints, a longitudinal scan along the lateral and medial border of the distal humerus, and a posterior longitudinal scan at the level of the distal humerus. A total of 107 patients with an average age of 5.8 years (range, 0-12 years) at the time of diagnosis were included. Of 46 (43.0%) patients misdiagnosed at the initial radiograph, 19 (17.8%) needed additional treatments due to inappropriate initial management. Ultrasonography using the standard planes was useful for prompt diagnosis and appropriate treatment. Prompt and appropriate evaluation with ultrasonography can prevent the mismanagement of pediatric elbow injuries. Level of evidence: Level IV-retrospective case series.
MeSH term(s)	Humans ; Child ; Child, Preschool ; Elbow/diagnostic imaging ; Retrospective Studies ; Elbow Joint/diagnostic imaging ; Radiography ; Ultrasonography ; Fractures, Bone ; Elbow Fractures ; Humeral Fractures/diagnostic imaging
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ISSN	1473-5865
ISSN (online)	1473-5865
DOI	10.1097/BPB.0000000000001062
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Article ; Online: Deletion of Nmnat1 in Skeletal Muscle Leads to the Reduction of NAD

Karim, Mariam / Iqbal, Tooba / Nawaz, Allah / Yaku, Keisuke / Nakagawa, Takashi

Journal of nutritional science and vitaminology

2023 Volume 69, Issue 3, Page(s) 184–189

Abstract: Nicotinamide adenine dinucleotide ( ... ...

Abstract	Nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Mice ; Animals ; NAD/metabolism ; Muscle, Skeletal/metabolism ; Muscle Fibers, Skeletal/metabolism ; Mice, Knockout ; Nicotinamide-Nucleotide Adenylyltransferase/genetics ; Nicotinamide-Nucleotide Adenylyltransferase/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; Nmnat1 protein, mouse (EC 2.7.7.1) ; Nicotinamide-Nucleotide Adenylyltransferase (EC 2.7.7.1)
Language	English
Publishing date	2023-07-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.69.184
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Zs.B 596: Show issues

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Article ; Online: Molecular survey of infectious bronchitis virus on poultry farms in Gifu Prefecture, Japan from 2021 to 2022 by RT-PCR with an enhanced level of detection sensitivity for the S1 gene.

Saito, Harunobu / Nakagawa, Keisuke / Kitamura, Yuko / Kuwata, Keisuke / Tanaka, Eiji

The Journal of veterinary medical science

2022 Volume 84, Issue 9, Page(s) 1157–1163

Abstract: Infectious bronchitis virus (IBV) is the causative agent of infectious bronchitis (IB) in chickens. There is a correlation between cross-protection and percentage of similarity between nucleotide sequences encoding the S1 subunit, which is responsible ... ...

Abstract	Infectious bronchitis virus (IBV) is the causative agent of infectious bronchitis (IB) in chickens. There is a correlation between cross-protection and percentage of similarity between nucleotide sequences encoding the S1 subunit, which is responsible for generating neutralizing and serotype-specific antibodies. Therefore, RT-PCR is commonly used to amplify the IBV-S1 gene following DNA sequencing in order to predict the efficacy of vaccines against IBV strains. We successfully enhanced the sensitivity for detection of the IBV-S1 gene by second PCR after purification of the 1st RT-PCR product. Using that method, we obtained detailed information on the prevalence of IBV on poultry farms in Gifu Prefecture, Japan. The IBV-S1 gene detection method used in the current study will enable accurate information on the prevalence of IBV in Japan to be obtained.
MeSH term(s)	Animals ; Chickens ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/veterinary ; Farms ; Infectious bronchitis virus ; Japan/epidemiology ; Poultry ; Poultry Diseases/diagnosis ; Poultry Diseases/epidemiology ; Poultry Diseases/prevention & control ; Reverse Transcriptase Polymerase Chain Reaction/veterinary
Language	English
Publishing date	2022-07-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.22-0206
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Article ; Online: Loss of hepatic Nmnat1 has no impact on diet-induced fatty liver disease.

Iqbal, Tooba / Nawaz, Allah / Karim, Mariam / Yaku, Keisuke / Hikosaka, Keisuke / Matsumoto, Michihiro / Nakagawa, Takashi

Biochemical and biophysical research communications

2022 Volume 636, Issue Pt 1, Page(s) 89–95

Abstract: Nicotinamide adenine dinucleotide ( ... ...

Abstract	Nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Mice ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; NAD/metabolism ; Liver/metabolism ; Nicotinamide-Nucleotide Adenylyltransferase/genetics ; Nicotinamide-Nucleotide Adenylyltransferase/metabolism ; Obesity/metabolism ; Diet ; Mice, Inbred C57BL
Chemical Substances	NAD (0U46U6E8UK) ; Nicotinamide-Nucleotide Adenylyltransferase (EC 2.7.7.1) ; Nmnat1 protein, mouse (EC 2.7.7.1)
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.10.072
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Article ; Online: Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression.

Nakagawa, Keisuke / Makino, Shinji

Cells

2021 Volume 10, Issue 2

Abstract: Many viruses disrupt host gene expression by degrading host mRNAs and/or manipulating translation activities to create a cellular environment favorable for viral replication. Often, virus-induced suppression of host gene expression, including those ... ...

Abstract	Many viruses disrupt host gene expression by degrading host mRNAs and/or manipulating translation activities to create a cellular environment favorable for viral replication. Often, virus-induced suppression of host gene expression, including those involved in antiviral responses, contributes to viral pathogenicity. Accordingly, clarifying the mechanisms of virus-induced disruption of host gene expression is important for understanding virus-host cell interactions and virus pathogenesis. Three highly pathogenic human coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome (MERS)-CoV, and SARS-CoV-2, have emerged in the past two decades. All of them encode nonstructural protein 1 (nsp1) in their genomes. Nsp1 of SARS-CoV and MERS-CoV exhibit common biological functions for inducing endonucleolytic cleavage of host mRNAs and inhibition of host translation, while viral mRNAs evade the nsp1-induced mRNA cleavage. SARS-CoV nsp1 is a major pathogenic determinant for this virus, supporting the notion that a viral protein that suppresses host gene expression can be a virulence factor, and further suggesting the possibility that SARS-CoV-2 nsp1, which has high amino acid identity with SARS-CoV nsp1, may serve as a major virulence factor. This review summarizes the gene expression suppression functions of nsp1 of CoVs, with a primary focus on SARS-CoV nsp1 and MERS-CoV nsp1.
MeSH term(s)	Animals ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; Coronavirus Infections/virology ; Gene Expression Regulation ; Host Microbial Interactions ; Humans ; Mice ; RNA, Messenger/genetics ; RNA-Dependent RNA Polymerase/physiology ; Viral Nonstructural Proteins/physiology ; Virus Replication
Chemical Substances	RNA, Messenger ; Viral Nonstructural Proteins ; Nsp1 protein, SARS coronavirus (EC 2.7.7.48) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2021-02-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10020300
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Article ; Online: Optimization of wrist tendon detection in virtual monochromatic images using dual energy-computed tomography.

Nishiyama, Norimi / Masuda, Takanori / Nakagawa, Junnichi / Terami, Keisuke / Nakaura, Takeshi

Japanese journal of radiology

2023 Volume 41, Issue 12, Page(s) 1397–1404

Abstract: Objectives: To evaluate the depiction of wrist tendons in virtual monochromatic images (VMIs) during a dual-energy CT (DE-CT) with the VMI image of conventional equivalent to 120 kVp.: Materials and methods: Using Catphan600 and phantom analysis ... ...

Abstract	Objectives: To evaluate the depiction of wrist tendons in virtual monochromatic images (VMIs) during a dual-energy CT (DE-CT) with the VMI image of conventional equivalent to 120 kVp. Materials and methods: Using Catphan600 and phantom analysis software for CT evaluation, measurements of VMI in a DE-CT were performed corresponding to the tube voltages of single-energy CT at 120 kVp. Using a Discovery CT750 HD CT scanner (GE Healthcare) with DE-CT technology, 73 patients were scanned. We calculated the CT number, image noise, visual score, and contrast noise ratio (CNR) at the extensor pollicis tendon, extensor digitorum tendon, and flexor tendon in 11 VMIs from the DE-CT and VMI image of conventional equivalent to 120 kVp. The results from the optimal VMIs were then compared with that of the VMI image of the conventional equivalent to 120 kVp. Results: The highest CT number and CNR for the tendon were for the 140 keV VMI in the DE-CT compared to the other energy levels. There were significantly higher CT numbers, CNR values, and visual scores for each tendon at 140 keV VMI with the DE-CT (p < 0.01) compared with a VMI image of conventional equivalent to 120 kVp. Conclusion: Energy level of the VMIs during DE-CT for the best wrist tendon delineation was 140 keV. This value of 140 keV for the DE-CT was significantly higher than the CT number and CNR for the extensor pollicis, extensor digitorum, and flexor tendon compared with a VMI image of conventional equivalent to 120 kVp.
MeSH term(s)	Humans ; Wrist/diagnostic imaging ; Signal-To-Noise Ratio ; Retrospective Studies ; Tomography, X-Ray Computed/methods ; Tendons/diagnostic imaging ; Radiographic Image Interpretation, Computer-Assisted/methods ; Radiography, Dual-Energy Scanned Projection/methods
Language	English
Publishing date	2023-07-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-023-01467-2
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