Article ; Online: Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats.
2019 Volume 8, Issue 11
Abstract: Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we ... ...
| Abstract | Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aorta, NO bioavailability, oxidative stress, systolic blood pressure (SBP), and fetal-placental development at the early, middle, and late pregnancy stages in normotensive and Nω-Nitro-L-arginine methyl-ester (L-NAME)-induced hypertensive pregnancy in rats. Reduced MMP-2 activity in uterus, placenta, and aorta and reduced MMP-9 activity in plasma and placenta with concomitant increased NO levels were found in normotensive pregnant rats. By contrast, increased MMP-2 activity in uterus, placenta, and aorta, and increased MMP-9 activity in plasma and placenta with concomitant reduced NO levels were observed in hypertensive pregnant rats. Also, elevated oxidative stress was displayed by hypertensive pregnant rats at the middle and late stages. These findings in the L-NAME-treated pregnant rats were also followed by increases in SBP and associated with fetal growth restrictions at the middle and late pregnancy stages. We concluded that NO bioavailability may regulate MMPs activation during normal and hypertensive pregnancy. |
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| MeSH term(s) | Animals ; Biomarkers ; Blood Pressure/drug effects ; Enzyme Activation ; Female ; Gestational Age ; Hypertension/blood ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/metabolism ; Lipid Metabolism/drug effects ; Lipid Peroxidation ; Matrix Metalloproteinase 2/blood ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/blood ; Matrix Metalloproteinase 9/metabolism ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/blood ; Oxidative Stress ; Pregnancy ; Pregnancy Complications, Cardiovascular/blood ; Pregnancy Complications, Cardiovascular/etiology ; Pregnancy Complications, Cardiovascular/metabolism ; Rats |
| Chemical Substances | Biomarkers ; Nitric Oxide (31C4KY9ESH) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X) |
| Language | English |
| Publishing date | 2019-11-07 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2661518-6 |
| ISSN | 2073-4409 ; 2073-4409 |
| ISSN (online) | 2073-4409 |
| ISSN | 2073-4409 |
| DOI | 10.3390/cells8111402 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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