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  1. Article ; Online: Polydopamine-Coated Liposomes for Methylene Blue Delivery in Anticancer Photodynamic Therapy: Effects in 2D and 3D Cellular Models.

    De Leo, Vincenzo / Marras, Emanuela / Maurelli, Anna Maria / Catucci, Lucia / Milano, Francesco / Gariboldi, Marzia Bruna

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Photodynamic therapy (PDT) is a therapeutic option for cancer, in which photosensitizer (PS) drugs, light, and molecular oxygen generate reactive oxygen species (ROS) and induce cell death. First- and second-generation PSs presented with problems that ... ...

    Abstract Photodynamic therapy (PDT) is a therapeutic option for cancer, in which photosensitizer (PS) drugs, light, and molecular oxygen generate reactive oxygen species (ROS) and induce cell death. First- and second-generation PSs presented with problems that hindered their efficacy, including low solubility. Thus, second-generation PSs loaded into nanocarriers were produced to enhance their cellular uptake and therapeutic efficacy. Among other compounds investigated, the dye methylene blue (MB) showed potential as a PS, and its photodynamic activity in tumor cells was reported even in its nanocarrier-delivered form, including liposomes. Here, we prepared polydopamine (PDA)-coated liposomes and efficiently adsorbed MB onto their surface. lipoPDA@MB vesicles were first physico-chemically characterized and studies on their light stability and on the in vitro release of MB were performed. Photodynamic effects were then assessed on a panel of 2D- and 3D-cultured cancer cell lines, comparing the results with those obtained using free MB. lipoPDA@MB uptake, type of cell death induced, and ability to generate ROS were also investigated. Our results show that lipoPDA@MB possesses higher photodynamic potency compared to MB in both 2D and 3D cell models, probably thanks to its higher uptake, ROS production, and apoptotic cell death induction. Therefore, lipoPDA@MB appears as an efficient drug delivery system for MB-based PDT.
    MeSH term(s) Photochemotherapy/methods ; Liposomes ; Methylene Blue/pharmacology ; Methylene Blue/chemistry ; Reactive Oxygen Species ; Photosensitizing Agents/chemistry ; Cell Line, Tumor ; Indoles ; Polymers
    Chemical Substances polydopamine ; Liposomes ; Methylene Blue (T42P99266K) ; Reactive Oxygen Species ; Photosensitizing Agents ; Indoles ; Polymers
    Language English
    Publishing date 2024-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063392
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  2. Article: Mass Spectrometry Characterization of the SDS-PAGE Protein Profile of Legumins and Vicilins from Chickpea Seed.

    Di Francesco, Antonella / De Santis, Michele Andrea / Lanzoni, Aldo / Pittalà, Maria Gaetana Giovanna / Saletti, Rosaria / Flagella, Zina / Cunsolo, Vincenzo

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 6

    Abstract: Chickpea ( ...

    Abstract Chickpea (
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13060887
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  3. Article: A centralized contact-tracing protocol for the COVID-19 pandemic.

    Buccafurri, Francesco / De Angelis, Vincenzo / Labrini, Cecilia

    Information sciences

    2022  Volume 617, Page(s) 103–132

    Abstract: ... detrimental to people's privacy, up to mass surveillance. This paper presents a new centralized DCT protocol ...

    Abstract Digital contact tracing (DCT) is one of the weapons to be used against the COVID-19 pandemic, especially in a post-lockdown phase, to prevent or block foci of infection. As DCT systems can handle highly private information about people, great care must be taken to prevent misuse of the system and actions detrimental to people's privacy, up to mass surveillance. This paper presents a new centralized DCT protocol, called ZE2-P3T (Zero Ephemeral Exchanging Privacy-Preserving Proximity Protocol), which relies on smartphone localization but does not give any information about the user's location and identity to the server. Importantly, the fact that no exchange of ephemeral identities among users is required is the basis of the strong security of the protocol, which is proven to be more secure than the state-of-the-art protocol DP-3T/GAEN.
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 0020-0255
    ISSN 0020-0255
    DOI 10.1016/j.ins.2022.10.101
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  4. Article ; Online: Apolipoprotein B and Lipid Profile in Italian Children and Adolescents.

    Martino, Francesco / Niglio, Tarcisio / Martino, Eliana / Paravati, Vincenzo / de Sanctis, Luisa / Guardamagna, Ornella

    Journal of cardiovascular development and disease

    2024  Volume 11, Issue 2

    Abstract: Rationale: The prevention of cardiovascular (CV) disease is mandatory from childhood onwards. Among biochemical markers related to the clinical cardiovascular outcome, LDL cholesterol (LDL-C), non-HDL-C and apolipoprotein B (ApoB) are recognized as main ...

    Abstract Rationale: The prevention of cardiovascular (CV) disease is mandatory from childhood onwards. Among biochemical markers related to the clinical cardiovascular outcome, LDL cholesterol (LDL-C), non-HDL-C and apolipoprotein B (ApoB) are recognized as main target parameters. Emphasis on ApoB concentrations is growing, as representative of any class of atherogenic lipoprotein. This consideration allows checking of subjects under 18 years of age when the CV risk occurs. The aim of this study is to evaluate ApoB levels in a sample of Italian hyperlipidemic children and adolescents, and their siblings, to test any relationship with their lipid profile.
    Methods: A retrospective study, including 1877 children and adolescents (aged 0-18 years), was performed. Clinical and biochemical data were selected from a database, including the lipid profile, ApoB analysis and anthropometric parameters of any proband. Participants had been checked as potentially hyperlipidemia affected, the suspicion raised by familial CV risk or because the dyslipidemia was already known. Data from the first visit at the University Hospitals in Rome and Turin were collected. Patients affected by secondary hyperlipidemia or obesity were excluded. Blood test analysis was performed in fasting conditions by automated commercial kits. Participants were classified according to gender, age (stratified in subgroups: 0-5, 6-10, 11-14, and 15-18 years old) and anthropometric parameters, referred to as weight in Kg and height in cm, and BMI calculated. Lipid profile results were stratified in relation to acceptable, borderline, or increased levels, as indicated by NCEP, and any potential relation with ApoB established. Statistics were performed by Epi-Info 7 programs to evaluate the variance analysis. Either parent could sign the informed consent.
    Results: Among the whole sample n.1010 and n.867 participants were females and males, respectively. TC values acceptable (≤170 mg/dL), borderline (171-200 mg/dL) and elevated (≥201 mg/dL) were found in 411 (22%), 585 (31%) and 881 (47%) participants, respectively. The LDL-C cut-off considered was 110 mg/dL (90° percentile). Mean ApoB progressively increased from 65 to 110 mg/dL according to TC levels and resulted in significant correlation when any age subgroup and gender was considered. The highest ApoB values, TC and LDL-C related, were found in the youngest subgroup, regardless of gender.
    Conclusion: ApoB results increase progressively and in parallel with TC and LDL-C and represent a further parameter to distinguish between normal and hyperlipidemic subjects. Serum levels are close to 70 mg/dL and to 100 mg/dL in the former and latter group, respectively.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd11020044
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  5. Article: Extracranial Nasosinusal Meningioma: A Case Report of a Rare Entity.

    Romano, Antonio / Maffia, Francesco / Iaquino, Vincenzo / Tarallo, Giuseppe / Abbate, Vincenzo / De Fazio, Gianluca Renato / Committeri, Umberto / Bonavolontà, Paola / Califano, Luigi / Dell'Aversana Orabona, Giovanni

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2023  Volume 75, Issue Suppl 1, Page(s) 836–839

    Abstract: Meningiomas are the most common neoformations of the central nervous system, and represent the 33% of all intracranial neoplasms. The nasosinusal tract is involved in 24% of cases of extracranial localization. The aim of our paper is to present the case ... ...

    Abstract Meningiomas are the most common neoformations of the central nervous system, and represent the 33% of all intracranial neoplasms. The nasosinusal tract is involved in 24% of cases of extracranial localization. The aim of our paper is to present the case of a patient with an ethmoidal sinus meningioma.
    Language English
    Publishing date 2023-01-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-022-03462-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5300: Show issues Location:
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  6. Article ; Online: Omics-based monitoring of microbial dynamics across the food chain for the improvement of food safety and quality.

    Sequino, Giuseppina / Valentino, Vincenzo / Villani, Francesco / De Filippis, Francesca

    Food research international (Ottawa, Ont.)

    2022  Volume 157, Page(s) 111242

    Abstract: The diffusion of high-throughput sequencing has dramatically changed the study of food microbial ecology. Amplicon-based description of the microbial community may be routinary implemented in the food industry to understand how the processing parameters ... ...

    Abstract The diffusion of high-throughput sequencing has dramatically changed the study of food microbial ecology. Amplicon-based description of the microbial community may be routinary implemented in the food industry to understand how the processing parameters and the raw material quality may affect the microbial community of the final product, as well as how the community changes during the shelf-life. In addition, application of shotgun metagenomics may represent an invaluable resource to understand the functional potential of the microbial community, identifying the presence of spoilage-associated activities or genes related to pathogenesis. Finally, retrieving Metagenome-Assembled Genomes (MAGs) of relevant species may be useful for strain-tracking along the food chain and in case of food poisoning outbreaks. This review gives an overview of the possible applications of sequencing-based approaches in the study of food microbial ecology, highlighting limitations that still prevent the spreading of these techniques to the food industry.
    MeSH term(s) Food Chain ; Food Safety ; Metagenome ; Metagenomics/methods ; Microbiota/genetics
    Language English
    Publishing date 2022-04-16
    Publishing country Canada
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2022.111242
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  7. Article: Promoting post-traumatic growth in cancer patients: a randomized controlled trial of guided written disclosure.

    Cafaro, Valentina / Rabitti, Elisa / Artioli, Giovanna / Costantini, Massimo / De Vincenzo, Francesco / Franzoni, Francesca / Cavuto, Silvio / Bertelli, Tatiana / Deledda, Giuseppe / Piattelli, Angela / Cardinali, Lisa / De Padova, Silvia / Poli, Sara / Iuvaro, Maria Domenica / Fantoni, Giovanna / Di Leo, Silvia

    Frontiers in psychology

    2024  Volume 15, Page(s) 1285998

    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1285998
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  8. Article ; Online: Assessment of Sexual Dysfunction in Cervical Cancer Patients after Different Treatment Modality: A Systematic Review.

    Tramacere, Francesco / Lancellotta, Valentina / Casà, Calogero / Fionda, Bruno / Cornacchione, Patrizia / Mazzarella, Ciro / De Vincenzo, Rosa Pasqualina / Macchia, Gabriella / Ferioli, Martina / Rovirosa, Angeles / Gambacorta, Maria Antonietta / Colosimo, Cesare / Valentini, Vincenzo / Iezzi, Roberto / Tagliaferri, Luca

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 9

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Dyspareunia/etiology ; Female ; Humans ; Middle Aged ; Orgasm ; Sexual Dysfunction, Physiological/etiology ; Sexual Dysfunction, Physiological/therapy ; Sexual Dysfunctions, Psychological/complications ; Uterine Cervical Neoplasms/complications ; Uterine Cervical Neoplasms/therapy
    Language English
    Publishing date 2022-09-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58091223
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  9. Article: Lymphocyte to Monocyte Ratio: A New Independent Prognostic Factor in Bladder Cancer Progression?

    Ferro, Matteo / Caputo, Vincenzo Francesco / Barone, Biagio / Imbimbo, Ciro / de Cobelli, Ottavio / Crocetto, Felice

    Frontiers in oncology

    2021  Volume 11, Page(s) 754649

    Language English
    Publishing date 2021-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.754649
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  10. Article ; Online: Three-dimensional (3D) polylactic acid gradient scaffold to study the behavior of osteosarcoma cells under dynamic conditions.

    De Luca, Angela / Capuana, Elisa / Carbone, Camilla / Raimondi, Lavinia / Carfì Pavia, Francesco / Brucato, Valerio / La Carrubba, Vincenzo / Giavaresi, Gianluca

    Journal of biomedical materials research. Part A

    2024  Volume 112, Issue 6, Page(s) 841–851

    Abstract: This study adopts an in vitro method to recapitulate the behavior of Saos-2 cells, using a system composed of a perfusion bioreactor and poly-L-lactic acid (PLLA) scaffold fabricated using the low-cost thermally-induced phase separation (TIPS) technique. ...

    Abstract This study adopts an in vitro method to recapitulate the behavior of Saos-2 cells, using a system composed of a perfusion bioreactor and poly-L-lactic acid (PLLA) scaffold fabricated using the low-cost thermally-induced phase separation (TIPS) technique. Four distinct scaffold morphologies with different pore sizes were fabricated, characterized by Scanning electron microscopy and micro-CT analysis and tested with osteosarcoma cells under static and dynamic environments to identify the best morphology for cellular growth. In order to accomplish this purpose, cell growth and matrix deposition of the Saos-2 osteosarcoma cell line were assessed using Picogreen and OsteoImage assays. The obtained data allowed us to identify the morphology that better promotes Saos-2 cellular activity in static and dynamic conditions. These findings provided valuable insights into scaffold design and fabrication strategies, emphasizing the importance of the dynamic culture to recreate an appropriate 3D osteosarcoma model. Remarkably, the gradient scaffold exhibits promise for osteosarcoma applications, offering the potential for targeted tissue engineering approaches.
    MeSH term(s) Humans ; Tissue Scaffolds ; Polyesters/pharmacology ; Tissue Engineering/methods ; Osteosarcoma
    Chemical Substances poly(lactide) (459TN2L5F5) ; Polyesters
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37665
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6195: Show issues Location:
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