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  1. Book ; Conference proceedings: Insecticide action

    Narahashi, Toshio

    from molecule to organism ; [proceedings of the Symposium on Insecticide Action: From Molecule to Organism, held as part of the national meeting of the Agrochemicals Division of the American Chemical Society, September 25 - 30, 1988, in Los Angeles, California]

    1989  

    Institution American Chemical Society / Division of Agrochemicals
    Event/congress Symposium on Insecticide Action: From Molecule to Organism (1988, LosAngelesCalif.)
    Author's details ed. by Toshio Narahashi
    Keywords Insecticides / pharmacology / congresses ; Pflanzenschädling ; Insektizid ; Wirkung
    Subject Effekt ; Wirkungen ; Effekte ; Insektengift
    Size VIII, 275 S. : Ill., graph. Darst.
    Publisher Plenum Pr
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003697715
    ISBN 0-306-43406-7 ; 978-0-306-43406-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    938/985 available for loan (reading room) Freihandmagazin (U1)

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  2. Book ; Conference proceedings: Insecticide action

    Narahashi, Toshio

    from molecule to organism ; [proceedings of the Symposium on Insecticide Action: From Molecule to Organism, held as part of the national meeting of the Agrochemicals Division of the American Chemical Society, September 25 - 30, 1988, in Los Angeles, California]

    1989  

    Institution American Chemical Society / Division of Agrochemicals
    Event/congress Symposium on Insecticide Action: From Molecule to Organism (1988, LosAngelesCalif.)
    Author's details ed. by Toshio Narahashi
    Keywords Insecticides / pharmacology / congresses ; Pflanzenschädling ; Insektizid ; Wirkung
    Subject Effekt ; Wirkungen ; Effekte ; Insektengift
    Size VIII, 275 S. : Ill., graph. Darst.
    Publisher Plenum Pr
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003697715
    ISBN 0-306-43406-7 ; 978-0-306-43406-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 363 order for loan Magazin

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  3. Book ; Conference proceedings: Cellular and molecular neurotoxicology

    Narahashi, Toshio

    [based on the proceedings of the Satellite Symposium "Cellular and Molecular Basis of Neurotoxicity of Environmental Agents" held in San Diego, Calif., on Aug. 26 and 27, 1983 ...]

    1984  

    Event/congress Satellite Symposium Cellular and Molecular Basis of Neurotoxicity of Environmental Agents (1983, SanDiegoCalif.)
    Keywords ENVIRONMENTAL POLLUTANTS / TOXICITY / CONGRESSES ; NERVOUS SYSTEM / DRUG EFFECTS / CONGRESSES ; NERVOUS SYSTEM DISEASES / CHEMICALLY INDUCED / CONGRESSES ; Neurotoxikologie
    Subject Nervensystem
    Size 304 S.
    Publisher Raven Pr
    Publishing place New York, NY
    Document type Book ; Conference proceedings
    HBZ-ID HT002721447
    ISBN 0-88167-028-6 ; 978-0-88167-028-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1985 A 530 order for loan Magazin

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  4. Book: NEUROTOXICOLOGY OF INSECTICIDES AND PHEROMONES

    Narahashi, Toshio

    1979  

    Author's details ED. BY TOSHIO NARAHASHI
    Keywords INSECTICIDES / TOXICITY / CONGRESSES ; INSECTS / DRUG EFFECTS / CONGRESSES ; NERVOUS SYSTEM / DRUG EFFECTS / CONGRESSES ; PHEROMONES / TOXICITY / CONGRESSES
    Size VIII, 308 S.
    Publisher PLENUM PRESS
    Publishing place NEW YORK (U.A.)
    Document type Book
    Note PROCEEDINGS OF THE SYMPOSIUM ON CHEMISTRY OF NEUROHORMONES AND NEUROTRANSMISSION HELD IN CONJUNCTION WITH THE 175TH ANNIVERSARY OF THE AMERICAN CHEMICAL SOCIETY, AT ANAHEIM, CALIF., MARCH 14 - 15, 1978
    HBZ-ID HT000291235
    ISBN 0-306-40067-7 ; 978-0-306-40067-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1980 A 1977 order for loan Magazin

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  5. Book: Cellular Pharmacology of excitable tissues

    Narahashi, Toshio

    1975  

    Author's details ed. by Toshio Narahashi
    Language English
    Size IX, 537 S. ; 8-o
    Publisher Thomas
    Publishing place Springfield, Ill
    Publishing country United States
    Document type Book
    HBZ-ID HT009679116
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1976 A 400 order for loan Magazin

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  6. Article ; Online: Tetrodotoxin: a brief history.

    Narahashi, Toshio

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2008  Volume 84, Issue 5, Page(s) 147–154

    Abstract: Tetrodotoxin (TTX), contained in puffer, has become an extremely popular chemical tool in the physiological and pharmacological laboratories since our discovery of its channel blocking action in the early 1960s. This brief review describes the history of ...

    Abstract Tetrodotoxin (TTX), contained in puffer, has become an extremely popular chemical tool in the physiological and pharmacological laboratories since our discovery of its channel blocking action in the early 1960s. This brief review describes the history of discovery of TTX action on sodium channels, and represents a story primarily of my own work. TTX inhibits voltage-gated sodium channels in a highly potent and selective manner without effects on any other receptor and ion channel systems. TTX blocks the sodium channel only from outside of the nerve membrane, and is due to binding to the selectivity filter resulting in prevention of sodium ion flow. It does not impairs the channel gating mechanism. More recently, the TTX-resistant sodium channels have been discovered in the nervous system and received much attention because of their role in pain sensation. TTX is now known to be produced not by puffer but by bacteria, and reaches various species of animals via food chain.(Communicated by Masanori OTSUKA, M.J.A.).
    MeSH term(s) Action Potentials/drug effects ; Animals ; Ion Channel Gating ; Sodium Channel Blockers/pharmacology ; Sodium Channels/drug effects ; Tetraodontiformes ; Tetrodotoxin/pharmacology
    Chemical Substances Sodium Channel Blockers ; Sodium Channels ; Tetrodotoxin (4368-28-9)
    Language English
    Publishing date 2008-10-18
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.84.147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/60 b: Show issues
    Z PRO 15: Show issues

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  7. Article ; Online: Principles of electrophysiology: an overview.

    Narahashi, Toshio

    Current protocols in toxicology

    2003  Volume Chapter 11, Page(s) Unit11.10

    Abstract: This overview gives brief accounts of the mechanism of nerve excitation, receptor/channel functions, cable properties of neurons, and voltage clamp and patch clamp principles. Among various aspects of electrophysiology, emphasis is placed on the ... ...

    Abstract This overview gives brief accounts of the mechanism of nerve excitation, receptor/channel functions, cable properties of neurons, and voltage clamp and patch clamp principles. Among various aspects of electrophysiology, emphasis is placed on the mechanistic studies of receptors/channels. A few sample records of membrane currents are illustrated to aid reader's comprehension. Finally some useful reference books are given for more comprehensive information.
    MeSH term(s) Animals ; Humans ; Ion Channels/physiology ; Receptors, Cell Surface/physiology
    Chemical Substances Ion Channels ; Receptors, Cell Surface
    Language English
    Publishing date 2003-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1934-9262
    ISSN (online) 1934-9262
    DOI 10.1002/0471140856.tx1110s17
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article: Nerve membrane ion channels as the target site of insecticides.

    Narahashi, Toshio

    Mini reviews in medicinal chemistry

    2002  Volume 2, Issue 4, Page(s) 419–432

    Abstract: Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly ... ...

    Abstract Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly on sodium channels to keep them open leading to hyperexcitation. Indoxacarb inhibits sodium channels and certain subtypes of nicotinic receptors. Dieldrin, lindane and fipronil block GABA receptors. Imidacloprid modulates nicotinic receptors in a complex manner. Spinosad's major target site appears to be nicotinic receptors.
    MeSH term(s) Animals ; Drug Design ; Humans ; Insecticides/pharmacology ; Insecticides/toxicity ; Ion Channels/drug effects ; Membrane Potentials/drug effects ; Neurons/chemistry ; Neurons/drug effects ; Neurons/ultrastructure
    Chemical Substances Insecticides ; Ion Channels
    Language English
    Publishing date 2002-07-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/1389557023405927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5891: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor.

    Moriguchi, Shigeki / Tanaka, Tomoya / Narahashi, Toshio / Fukunaga, Kohji

    Hippocampus

    2013  Volume 23, Issue 10, Page(s) 942–951

    Abstract: Sunifiram is a novel pyrrolidone nootropic drug structurally related to piracetam, which was developed for neurodegenerative disorder like Alzheimer's disease. Sunifiram is known to enhance cognitive function in some behavioral experiments such as Morris ...

    Abstract Sunifiram is a novel pyrrolidone nootropic drug structurally related to piracetam, which was developed for neurodegenerative disorder like Alzheimer's disease. Sunifiram is known to enhance cognitive function in some behavioral experiments such as Morris water maze task. To address question whether sunifiram affects N-methyl-D-aspartate receptor (NMDAR)-dependent synaptic function in the hippocampal CA1 region, we assessed the effects of sunifiram on NMDAR-dependent long-term potentiation (LTP) by electrophysiology and on phosphorylation of synaptic proteins by immunoblotting analysis. In mouse hippocampal slices, sunifiram at 10-100 nM significantly enhanced LTP in a bell-shaped dose-response relationship which peaked at 10 nM. The enhancement of LTP by sunifiram treatment was inhibited by 7-chloro-kynurenic acid (7-ClKN), an antagonist for glycine-binding site of NMDAR, but not by ifenprodil, an inhibitor for polyamine site of NMDAR. The enhancement of LTP by sunifilam was associated with an increase in phosphorylation of α-amino-3-hydroxy-5-methylisozazole-4-propionate receptor (AMPAR) through activation of calcium/calmodulin-dependent protein kinase II (CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase Cα (PKCα). Sunifiram treatments at 1-1000 nM increased the slope of field excitatory postsynaptic potentials (fEPSPs) in a dose-dependent manner. The enhancement was associated with an increase in phosphorylation of AMPAR receptor through activation of CaMKII. Interestingly, under the basal condition, sunifiram treatments increased PKCα (Ser-657) and Src family (Tyr-416) activities with the same bell-shaped dose-response curve as that of LTP peaking at 10 nM. The increase in phosphorylation of PKCα (Ser-657) and Src (Tyr-416) induced by sunifiram was inhibited by 7-ClKN treatment. The LTP enhancement by sunifiram was significantly inhibited by PP2, a Src family inhibitor. Finally, when pretreated with a high concentration of glycine (300 μM), sunifiram treatments failed to potentiate LTP in the CA1 region. Taken together, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCα activation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation.
    MeSH term(s) Animals ; CA1 Region, Hippocampal/drug effects ; CA1 Region, Hippocampal/surgery ; Dose-Response Relationship, Drug ; Electrodes, Implanted ; Excitatory Amino Acid Antagonists/administration & dosage ; Excitatory Amino Acid Antagonists/pharmacology ; Glycine/metabolism ; Kynurenic Acid/administration & dosage ; Kynurenic Acid/pharmacology ; Long-Term Potentiation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Nootropic Agents/administration & dosage ; Nootropic Agents/pharmacology ; Piperazines/administration & dosage ; Piperazines/pharmacology ; Piperidines/administration & dosage ; Piperidines/pharmacology ; Polyamines/metabolism ; Protein Binding/physiology ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/drug effects ; Synaptic Transmission/drug effects
    Chemical Substances Excitatory Amino Acid Antagonists ; Nootropic Agents ; Piperazines ; Piperidines ; Polyamines ; Receptors, N-Methyl-D-Aspartate ; DM 235 (66924E735K) ; Kynurenic Acid (H030S2S85J) ; ifenprodil (R8OE3P6O5S) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2013-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.22150
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book: Ion channels

    Narahashi, Toshio

    1996  

    Author's details ed. by Toshio Narahashi
    Language English
    Size XVII, 457 S, graph. Darst
    Publisher Plenum Press
    Publishing place New York, NY u.a.
    Document type Book
    Note Literaturangaben
    ISBN 0306452243 ; 9780306452246
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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