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Article ; Online: Renal handling of aluminium.

Shirley, D G / Lote, C J

2005 Volume 101, Issue 4, Page(s) p99–103

Abstract: Aluminium (Al) is absorbed from a variety of foodstuffs and medications. Its major route of elimination from the body is in the urine. However, current knowledge concerning its glomerular filtration and, more particularly, its reabsorption/secretion is ... ...

Abstract	Aluminium (Al) is absorbed from a variety of foodstuffs and medications. Its major route of elimination from the body is in the urine. However, current knowledge concerning its glomerular filtration and, more particularly, its reabsorption/secretion is fragmentary. Most (80-90%) of Al in the plasma is normally bound to protein (mainly transferrin) and is therefore unfilterable; the remainder is bound to low molecular mass compounds, of which citrate appears to be the most important. In vitro determinations using artificial membranes indicate that approximately 10% of Al is filtered at normal plasma concentrations. However, when plasma Al is raised experimentally, its filterability falls, unless the excess Al is complexed with citrate; the aluminium citrate complex appears to be freely filtered. Information on tubular Al reabsorption at normal plasma concentrations is inconsistent. Filtered Al appears to be at least partially reabsorbed, although the reabsorptive mechanisms remain speculative. A consensus is emerging that elevated plasma Al concentrations result in a fall in fractional Al reabsorption, and a recent micropuncture study indicates that under these circumstances the only significant site of Al reabsorption is the loop of Henle.
MeSH term(s)	Aluminum/pharmacokinetics ; Animals ; Humans ; Kidney/metabolism
Chemical Substances	Aluminum (CPD4NFA903)
Language	English
Publishing date	2005
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	207121-6
ISSN	1660-2137 ; 1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
ISSN (online)	1660-2137 ; 1423-0186 ; 2235-3186
ISSN	1660-8151 ; 0028-2766
DOI	10.1159/000088331
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Article: Renal Handling of Aluminium

Shirley, D.G. / Lote, C.J.

Nephron Physiology

2005 Volume 101, Issue 4, Page(s) p99–p103

Institution	Department of Physiology and Centre for Nephrology, University College London, London, and Division of Medical Sciences, University of Birmingham, Birmingham, UK
Abstract	Aluminium (Al) is absorbed from a variety of foodstuffs and medications. Its major route of elimination from the body is in the urine. However, current knowledge concerning its glomerular filtration and, more particularly, its reabsorption/secretion is fragmentary. Most (80–90%) of Al in the plasma is normally bound to protein (mainly transferrin) and is therefore unfilterable; the remainder is bound to low molecular mass compounds, of which citrate appears to be the most important. In vitro determinations using artificial membranes indicate that ∼10% of Al is filtered at normal plasma concentrations. However, when plasma Al is raised experimentally, its filterability falls, unless the excess Al is complexed with citrate; the aluminium citrate complex appears to be freely filtered. Information on tubular Al reabsorption at normal plasma concentrations is inconsistent. Filtered Al appears to be at least partially reabsorbed, although the reabsorptive mechanisms remain speculative. A consensus is emerging that elevated plasma Al concentrations result in a fall in fractional Al reabsorption, and a recent micropuncture study indicates that under these circumstances the only significant site of Al reabsorption is the loop of Henle.
Keywords	Aluminium excretion ; Aluminium filterability ; Aluminium reabsorption ; Citrate ; Micropuncture
Language	English
Publishing date	2005-11-14
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Minireview
ZDB-ID	207121-6
ISSN	1660-2137 ; 1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
ISSN (online)	1660-2137 ; 1423-0186 ; 2235-3186
ISSN	1660-8151 ; 0028-2766
DOI	10.1159/000088331
Database	Karger publisher's database

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Article ; Online: Renal Handling of Aluminium

Shirley, D. G. / Lote, C. J.

Nephron Physiology

2005 Volume 101, Issue 4, Page(s) p103–p99

Abstract	Aluminium (Al) is absorbed from a variety of foodstuffs and medications. Its major route of elimination from the body is in the urine. However, current knowledge concerning its glomerular filtration and, more particularly, its reabsorption/secretion is fragmentary. Most (80-90%) of Al in the plasma is normally bound to protein (mainly transferrin) and is therefore unfilterable; the remainder is bound to low molecular mass compounds, of which citrate appears to be the most important. In vitro determinations using artificial membranes indicate that ∼10% of Al is filtered at normal plasma concentrations. However, when plasma Al is raised experimentally, its filterability falls, unless the excess Al is complexed with citrate; the aluminium citrate complex appears to be freely filtered. Information on tubular Al reabsorption at normal plasma concentrations is inconsistent. Filtered Al appears to be at least partially reabsorbed, although the reabsorptive mechanisms remain speculative. A consensus is emerging that elevated plasma Al concentrations result in a fall in fractional Al reabsorption, and a recent micropuncture study indicates that under these circumstances the only significant site of Al reabsorption is the loop of Henle.
Keywords	Aluminium excretion ; Aluminium filterability ; Aluminium reabsorption ; Citrate ; Micropuncture
Language	English
Publisher	S. Karger AG
Publishing place	Basel
Publishing country	Switzerland
Document type	Article ; Online
ZDB-ID	207121-6
ISSN	1660-2137 ; 1423-0186 ; 0028-2766 ; 1660-8151 ; 1660-2137 ; 0028-2766 ; 1660-8151
ISSN (online)	1660-2137 ; 1423-0186
ISSN	1660-2137 ; 0028-2766 ; 1660-8151
DOI	10.1159/000088331
Database	Karger publisher's database

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Zs.A 169: Show issues

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Article: Interactions between renal tubules and interstitium.

Howie, A J / Lote, C J

Journal of clinical pathology

1996 Volume 49, Issue 10, Page(s) 783–786

Abstract: Renal tubules and interstitium have close physiological associations. Changes in both are often seen in renal disease. Damaged tubules can attract inflammatory cells and stimulate interstitial fibrosis, but do not always do so. Interstitial inflammation ... ...

Abstract	Renal tubules and interstitium have close physiological associations. Changes in both are often seen in renal disease. Damaged tubules can attract inflammatory cells and stimulate interstitial fibrosis, but do not always do so. Interstitial inflammation can damage tubules and can also stimulate fibrosis, and is probably always initiated by tubular events. Interstitial and tubular abnormalities are closely associated with changes in renal excretory function, but tubular events are more important. A main determinant of the outcome of renal disease is whether tubules can recover, not the extent of interstitial changes. If tubules are atrophic, they will not recover and renal function will be permanently impaired.
MeSH term(s)	Extracellular Space/immunology ; Extracellular Space/physiology ; Humans ; Kidney Cortex/physiology ; Kidney Diseases/immunology ; Kidney Diseases/pathology ; Kidney Diseases/physiopathology ; Kidney Medulla/physiology ; Kidney Tubules/immunology ; Kidney Tubules/pathology ; Kidney Tubules/physiology
Language	English
Publishing date	1996-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jcp.49.10.783
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Ud II Zs.139: Show issues

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Article: Renal prostaglandins and sodium excretion.

Lote, C J

Quarterly journal of experimental physiology (Cambridge, England)

1982 Volume 67, Issue 3, Page(s) 377–385

MeSH term(s)	Animals ; Anura ; Glomerular Filtration Rate ; Humans ; Kidney/metabolism ; Kidney/physiology ; Natriuresis ; Osmolar Concentration ; Prostaglandins/biosynthesis ; Prostaglandins/physiology ; Rats ; Renal Circulation ; Renin/metabolism ; Sodium/urine
Chemical Substances	Prostaglandins ; Sodium (9NEZ333N27) ; Renin (EC 3.4.23.15)
Language	English
Publishing date	1982-07
Publishing country	England
Document type	Journal Article
ZDB-ID	80192-6
ISSN	0144-8757 ; 0033-5541 ; 0370-2901
ISSN	0144-8757 ; 0033-5541 ; 0370-2901
DOI	10.1113/expphysiol.1982.sp002652
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Uc I Zs.102: Show issues

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Article ; Online: miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial.

Anandappa, Gayathri / Lampis, Andrea / Cunningham, David / Khan, Khurum H / Kouvelakis, Kyriakos / Vlachogiannis, Georgios / Hedayat, Somaieh / Tunariu, Nina / Rao, Sheela / Watkins, David / Starling, Naureen / Braconi, Chiara / Darvish-Damavandi, Mahnaz / Lote, Hazel / Thomas, Janet / Peckitt, Clare / Kalaitzaki, Ria / Khan, Nasir / Fotiadis, Nicos /

Rugge, Massimo / Begum, Ruwaida / Rana, Isma / Bryant, Annette / Hahne, Jens C / Chau, Ian / Fassan, Matteo / Valeri, Nicola

Clinical cancer research : an official journal of the American Association for Cancer Research

2019 Volume 25, Issue 13, Page(s) 3830–3838

Abstract: Purpose: Anti-EGFR mAbs are effective in the treatment of metastatic colorectal cancer (mCRC) patients. : Experimental design: miR-31-3p was tested by : Results: Patients with low miR-31-3p expression in pretreatment biopsies showed better overall ...

Abstract	Purpose: Anti-EGFR mAbs are effective in the treatment of metastatic colorectal cancer (mCRC) patients. Experimental design: miR-31-3p was tested by Results: Patients with low miR-31-3p expression in pretreatment biopsies showed better overall response rate, as well as better progression-free survival and overall survival, compared to those with high miR-31-3p expression. The prognostic effect of miR-31-3p was independent from age, gender, and sidedness. No significant changes in the expression of miR-31-3p were observed when sequential tissue biopsies were tested in long-term or poor responders to anti-EGFR mAbs. miR-31-3p scores were similar when pretreatment biopsies were compared with treatment-naïve archival tissues (often primary colorectal cancer). Conclusions: Our study validates the role of miR-31-3p as potential predictive biomarker of selection for anti-EGFR mAbs.
MeSH term(s)	Aged ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/mortality ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Male ; MicroRNAs/genetics ; Middle Aged ; Molecular Targeted Therapy ; Prognosis ; Retreatment ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Antineoplastic Agents, Immunological ; Biomarkers, Tumor ; MIRN31 microRNA, human ; MicroRNAs ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2019-04-05
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-18-3769
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Zs.A 4223: Show issues

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Article: Prostacyclin in diarrhoea-associated haemolytic uraemic syndrome.

Taylor, C M / Lote, C J

Pediatric nephrology (Berlin, Germany)

1993 Volume 7, Issue 5, Page(s) 515–519

Abstract: The role of prostacyclin (PGI2) in the pathogenesis of haemolytic uraemic syndrome (HUS) is controversial. In part, confusion has been caused by failure to distinguish between two main sub-types of the syndrome: extrinsic, diarrhoea-associated HUS (D+ ... ...

Abstract	The role of prostacyclin (PGI2) in the pathogenesis of haemolytic uraemic syndrome (HUS) is controversial. In part, confusion has been caused by failure to distinguish between two main sub-types of the syndrome: extrinsic, diarrhoea-associated HUS (D+ HUS), usually caused by infection with verocytotoxin-producing Escherichia coli or Shigella dysenteriae, and the heterogeneous group of non-prodromal forms where intrinsic factors predominate (D- HUS). This paper critically reviews data confined to D+ HUS. Two methods have been used to assess PGI2 synthesis; the generation of PGI2 from endothelium in the presence of HUS plasma in vitro and the measurement of stable metabolites in body fluids. No concensus could be reached with regard to the former. The reported increase of PGI2 stable metabolites in plasma may represent reduced clearance or increased carriage by plasma lipids. Apparent differences between studies of urinary excretion of PGI2 metabolites may reflect the way excretion was expressed. If the metabolite concentration is factored for urinary creatinine, it appears that renal excretion and thus renal synthesis of PGI2 is reduced. However, these are insufficient data on which to attribute the pathogenesis of D+ HUS to disordered PGI2 metabolism.
MeSH term(s)	6-Ketoprostaglandin F1 alpha/blood ; 6-Ketoprostaglandin F1 alpha/urine ; Animals ; Diarrhea/blood ; Diarrhea/complications ; Diarrhea/physiopathology ; Endothelium, Vascular/physiology ; Epoprostenol/blood ; Epoprostenol/physiology ; Epoprostenol/urine ; Gas Chromatography-Mass Spectrometry ; Hemolytic-Uremic Syndrome/blood ; Hemolytic-Uremic Syndrome/complications ; Hemolytic-Uremic Syndrome/physiopathology ; Humans ; Radioimmunoassay ; Rats
Chemical Substances	6-Ketoprostaglandin F1 alpha (58962-34-8) ; Epoprostenol (DCR9Z582X0)
Language	English
Publishing date	1993-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/bf00852530
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Article ; Online: Prostacyclin concentrations in haemolytic uraemic syndrome after acute shigellosis.

Taylor, C M / Lote, C J

Archives of disease in childhood

1992 Volume 67, Issue 11, Page(s) 1412–1413

MeSH term(s)	Acute Disease ; Dysentery, Bacillary/blood ; Epoprostenol/blood ; Hemolytic-Uremic Syndrome/blood ; Humans
Chemical Substances	Epoprostenol (DCR9Z582X0)
Language	English
Publishing date	1992-11
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/adc.67.11.1412-b
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Um IV Zs.106: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Aluminium: gastrointestinal absorption and renal excretion.

Lote, C J / Saunders, H

Clinical science (London, England : 1979)

1991 Volume 81, Issue 3, Page(s) 289–295

MeSH term(s)	Adolescent ; Adult ; Aluminum/metabolism ; Aluminum/pharmacokinetics ; Biological Availability ; Diet ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption/physiology ; Kidney/metabolism ; Male
Chemical Substances	Aluminum (CPD4NFA903)
Language	English
Publishing date	1991-09
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	760216-9
ISSN	0143-5221 ; 0144-9664
ISSN	0143-5221 ; 0144-9664
DOI	10.1042/cs0810289
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Ua VI Zs.220 -Suppl.: Show issues

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Article ; Online: Factors Influencing Antiretroviral Adherence and Virological Outcomes in People Living with HIV in the Highlands of Papua New Guinea.

Gare, Janet / Kelly-Hanku, Angela / Ryan, Claire E / David, Matthew / Kaima, Petronia / Imara, Ulato / Lote, Namarola / Crowe, Suzanne M / Hearps, Anna C

PloS one

2015 Volume 10, Issue 8, Page(s) e0134918

Abstract: Adherence to antiretroviral therapy (ART) is paramount for virological suppression and positive treatment outcomes. ART has been rapidly scaled up in Papua New Guinea (PNG) in recent years, however clinical monitoring of HIV+ individuals on ART is ... ...

Abstract	Adherence to antiretroviral therapy (ART) is paramount for virological suppression and positive treatment outcomes. ART has been rapidly scaled up in Papua New Guinea (PNG) in recent years, however clinical monitoring of HIV+ individuals on ART is limited. A cross-sectional study was conducted at two major sexual health clinics in high HIV prevalence provinces in the Highlands Region of PNG to assess ART adherence, factors affecting adherence and the relationship between ART adherence and virological outcomes. Ninety-five HIV+ individuals were recruited and administered a questionnaire to gather demographic and ART adherence information whilst clinical data and pill counts were extracted from patient charts and blood was collected for viral load testing. Bivariate analysis was performed to identify independent predictors of ART adherence. Fourteen percent (n = 12) of participants showed evidence of virological failure. Although the majority of participants self-reported excellent ART adherence in the last seven days (78.9%, 75/91), pill count measurements indicated only 40% (34/84) with >95% adherence in the last month. Taking other medications while on ART (p = 0.01) and taking ART for ≥1 year (p = 0.037) were positively associated with adherence by self-report and pill count, respectively. Participants who had never heard of drug resistance were more likely to show virological failure (p = 0.033). Misconception on routes of HIV transmission still persists in the studied population. These findings indicate that non-adherence to ART is high in this region of PNG and continued education and strategies to improve adherence are required to ensure the efficacy of ART and prevent HIV drug resistance.
MeSH term(s)	Adult ; Altitude ; Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; Cross-Sectional Studies ; Epidemics/prevention & control ; Female ; Geography ; HIV/drug effects ; HIV/physiology ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/virology ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Outcome Assessment (Health Care)/methods ; Outcome Assessment (Health Care)/statistics & numerical data ; Papua New Guinea/epidemiology ; Socioeconomic Factors ; Surveys and Questionnaires ; Viral Load/drug effects
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0134918
Database	MEDical Literature Analysis and Retrieval System OnLINE

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