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Article ; Online: Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti-PD-1 therapy-induced adverse events.

Tsukamoto, Hirotake / Komohara, Yoshihiro / Tomita, Yusuke / Miura, Yuji / Motoshima, Takanobu / Imamura, Kosuke / Kimura, Toshiki / Ikeda, Tokunori / Fujiwara, Yukio / Yano, Hiromu / Kamba, Tomomi / Sakagami, Takuro / Oshiumi, Hiroyuki

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 29, Page(s) e2205378119

Abstract: ... with ectopic accumulation of T and B cells in damaged organs. In this preclinical model, the organ toxicities ... mice induced the pathogenicity specifically in naïve aged hosts. Mechanistically, CD4 T-cell-derived ...

Abstract	Clinical success of immune-checkpoint blockade (ICB) cancer immunotherapy is compromised by increased risk of immune-related adverse events (irAEs). However, mechanistic action(s) of immune responses underlying development of irAE remain not fully explored. Here, we found that in tumor-bearing aged, but not young, mice, antiprogrammed death receptor (PD)-1 therapy elicited irAE-like multiorgan dysfunctions with ectopic accumulation of T and B cells in damaged organs. In this preclinical model, the organ toxicities were mediated by immunoglobulin G (IgG) deposition because administration of IG from ICB-treated aged mice induced the pathogenicity specifically in naïve aged hosts. Mechanistically, CD4 T-cell-derived interleukin (IL)-21 upregulated B-cell-homing chemokine, CXCL13, preferentially in irAE organs from aged mice treated with anti-PD-1 therapy. The ICB-induced pathogenicity was alleviated by B-cell depletion or by blockade of IL-21 or CXCL13 activity. These results suggest that age-associated immune regulatory milieu contributes to the formation of tertiary lymphoid structure-like lymphocytic aggregates in irAE organs and irAE-related toxicity employing IL-21-CXCL13-auto-antibody axis. Supporting this, a systemic increase in CXCL13 and
MeSH term(s)	Aging/immunology ; Animals ; CD4-Positive T-Lymphocytes/immunology ; Chemokine CXCL13/immunology ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Immune System Diseases/etiology ; Immunotherapy/adverse effects ; Lymphocyte Activation ; Mice ; Neoplasms/therapy ; Programmed Cell Death 1 Receptor/antagonists & inhibitors
Chemical Substances	Chemokine CXCL13 ; Cxcl13 protein, mouse ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2205378119
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Zs.A 1148: Show issues

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Article ; Online: t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization.

Nishizawa, Hidekazu / Baba, Masaya / Furuya, Mitsuko / Kato, Ikuma / Kurahashi, Ryoma / Honda, Yumi / Mikami, Yoshiki / Nagashima, Yoji / Eto, Masatoshi / Kamba, Tomomi

IJU case reports

2021 Volume 4, Issue 6, Page(s) 375–378

Abstract: ... of t(6; 11) renal cell carcinoma was made. There has been no recurrence for 5 years.: Conclusion ...

Abstract	Introduction: Definitive diagnosis of translocation renal cell carcinoma is challenging. We herein experienced a case of translocation(6;11) renal cell carcinoma, successfully diagnosed by using fluorescence in situ hybridization. Case presentation: During the follow-up of a 21-year-old man with Crohn's disease, computed tomography revealed a 40-mm mass in the right kidney. Since imaging could not exclude malignancy, needle biopsy was performed. The histological diagnosis from the biopsy specimen was renal cell carcinoma, but histological typing had not been done adequately. A laparoscopic partial nephrectomy was then performed. Transcription factor EB immunoreactivity was positive, transcription factor EB rearrangement was shown by break apart and fusion fluorescence in situ hybridization. As a result, a definitive diagnosis of t(6; 11) renal cell carcinoma was made. There has been no recurrence for 5 years. Conclusion: Transcription factor EB immunohistochemistry and fluorescence in situ hybridization are useful diagnostic tools for renal tumors of young generation.
Language	English
Publishing date	2021-08-12
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12353
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Article ; Online: High T-cell infiltration in tumor tissue and younger age predict the response to pembrolizumab in recurrent urothelial cancer.

Anami, Toshiki / Komohara, Yoshihiro / Miura, Yuji / Yamanaka, Kotaro / Kurahashi, Ryoma / Segawa, Takuya / Motoshima, Takanobu / Murakami, Yoji / Yatsuda, Junji / Yamaguchi, Takahiro / Sugiyama, Yutaka / Jinnouchi, Yoshiteru / Kamba, Tomomi

Medical molecular morphology

2021 Volume 54, Issue 4, Page(s) 316–323

Abstract: ... of CD8-positive T-cells and Tregs was significantly increased in the responder group than in the non ...

Abstract	Targeting the programmed cell death-1 signaling pathway has been approved for the anti-cancer therapy in several cancers including urothelial cancer. To determine predictive factors of the responsiveness to pembrolizumab in urothelial cancer patients, a retrospective study that used clinical information and paraffin-embedded samples obtained from patients diagnosed with urothelial cancer between 2015 and 2020 were performed. Seventeen patients who underwent total cystectomy or nephroureterectomy of the primary lesion and were treated with pembrolizumab for chemo-resistant disease were enrolled, and immunohistochemical analysis was performed. A key difference in the characteristics between the non-responder group and the responder group was the age of the patients (74 vs. 63 years, p = 0.0194). Although there was no statistically significant difference, the histological subtype with sarcomatoid and micropapillary components was only seen in the non-responder group, and squamous differentiation and lymph node metastasis were only seen in cases with a complete response. In the results of immunohistochemistry, the density of CD8-positive T-cells and Tregs was significantly increased in the responder group than in the non-responder group. In conclusion, younger age and a high number of tumor-infiltrating lymphocytes were predictive factors of a good response to immune checkpoint inhibitors, although further studies with more enrolled patients are necessary.
MeSH term(s)	Age Factors ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; CD8-Positive T-Lymphocytes ; Humans ; Middle Aged ; Retrospective Studies ; T-Lymphocytes, Regulatory ; Urinary Bladder Neoplasms/drug therapy
Chemical Substances	Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2021-06-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2190059-0
ISSN	1860-1499 ; 1860-1480
ISSN (online)	1860-1499
ISSN	1860-1480
DOI	10.1007/s00795-021-00292-8
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Zs.A 4019: Show issues

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Article: [Ⅳ. The First Japanese Clinical Practice Guidelines on Penile Cancer 2021].

Kamba, Tomomi

Gan to kagaku ryoho. Cancer & chemotherapy

2023 Volume 50, Issue 1, Page(s) 55–58

MeSH term(s)	Humans ; Male ; Lymphatic Metastasis ; Penile Neoplasms/therapy ; Japan
Language	Japanese
Publishing date	2023-02-08
Publishing country	Japan
Document type	Journal Article ; Practice Guideline
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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Article ; Online: Utilisation of indigenous knowledge to control gastrointestinal nematodes in Southern Africa.

Kamba, E T / Chimonyo, M

Tropical animal health and production

2024 Volume 56, Issue 2, Page(s) 100

Abstract: Gastrointestinal nematodes (GIN) exacerbate the impact of droughts on the survival of cattle. The inadequacies of the conventional system make it increasingly important to explore indigenous knowledge (IK) to create drought-tolerant and GIN resilient ... ...

Abstract	Gastrointestinal nematodes (GIN) exacerbate the impact of droughts on the survival of cattle. The inadequacies of the conventional system make it increasingly important to explore indigenous knowledge (IK) to create drought-tolerant and GIN resilient herds. The objective of the study was to assess the indigenous strategies for controlling GIN during droughts. Face-to-face interviews with experts on IK were conducted to give insight into the importance, methods and ranking of GIN control. The experts identified 86 cattle that were used to test their assertions. The control methods used were identifying cattle that were susceptible to high GIN loads using predisposing factors, diagnosis of GIN burdens using faecal appearance, and treatment using phytotherapy. Experts ranked predisposing factors as the most critical control strategy and identified body condition, class, sex, coat colour, pregnancy status and lactation status as predisposing factors to high GIN burdens. Thin, older, dark-coloured cattle, as well as pregnant and lactating cows, were considered susceptible to GIN. However, pregnancy status, coat colour and sex were significantly associated with high GIN burdens. Cows were 2.6 times more likely to have high GIN burdens than bulls. Dark-coloured cattle were 3.5 times more likely to have high GIN burdens than light-coloured ones, and the likelihood of pregnant cows was 4.9 times higher than non-pregnant cows. A dark-coloured pregnant cow was extremely susceptible to high GIN burdens. In conclusion, knowledge of predisposing factors informs selection decisions when purchasing foundation stock. Cattle that are susceptible to high GIN loads are prioritised during droughts or culled where resources are scarce.
MeSH term(s)	Female ; Animals ; Cattle ; Male ; Pregnancy ; Lactation ; Cattle Diseases ; Nematoda ; Gastrointestinal Tract ; Africa, Southern
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	603363-5
ISSN	1573-7438 ; 0049-4747
ISSN (online)	1573-7438
ISSN	0049-4747
DOI	10.1007/s11250-024-03941-z
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Zs.B 2159: Show issues

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Article: [Roles of enzalutamide in castrate-resistant prostate cancer].

Kamba, Tomomi

Nihon rinsho. Japanese journal of clinical medicine

2016 Volume 74 Suppl 3, Page(s) 632–639

MeSH term(s)	Clinical Trials as Topic ; Drug Design ; Drug Resistance, Neoplasm ; Humans ; Male ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/drug therapy
Chemical Substances	Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU)
Language	Japanese
Publishing date	2016-06-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Zs.A 429: Show issues

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Article ; Online: Factors influencing the integration of indigenous and conventional knowledge of water security for livestock.

Getyengana, K / Kamba, E T / Mkwanazi, M V / Ndlela, S Z / Mwale, M / Chimonyo, M

Tropical animal health and production

2023 Volume 55, Issue 2, Page(s) 136

Abstract: Farmers have developed indigenous knowledge (IK) on predictive and adaptation strategies to sustain water security. The objective of the study was to determine factors that influence the integration of IK and conventional knowledge (CK) to ensure water ... ...

Abstract	Farmers have developed indigenous knowledge (IK) on predictive and adaptation strategies to sustain water security. The objective of the study was to determine factors that influence the integration of IK and conventional knowledge (CK) to ensure water security for livestock. Focus group discussions and semi-structured interviews were used to gather data. Farmers in Musina and uMhlabuyalingana use IK indicators to predict rain for water security. Farmers in uMhlabuyalingana predicted rain using wind movement more than their counterparts in Musina (P < 0.05). Taboos were used (P > 0.05) in both Musina and uMhlabuyalingana to ensure water security. Cultural prohibitions were used more in uMhlabuyalingana to cope with water shortages than in Musina (P < 0.05). Boreholes, home taps and municipal water were not properly maintained (P > 0.05). Socio-economic factors had greater influence on the integration of IK and CK. Males were 2.24 times likely to support integration of IK and CK compared to women. Adults were 7.1 times likely to support integration of IK and CK compared to those that were younger. Farmers were open to the integration of conventional and indigenous knowledge to ensure water security. Promoting the integration of IK and CK enables stakeholders to gain access to valuable information which can, in turn, promote sustainable community development.
MeSH term(s)	Male ; Female ; Animals ; Humans ; Livestock ; Water ; Farmers ; Rain ; Water Supply
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	603363-5
ISSN	1573-7438 ; 0049-4747
ISSN (online)	1573-7438
ISSN	0049-4747
DOI	10.1007/s11250-023-03529-z
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Article ; Online: Detection of semenogelin 1 amyloidosis through immunohistochemical staining with novel antiserum developed based on mass spectrometric peptide mapping analysis.

Tasaki, Masayoshi / Misumi, Yohei / Nomura, Toshiya / Kamba, Tomomi / Ueda, Mitsuharu

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

2022 , Page(s) 1–3

Language	English
Publishing date	2022-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1205246-2
ISSN	1744-2818 ; 1350-6129
ISSN (online)	1744-2818
ISSN	1350-6129
DOI	10.1080/13506129.2022.2101920
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Article ; Online: Anisakiasis in the Upper Esophagus: A Case Report.

Kamba, Eiji / Murakami, Takashi / Ueyama, Hiroya / Shibuya, Tomoyoshi / Hojo, Mariko / Yamaji, Ken / Nagahara, Akihito

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 10

Abstract: Anisakiasis is caused by consuming raw fish contaminated ... ...

Abstract	Anisakiasis is caused by consuming raw fish contaminated with
MeSH term(s)	Male ; Animals ; Humans ; Middle Aged ; Anisakiasis/diagnosis ; Anisakis ; Esophagus ; Fishes ; Larva
Language	English
Publishing date	2023-10-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59101888
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Article ; Online: Improvement of obsessive-compulsive disorder after pallidothalamic tractotomy for cervical dystonia.

Horisawa, Shiro / Kamba, Rumiko / Sato, Moeko / Sueki, Akitsugu / Kawamata, Takakazu / Nishimura, Katsuji / Taira, Takaomi

Annals of clinical and translational neurology

2023 Volume 10, Issue 5, Page(s) 832–835

Abstract: A 30-year-old woman with tardive dystonia in the cervical region from long-term antipsychotic meds was treated with radiofrequency ablation of the right pallidothalamic tract in the fields of Forel. The patient showed improvement in both cervical ... ...

Abstract	A 30-year-old woman with tardive dystonia in the cervical region from long-term antipsychotic meds was treated with radiofrequency ablation of the right pallidothalamic tract in the fields of Forel. The patient showed improvement in both cervical dystonia and obsessive-compulsive disorder after the procedure, with 77.4% improvement in cervical dystonia and 86.7% improvement in obsessive-compulsive disorder. Although the treatment site in this case was intended to treat cervical dystonia, the lesion was located in the optimal stimulation network for both obsessive-compulsive disorder and cervical dystonia, suggesting that neuromodulation of this region could potentially treat both simultaneously.
MeSH term(s)	Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/surgery ; Pallidotomy/methods ; Globus Pallidus/surgery ; Humans ; Female ; Adult ; Subthalamus/surgery ; Antipsychotic Agents/adverse effects ; Radiofrequency Ablation ; Torticollis/chemically induced ; Torticollis/complications ; Torticollis/surgery ; Treatment Outcome
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2740696-9
ISSN	2328-9503 ; 2328-9503
ISSN (online)	2328-9503
ISSN	2328-9503
DOI	10.1002/acn3.51764
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