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  1. Book: Nanostructure design

    Gazit, Ehud

    methods and protocols

    (Methods in molecular biology ; 474)

    2008  

    Author's details ed. by Ehud Gazit
    Series title Methods in molecular biology ; 474
    Collection
    Keywords Nanostructures ; Nanotechnology / methods ; Molecular biology/Technique
    Subject code 572.8
    Language English
    Size 24cm
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015806334
    ISBN 1-934115-35-5 ; 978-1-934115-35-0 ; 9781597454803 ; 159745480X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 425 order for loan Magazin

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  2. Article ; Online: Preventing biofilm formation and eradicating pathogenic bacteria by Zn doped histidine derived carbon quantum dots.

    Kumar, Vijay Bhooshan / Lahav, Maoz / Gazit, Ehud

    Journal of materials chemistry. B

    2024  Volume 12, Issue 11, Page(s) 2855–2868

    Abstract: Bacterial infections are of major medical concern due to antibiotic resistance. Carbon quantum dots (CDs) have emerged as potentially excellent biomaterials for multifunctional applications due to their low toxicity, outstanding water solubility, high ... ...

    Abstract Bacterial infections are of major medical concern due to antibiotic resistance. Carbon quantum dots (CDs) have emerged as potentially excellent biomaterials for multifunctional applications due to their low toxicity, outstanding water solubility, high fluorescence, and high biocompatibility. All of these properties allow CDs to be exceptional biomaterials for inhibiting the growth of bacteria and stopping biofilm formation due to their strong binding affinity, cell wall penetration, and solubilizing biofilm in water. Here, we describe a strategy for one-pot synthesis of histidine-derived zinc-doped N-doped CDs (Zn-NCDs) by a hydrothermal method for inhibiting the growth of both Gram-positive and Gram-negative bacteria without harming mammalian cells. The NCDs and Zn-NCDs showed uniform sizes (∼6 nm), crystallinity, good photostability, high quantum yield (76%), and long decay time (∼5 ns). We also studied their utilization for live cell bio-imaging and the antimicrobial properties towards the Gram-positive
    MeSH term(s) Animals ; Quantum Dots/chemistry ; Anti-Bacterial Agents/pharmacology ; Histidine ; Carbon/chemistry ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Zinc/chemistry ; Water ; Biofilms ; Biocompatible Materials/pharmacology ; Mammals
    Chemical Substances Anti-Bacterial Agents ; Histidine (4QD397987E) ; Carbon (7440-44-0) ; Zinc (J41CSQ7QDS) ; Water (059QF0KO0R) ; Biocompatible Materials
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02488a
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  3. Article ; Online: High Quantum Yield Amino Acid Carbon Quantum Dots with Unparalleled Refractive Index.

    Kumar, Vijay Bhooshan / Mirsky, Simcha K / Shaked, Natan T / Gazit, Ehud

    ACS nano

    2024  Volume 18, Issue 3, Page(s) 2421–2433

    Abstract: Carbon quantum dots (CQDs) are one of the most promising types of fluorescent nanomaterials due to their exceptional water solubility, excellent optical properties, biocompatibility, chemical inertness, excellent refractive index, and photostability. ... ...

    Abstract Carbon quantum dots (CQDs) are one of the most promising types of fluorescent nanomaterials due to their exceptional water solubility, excellent optical properties, biocompatibility, chemical inertness, excellent refractive index, and photostability. Nitrogen-containing CQDs, which include amino acid based CQDs, are especially attractive due to their high quantum yield, thermal stability, and potential biomedical applications. Recent studies have attempted to improve the preparation of amino acid based CQDs. However, the highest quantum yield obtained for these dots was only 44%. Furthermore, the refractive indices of amino acid derived CQDs were not determined. Here, we systematically explored the performance of CQDs prepared from all 20 coded amino acids using modified hydrothermal techniques allowing more passivation layers on the surface of the dots to optimize their performance. Intriguingly, we obtained the highest refractive indices ever reported for any CQDs. The values differed among the amino acids, with the highest refractive indices found for positively charged amino acids including arginine-CQDs (∼2.1), histidine-CQDs (∼2.0), and lysine-CQDs (∼1.8). Furthermore, the arginine-CQDs reported here showed a nearly 2-fold increase in the quantum yield (∼86%) and a longer decay time (∼8.0 ns) compared to previous reports. In addition, we also demonstrated that all amino acid based CQD materials displayed excitation-dependent emission profiles (from UV to visible) and were photostable, water-soluble, noncytotoxic, and excellent for high contrast live cell imaging or bioimaging. These results indicate that amino acid based CQD materials are high-refractive-index materials applicable for optoelectronic devices, bioimaging, biosensing, and studying cellular organelles
    MeSH term(s) Refractometry ; Amino Acids ; Quantum Dots/chemistry ; Carbon/chemistry ; Water ; Arginine
    Chemical Substances Amino Acids ; Carbon (7440-44-0) ; Water (059QF0KO0R) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c10792
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  4. Article ; Online: Reductionist Approach in Peptide-Based Nanotechnology.

    Gazit, Ehud

    Annual review of biochemistry

    2018  Volume 87, Page(s) 533–553

    Abstract: The formation of ordered nanostructures by molecular self-assembly of proteins and peptides represents one of the principal directions in nanotechnology. Indeed, polyamides provide superior features as materials with diverse physical properties. A ... ...

    Abstract The formation of ordered nanostructures by molecular self-assembly of proteins and peptides represents one of the principal directions in nanotechnology. Indeed, polyamides provide superior features as materials with diverse physical properties. A reductionist approach allowed the identification of extremely short peptide sequences, as short as dipeptides, which could form well-ordered amyloid-like β-sheet-rich assemblies comparable to supramolecular structures made of much larger proteins. Some of the peptide assemblies show remarkable mechanical, optical, and electrical characteristics. Another direction of reductionism utilized a natural noncoded amino acid, α-aminoisobutryic acid, to form short superhelical assemblies. The use of this exceptional helix inducer motif allowed the fabrication of single heptad repeats used in various biointerfaces, including their use as surfactants and DNA-binding agents. Two additional directions of the reductionist approach include the use of peptide nucleic acids (PNAs) and coassembly techniques. The diversified accomplishments of the reductionist approach, as well as the exciting future advances it bears, are discussed.
    MeSH term(s) Amyloidogenic Proteins/chemistry ; Animals ; Biotechnology ; Humans ; Models, Molecular ; Nanostructures/chemistry ; Nanotechnology/methods ; Oligopeptides/chemistry ; Peptide Nucleic Acids/chemistry ; Peptides/chemistry ; Protein Engineering
    Chemical Substances Amyloidogenic Proteins ; Oligopeptides ; Peptide Nucleic Acids ; Peptides
    Language English
    Publishing date 2018-06-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207924-0
    ISSN 1545-4509 ; 0066-4154
    ISSN (online) 1545-4509
    ISSN 0066-4154
    DOI 10.1146/annurev-biochem-062917-012541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Peptide- and Metabolite-Based Hydrogels: Minimalistic Approach for the Identification and Characterization of Gelating Building Blocks.

    Tiwari, Om Shanker / Rencus-Lazar, Sigal / Gazit, Ehud

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Minimalistic peptide- and metabolite-based supramolecular hydrogels have great potential relative to traditional polymeric hydrogels in various biomedical and technological applications. Advantages such as remarkable biodegradability, high water content, ...

    Abstract Minimalistic peptide- and metabolite-based supramolecular hydrogels have great potential relative to traditional polymeric hydrogels in various biomedical and technological applications. Advantages such as remarkable biodegradability, high water content, favorable mechanical properties, biocompatibility, self-healing, synthetic feasibility, low cost, easy design, biological function, remarkable injectability, and multi-responsiveness to external stimuli make supramolecular hydrogels promising candidates for drug delivery, tissue engineering, tissue regeneration, and wound healing. Non-covalent interactions such as hydrogen bonding, hydrophobic interactions, electrostatic interactions, and π-π stacking interactions play key roles in the formation of peptide- and metabolite-containing low-molecular-weight hydrogels. Peptide- and metabolite-based hydrogels display shear-thinning and immediate recovery behavior due to the involvement of weak non-covalent interactions, making them supreme models for the delivery of drug molecules. In the areas of regenerative medicine, tissue engineering, pre-clinical evaluation, and numerous other biomedical applications, peptide- and metabolite-based hydrogelators with rationally designed architectures have intriguing uses. In this review, we summarize the recent advancements in the field of peptide- and metabolite-based hydrogels, including their modifications using a minimalistic building-blocks approach for various applications.
    MeSH term(s) Hydrogels/chemistry ; Peptides/chemistry ; Regenerative Medicine ; Tissue Engineering ; Drug Delivery Systems
    Chemical Substances Hydrogels ; Peptides
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210330
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  6. Article ; Online: Peptide nanostructures: Aromatic dipeptides light up.

    Gazit, Ehud

    Nature nanotechnology

    2016  Volume 11, Issue 4, Page(s) 309–310

    MeSH term(s) Dipeptides ; Humans ; Light ; Nanostructures ; Peptides
    Chemical Substances Dipeptides ; Peptides
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/nnano.2015.321
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  7. Article ; Online: Peptide- and Metabolite-Based Hydrogels

    Om Shanker Tiwari / Sigal Rencus-Lazar / Ehud Gazit

    International Journal of Molecular Sciences, Vol 24, Iss 10330, p

    Minimalistic Approach for the Identification and Characterization of Gelating Building Blocks

    2023  Volume 10330

    Abstract: Minimalistic peptide- and metabolite-based supramolecular hydrogels have great potential relative to traditional polymeric hydrogels in various biomedical and technological applications. Advantages such as remarkable biodegradability, high water content, ...

    Abstract Minimalistic peptide- and metabolite-based supramolecular hydrogels have great potential relative to traditional polymeric hydrogels in various biomedical and technological applications. Advantages such as remarkable biodegradability, high water content, favorable mechanical properties, biocompatibility, self-healing, synthetic feasibility, low cost, easy design, biological function, remarkable injectability, and multi-responsiveness to external stimuli make supramolecular hydrogels promising candidates for drug delivery, tissue engineering, tissue regeneration, and wound healing. Non-covalent interactions such as hydrogen bonding, hydrophobic interactions, electrostatic interactions, and π–π stacking interactions play key roles in the formation of peptide- and metabolite-containing low-molecular-weight hydrogels. Peptide- and metabolite-based hydrogels display shear-thinning and immediate recovery behavior due to the involvement of weak non-covalent interactions, making them supreme models for the delivery of drug molecules. In the areas of regenerative medicine, tissue engineering, pre-clinical evaluation, and numerous other biomedical applications, peptide- and metabolite-based hydrogelators with rationally designed architectures have intriguing uses. In this review, we summarize the recent advancements in the field of peptide- and metabolite-based hydrogels, including their modifications using a minimalistic building-blocks approach for various applications.
    Keywords peptide ; metabolite ; supramolecular hydrogel ; amino acids ; drug delivery ; tissue regeneration ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Metabolite assemblies: A surprising extension to the amyloid hypothesis.

    Gour, Nidhi / Gazit, Ehud

    Current opinion in chemical biology

    2021  Volume 64, Page(s) 154–164

    Abstract: The realization of the ability of metabolites to form self-assembled amyloid-like nanostructures was a surprising phenomenon. This discovery paved the way towards understanding the pathophysiology of the inborn error of metabolism disorders from a new ... ...

    Abstract The realization of the ability of metabolites to form self-assembled amyloid-like nanostructures was a surprising phenomenon. This discovery paved the way towards understanding the pathophysiology of the inborn error of metabolism disorders from a new perspective, relating them to amyloid-associated diseases that are characterized by the aggregation of proteins and polypeptides. Hence, a 'generic amyloid hypothesis' can be proposed. This theory implies that the formation of amyloid-like structures is a general phenomenon not limited to proteins and reflects a common etiology for both age-related amyloid-associated diseases and inborn error of metabolism disorders. Here, we present a comprehensive survey of the recent research related to metabolite amyloids including their structure formation through self-association, propagation, interactions, transmission, and their role in metabolic disorders and neurodegenerative diseases and their applications for the fabrication of novel materials which implicate metabolite assemblies as a surprising extension to the amyloid scheme.
    MeSH term(s) Amyloid/chemistry ; Humans ; Metabolic Diseases/metabolism ; Neurodegenerative Diseases/metabolism ; Peptides
    Chemical Substances Amyloid ; Peptides
    Language English
    Publishing date 2021-09-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2021.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4986: Show issues Location:
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  9. Article ; Online: Mind your marker: the effect of common auxotrophic markers on complex traits in yeast.

    Kaplan, Keila / Levkovich, Shon A / DeRowe, Yasmin / Gazit, Ehud / Laor Bar-Yosef, Dana

    The FEBS journal

    2024  

    Abstract: Yeast cells are extensively used as a key model organism owing to their highly conserved genome, metabolic pathways, and cell biology processes. To assist in genetic engineering and analysis, laboratory yeast strains typically harbor auxotrophic ... ...

    Abstract Yeast cells are extensively used as a key model organism owing to their highly conserved genome, metabolic pathways, and cell biology processes. To assist in genetic engineering and analysis, laboratory yeast strains typically harbor auxotrophic selection markers. When uncompensated, auxotrophic markers cause significant phenotypic bias compared to prototrophic strains and have different combinatorial influences on the metabolic network. Here, we used BY4741, a laboratory strain commonly used as a "wild type" strain in yeast studies, to generate a set of revertant strains, containing all possible combinations of four common auxotrophic markers (leu2∆, ura3∆, his3∆1, met15∆). We examined the effect of the auxotrophic combinations on complex phenotypes such as resistance to rapamycin, acetic acid, and ethanol. Among the markers, we found that leucine auxotrophy most significantly affected the phenotype. We analyzed the phenotypic bias caused by auxotrophy at the genomic level using a prototrophic version of a genome-wide deletion library and a decreased mRNA perturbation (DAmP) library. Prototrophy was found to suppress rapamycin sensitivity in many mutants previously annotated for the phenotype, raising a possible need for reevaluation of the findings in a native metabolic context. These results reveal a significant phenotypic bias caused by common auxotrophic markers and support the use of prototrophic wild-type strains in yeast research.
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.17095
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    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Metabolite medicine offers a path beyond lists of metabolites.

    Shaham-Niv, Shira / Rencus-Lazar, Sigal / Gazit, Ehud

    Communications chemistry

    2021  Volume 4, Issue 1, Page(s) 115

    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-021-00551-w
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