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  1. Article ; Online: Albumin binding improves nanobody pharmacokinetics for dual-modality PET/NIRF imaging of CEACAM5 in colorectal cancer models.

    Song, Wenyu / Wei, Weijun / Lan, Xiaoli / Cai, Weibo

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 9, Page(s) 2591–2594

    MeSH term(s) Humans ; Positron-Emission Tomography/methods ; Cell Line, Tumor ; Colorectal Neoplasms/diagnostic imaging ; Albumins ; Carcinoembryonic Antigen ; GPI-Linked Proteins
    Chemical Substances Albumins ; CEACAM5 protein, human ; Carcinoembryonic Antigen ; GPI-Linked Proteins
    Language English
    Publishing date 2023-05-04
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06266-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Antibody-Based Imaging and Therapy for Precision Medicine.

    Wei, Weijun / Jiang, Dawei / Evangelista, Laura / Cai, Weibo

    Molecular pharmaceutics

    2022  Volume 19, Issue 10, Page(s) 3453–3455

    MeSH term(s) Antibodies ; Diagnostic Imaging/methods ; Molecular Targeted Therapy ; Precision Medicine/methods
    Chemical Substances Antibodies
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6250: Show issues Location:
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  3. Article ; Online: PD-L1 - targeted magnetic fluorescent hybrid nanoparticles: Illuminating the path of image-guided cancer immunotherapy.

    Li, Xiaoyan / Younis, Muhsin H / Wei, Weijun / Cai, Weibo

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 8, Page(s) 2240–2243

    MeSH term(s) Humans ; B7-H1 Antigen ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Immunotherapy ; Nanoparticles ; Magnetic Phenomena ; Cell Line, Tumor
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2023-12-08
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06202-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Antioxidant properties and changes in vitro digestion of the fermented kiwifruit extract prepared by lactic acid bacteria and yeasts.

    Li, Yanhua / Wang, Weijun / Deng, Yangyong / Gao, Junlong / Shi, Jiayun / Cai, Liqin

    Food chemistry

    2024  Volume 442, Page(s) 138416

    Abstract: The health benefits of fermented fruits have attracted consumers' attention. High levels of antioxidant ability in the fermented kiwifruit extract were found at the early stage of fermentation. The co-fermention with Lactobacillus paracasei LG0260 and ... ...

    Abstract The health benefits of fermented fruits have attracted consumers' attention. High levels of antioxidant ability in the fermented kiwifruit extract were found at the early stage of fermentation. The co-fermention with Lactobacillus paracasei LG0260 and Kluyveromyces marxianus J2853 showed the highest ABTS radical scavenging ability (ABTS
    MeSH term(s) Antioxidants/metabolism ; Lactobacillales/metabolism ; Plant Extracts ; Superoxide Dismutase ; Digestion ; Fermentation ; Sulfonic Acids ; Benzothiazoles
    Chemical Substances Antioxidants ; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (28752-68-3) ; Plant Extracts ; Superoxide Dismutase (EC 1.15.1.1) ; Sulfonic Acids ; Benzothiazoles
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138416
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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  5. Article ; Online: Novel antibiotic susceptibility of an RNA polymerase α-subunit mutant in Pseudomonas aeruginosa.

    Cai, Wenjie / Lu, Mingqi / Dai, Weijun

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 9, Page(s) 2162–2169

    Abstract: Background: RNA polymerase (RNAP) is highly conserved and essential for prokaryotic housekeeping activities, making it an important target for the development of new antibiotics. The rpoB gene, encoding a β-subunit of bacterial RNAP, has a well-known ... ...

    Abstract Background: RNA polymerase (RNAP) is highly conserved and essential for prokaryotic housekeeping activities, making it an important target for the development of new antibiotics. The rpoB gene, encoding a β-subunit of bacterial RNAP, has a well-known association with rifampicin resistance. However, the roles of other RNAP component genes such as rpoA, encoding an α-subunit of RNAP, in antibiotic resistance remain unexplored.
    Objectives: To characterize the antibiotic resistance-related role of RpoA.
    Methods: We measured the expression of the MexEF-OprN efflux pump in an RpoA mutant using a transcriptional reporter. The MICs of various antibiotics for this RpoA mutant were determined.
    Results: We uncover a novel role of antibiotic susceptibility for an RpoA mutant in Pseudomonas aeruginosa. We found that a single amino acid substitution in RpoA resulted in reduced activity of the MexEF-OprN efflux pump, which is responsible for the exportation of various antibiotics, including ciprofloxacin, chloramphenicol, ofloxacin and norfloxacin. This attenuated efflux pump activity, caused by the RpoA mutation, conferred the bacteria further susceptibility to antibiotics regulated by MexEF-OprN. Our work further revealed that certain clinical P. aeruginosa isolates also contained the same RpoA mutation, providing clinical relevance to our findings. Our results elucidate why this new antibiotic-susceptible function of RpoA mutants would have remained undetected in conventional screens for mutants involving antibiotic resistance.
    Conclusions: The discovery of antibiotic susceptibility in an RpoA mutant implicates a new therapeutic approach for treating clinical isolates of P. aeruginosa with RpoA mutations, using specific antibiotics regulated by MexEF-OprN. More generally, our work suggests that RpoA could serve as a promising candidate target for anti-pathogen therapeutic purposes.
    MeSH term(s) Pseudomonas aeruginosa ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Ciprofloxacin/pharmacology ; Chloramphenicol/metabolism ; DNA-Directed RNA Polymerases/genetics ; Bacterial Outer Membrane Proteins/genetics
    Chemical Substances Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Chloramphenicol (66974FR9Q1) ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; Bacterial Outer Membrane Proteins
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad207
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  6. Article ; Online: Improved probe detection sensitivity by flexible tandem biotin labeling.

    Cai, Wenjie / Lu, Mingqi / Cheng, Xiaoyan / Dai, Weijun

    Journal of microbiological methods

    2022  Volume 204, Page(s) 106654

    Abstract: We develop a biotin-based tandem labeling approach to improve detection sensitivity of DNA probe. Through DNA polymerase-mediated overhand filling, the 3'end of DNA probe was tandemly labeled with biotin molecules. The intensity of biotin signals could ... ...

    Abstract We develop a biotin-based tandem labeling approach to improve detection sensitivity of DNA probe. Through DNA polymerase-mediated overhand filling, the 3'end of DNA probe was tandemly labeled with biotin molecules. The intensity of biotin signals could be flexibly manipulated by controlling the introduced length of poly(A) in the 5' overhang.
    MeSH term(s) Biotin ; Biotinylation ; DNA Probes
    Chemical Substances Biotin (6SO6U10H04) ; DNA Probes
    Language English
    Publishing date 2022-12-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2022.106654
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    Zs.A 1849: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Path analysis of social engagement, loneliness and cognitive function among Chinese older adults.

    Mai, Shumin / Cai, Jingjing / Zheng, Weijun / Li, Lu

    Psychology, health & medicine

    2022  Volume 28, Issue 4, Page(s) 1087–1099

    Abstract: This study established a research model to fully understand the relationship of social engagement, loneliness and cognitive function among Chinese older adults. In the latest wave (2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a ... ...

    Abstract This study established a research model to fully understand the relationship of social engagement, loneliness and cognitive function among Chinese older adults. In the latest wave (2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a total of 12,852 participants aged 65 years and older were included in the study. Path analysis was performed to examine our hypotheses. The social engagement had a positive relationship with normal cognitive function while loneliness had a negative one, and the standardized regression weights were 0.618 (
    MeSH term(s) Humans ; Loneliness/psychology ; Social Participation ; East Asian People ; Cognition ; Longitudinal Studies ; China/epidemiology
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1477841-5
    ISSN 1465-3966 ; 1354-8506
    ISSN (online) 1465-3966
    ISSN 1354-8506
    DOI 10.1080/13548506.2022.2151635
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  8. Article: Identification of an Exopolysaccharide Biosynthesis Gene in

    Xu, Chunxia / Ruan, Huaqin / Cai, Wenjie / Staehelin, Christian / Dai, Weijun

    Microorganisms

    2021  Volume 9, Issue 12

    Abstract: Exopolysaccharides (EPS) play critical roles in rhizobium-plant interactions. However, the EPS biosynthesis pathway ... ...

    Abstract Exopolysaccharides (EPS) play critical roles in rhizobium-plant interactions. However, the EPS biosynthesis pathway in
    Language English
    Publishing date 2021-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9122490
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  9. Article ; Online: METTL3 promotes proliferation and myogenic differentiation through m

    Zhao, Tiantian / Zhao, Rui / Yi, Xudong / Cai, Rui / Pang, Weijun

    Life sciences

    2022  Volume 298, Page(s) 120496

    Abstract: Skeletal muscle development has an important impact on muscle-related diseases and domestic animal meat production. The ... ...

    Abstract Skeletal muscle development has an important impact on muscle-related diseases and domestic animal meat production. The m
    MeSH term(s) Animals ; Cell Proliferation/genetics ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Muscle Development/genetics ; Myoblasts/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism
    Chemical Substances RNA, Messenger ; RNA-Binding Proteins ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2022-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2022.120496
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
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  10. Article ; Online: Mechanistic insights into chemical conditioning on transformation of dissolved organic matter and plant biostimulants production during sludge aerobic composting.

    Zhang, Yu / Yang, Boyuan / Peng, Siwei / Zhang, Ziwei / Cai, Siying / Yu, Junxia / Wang, Dongsheng / Zhang, Weijun

    Water research

    2024  Volume 255, Page(s) 121446

    Abstract: Inorganic coagulants (aluminum and iron salt) are widely used to improve sludge dewaterability, resulting in numerous residues in dewatered sludge. Composting refers to the controlled microbial process that converts organic wastes into fertilizer, and ... ...

    Abstract Inorganic coagulants (aluminum and iron salt) are widely used to improve sludge dewaterability, resulting in numerous residues in dewatered sludge. Composting refers to the controlled microbial process that converts organic wastes into fertilizer, and coagulant residues in dewatered sludge can affect subsequent compost efficiency and resource recycling, which remains unclear. This work investigated the effects of two typical metal salt coagulants (poly aluminum chloride [PAC] and poly ferric sulfate [PFS]) conditioning on sludge compost. Our results revealed that PAC conditioning inhibited composting with decreased peak temperature, microbial richness, enzymatic reaction intensities, and compost quality, associated with decreased pH and microbial toxicity of aluminum. Nevertheless, PFS conditioning selectively enriched Pseudoxanthomonas sp. and resulted in more fertile compost with increased peak temperature, enzymatic reaction intensities, and humification degree. Spectroscopy and mass difference analyses indicated that PFS conditioning enhanced reaction intensities of labile biopolymers at the thermophilic stage, mainly comprising hydrolyzation (H
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2024.121446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 78/260: Show issues
    Z 3381: Show issues

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