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  1. Article ; Online: Association of age with emergency department visits and hospital admissions: A nationwide study.

    Fimognari, Filippo Luca / Lelli, Diana / Landi, Francesco / Antonelli Incalzi, Raffaele

    Geriatrics & gerontology international

    2022  Volume 22, Issue 11, Page(s) 917–923

    Abstract: Aim: Older adults are frequently stigmatized for improper emergency department (ED) visits and hospitalizations. In this study, we aimed to investigate the relationship between age and appropriateness of ED visits, and the mismatching between ED ... ...

    Abstract Aim: Older adults are frequently stigmatized for improper emergency department (ED) visits and hospitalizations. In this study, we aimed to investigate the relationship between age and appropriateness of ED visits, and the mismatching between ED clinical severity and hospitalizations.
    Methods: We carried out a nationwide assessment of Italian Informative System for the Emergency and Urgency data from 1 January 2015 to 31 December 2015 including patients admitted to all the Italian EDs for any reason. Appropriateness of ED visits was defined as a yellow/red/black color code (potentially life-threatening/dead patients), whereas clinical severity/hospitalization mismatching was defined as hospital admission after validated ED green/white codes. Analyses dedicated to people aged ≥75 years were carried out.
    Results: There were 20 400 071 ED visits (3 444 091 aged ≥75 years), which increased with age, up to >650/1000 inhabitants aged ≥90 years. The appropriateness of ED visits increased with age, from 6.3% in the 5-9 years age group to 44.2% in the 95-99 years age group. Clinical severity/hospitalization mismatching decreased with age, from 62.9% in the 30-34 years age group to 27.7% in the 95-99 years age group. At ED presentation, 21.6% of patients aged ≥75 years complained of non-specific symptoms, and hospital discharge diagnoses frequently differed from the ED admission diagnoses; 11.4% died during hospitalization and 8.8% were discharged to long-term care facilities.
    Conclusions: The request for ED care and the admission to acute care ward are commonly appropriate for older patients. Clinical presentation at ED admission is frequently atypical. Health care systems should aim at improving outpatients' management to reduce the ED care need, but also at optimizing in-hospital strategies and pathways for older adults. Geriatr Gerontol Int 2022; 22: 917-923.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Emergency Service, Hospital ; Hospitalization ; Patient Discharge ; Emergency Medical Services ; Hospitals
    Language English
    Publishing date 2022-09-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Contribution of clinical severity and geriatric risk factors in predicting short-term mortality of older hospitalized pneumonia patients: the Pneumonia in Italian Acute Care for Elderly units (PIACE) study.

    Fimognari, Filippo Luca / Corsonello, Andrea / Rizzo, Massimo / Bambara, Valentina / Fabbietti, Paolo / Arone, Andrea / Cuccurullo, Olga / Pilotto, Alberto / Ferrari, Alberto

    Aging clinical and experimental research

    2022  Volume 34, Issue 6, Page(s) 1419–1427

    Abstract: Background: Clinical severity of pneumonia in older persons increases the risk for short-term mortality. Comprehensive geriatric assessment (CGA) may provide further insight in prognostic stratification.: Aims: To investigate whether CGA may improve ... ...

    Abstract Background: Clinical severity of pneumonia in older persons increases the risk for short-term mortality. Comprehensive geriatric assessment (CGA) may provide further insight in prognostic stratification.
    Aims: To investigate whether CGA may improve prognostic stratification among older patients with pneumonia admitted to hospital.
    Methods: Our series consisted of 318 consecutive patients hospitalized for pneumonia in a multicenter observational study. Disease severity was assessed by Sequential Organ Failure Assessment (SOFA) and Pneumonia Severity Index (PSI). CGA included the occurrence of delirium, Basic Activities of Daily Living (BADL) disability, cognitive impairment at Short Portable Mental Status Questionnaire (SPMSQ) and overall comorbidity assessed by Cumulative Illness Rating Scale (CIRS). The outcomes were in-hospital and post-discharge 3 month mortality. Statistical analysis was carried out by Cox regression, area under receiver operating curve (AUC) and net reclassification index (NRI).
    Results: Overall, 53 patients died during hospitalization and 52 after discharge. Delirium, SOFA score and admission BADL disability were significant predictors of in-hospital mortality. SOFA score, CIRS, previous long-term oxygen therapy and discharge BADL dependency significantly predicted post-discharge mortality. The accuracy of SOFA in predicting in-hospital and post-discharge mortality was fair (AUC = 0.685, 95% CI = 0.610-0.761 and AUC = 0.663, 95% CI = 0.593-0.734, respectively). BADL dependency and delirium improved predictive accuracy for in-hospital mortality (ΔAUC = 0.144, 95% CI = 0.062-0.227, p < 0.001), while pre-admission oxygen therapy, CIRS and BADL dependency improved predictivity for 3 month mortality (ΔAUC = 0.177, 95% CI = 0.102-0.252, p < 0.001).
    Discussion: Among older pneumonia patients, prognostic stratification obtained by clinical severity indexes is significantly improved by CGA risk factors.
    Conclusions: CGA provides important information for prognostic stratification and clinical management of older pneumonia patients.
    MeSH term(s) Activities of Daily Living ; Aftercare ; Aged ; Aged, 80 and over ; Delirium ; Geriatric Assessment ; Humans ; Oxygen ; Patient Discharge ; Pneumonia ; Prognosis ; Risk Factors
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-02-23
    Publishing country Germany
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-021-02063-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Functional recovery in hospitalized elderly adults.

    Fimognari, Filippo Luca / Palleschi, Lorenzo

    Journal of the American Geriatrics Society

    2012  Volume 60, Issue 9, Page(s) 1795–1796

    MeSH term(s) Disabled Persons/rehabilitation ; Female ; Geriatric Assessment ; Hospitalization ; Humans ; Male ; Motor Activity/physiology ; Recovery of Function
    Language English
    Publishing date 2012-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/j.1532-5415.2012.04124.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High-flow nasal cannula oxygen therapy for acute respiratory failure in a non-intensive geriatric setting.

    Fimognari, Filippo Luca / Rizzo, Massimo / Cuccurullo, Olga / Cristiano, Giovanna / Ricchio, Roberto / Ricci, Consalvo / Iorio, Claudio / Borrelli, Eugenio

    Geriatrics & gerontology international

    2018  Volume 18, Issue 12, Page(s) 1652–1653

    MeSH term(s) Aged, 80 and over ; Female ; Humans ; Italy ; Male ; Oxygen Inhalation Therapy/instrumentation ; Oxygen Inhalation Therapy/methods ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2018-12-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.13557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Corticosteroids may worsen gastroesophageal reflux in patients with idiopathic pulmonary fibrosis.

    Fimognari, Filippo Luca / Pastorelli, Ruggero

    Chest

    2007  Volume 132, Issue 5, Page(s) 1719; author reply 1719–20

    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Aged ; Disease Progression ; Exercise Test ; Female ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/etiology ; Humans ; Middle Aged ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/epidemiology ; Pulmonary Fibrosis/physiopathology ; Pulmonary Fibrosis/prevention & control ; Respiratory Function Tests ; Retrospective Studies
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2007-11
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.06-2659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Respiratory "Overlap Syndrome": Efficacy and Usefulness of the Combined Double Bronchodilation.

    Petrone, Albino / Fimognari, Filippo Luca / Mormile, Francesco / Fuso, Leonello / Quartieri, Michela / Petrone, Ludovico / Romano, Francesco

    Respiration; international review of thoracic diseases

    2018  Volume 95 Suppl 1, Page(s) 15–18

    Abstract: The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome in a single patient is known as "overlap syndrome," and worsens the prognosis of the affected subjects. A marked bronchodilation may be useful for the ... ...

    Abstract The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome in a single patient is known as "overlap syndrome," and worsens the prognosis of the affected subjects. A marked bronchodilation may be useful for the treatment of this condition. In fact, as stated in the GOLD 2017 guidelines, the combination of indacaterol/glycopyrronium may exert positive synergistic effects on smooth muscle cell and airway resistance, with a more pronounced efficiency in reducing lung hyperinflation. Noteworthy, inhaled bronchodilators favorably alter the dynamically determined components of resting lung hyperinflation and help deflate the overinflated lungs. This is particularly important in order to improve dyspnea, exercise performance, and night saturation, especially when combined with continuous positive airway pressure ventilation, as reported in our case series. We report 3 cases of patients with COPD in a stable clinical condition, referred to the Department of Respiratory Pathophysiology at the "Mariano Santo" Hospital in Cosenza, due to possible symptoms suggestive of obstructive sleep apnea, and who were successfully treated with indacaterol/glycopyrronium at a fixed dose.
    MeSH term(s) Adrenergic beta-2 Receptor Agonists/therapeutic use ; Aged ; Drug Therapy, Combination ; Female ; Glycopyrrolate/therapeutic use ; Humans ; Indans/therapeutic use ; Male ; Muscarinic Antagonists/therapeutic use ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Quinolones/therapeutic use ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy
    Chemical Substances Adrenergic beta-2 Receptor Agonists ; Indans ; Muscarinic Antagonists ; Quinolones ; indacaterol (8OR09251MQ) ; Glycopyrrolate (V92SO9WP2I)
    Language English
    Publishing date 2018-04-27
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000487179
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  7. Article: Portal vein thrombosis in liver cirrhosis.

    Fimognari, Filippo Luca / Violi, Francesco

    Internal and emergency medicine

    2008  Volume 3, Issue 3, Page(s) 213–218

    Abstract: Portal vein thrombosis (PVT) is observed in 10-20% of patients with liver cirrhosis, which is responsible for 20% of all PVT cases. The main pathogenic factor of PVT in cirrhosis is the obstacle to portal flow, but acquired and inherited clotting ... ...

    Abstract Portal vein thrombosis (PVT) is observed in 10-20% of patients with liver cirrhosis, which is responsible for 20% of all PVT cases. The main pathogenic factor of PVT in cirrhosis is the obstacle to portal flow, but acquired and inherited clotting abnormalities may play a role. The formation of collateral veins allows many patients to remain asymptomatic and prevents the onset of clinical complications also in patients with totally occlusive PVT. Gastrointestinal bleeding, thrombosis of superior mesenteric vein and refractory ascites are typical manifestations of PVT. Instrumental diagnosis can be obtained by colour-doppler ultrasonography. Future studies should verify whether asymptomatic PVT worsens liver failure, or if its life-threatening complications reduce survival in patients with cirrhosis. Moreover, randomized controlled trials should clarify the potential effectiveness of anticoagulant therapy in the treatment of PVT.
    MeSH term(s) Humans ; Liver Cirrhosis/complications ; Portal Vein ; Venous Thrombosis/diagnosis ; Venous Thrombosis/etiology ; Venous Thrombosis/physiopathology ; Venous Thrombosis/therapy
    Language English
    Publishing date 2008-02-15
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-008-0128-0
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  8. Article ; Online: The Severity of Acute Illness and Functional Trajectories in Hospitalized Older Medical Patients.

    Fimognari, Filippo Luca / Pierantozzi, Andrea / De Alfieri, Walter / Salani, Bernardo / Zuccaro, Stefano Maria / Arone, Andrea / Palleschi, Giacomo / Palleschi, Lorenzo

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2017  Volume 72, Issue 1, Page(s) 102–108

    Abstract: Background: Acute diseases and hospitalization are associated with functional deterioration in older persons. Although most of the functional decline occurs before hospitalization in response to the acute diseases, the role played by comorbidity in the ... ...

    Abstract Background: Acute diseases and hospitalization are associated with functional deterioration in older persons. Although most of the functional decline occurs before hospitalization in response to the acute diseases, the role played by comorbidity in the functional trajectories around hospitalization is unclear.
    Methods: Observational prospective study of 696 elderly individuals hospitalized in two Italian general medicine wards. Functional status of the elderly patients at 2 weeks before hospitalization (baseline), at hospital admission, and at discharge was measured by the Barthel Index. Comorbidity was measured at admission by the Geriatric Index of Comorbidity (GIC), a tool mostly based on illness severity. The association of GIC with changes in functional status before hospitalization (between baseline and admission), during hospitalization (between admission and discharge), and in the overall period between baseline and discharge was assessed by logistic regression analyses. Hospitalization-associated disability (HAD) was defined as a functional decline between baseline and discharge.
    Results: Illness severity (GIC 3-4 vs 1-2: odds ratio [OR] 2.2, 95% CI [confidence interval] 1.5-3.3, p < .0001) and older age significantly predicted prehospital functional decline (between baseline and admission). Illness severity (OR 1.9, 95% CI 1.2-3, p = .004) and older age were also predictive of HAD, even after adjustment for each coded primary discharge diagnosis. After adjustment for the occurrence of prehospital functional decline, however, illness severity and older age were not predictive of HAD anymore.
    Conclusions: The severity of illnesses was strongly associated with adverse functional outcomes around hospitalization, but frailty, intended as functional vulnerability to the acute disease before hospitalization, was a stronger predictor of HAD than illness severity and age.
    MeSH term(s) Activities of Daily Living ; Acute Disease ; Age Factors ; Aged ; Disease Progression ; Female ; Geriatric Assessment ; Health Status ; Hospitalization ; Humans ; Italy ; Male ; Prospective Studies ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glw096
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  9. Article ; Online: Why are people with "poor lung function" at increased atherothrombotic risk? A critical review with potential therapeutic indications.

    Fimognari, Filippo Luca / Scarlata, Simone / Antonelli-Incalzi, Raffaele

    Current vascular pharmacology

    2009  Volume 8, Issue 4, Page(s) 573–586

    Abstract: Patients classified as having a "poor lung function" in large populations studies are at increased risk of atherothrombosis, but potential mechanisms are unclear. A large proportion of these people are affected by chronic obstructive pulmonary disease ( ... ...

    Abstract Patients classified as having a "poor lung function" in large populations studies are at increased risk of atherothrombosis, but potential mechanisms are unclear. A large proportion of these people are affected by chronic obstructive pulmonary disease (COPD), a recognized risk factor for vascular events. Systemic inflammation is the main atherothrombotic abnormality in COPD, but hypoxia-related platelet activation, pro-coagulant status and oxidative stress may play a role. Systemic inflammation is presumably a leading mechanism of atherothrombosis also in people who have a "restrictive" spirometric dysfunction, rather than the classic obstructive pattern of COPD. Many persons with "poor lung function" are affected by diabetes and their cardiovascular risk is therefore linked to the diabetic status. Patients affected by diabetes tend to have a "restrictive" dysfunction, rather than COPD. Recent studies show that restriction at spirometry precedes the onset of diabetes, thereby representing a marker of mechanisms involved in the pre-diabetic, insulin-resistant state. This is also proved by the fact that most patients with metabolic syndrome, a pre-diabetic condition, have a restrictive ventilatory pattern at spirometry. A significant proportion of people with "poor lung function" have visceral obesity, a cardiovascular risk factor. By hampering lung expansion, visceral obesity causes a restrictive ventilatory pattern. In conclusion, the term "poor lung function" includes various chronic illnesses with different mechanisms of atherothrombosis. Research is needed for better understanding why persons with lung dysfunctions have higher cardiovascular risk, and for identifying adequate preventive strategies.
    MeSH term(s) Adrenergic beta-Agonists/therapeutic use ; Animals ; Anti-Inflammatory Agents/therapeutic use ; Atherosclerosis/complications ; Atherosclerosis/physiopathology ; Blood Coagulation Disorders/physiopathology ; Bronchodilator Agents/therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Inflammation Mediators/blood ; Lung Diseases/complications ; Lung Diseases/drug therapy ; Lung Diseases/physiopathology ; Metabolic Diseases/physiopathology ; Obesity/physiopathology ; Oxidative Stress/physiology ; Platelet Activation/physiology ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Risk Factors ; Thrombosis/complications ; Thrombosis/physiopathology
    Chemical Substances Adrenergic beta-Agonists ; Anti-Inflammatory Agents ; Bronchodilator Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Inflammation Mediators
    Language English
    Publishing date 2009-04-01
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192362-0
    ISSN 1875-6212 ; 1570-1611
    ISSN (online) 1875-6212
    ISSN 1570-1611
    DOI 10.2174/157016110791330780
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  10. Article ; Online: Visceral obesity and different phenotypes of COPD.

    Fimognari, Filippo Luca / Scarlata, Simone / Pastorelli, Ruggero / Antonelli-Incalzi, Raffaele

    American journal of respiratory and critical care medicine

    2009  Volume 180, Issue 2, Page(s) 192–3; author reply 193

    MeSH term(s) Humans ; Intra-Abdominal Fat ; Metabolic Syndrome/complications ; Obesity/complications ; Obesity/pathology ; Obesity/physiopathology ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Disease, Chronic Obstructive/physiopathology
    Language English
    Publishing date 2009-04-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/ajrccm.180.2.192a
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