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Article ; Online: Visible light degradable micelles for intraocular corticosteroid delivery.

Qi, Ronghui / Mundy, Emily / Amsden, Brian G

2024 Volume 12, Issue 8, Page(s) 2099–2113

Abstract: Visible light responsive micellar drug delivery formulations are of notable interest for the treatment of ocular diseases, as their successful development would enable controlled drug release at the back of the eye, improving efficacy and reducing side- ... ...

Abstract	Visible light responsive micellar drug delivery formulations are of notable interest for the treatment of ocular diseases, as their successful development would enable controlled drug release at the back of the eye, improving efficacy and reducing side-effects when compared to existing approaches. In this work, an aliphatic polycarbonate-based visible light responsive micelle formulation based on mPEG-
MeSH term(s)	Micelles ; Adrenal Cortex Hormones ; Light ; Eye ; Drug Liberation
Chemical Substances	Micelles ; Adrenal Cortex Hormones
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02793g
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Article ; Online: Hypothyroxinemia and weight velocity in preterm infants.

Zibitt, Meira / Ange, Brittany / Wynter, Zanna / Mundy, Cynthia / Herrmann, Steve / Stansfield, Brian K

Journal of pediatric endocrinology & metabolism : JPEM

2024 Volume 37, Issue 3, Page(s) 236–242

Abstract: ... velocity (g/kg/day) from DOL 14 to DOL 28 and 36-weeks PMA were calculated for each neonate and potential ... associated inversely with FT4 (R=0.5845) and modestly with TSH (R=0.2740). Both FT4 and gestational age ...

Abstract	Objectives: Hypothyroxinemia of prematurity (HOP) is characterized by low free thyroxine (FT4) associated with low or normal thyroid stimulating hormone (TSH). The objective of this study is to define FT4 and TSH values in very preterm infants (<32 weeks postmenstrual age, PMA) and correlate hypothyroxinemia and levothyroxine treatment with growth velocity at 28 days and 36 weeks PMA. Methods: Preterm neonates <32 weeks PMA admitted to the regional neonatal intensive care unit (NICU) at the Children's Hospital of Georgia (USA) between January 2010 and July 2022 were routinely screened for hypothyroxinemia. FT4 and TSH values were obtained on 589 eligible neonates between day of life (DOL) 4 and 14. Growth velocity (g/kg/day) from DOL 14 to DOL 28 and 36-weeks PMA were calculated for each neonate and potential explanatory variables (PMA, sex, and race) were incorporated into multivariate regression models to identify associations between HOP and growth velocity. Results: In 589 preterm infants, PMA at birth was strongly associated inversely with FT4 (R=0.5845) and modestly with TSH (R=0.2740). Both FT4 and gestational age, but not TSH or levothyroxine treatment, were associated with growth velocity at 28 days of life and at 36 weeks PMA. Conclusions: We provide a large data set for identifying FT4 and TSH measurements and identify hypothyroxinemia of prematurity as a potential mediator of slow postnatal growth in very preterm infants.
MeSH term(s)	Infant ; Child ; Infant, Newborn ; Humans ; Infant, Premature ; Thyroxine ; Thyroid Diseases ; Gestational Age ; Thyrotropin
Chemical Substances	Thyroxine (Q51BO43MG4) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2024-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2023-0496
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Zs.A 2258: Show issues

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Article: Immune system and bone remodeling.

Mundy, G R

Trends in endocrinology and metabolism: TEM

2008 Volume 1, Issue 6, Page(s) 307–311

Abstract: The skeleton undergoes continuous cellular remodeling in a manner similar to that of replacement of a wall, brick by brick. Products of immune cells are likely to modulate all of the cellular events involved in bone remodeling. The local factors that ... ...

Abstract	The skeleton undergoes continuous cellular remodeling in a manner similar to that of replacement of a wall, brick by brick. Products of immune cells are likely to modulate all of the cellular events involved in bone remodeling. The local factors that modulate bone cell function and bone remodeling-osteotropic cytokines or growth-regulatory factors-are similar to those involved in other body processes such as wound healing, immune function, oncogenesis, angiogenesis, and embryogenesis.
Language	English
Publishing date	2008-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/1043-2760(90)90069-f
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Zs.A 2999: Show issues

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Article ; Online: Treatment recommendations for glycogen storage disease type IB- associated neutropenia and neutrophil dysfunction with empagliflozin: Consensus from an international workshop.

Grünert, Sarah C / Derks, Terry G J / Mundy, Helen / Dalton, R Neil / Donadieu, Jean / Hofbauer, Peter / Jones, Neil / Uçar, Sema Kalkan / LaFreniere, Jamas / Contreras, Enrique Landelino / Pendyal, Surekha / Rossi, Alessandro / Schneider, Blair / Spiegel, Ronen / Stepien, Karolina M / Wesol-Kucharska, Dorota / Veiga-da-Cunha, Maria / Wortmann, Saskia B

Molecular genetics and metabolism

2024 Volume 141, Issue 3, Page(s) 108144

Abstract: ... dysfunction (e.g. mucosal lesions, inflammatory bowel disease). Because of the rarity of GSD Ib, the published ... dehydration and before planned longer surgeries. Discontinuation of G-CSF therapy should be attempted ...

Abstract	Glycogen storage disease type Ib (GSD Ib, biallelic variants in SLC37A4) is a rare disorder of glycogen metabolism complicated by neutropenia/neutrophil dysfunction. Since 2019, the SGLT2-inhibitor empagliflozin has provided a mechanism-based treatment option for the symptoms caused by neutropenia/neutrophil dysfunction (e.g. mucosal lesions, inflammatory bowel disease). Because of the rarity of GSD Ib, the published evidence on safety and efficacy of empagliflozin is still limited and does not allow to develop evidence-based guidelines. Here, an international group of experts provides 14 best practice consensus treatment recommendations based on expert practice and review of the published evidence. We recommend to start empagliflozin in all GSD Ib individuals with clinical or laboratory signs related to neutropenia/neutrophil dysfunction with a dose of 0.3-0.4 mg/kg/d given as a single dose in the morning. Treatment can be started in an outpatient setting. The dose should be adapted to the weight and in case of inadequate clinical treatment response or side effects. We strongly recommend to pause empagliflozin immediately in case of threatening dehydration and before planned longer surgeries. Discontinuation of G-CSF therapy should be attempted in all individuals. If available, 1,5-AG should be monitored. Individuals who have previously not tolerated starches should be encouraged to make a new attempt to introduce starch in their diet after initiation of empagliflozin treatment. We advise to monitor certain safety and efficacy parameters and recommend continuous, alternatively frequent glucose measurements during the introduction of empagliflozin. We provide specific recommendations for special circumstances like pregnancy and liver transplantation.
MeSH term(s)	Humans ; Neutrophils/metabolism ; Consensus ; Glycogen Storage Disease Type I/complications ; Glycogen Storage Disease Type I/drug therapy ; Glycogen Storage Disease Type I/genetics ; Neutropenia/drug therapy ; Neutropenia/etiology ; Monosaccharide Transport Proteins ; Antiporters/metabolism ; Benzhydryl Compounds ; Glucosides
Chemical Substances	empagliflozin (HDC1R2M35U) ; SLC37A4 protein, human ; Monosaccharide Transport Proteins ; Antiporters ; Benzhydryl Compounds ; Glucosides
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1418518-0
ISSN	1096-7206 ; 1096-7192
ISSN (online)	1096-7206
ISSN	1096-7192
DOI	10.1016/j.ymgme.2024.108144
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Zs.A 617: Show issues

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Article: Unraveling the Role of Innate Lymphoid Cells in AcuteMyeloid Leukemia.

Lordo, Matthew R / Scoville, Steven D / Goel, Akul / Yu, Jianhua / Freud, Aharon G / Caligiuri, Michael A / Mundy-Bosse, Bethany L

Cancers

2021 Volume 13, Issue 2

Abstract: Over the past 50 years, few therapeutic advances have been made in treating acute myeloid leukemia (AML), an aggressive form of blood cancer, despite vast improvements in our ability to classify the disease. Emerging evidence suggests the immune system ... ...

Abstract	Over the past 50 years, few therapeutic advances have been made in treating acute myeloid leukemia (AML), an aggressive form of blood cancer, despite vast improvements in our ability to classify the disease. Emerging evidence suggests the immune system is important in controlling AML progression and in determining prognosis. Natural killer (NK) cells are important cytotoxic effector cells of the innate lymphoid cell (ILC) family that have been shown to have potent anti-leukemic functions. Recent studies are now revealing impairment or dysregulation of other ILCs in various types of cancers, including AML, which limits the effectiveness of NK cells in controlling cancer progression. NK cell development and function are inhibited in AML patients, which results in worse clinical outcomes; however, the specific roles of other ILC populations in AML are just now beginning to be unraveled. In this review, we summarize what is known about the role of ILC populations in AML.
Language	English
Publishing date	2021-01-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13020320
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Article ; Online: Research priorities in psychiatric genetic counselling: how to talk to children and adolescents about genetics and psychiatric disorders.

Mundy, Jessica / Davies, Helena L / Radu, Mădălina / Austin, Jehannine / Vassos, Evangelos / Eley, Thalia C / Breen, Gerome / Moldovan, Ramona

European journal of human genetics : EJHG

2022 Volume 31, Issue 3, Page(s) 262–264

MeSH term(s)	Humans ; Child ; Adolescent ; Genetic Counseling ; Mental Disorders/genetics ; Mental Disorders/therapy ; Mental Disorders/psychology ; Research
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-022-01253-0
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Zs.A 3589: Show issues

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Article ; Online: Hexapeptides from mammalian inhibitory hormone hunt activate and inactivate nematode reproduction.

Hart, John E / Mohan, Sharad / Davies, Keith G / Ferneyhough, Ben / Clarke, Iain J / Hunt, John A / Shnyder, Steve D / Mundy, Christopher R / Howlett, David R / Newton, Russell P

PloS one

2022 Volume 17, Issue 12, Page(s) e0278049

Abstract: Background: Biopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine materials yielded via Edman ... ...

Abstract	Background: Biopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine materials yielded via Edman degradation a 14-residue amino acid (aa) sequence. As a 14mer synthetic peptide (EPL001) this displayed antiproliferative and reproduction-modulating activity, while representing only a part of the native polypeptide. Even more unexpectedly, a scrambled-sequence control peptide (EPL030) did likewise. Methods: Reproduction has been investigated in the nematode Steinernema siamkayai, using a fermentation system supplemented with different concentrations of exogenous hexapeptides. Peptide structure-activity relationships have also been studied using prostate cancer and other mammalian cells in vitro, with peptides in solution or immobilized, and via the use of mammalian assays in vivo and through molecular modelling. Results: Reproduction increased (x3) in the entomopathogenic nematode Steinernema siamkayai after exposure to one synthetic peptide (IEPVFT), while fecundity was reduced (x0.5) after exposure to another (KLKMNG), both effects being dose-dependent. These hexamers are opposite ends of the synthetic peptide KLKMNGKNIEPVFT (EPL030). Bioactivity is unexpected as EPL030 is a control compound, based on a scrambled sequence of the test peptide MKPLTGKVKEFNNI (EPL001). EPL030 and EPL001 are both bioinformatically obscure, having no convincing matches to aa sequences in the protein databases. EPL001 has antiproliferative effects on human prostate cancer cells and rat bone marrow cells in vitro. Intracerebroventricular infusion of EPL001 in sheep was associated with elevated growth hormone in peripheral blood and reduced prolactin. The highly dissimilar EPL001 and EPL030 nonetheless have the foregoing biological effects in common in mammalian systems, while being divergently pro- and anti-fecundity respectively in the nematode Caenorhabditis elegans. Peptides up to a 20mer have also been shown to inhibit the proliferation of human cancer and other mammalian cells in vitro, with reproductive upregulation demonstrated previously in fish and frogs, as well as nematodes. EPL001 encodes the sheep neuroendocrine prohormone secretogranin II (sSgII), as deduced on the basis of immunoprecipitation using an anti-EPL001 antibody, with bespoke bioinformatics. Six sSgII residues are key to EPL001's bioactivity: MKPLTGKVKEFNNI. A stereospecific bimodular tri-residue signature is described involving simultaneous accessibility for binding of the side chains of two specific trios of amino acids, MKP & VFN. An evolutionarily conserved receptor is conceptualised having dimeric binding sites, each with ligand-matching bimodular stereocentres. The bioactivity of the 14mer control peptide EPL030 and its hexapeptide progeny is due to the fortuitous assembly of subsets of the novel hormonal motif, MKPVFN, a default reproductive and tissue-building OFF signal.
MeSH term(s)	Humans ; Male ; Animals ; Sheep ; Rats ; Reproduction ; Mammals ; Rhabditida ; Caenorhabditis elegans ; Hormones ; Prostatic Neoplasms
Chemical Substances	Hormones
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0278049
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Article ; Online: Seeking help for mental health during the COVID-19 pandemic: A longitudinal analysis of adults' experiences with digital technologies and services.

Parsons, Christine E / Purves, Kirstin L / Davies, Molly R / Mundy, Jessica / Bristow, Shannon / Eley, Thalia C / Breen, Gerome / Hirsch, Colette R / Young, Katherine S

PLOS digital health

2023 Volume 2, Issue 12, Page(s) e0000402

Abstract: The COVID-19 pandemic brought about dramatic changes in how patients access healthcare from its outset. Lockdown restrictions and remote working led to a proliferation of digital technologies and services, which also impacted mental health provisions. ... ...

Abstract	The COVID-19 pandemic brought about dramatic changes in how patients access healthcare from its outset. Lockdown restrictions and remote working led to a proliferation of digital technologies and services, which also impacted mental health provisions. Against the backdrop of new and changing support services, along with an unprecedented emphasis on mental health, relatively little is known about how adults sought out and received support for their mental health during this period. With a sample of 27,574 adults assessed longitudinally online over 12 months of the pandemic in the UK, we analysed reports of help-seeking for mental health, as well as sources of treatment or support and the perceived helpfulness of treatments received. We observed that the proportions of participants who reported seeking help remained relatively consistent throughout the 12-month period (ranging from 12.6% to 17.0%). Online talking therapies were among the most frequently sought sources (15.3%), whereas online self-guided treatments were among the least frequently sought sources (5%). Telephone lines, both NHS and non-governmental, had marked treatment 'gaps'. These treatment gaps, where individuals sought treatment but did not receive it, were especially evident for men and older adults. Our findings underscore online talking therapies as being a widely-sought and helpful source of mental health support. This is important given the current global need for accessible treatment options.
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ISSN	2767-3170
ISSN (online)	2767-3170
DOI	10.1371/journal.pdig.0000402
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Article ; Online: Active Hexose-Correlated Compound Shows Direct and Indirect Effects against Chronic Lymphocytic Leukemia.

Merchand-Reyes, Giovanna / Santhanam, Ramasamy / Valencia-Pena, Maria L / Kumar, Krishan / Mo, Xiaokui / Belay, Tesfaye / Woyach, Jennifer A / Mundy-Bosse, Bethany / Tridandapani, Susheela / Butchar, Jonathan P

Nutrients

2023 Volume 15, Issue 24

Abstract: Chronic lymphocytic leukemia (CLL) is a disease characterized by the accumulation of mature ... ...

Abstract	Chronic lymphocytic leukemia (CLL) is a disease characterized by the accumulation of mature CD19
MeSH term(s)	Mice ; Animals ; Humans ; Aged ; Aged, 80 and over ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Myeloid Cells/metabolism ; Monocytes/metabolism ; Leukemia, Myeloid, Acute ; Hexoses/pharmacology ; Tumor Microenvironment
Chemical Substances	Hexoses
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15245138
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Article ; Online: High interannual surface p CO 2 variability in the southern Canadian Arctic Archipelago's Kitikmeot Sea

R. P. Sims / M. M. M. Ahmed / B. J. Butterworth / P. J. Duke / S. F. Gonski / S. F. Jones / K. A. Brown / C. J. Mundy / W. J. Williams / B. G. T. Else

Ocean Science, Vol 19, Pp 837-

2023 Volume 856

Abstract: Warming of the Arctic due to climate change means the Arctic Ocean is now free from ice for longer, as sea ice melts earlier and refreezes later. Yet, it remains unclear how this extended ice-free period will impact carbon dioxide (CO 2 ) fluxes due to ... ...

Abstract	Warming of the Arctic due to climate change means the Arctic Ocean is now free from ice for longer, as sea ice melts earlier and refreezes later. Yet, it remains unclear how this extended ice-free period will impact carbon dioxide (CO 2 ) fluxes due to scarcity of surface ocean CO 2 measurements. Baseline measurements are urgently needed to understand spatial and temporal air–sea CO 2 flux variability in the changing Arctic Ocean. There is also uncertainty as to whether the previous basin-wide surveys are representative of the many smaller bays and inlets that make up the Canadian Arctic Archipelago (CAA). By using a research vessel that is based in the remote Inuit community of Ikaluqtuutiak (Cambridge Bay, Nunavut), we have been able to reliably survey p CO 2 shortly after ice melt and access previously unsampled bays and inlets in the nearby region. Here we present 4 years of consecutive summertime p CO 2 measurements collected in the Kitikmeot Sea in the southern CAA. Overall, we found that this region is a sink for atmospheric CO 2 in August (average of all calculated fluxes over the four cruises was − 4.64 mmol m −2 d −1 ), but the magnitude of this sink varies substantially between years and locations (average calculated fluxes of + 3.58, − 2.96, − 16.79 and − 0.57 mmol m −2 d −1 during the 2016, 2017, 2018 and 2019 cruises, respectively). Surface ocean p CO 2 varied by up to 156 µ atm between years, highlighting the importance of repeat observations in this region, as this high interannual variability would not have been captured by sparse and infrequent measurements. We find that the surface ocean p CO 2 value at the time of ice melt is extremely important in constraining the magnitude of the air–sea CO 2 flux throughout the ice-free season. However, further constraining the air–sea CO 2 flux in the Kitikmeot Sea will require a better understanding of how p CO 2 changes outside of the summer season. Surface ocean p CO 2 measurements made in small bays and inlets of the Kitikmeot Sea were ∼ 20–40 µ atm ...
Keywords	Geography. Anthropology. Recreation ; G ; Environmental sciences ; GE1-350
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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