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  1. Article ; Online: An Unexpected Lewis Acid-Catalyzed Cascade during the Synthesis of the DEF-Benzoxocin Ring System of Nogalamycin and Menogaril: Mechanistic Elucidation by Intermediate Trapping Experiments and Density Functional Theory Studies.

    Liu, Haijuan / Laporte, Adrien G / Gónzalez Pinardo, Daniel / Fernández, Israel / Hazelard, Damien / Compain, Philippe

    The Journal of organic chemistry

    2024  Volume 89, Issue 8, Page(s) 5634–5649

    Abstract: An unexpected Lewis acid-catalyzed carbohydrate rearrangement of a 1,5-bis-glycopyranoside to the product of a formal ... ...

    Abstract An unexpected Lewis acid-catalyzed carbohydrate rearrangement of a 1,5-bis-glycopyranoside to the product of a formal intramolecular
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.4c00134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  2. Article ; Online: Formal Glycosylation of Quinones with

    Liu, Haijuan / Laporte, Adrien G / Tardieu, Damien / Hazelard, Damien / Compain, Philippe

    The Journal of organic chemistry

    2022  Volume 87, Issue 19, Page(s) 13178–13194

    Abstract: The intermolecular C-O coupling reaction of 1,4-quinones ... ...

    Abstract The intermolecular C-O coupling reaction of 1,4-quinones with
    MeSH term(s) Biological Products ; Glycosylation ; Hydrogen ; Iron ; Oxidative Stress ; Quinones
    Chemical Substances Biological Products ; Quinones ; Hydrogen (7YNJ3PO35Z) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01635
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Quiescence Through the Prism of Evolution.

    Daignan-Fornier, Bertrand / Laporte, Damien / Sagot, Isabelle

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 745069

    Abstract: Being able to reproduce and survive is fundamental to all forms of life. In primitive unicellular organisms, the emergence of quiescence as a reversible proliferation arrest has most likely improved cell survival under unfavorable environmental ... ...

    Abstract Being able to reproduce and survive is fundamental to all forms of life. In primitive unicellular organisms, the emergence of quiescence as a reversible proliferation arrest has most likely improved cell survival under unfavorable environmental conditions. During evolution, with the repeated appearances of multicellularity, several aspects of unicellular quiescence were conserved while new quiescent cell intrinsic abilities arose. We propose that the formation of a microenvironment by neighboring cells has allowed disconnecting quiescence from nutritional cues. In this new context, non-proliferative cells can stay metabolically active, potentially authorizing the emergence of new quiescent cell properties, and thereby favoring cell specialization. Through its co-evolution with cell specialization, quiescence may have been a key motor of the fascinating diversity of multicellular complexity.
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.745069
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  4. Article ; Online: Quiescence, an individual journey.

    Sagot, Isabelle / Laporte, Damien

    Current genetics

    2019  Volume 65, Issue 3, Page(s) 695–699

    Abstract: Quiescence is operationally characterized as a temporary and reversible proliferation arrest. There are many preconceived ideas about quiescence, quiescent cells being generally viewed as insignificant sleeping G1 cells. In fact, quiescence is central ... ...

    Abstract Quiescence is operationally characterized as a temporary and reversible proliferation arrest. There are many preconceived ideas about quiescence, quiescent cells being generally viewed as insignificant sleeping G1 cells. In fact, quiescence is central for organism physiology and its dysregulation involved in many pathologies. The quiescent state encompasses very diverse cellular situations depending on the cell type and its environment. This diversity challenges not only quiescence uniformity but also the universality of the molecular mechanisms beyond quiescence regulation. In this mini-perspective, we discuss recent advances in the concept of quiescence, and illustrate that this multifaceted cellular state is gaining increasing attention in many fields of biology.
    MeSH term(s) Animals ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Cell Division ; Cell Proliferation ; Humans
    Chemical Substances Cell Cycle Proteins
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-018-00928-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2586: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit.

    Laporte, Damien / Massoni-Laporte, Aurelie / Lefranc, Charles / Dompierre, Jim / Mauboules, David / Nsamba, Emmanuel T / Royou, Anne / Gal, Lihi / Schuldiner, Maya / Gupta, Mohan L / Sagot, Isabelle

    eLife

    2024  Volume 12

    Abstract: Cells fine-tune microtubule assembly in both space and time to give rise to distinct edifices with specific cellular functions. In proliferating cells, microtubules are highly dynamics, and proliferation cessation often leads to their stabilization. One ... ...

    Abstract Cells fine-tune microtubule assembly in both space and time to give rise to distinct edifices with specific cellular functions. In proliferating cells, microtubules are highly dynamics, and proliferation cessation often leads to their stabilization. One of the most stable microtubule structures identified to date is the nuclear bundle assembled in quiescent yeast. In this article, we characterize the original multistep process driving the assembly of this structure. This Aurora B-dependent mechanism follows a precise temporality that relies on the sequential actions of kinesin-14, kinesin-5, and involves both microtubule-kinetochore and kinetochore-kinetochore interactions. Upon quiescence exit, the microtubule bundle is disassembled via a cooperative process involving kinesin-8 and its full disassembly is required prior to cells re-entry into proliferation. Overall, our study provides the first description, at the molecular scale, of the entire life cycle of a stable microtubule structure in vivo and sheds light on its physiological function.
    MeSH term(s) Kinesins/genetics ; Microtubules ; Kinetochores ; Cell Division ; Saccharomyces cerevisiae ; Microtubule-Associated Proteins
    Chemical Substances Kinesins (EC 3.6.4.4) ; Microtubule-Associated Proteins
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89958
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  6. Article ; Online: The cell biology of quiescent yeast - a diversity of individual scenarios.

    Sagot, Isabelle / Laporte, Damien

    Journal of cell science

    2019  Volume 132, Issue 1

    Abstract: Most cells, from unicellular to complex organisms, spend part of their life in quiescence, a temporary non-proliferating state. Although central for a variety of essential processes including tissue homeostasis, development and aging, quiescence is ... ...

    Abstract Most cells, from unicellular to complex organisms, spend part of their life in quiescence, a temporary non-proliferating state. Although central for a variety of essential processes including tissue homeostasis, development and aging, quiescence is poorly understood. In fact, quiescence encompasses various cellular situations depending on the cell type and the environmental niche. Quiescent cell properties also evolve with time, adding another layer of complexity. Studying quiescence is, above all, limited by the fact that a quiescent cell can be recognized as such only after having proved that it is capable of re-proliferating. Recent cellular biology studies in yeast have reported the relocalization of hundreds of proteins and the reorganization of several cellular machineries upon proliferation cessation. These works have revealed that quiescent cells can display various properties, shedding light on a plethora of individual behaviors. The deciphering of the molecular mechanisms beyond these reorganizations, together with the understanding of their cellular functions, have begun to provide insights into the physiology of quiescent cells. In this Review, we discuss recent findings and emerging concepts in
    MeSH term(s) Cell Cycle ; Cell Proliferation ; Homeostasis ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae/physiology
    Language English
    Publishing date 2019-01-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.213025
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
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  7. Article ; Online: Quiescence Through the Prism of Evolution

    Bertrand Daignan-Fornier / Damien Laporte / Isabelle Sagot

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: Being able to reproduce and survive is fundamental to all forms of life. In primitive unicellular organisms, the emergence of quiescence as a reversible proliferation arrest has most likely improved cell survival under unfavorable environmental ... ...

    Abstract Being able to reproduce and survive is fundamental to all forms of life. In primitive unicellular organisms, the emergence of quiescence as a reversible proliferation arrest has most likely improved cell survival under unfavorable environmental conditions. During evolution, with the repeated appearances of multicellularity, several aspects of unicellular quiescence were conserved while new quiescent cell intrinsic abilities arose. We propose that the formation of a microenvironment by neighboring cells has allowed disconnecting quiescence from nutritional cues. In this new context, non-proliferative cells can stay metabolically active, potentially authorizing the emergence of new quiescent cell properties, and thereby favoring cell specialization. Through its co-evolution with cell specialization, quiescence may have been a key motor of the fascinating diversity of multicellular complexity.
    Keywords quiescence ; multicellularity ; evolution ; unicellular organism ; microenvironment ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Monitoring single-cell dynamics of entry into quiescence during an unperturbed life cycle.

    Jacquel, Basile / Aspert, Théo / Laporte, Damien / Sagot, Isabelle / Charvin, Gilles

    eLife

    2021  Volume 10

    Abstract: The life cycle of microorganisms is associated with dynamic metabolic transitions and complex cellular responses. In yeast, how metabolic signals control the progressive choreography of structural reorganizations observed in quiescent cells during a ... ...

    Abstract The life cycle of microorganisms is associated with dynamic metabolic transitions and complex cellular responses. In yeast, how metabolic signals control the progressive choreography of structural reorganizations observed in quiescent cells during a natural life cycle remains unclear. We have developed an integrated microfluidic device to address this question, enabling continuous single-cell tracking in a batch culture experiencing unperturbed nutrient exhaustion to unravel the coordination between metabolic and structural transitions within cells. Our technique reveals an abrupt fate divergence in the population, whereby a fraction of cells is unable to transition to respiratory metabolism and undergoes a reversible entry into a quiescence-like state leading to premature cell death. Further observations reveal that nonmonotonous internal pH fluctuations in respiration-competent cells orchestrate the successive waves of protein superassemblies formation that accompany the entry into a
    MeSH term(s) Cell Cycle ; Cell Proliferation ; Saccharomyces cerevisiae/physiology ; Single-Cell Analysis
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.73186
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  9. Article ; Online: Monitoring single-cell dynamics of entry into quiescence during an unperturbed life cycle

    Basile Jacquel / Théo Aspert / Damien Laporte / Isabelle Sagot / Gilles Charvin

    eLife, Vol

    2021  Volume 10

    Abstract: The life cycle of microorganisms is associated with dynamic metabolic transitions and complex cellular responses. In yeast, how metabolic signals control the progressive choreography of structural reorganizations observed in quiescent cells during a ... ...

    Abstract The life cycle of microorganisms is associated with dynamic metabolic transitions and complex cellular responses. In yeast, how metabolic signals control the progressive choreography of structural reorganizations observed in quiescent cells during a natural life cycle remains unclear. We have developed an integrated microfluidic device to address this question, enabling continuous single-cell tracking in a batch culture experiencing unperturbed nutrient exhaustion to unravel the coordination between metabolic and structural transitions within cells. Our technique reveals an abrupt fate divergence in the population, whereby a fraction of cells is unable to transition to respiratory metabolism and undergoes a reversible entry into a quiescence-like state leading to premature cell death. Further observations reveal that nonmonotonous internal pH fluctuations in respiration-competent cells orchestrate the successive waves of protein superassemblies formation that accompany the entry into a bona fide quiescent state. This ultimately leads to an abrupt cytosolic glass transition that occurs stochastically long after proliferation cessation. This new experimental framework provides a unique way to track single-cell fate dynamics over a long timescale in a population of cells that continuously modify their ecological niche.
    Keywords quiescence ; microfluidics ; single-cell dynamics ; cytosolic pH ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Quiescence, an individual journey

    Sagot, Isabelle / Laporte, Damien

    Current genetics. 2019 June, v. 65, no. 3

    2019  

    Abstract: Quiescence is operationally characterized as a temporary and reversible proliferation arrest. There are many preconceived ideas about quiescence, quiescent cells being generally viewed as insignificant sleeping G1 cells. In fact, quiescence is central ... ...

    Abstract Quiescence is operationally characterized as a temporary and reversible proliferation arrest. There are many preconceived ideas about quiescence, quiescent cells being generally viewed as insignificant sleeping G1 cells. In fact, quiescence is central for organism physiology and its dysregulation involved in many pathologies. The quiescent state encompasses very diverse cellular situations depending on the cell type and its environment. This diversity challenges not only quiescence uniformity but also the universality of the molecular mechanisms beyond quiescence regulation. In this mini-perspective, we discuss recent advances in the concept of quiescence, and illustrate that this multifaceted cellular state is gaining increasing attention in many fields of biology.
    Keywords animal diseases ; molecular genetics ; physiology
    Language English
    Dates of publication 2019-06
    Size p. 695-699.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-018-00928-w
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 81/707: Show issues

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