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  1. Article ; Online: HIPPO and Hyaluronan: Partners in Tumor Resistance?

    Turley, Eva A

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2020  Volume 42, Issue 7, Page(s) e2000090

    MeSH term(s) Humans ; Hyaluronic Acid ; Neoplasms/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Hippo protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-05-24
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202000090
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2024: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Association of Squamous Cell Carcinoma and Hyaluronan: A Scope of the Literature.

    Al Ghanim, Khalifa / Jaszkul, Katrina M / Simpson, Andrew / Turley, Eva A

    Eplasty

    2024  Volume 24, Page(s) e11

    Abstract: Background: Nonmelanotic skin cancer (NMSC) refers to cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma. There have been many factors linked with the development of cSCC; however, ultraviolet radiation is the most notable culprit. ... ...

    Abstract Background: Nonmelanotic skin cancer (NMSC) refers to cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma. There have been many factors linked with the development of cSCC; however, ultraviolet radiation is the most notable culprit. Mutations in
    Methods: A narrative literature review was conducted on the available literature regarding NMSC, and various treatment strategies were identified.
    Conclusions: Recent research investigating whether long-lived cancer-resistant species could yield any potential clues against skin carcinogenesis has highlighted naked mole rats (
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2412803-X
    ISSN 1937-5719
    ISSN 1937-5719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CD44 and RHAMM Are Microenvironmental Sensors with Dual Metastasis Promoter and Suppressor Functions.

    Tolg, Cornelia / Hill, Kathleen Allen / Turley, Eva Ann

    Advanced biology

    2024  , Page(s) e2300693

    Abstract: The progression of primary tumors to metastases remains a significant roadblock to the treatment of most cancers. Emerging evidence has identified genes that specifically affect metastasis and are potential therapeutic targets for managing tumor ... ...

    Abstract The progression of primary tumors to metastases remains a significant roadblock to the treatment of most cancers. Emerging evidence has identified genes that specifically affect metastasis and are potential therapeutic targets for managing tumor progression. However, these genes can have dual tumor promoter and suppressor functions that are contextual in manifestation, and that complicate their development as targeted therapies. CD44 and RHAMM/HMMR are examples of multifunctional proteins that can either promote or suppress metastases, as demonstrated in experimental models. These two proteins can be viewed as microenvironmental sensors and this minireview addresses the known mechanistic underpinnings that may determine their metastasis suppressor versus promoter functions. Leveraging this mechanistic knowledge for CD44, RHAMM, and other multifunctional proteins is predicted to improve the precision of therapeutic targeting to achieve more effective management of metastasis.
    Language English
    Publishing date 2024-04-18
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202300693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Biodiversity of Calcaxonian Octocorals from the Irish Continental Slope Inferred from Multilocus Mitochondrial Barcoding

    Declan Morrissey / Candice B. Untiedt / Karen Croke / Aisling Robinson / Eva Turley / A. Louise Allcock

    Diversity, Vol 14, Iss 576, p

    2022  Volume 576

    Abstract: Deep-sea corals are important benthic inhabitants that support the biodiversity and function of the wider faunal community; however, their taxonomy is underdeveloped and their accurate identification is often difficult. In our study, we investigated the ... ...

    Abstract Deep-sea corals are important benthic inhabitants that support the biodiversity and function of the wider faunal community; however, their taxonomy is underdeveloped and their accurate identification is often difficult. In our study, we investigated the utility of a superextended (>3000 bp) barcode and explored the effectiveness of various molecular species delimitation techniques with an aim to put upper and lower bounds on the estimated number of calcaxonian species in Irish waters. We collected 112 calcaxonians (70 Keratoisididae, 22 Primnoidae, 20 Chrysogorgiidae) and one chelidonisid from the Irish continental slope and sequenced a 3390 bp DNA barcode comprising four mitochondrial regions ( mtMutS , COI + igr1, 16S rRNA- ND2 , and igr4), recovering 38 haplotypes. Individuals that shared a haplotype were often morphologically distinct, and we thus undertook detailed morphological work, including SEM of sclerites, on one representative of each morphotype within each haplotype. GMYC, bGMYC, and mPTP returned incongruent estimates of species numbers. In total, there are between 25 and 40 species, although no definitive number could be assigned, primarily due to poorly defined keratoisidid species boundaries. As expected, the superextended barcode provided greater discrimination power than single markers; bGMYC appeared to be the most effective delimiter. Among the identified species were Chelidonisis aurantiaca , collected deeper than previously known at 1507 m, and Calyptrophora clinata, recorded for the second time from the Northeast Atlantic. A full understanding of the diversity and distribution of calcaxonians requires substantial taxonomic work, but we highlight the Irish continental slope as harbouring significant diversity.
    Keywords Keratoisididae ; Primnoidae ; Chrysogorgiidae ; Chelidonisididae ; deep sea ; species delimitation ; Biology (General) ; QH301-705.5
    Subject code 590
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: RHAMM Is a Multifunctional Protein That Regulates Cancer Progression.

    Messam, Britney J / Tolg, Cornelia / McCarthy, James B / Nelson, Andrew C / Turley, Eva A

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: The functional complexity of higher organisms is not easily accounted for by the size of their genomes. Rather, complexity appears to be generated by transcriptional, translational, and post-translational mechanisms and tissue organization that produces ... ...

    Abstract The functional complexity of higher organisms is not easily accounted for by the size of their genomes. Rather, complexity appears to be generated by transcriptional, translational, and post-translational mechanisms and tissue organization that produces a context-dependent response of cells to specific stimuli. One property of gene products that likely increases the ability of cells to respond to stimuli with complexity is the multifunctionality of expressed proteins. Receptor for hyaluronan-mediated motility (RHAMM) is an example of a multifunctional protein that controls differential responses of cells in response-to-injury contexts. Here, we trace its evolution into a sensor-transducer of tissue injury signals in higher organisms through the detection of hyaluronan (HA) that accumulates in injured microenvironments. Our goal is to highlight the domain and isoform structures that generate RHAMM's function complexity and model approaches for targeting its key functions to control cancer progression.
    MeSH term(s) Animals ; Disease Progression ; Extracellular Matrix Proteins/metabolism ; Humans ; Hyaluronan Receptors/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Tumor Microenvironment/physiology
    Chemical Substances Extracellular Matrix Proteins ; Hyaluronan Receptors ; hyaluronan-mediated motility receptor
    Language English
    Publishing date 2021-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Corrigendum to "A truncated RHAMM protein for discovering novel therapeutic peptides" [Bioorg. Med. Chem. 26 (2018) 5194-5203].

    Hauser-Kawaguchi, Alexandra / Tolg, Cornelia / Peart, Teresa / Milne, Mark / Turley, Eva A / Luyt, Leonard G

    Bioorganic & medicinal chemistry

    2020  Volume 28, Issue 13, Page(s) 115543

    Language English
    Publishing date 2020-05-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2020.115543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Hyaluronan Isolation from Mouse Mammary Gland.

    Tolg, Cornelia / Cowman, Mary / Turley, Eva A

    Bio-protocol

    2018  Volume 8, Issue 11, Page(s) e2865

    Abstract: The glycosaminoglycan hyaluronan (HA) is a key component of the extracellular matrix. The molecular weight of HA is heterogeneous and can reach from several million to several hundred daltons. The effect of HA on cell behavior is size dependent; ... ...

    Abstract The glycosaminoglycan hyaluronan (HA) is a key component of the extracellular matrix. The molecular weight of HA is heterogeneous and can reach from several million to several hundred daltons. The effect of HA on cell behavior is size dependent; fragmented HA acts as a danger signal, stimulates cell migration and proliferation and is proinflammatory, native high molecular weight HA suppresses inflammation. Therefore, it is important to analyze HA size distribution when studying the role of HA in tissue homeostasis and pathology. This protocol describes isolation of HA from mouse mammary glands but can also be applied to other tissues. The quality of the isolated HA is sufficient to analyze size distribution by gel electrophoresis ( Calabro
    Language English
    Publishing date 2018-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.2865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Biodiversity of Calcaxonian Octocorals from the Irish Continental Slope Inferred from Multilocus Mitochondrial Barcoding

    Morrissey, Declan / Untiedt, Candice B. / Croke, Karen / Robinson, Aisling / Turley, Eva / Allcock, A. Louise

    Diversity. 2022 July 18, v. 14, no. 7

    2022  

    Abstract: Deep-sea corals are important benthic inhabitants that support the biodiversity and function of the wider faunal community; however, their taxonomy is underdeveloped and their accurate identification is often difficult. In our study, we investigated the ... ...

    Abstract Deep-sea corals are important benthic inhabitants that support the biodiversity and function of the wider faunal community; however, their taxonomy is underdeveloped and their accurate identification is often difficult. In our study, we investigated the utility of a superextended (>3000 bp) barcode and explored the effectiveness of various molecular species delimitation techniques with an aim to put upper and lower bounds on the estimated number of calcaxonian species in Irish waters. We collected 112 calcaxonians (70 Keratoisididae, 22 Primnoidae, 20 Chrysogorgiidae) and one chelidonisid from the Irish continental slope and sequenced a 3390 bp DNA barcode comprising four mitochondrial regions (mtMutS, COI + igr1, 16S rRNA-ND2, and igr4), recovering 38 haplotypes. Individuals that shared a haplotype were often morphologically distinct, and we thus undertook detailed morphological work, including SEM of sclerites, on one representative of each morphotype within each haplotype. GMYC, bGMYC, and mPTP returned incongruent estimates of species numbers. In total, there are between 25 and 40 species, although no definitive number could be assigned, primarily due to poorly defined keratoisidid species boundaries. As expected, the superextended barcode provided greater discrimination power than single markers; bGMYC appeared to be the most effective delimiter. Among the identified species were Chelidonisis aurantiaca, collected deeper than previously known at 1507 m, and Calyptrophora clinata, recorded for the second time from the Northeast Atlantic. A full understanding of the diversity and distribution of calcaxonians requires substantial taxonomic work, but we highlight the Irish continental slope as harbouring significant diversity.
    Keywords DNA barcoding ; biodiversity ; fauna ; haplotypes ; mitochondria ; morphs ; taxonomy
    Language English
    Dates of publication 2022-0718
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518137-3
    ISSN 1424-2818
    ISSN 1424-2818
    DOI 10.3390/d14070576
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Mouse Mammary Gland Whole Mount Preparation and Analysis.

    Tolg, Cornelia / Cowman, Mary / Turley, Eva A

    Bio-protocol

    2018  Volume 8, Issue 13, Page(s) e2915

    Abstract: The mammary gland undergoes extensive remodeling during pregnancy and is also subject to neoplastic processes both of which result in histological changes of the gland epithelial structure. Since the mammary tree is a complex three-dimensional structure ... ...

    Abstract The mammary gland undergoes extensive remodeling during pregnancy and is also subject to neoplastic processes both of which result in histological changes of the gland epithelial structure. Since the mammary tree is a complex three-dimensional structure a method is needed that provides an overview of the entire gland. Whole mounts provide this information, are inexpensive and do not require specialized equipment. This protocol describes mammary gland isolation, whole mount preparation and analysis. Mammary gland tissue, which is removed postmortem, is stained with Carmine Alum, a nuclear stain, allowing detection of epithelial structures embedded in the adipose tissue of the mammary fat pad. Stained mammary glands are imaged by light microscopy or embedded and sectioned for histological examination. Image analysis software such as Image J can be used to quantify extensity of branching complexity, epithelial structure remodeling or hyperplastic changes.
    Language English
    Publishing date 2018-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.2915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Design of peptide mimetics to block pro-inflammatory functions of HA fragments.

    Hauser-Kawaguchi, Alexandra / Luyt, Leonard G / Turley, Eva

    Matrix biology : journal of the International Society for Matrix Biology

    2018  Volume 78-79, Page(s) 346–356

    Abstract: Hyaluronan is a simple extracellular matrix polysaccharide that actively regulates inflammation in tissue repair and disease processes. The native HA polymer, which is large (>500 kDa), contributes to the maintenance of homeostasis. In remodeling and ... ...

    Abstract Hyaluronan is a simple extracellular matrix polysaccharide that actively regulates inflammation in tissue repair and disease processes. The native HA polymer, which is large (>500 kDa), contributes to the maintenance of homeostasis. In remodeling and diseased tissues, polymer size is strikingly polydisperse, ranging from <10 kDa to >500 kDa. In a diseased or stressed tissue context, both smaller HA fragments and high molecular weight HA polymers can acquire pro-inflammatory functions, which result in the activation of multiple receptors, triggering pro-inflammatory signaling to diverse stimuli. Peptide mimics that bind and scavenge HA fragments have been developed, which show efficacy in animal models of inflammation. These studies indicate both that HA fragments are key to driving inflammation and that scavenging these is a viable therapeutic approach to blunting inflammation in disease processes. This mini-review summarizes the peptide-based methods that have been reported to date for blocking HA signaling events as an anti-inflammatory therapeutic approach.
    MeSH term(s) Animals ; Biomimetic Materials/chemical synthesis ; Biomimetic Materials/chemistry ; Disease Models, Animal ; Humans ; Hyaluronic Acid/chemistry ; Hyaluronic Acid/immunology ; Inflammation/immunology ; Molecular Weight ; Peptides/analysis ; Peptides/immunology ; Signal Transduction
    Chemical Substances Peptides ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2018-01-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2018.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1694: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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