Article ; Online: Mechanisms of escape phenomenon of spinal cord and brainstem in human rabies.
BMC infectious diseases
2005 Volume 5, Page(s) 104
Abstract: Background: Rabies virus preferentially involves brainstem, thalamus and spinal cord in human furious and paralytic rabies beginning in the early stage of illness. Nevertheless, rabies patient remains alert until the pre-terminal phase. Weakness of ... ...
| Abstract | Background: Rabies virus preferentially involves brainstem, thalamus and spinal cord in human furious and paralytic rabies beginning in the early stage of illness. Nevertheless, rabies patient remains alert until the pre-terminal phase. Weakness of extremities develops only when furious rabies patient becomes comatose; whereas peripheral nerve dysfunction is responsible for weakness in paralytic rabies. Methods: Evidence of apoptosis and mitochondrial outer membrane permeabilization in brain and spinal cord of 10 rabies patients was examined and these findings were correlated with the presence of rabies virus antigen. Results: Although apoptosis was evident in most of the regions, cytochrome c leakage was relatively absent in spinal cord of nearly all patients despite the abundant presence of rabies virus antigen. Such finding was also noted in brainstem of 5 patients. Conclusion: Cell death in human rabies may be delayed in spinal cord and the reticular activating system, such as brainstem, thus explaining absence of weakness due to spinal cord dysfunction and preservation of consciousness. |
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| MeSH term(s) | Adolescent ; Adult ; Aged, 80 and over ; Antigens, Viral/analysis ; Apoptosis ; Brain Stem/pathology ; Brain Stem/virology ; Child ; Cytochromes c/metabolism ; Female ; Humans ; Male ; Middle Aged ; Rabies/pathology ; Rabies/physiopathology ; Spinal Cord/pathology ; Spinal Cord/virology |
| Chemical Substances | Antigens, Viral ; Cytochromes c (9007-43-6) |
| Language | English |
| Publishing date | 2005-11-16 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1471-2334 |
| ISSN (online) | 1471-2334 |
| DOI | 10.1186/1471-2334-5-104 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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