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  1. Article ; Online: Principles of organelle positioning in motile and non-motile cells.

    Kroll, Janina / Renkawitz, Jörg

    EMBO reports

    2024  

    Abstract: Cells are equipped with asymmetrically localised and functionally specialised components, including cytoskeletal structures and organelles. Positioning these components to specific intracellular locations in an asymmetric manner is critical for their ... ...

    Abstract Cells are equipped with asymmetrically localised and functionally specialised components, including cytoskeletal structures and organelles. Positioning these components to specific intracellular locations in an asymmetric manner is critical for their functionality and affects processes like immune responses, tissue maintenance, muscle functionality, and neurobiology. Here, we provide an overview of strategies to actively move, position, and anchor organelles to specific locations. By conceptualizing the cytoskeletal forces and the organelle-to-cytoskeleton connectivity, we present a framework of active positioning of both membrane-enclosed and membrane-less organelles. Using this framework, we discuss how different principles of force generation and organelle anchorage are utilised by different cells, such as mesenchymal and amoeboid cells, and how the microenvironment influences the plasticity of organelle positioning. Given that motile cells face the challenge of coordinating the positioning of their content with cellular motion, we particularly focus on principles of organelle positioning during migration. In this context, we discuss novel findings on organelle positioning by anchorage-independent mechanisms and their advantages and disadvantages in motile as well as stationary cells.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-024-00135-4
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  2. Book ; Online ; Thesis: Spatiotemporal dynamics of nuclear positioning during amoeboid migration

    Kroll, Janina [Verfasser] / Renkawitz, Jörg [Akademischer Betreuer]

    2024  

    Author's details Janina Kroll ; Betreuer: Jörg Renkawitz
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  3. Book ; Online ; Thesis: Role of Coronin 1B on the regulation of endothelial cell function and angiogenesis

    Werner, Ann-Cathrin [Verfasser] / Renkawitz, Jörg [Akademischer Betreuer]

    2022  

    Author's details Ann-Cathrin Werner ; Betreuer: Jörg Renkawitz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Editorial: Immune Cell Migration in Health and Disease.

    Renkawitz, Jörg / Donnadieu, Emmanuel / Moreau, Hélène D

    Frontiers in immunology

    2022  Volume 13, Page(s) 897626

    MeSH term(s) Cell Movement/immunology ; Immune System Phenomena
    Language English
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.897626
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  5. Article ; Online: Principles of Leukocyte Migration Strategies.

    Kameritsch, Petra / Renkawitz, Jörg

    Trends in cell biology

    2020  Volume 30, Issue 10, Page(s) 818–832

    Abstract: Migration of leukocytes is essential for the induction, maintenance, and regulation of immune responses. On their trafficking routes, leukocytes encounter microenvironments of diverse mechanochemical composition, such as epithelial sheets, fibrillar ... ...

    Abstract Migration of leukocytes is essential for the induction, maintenance, and regulation of immune responses. On their trafficking routes, leukocytes encounter microenvironments of diverse mechanochemical composition, such as epithelial sheets, fibrillar networks, and cell-dense lymphatic organs. These microenvironments impose fundamental challenges on leukocytes, which include adhesive crawling under high shear stress, extreme cellular deformation while crossing physical barriers, and pathfinding in maze-like 3D environments. Crossing these microenvironments in a fast and efficient manner is a hallmark of leukocyte biology. We review the underlying cell biological principles and molecular mechanisms. By integrating knowledge from physiological in vivo and reductionistic in vitro approaches, we developed a holistic view of leukocyte migration strategies, including misregulation in disease and mechanistic hijacking by tumor cells.
    MeSH term(s) Adaptive Immunity ; Animals ; Cell Movement ; Cell Plasticity ; Cellular Microenvironment ; Humans ; Immunity, Innate ; Leukocytes/cytology ; Leukocytes/immunology
    Language English
    Publishing date 2020-07-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2020.06.007
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  6. Article ; Online: Centrosome Positioning in Migrating

    Ishikawa-Ankerhold, Hellen / Kroll, Janina / Heuvel, Dominic van den / Renkawitz, Jörg / Müller-Taubenberger, Annette

    Cells

    2022  Volume 11, Issue 11

    Abstract: Directional cell migration and the establishment of polarity play an important role in development, wound healing, and host cell defense. While actin polymerization provides the driving force at the cell front, the microtubule network assumes a ... ...

    Abstract Directional cell migration and the establishment of polarity play an important role in development, wound healing, and host cell defense. While actin polymerization provides the driving force at the cell front, the microtubule network assumes a regulatory function, in coordinating front protrusion and rear retraction. By using
    MeSH term(s) Cell Movement ; Cell Nucleus ; Centrosome ; Dictyostelium ; Humans ; Microtubules
    Language English
    Publishing date 2022-05-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11111776
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  7. Article ; Online: Quantifying the Probing and Selection of Microenvironmental Pores by Motile Immune Cells.

    Kroll, Janina / Ruiz-Fernandez, Mauricio J A / Braun, Malte B / Merrin, Jack / Renkawitz, Jörg

    Current protocols

    2022  Volume 2, Issue 4, Page(s) e407

    Abstract: Immune cells are constantly on the move through multicellular organisms to explore and respond to pathogens and other harmful insults. While moving, immune cells efficiently traverse microenvironments composed of tissue cells and extracellular fibers, ... ...

    Abstract Immune cells are constantly on the move through multicellular organisms to explore and respond to pathogens and other harmful insults. While moving, immune cells efficiently traverse microenvironments composed of tissue cells and extracellular fibers, which together form complex environments of various porosity, stiffness, topography, and chemical composition. In this protocol we describe experimental procedures to investigate immune cell migration through microenvironments of heterogeneous porosity. In particular, we describe micro-channels, micro-pillars, and collagen networks as cell migration paths with alternative pore size choices. Employing micro-channels or micro-pillars that divide at junctions into alternative paths with initially differentially sized pores allows us to precisely (1) measure the cellular translocation time through these porous path junctions, (2) quantify the cellular preference for individual pore sizes, and (3) image cellular components like the nucleus and the cytoskeleton. This reductionistic experimental setup thus can elucidate how immune cells perform decisions in complex microenvironments of various porosity like the interstitium. The setup further allows investigation of the underlying forces of cellular squeezing and the consequences of cellular deformation on the integrity of the cell and its organelles. As a complementary approach that does not require any micro-engineering expertise, we describe the usage of three-dimensional collagen networks with different pore sizes. Whereas we here focus on dendritic cells as a model for motile immune cells, the described protocols are versatile as they are also applicable for other immune cell types like neutrophils and non-immune cell types such as mesenchymal and cancer cells. In summary, we here describe protocols to identify the mechanisms and principles of cellular probing, decision making, and squeezing during cellular movement through microenvironments of heterogeneous porosity. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Immune cell migration in micro-channels and micro-pillars with defined pore sizes Support Protocol 1: Epoxy replica of generated and/or published micro-structures Support Protocol 2: Dendritic cell differentiation Basic Protocol 2: Immune cell migration in 3D collagen networks of variable pore sizes.
    MeSH term(s) Cell Movement ; Cellular Microenvironment ; Extracellular Matrix/metabolism ; Porosity
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.407
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  8. Article: Monitoring homology search during DNA double-strand repair in vivo

    Renkawitz, Jörg

    Futura

    2014  Volume 29, Issue 1, Page(s) 44

    Language German ; English
    Document type Article
    ZDB-ID 382906-6
    ISSN 0179-6372
    Database Current Contents Medicine

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  9. Article ; Online: Adaptive pathfinding by nucleokinesis during amoeboid migration.

    Kroll, Janina / Hauschild, Robert / Kuznetcov, Artur / Stefanowski, Kasia / Hermann, Monika D / Merrin, Jack / Shafeek, Lubuna / Müller-Taubenberger, Annette / Renkawitz, Jörg

    The EMBO journal

    2023  Volume 42, Issue 24, Page(s) e114557

    Abstract: Motile cells encounter microenvironments with locally heterogeneous mechanochemical composition. Individual compositional parameters, such as chemokines and extracellular matrix pore sizes, are well known to provide guidance cues for pathfinding. However, ...

    Abstract Motile cells encounter microenvironments with locally heterogeneous mechanochemical composition. Individual compositional parameters, such as chemokines and extracellular matrix pore sizes, are well known to provide guidance cues for pathfinding. However, motile cells face diverse cues at the same time, raising the question of how they respond to multiple and potentially competing signals on their paths. Here, we reveal that amoeboid cells require nuclear repositioning, termed nucleokinesis, for adaptive pathfinding in heterogeneous mechanochemical micro-environments. Using mammalian immune cells and the amoeba Dictyostelium discoideum, we discover that frequent, rapid and long-distance nucleokinesis is a basic component of amoeboid pathfinding, enabling cells to reorientate quickly between locally competing cues. Amoeboid nucleokinesis comprises a two-step polarity switch and is driven by myosin-II forces that readjust the nuclear to the cellular path. Impaired nucleokinesis distorts path adaptions and causes cellular arrest in the microenvironment. Our findings establish that nucleokinesis is required for amoeboid cell navigation. Given that many immune cells, amoebae, and some cancer cells utilize an amoeboid migration strategy, these results suggest that nucleokinesis underlies cellular navigation during unicellular biology, immunity, and disease.
    MeSH term(s) Animals ; Cell Movement ; Dictyostelium ; Amoeba ; Extracellular Matrix ; Mammals
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2023114557
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  10. Article ; Online: Meeting report - Cell dynamics: organelle-cytoskeleton interface.

    Mogessie, Binyam / Zenner, Helen / Renkawitz, Jörg

    Journal of cell science

    2019  Volume 132, Issue 16

    Abstract: A hallmark of eukaryotic cells is the spatial separation of molecular and biochemical processes into membrane-bound organelles, such as mitochondria, endoplasmic reticulum and Golgi. At the 'Cell dynamics: organelle-cytoskeleton interface' meeting held ... ...

    Abstract A hallmark of eukaryotic cells is the spatial separation of molecular and biochemical processes into membrane-bound organelles, such as mitochondria, endoplasmic reticulum and Golgi. At the 'Cell dynamics: organelle-cytoskeleton interface' meeting held in Lisbon, researchers from around the world discussed their findings of how the cytoskeleton regulates dynamics, interaction, and function of organelles in health and disease. Organised by Edgar Gomes, Heidi McBride, Sharon Tooze and Michael Way, the meeting created an open, stimulating and collaborative environment for scientific exchange and an opportunity to highlight the newest trends in the field.
    MeSH term(s) Animals ; Congresses as Topic ; Cytoskeleton/metabolism ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/metabolism ; Humans ; Mitochondria/metabolism
    Language English
    Publishing date 2019-08-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.236679
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