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  1. Article ; Online: The mystery of persistent, asymptomatic Plasmodium falciparum infections.

    Zhang, Xu / Deitsch, Kirk W

    Current opinion in microbiology

    2022  Volume 70, Page(s) 102231

    Abstract: Plasmodium falciparum causes millions of malaria infections and hundreds of thousands of deaths annually. These parasites avoid the adaptive immune response by systematically cycling through a limited repertoire of variant surface antigens after which ... ...

    Abstract Plasmodium falciparum causes millions of malaria infections and hundreds of thousands of deaths annually. These parasites avoid the adaptive immune response by systematically cycling through a limited repertoire of variant surface antigens after which the number of circulating parasites drops to extremely low levels, coinciding with a loss of symptoms and eventual clearance of the infection. However, in regions with extended dry seasons or in individuals who no longer reside in endemic areas, asymptomatic infections have been observed to persist for many months or years, potentially serving as reservoirs for transmission. Recent work suggests the possibility that parasites can assume a state in which no variant surface antigens are expressed, thus rendering them virtually invisible to the immune system and enabling them to persist at low levels indefinitely.
    MeSH term(s) Humans ; Plasmodium falciparum/genetics ; Malaria, Falciparum/parasitology ; Malaria/parasitology ; Seasons ; Antigens, Surface
    Chemical Substances Antigens, Surface
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2022.102231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book: Malaria parasites

    Carlton, Jane M. / Perkins, Susan L. / Deitsch, Kirk W.

    comparative genomics, evolution and molecular biology

    2013  

    Author's details ed. Jane M. Carter ; Susan L. Perkins ; Kirk W. Deitsch
    Language English
    Size X, 280 S. : Ill., graph. Darst.
    Publisher Caister
    Publishing place Norfolk
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017358211
    ISBN 978-1-908230-07-2 ; 1-908230-07-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 A 4879 order for loan Magazin

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  3. Article ; Online: Parasite pathogenesis: The dynamics of chronic malaria.

    Deitsch, Kirk W

    Nature microbiology

    2017  Volume 2, Page(s) 17039

    MeSH term(s) Animals ; Malaria ; Parasites ; Plasmodium
    Language English
    Publishing date 2017-03-28
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/nmicrobiol.2017.39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites.

    Florini, Francesca / Visone, Joseph E / Deitsch, Kirk W

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 852239

    Abstract: Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with adaptive advantages. A ...

    Abstract Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with adaptive advantages. A prime example is the mutually exclusive activation of a single gene from within a multicopy gene family. In mammals, this ranges from the activation of one of the two immunoglobulin (Ig) alleles to the choice in olfactory sensory neurons of a single odorant receptor (OR) gene from a family of more than 1,000. Similarly, in parasites like
    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.852239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Unifying Nature of Basic Science Research.

    Deitsch, Kirk W

    PLoS pathogens

    2016  Volume 12, Issue 3, Page(s) e1005329

    MeSH term(s) Humans ; Molecular Biology ; Research ; Science
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1005329
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  6. Article ; Online: CRISPR-Cas9 Editing of the Plasmodium falciparum Genome: Special Applications.

    Zhang, Xu / Deitsch, Kirk William / Dzikowski, Ron

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2470, Page(s) 241–253

    Abstract: The virulence of Plasmodium falciparum has been attributed in large part to the expression on the surface of infected red blood cells of the variant surface antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). Different forms of this ... ...

    Abstract The virulence of Plasmodium falciparum has been attributed in large part to the expression on the surface of infected red blood cells of the variant surface antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). Different forms of this protein are encoded by individual members of the multicopy gene family called var. Two attributes of the var gene family are key to the pathogenesis of malaria caused by P. falciparum; the hyperrecombinogenic nature of the var gene family that continuously generates antigenic diversity within parasite populations, and the ability of parasites to express only a single var gene at a time and to switch which gene is expressed over the course of an infection. The unique attributes of CRISPR-Cas9 have been applied to help decipher the molecular mechanisms underlying these unusual properties of the var gene family, both as a source of the DNA double strand breaks that initiate var gene recombination and as a way to recruit molecular probes to specific regions of the genome. In this chapter, we describe these somewhat unusual applications of the CRISPR-Cas9 system.
    MeSH term(s) Animals ; Antigenic Variation ; CRISPR-Cas Systems/genetics ; Gene Expression Regulation ; Malaria, Falciparum/genetics ; Malaria, Falciparum/parasitology ; Parasites/metabolism ; Plasmodium falciparum/metabolism ; Protozoan Proteins/metabolism
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2189-9_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chromatin structure and

    Lenz, Todd / Zhang, Xu / Chakraborty, Abhijit / Ardakany, Abbas Roayaei / Prudhomme, Jacques / Ay, Ferhat / Deitsch, Kirk / Le Roch, Karine G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Over the last few decades, novel methods have been developed to study how chromosome positioning within the nucleus may play a role in gene regulation. Adaptation of these methods in the human malaria parasite, ...

    Abstract Over the last few decades, novel methods have been developed to study how chromosome positioning within the nucleus may play a role in gene regulation. Adaptation of these methods in the human malaria parasite,
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.13.580059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity.

    Florini, Francesca / Visone, Joseph E / Hadjimichael, Evi / Malpotra, Shivali / Nötzel, Christopher / Kafsack, Björn F C / Deitsch, Kirk W

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Chronic, asymptomatic malaria infections contribute substantially to disease transmission and likely represent the most significant impediment preventing malaria elimination and eradication. ...

    Abstract Chronic, asymptomatic malaria infections contribute substantially to disease transmission and likely represent the most significant impediment preventing malaria elimination and eradication.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.08.584127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Vive la Différence: Exploiting the Differences between Rodent and Human Malarias.

    Kirkman, Laura A / Deitsch, Kirk W

    Trends in parasitology

    2020  Volume 36, Issue 6, Page(s) 504–511

    Abstract: Experimental research into malaria biology and pathogenesis has historically focused on two model systems, in vitro culture of the human parasite Plasmodium falciparum and in vivo infections of laboratory animals using rodent parasites. While there is ... ...

    Abstract Experimental research into malaria biology and pathogenesis has historically focused on two model systems, in vitro culture of the human parasite Plasmodium falciparum and in vivo infections of laboratory animals using rodent parasites. While there is clear value in having a manipulatable animal model for studying malaria, there have occasionally been controversies around how representative the rodent model is of the human disease, and therefore significant emphasis has been placed on the similarities between the two biological systems. By focusing on basic nuclear functions, we wish to highlight that identifying key differences in the parasites and their interactions with their mammalian hosts can be equally informative and provide remarkable insights into the biology and evolution of these important infectious organisms.
    MeSH term(s) Animals ; Disease Models, Animal ; Host-Parasite Interactions/physiology ; Humans ; Malaria/parasitology ; Plasmodium/physiology ; Rodentia/parasitology
    Language English
    Publishing date 2020-04-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2020.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 251: Show issues

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  10. Article ; Online: Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites

    Francesca Florini / Joseph E. Visone / Kirk W. Deitsch

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with adaptive advantages. A ...

    Abstract Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with adaptive advantages. A prime example is the mutually exclusive activation of a single gene from within a multicopy gene family. In mammals, this ranges from the activation of one of the two immunoglobulin (Ig) alleles to the choice in olfactory sensory neurons of a single odorant receptor (OR) gene from a family of more than 1,000. Similarly, in parasites like Trypanosoma brucei, Giardia lamblia or Plasmodium falciparum, the process of antigenic variation required to escape recognition by the host immune system involves the monoallelic expression of vsg, vsp or var genes, respectively. Despite the importance of this process, understanding how this choice is made remains an enigma. The development of powerful techniques such as single cell RNA-seq and Hi-C has provided new insights into the mechanisms these different systems employ to achieve monoallelic gene expression. Studies utilizing these techniques have shown how the complex interplay between nuclear architecture, physical interactions between chromosomes and different chromatin states lead to single allele expression. Additionally, in several instances it has been observed that high-level expression of a single gene is preceded by a transient state where multiple genes are expressed at a low level. In this review, we will describe and compare the different strategies that organisms have evolved to choose one gene from within a large family and how parasites employ this strategy to ensure survival within their hosts.
    Keywords mutually exclusive expression ; antigenic variation ; transcription ; chromatin ; nuclear organization ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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