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Article ; Online: Reply to S. Chakrabarti et al, R. Cohen et al, and D.C. Guven.

Gray, Richard / Seymour, Matt / Magill, Laura / Handley, Kelly / Quirke, Philip / West, Nick / Morton, Dion

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 30, Page(s) 4823–4824

Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.00694
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Availability of Network Psychiatrists Among the Largest Health Insurance Carriers in Washington, D.C.

Blech, Benzion / West, Joyce C / Yang, Zhuoyin / Barber, Keila D / Wang, Philip / Coyle, Colleen

Psychiatric services (Washington, D.C.)

2017 Volume 68, Issue 9, Page(s) 962–965

Abstract: ... of psychiatrists listed in insurance carrier network provider databases in the Washington, D.C., area.: Methods ... of the largest insurance carriers serving the Washington, D.C., area. The "mystery shopper" method was used ...

Abstract	Objective: Lack of access to mental health treatment remains a significant problem in the United States, even after implementation of mental health parity legislation. This study examined availability of psychiatrists listed in insurance carrier network provider databases in the Washington, D.C., area. Methods: Contact information was obtained for 1,184 psychiatrists listed in online directories for three of the largest insurance carriers serving the Washington, D.C., area. The "mystery shopper" method was used to assess the accuracy of listed contact information, new outpatient appointment availability, and average wait times for 50 psychiatrists randomly selected from each insurance directory. Results: Most (77%) physicians were successfully contacted, meaning that someone answered the phone or returned a voice mail message, and 51% of the psychiatrists had working telephone numbers verified to be correct. Fifteen percent of the psychiatrists were accepting new outpatients with the target insurance, with average wait times of 19 days; only 7% were able to schedule an appointment within two weeks. Conclusions: Inaccuracy of insurance provider directories significantly affected the ability of patients to obtain timely mental care.
Language	English
Publishing date	2017-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.201600454
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Zs.A 416: Show issues

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Article: Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs.

Rana, Natasha / Aziz, Marwa A / Oraby, Ahmed K / Wuest, Melinda / Dufour, Jennifer / Abouzid, Khaled A M / Wuest, Frank / West, F G

Pharmaceutics

2022 Volume 14, Issue 4

Abstract: Deregulation and changes in energy metabolism are emergent and important biomarkers of cancer cells. The uptake of hexoses in cancer cells is mediated by a family of facilitative hexose membrane-transporter proteins known as Glucose Transporters (GLUTs). ...

Abstract	Deregulation and changes in energy metabolism are emergent and important biomarkers of cancer cells. The uptake of hexoses in cancer cells is mediated by a family of facilitative hexose membrane-transporter proteins known as Glucose Transporters (GLUTs). In the clinic, numerous breast cancers do not show elevated glucose metabolism (which is mediated mainly through the GLUT1 transporter) and may use fructose as an alternative energy source. The principal fructose transporter in most cancer cells is GLUT5, and its mRNA was shown to be elevated in human breast cancer. This offers an alternative strategy for early detection using fructose analogs. In order to selectively scout GLUT5 binding-pocket requirements, we designed, synthesized and screened a new class of fructose mimics based upon the 2,5-anhydromannitol scaffold. Several of these compounds display low millimolar IC
Language	English
Publishing date	2022-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14040828
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Article ; Online: Implementing a novel citywide rapid HIV testing campaign in Washington, D.C.: findings and lessons learned.

Castel, Amanda D / Magnus, Manya / Peterson, James / Anand, Karishma / Wu, Charles / Martin, Marsha / Sansone, Marie / Rocha, Nestor / Jolaosho, Titilola / West, Tiffany / Hader, Shannon / Greenberg, Alan E

Public health reports (Washington, D.C. : 1974)

2012 Volume 127, Issue 4, Page(s) 422–431

Abstract: Objectives: In June 2006, the District of Columbia (DC) Department of Health launched a citywide rapid HIV screening campaign. Goals included raising HIV awareness, routinizing rapid HIV screening, identifying previously unrecognized infections, and ... ...

Abstract	Objectives: In June 2006, the District of Columbia (DC) Department of Health launched a citywide rapid HIV screening campaign. Goals included raising HIV awareness, routinizing rapid HIV screening, identifying previously unrecognized infections, and linking positives to care. We describe findings from this seminal campaign and identify lessons learned. Methods: We applied a mixed-methods approach using quantitative analysis of client data forms (CDFs) and qualitative evaluation of focus groups with DC residents. We measured characteristics and factors associated with client demographics, test results, and community perceptions regarding the campaign. Results: Data were available on 38,586 participants tested from July 2006 to September 2007. Of those, 68% had previously tested for HIV (44% within the last 12 months) and 23% would not have sought testing had it not been offered. Overall, 662 (1.7%) participants screened positive on the OraQuick® Advance™ rapid HIV test, with non-Hispanic black people, transgenders, and first-time testers being significantly more likely to screen positive for HIV than white people, males, and those tested within the last year, respectively. Of those screening positive for HIV, 47% had documented referrals for HIV care and treatment services. Focus groups reported continued stigma regarding HIV and minimal community saturation of the campaign. Conclusions: This widespread campaign tested thousands of people and identified hundreds of HIV-infected individuals; however, referrals to care were lower than anticipated, and awareness of the campaign was limited. Lessons learned through this scale-up of population-based HIV screening resulted in establishing citywide HIV testing processes that laid the foundation for the implementation of test-and-treat activities in DC.
MeSH term(s)	Adolescent ; Adult ; Aged ; Awareness ; District of Columbia/epidemiology ; Female ; Focus Groups ; HIV ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/therapy ; HIV Seropositivity/diagnosis ; Health Plan Implementation ; Health Promotion/methods ; Humans ; Male ; Mass Screening/statistics & numerical data ; Middle Aged ; Referral and Consultation/statistics & numerical data ; Self Report ; Young Adult
Language	English
Publishing date	2012-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	120953-x
ISSN	1468-2877 ; 0033-3549
ISSN (online)	1468-2877
ISSN	0033-3549
DOI	10.1177/003335491212700410
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Un I Zs.150: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 479: Show issues

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Article: A stable d.c. capillary arc plasma for solution analysis.

Denton, H / Sharp, B L / West, T S

Talanta

2006 Volume 22, Issue 4-5, Page(s) 379–386

Abstract: The analytical capability of a d.c. capillary arc plasma, operating on argon, is described ...

Abstract	The analytical capability of a d.c. capillary arc plasma, operating on argon, is described. Solutions containing Cd, Pb, Hg, I, As and Zn are introduced into the plasma from a tantalum-filament atomizer. Signals are observed from both the arc and the tail-flame. The problem of sample rejection by the hot plasma is illustrated and discussed.
Language	English
Publishing date	2006-01-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/0039-9140(75)80084-1
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Article: Recombination initiation: easy as A, B, C, D... chi?

Eggleston, A K / West, S C

Current biology : CB

1997 Volume 7, Issue 12, Page(s) R745–9

Abstract: The octameric Chi (chi) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which chi regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the ... ...

Abstract	The octameric Chi (chi) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which chi regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the strand exchange protein, RecA, onto chi-containing DNA.
MeSH term(s)	Binding Sites ; DNA, Bacterial/genetics ; Escherichia coli/genetics ; Exodeoxyribonuclease V ; Exodeoxyribonucleases/metabolism ; Mutation ; Rec A Recombinases/metabolism ; Recombination, Genetic
Chemical Substances	DNA, Bacterial ; Rec A Recombinases (EC 2.7.7.-) ; Exodeoxyribonucleases (EC 3.1.-) ; Exodeoxyribonuclease V (EC 3.1.11.5)
Language	English
Publishing date	1997-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/s0960-9822(06)00394-0
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Zs.A 3208: Show issues

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Article ; Online: Apparent agency: Hospitals must expressly disclaim agency to avoid liability. Knighten v. U.S., No. 06 C 1318 (N.D. Ill. Dec.16, 2008).

West, John C

Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management

2008 Volume 28, Issue 4, Page(s) 37–38

MeSH term(s)	Adult ; Brachial Plexus Neuropathies ; Female ; Humans ; Infant, Newborn ; Liability, Legal ; Malpractice/legislation & jurisprudence ; Obstetrics/legislation & jurisprudence ; Pregnancy ; Pregnancy Outcome ; Pregnancy, High-Risk ; Risk Management
Language	English
Publishing date	2008
Publishing country	United States
Document type	Journal Article ; Legal Cases
ZDB-ID	2546719-0
ISSN	2040-0861 ; 1074-4797
ISSN (online)	2040-0861
ISSN	1074-4797
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Article: A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination.

West, Kelly L / Singha, Netai C / De Ioannes, Pablo / Lacomis, Lynne / Erdjument-Bromage, Hediye / Tempst, Paul / Cortes, Patricia

Immunity

2005 Volume 23, Issue 2, Page(s) 203–212

Abstract: V(D)J recombination is a tightly controlled process of somatic recombination whose regulation is ... recombinase complex in a manner that is dependent on the RAG2 C terminus. Amino acids within the plant homeo ... domain (PHD)-like domain as well as a conserved acidic stretch of the RAG2 C terminus that is considered ...

Abstract	V(D)J recombination is a tightly controlled process of somatic recombination whose regulation is mediated in part by chromatin structure. Here, we report that RAG2 binds directly to the core histone proteins. The interaction with histones is observed in developing lymphocytes and within the RAG1/RAG2 recombinase complex in a manner that is dependent on the RAG2 C terminus. Amino acids within the plant homeo domain (PHD)-like domain as well as a conserved acidic stretch of the RAG2 C terminus that is considered to be a linker region are important for this interaction. Point mutations that disrupt the RAG2-histone association inhibit the efficiency of the V(D)J recombination reaction at the endogenous immunoglobulin locus, with the most dramatic effect in the V to DJ(H) rearrangement.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cell Line ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Gene Rearrangement/immunology ; Histones/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Immunoglobulins/genetics ; Mice ; Molecular Sequence Data ; Nuclear Proteins ; Peptide Fragments/metabolism ; Point Mutation ; Protein Binding/genetics ; Protein Structure, Tertiary/genetics ; Rabbits ; Recombination, Genetic/immunology ; Thymus Gland/cytology ; Thymus Gland/metabolism ; VDJ Recombinases/metabolism
Chemical Substances	DNA-Binding Proteins ; Histones ; Homeodomain Proteins ; Immunoglobulins ; Nuclear Proteins ; Peptide Fragments ; RAG2 protein, Oryctolagus cuniculus ; RAG2 protein, human ; Rag2 protein, mouse ; V(D)J recombination activating protein 2 ; RAG-1 protein (128559-51-3) ; VDJ Recombinases (EC 2.7.7.-)
Language	English
Publishing date	2005-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2005.07.004
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article: 1-beta-D-arabinofuranosylcytosine-phospholipid conjugates as prodrugs of Ara-C.

Hong, C I / An, S H / Buchheit, D J / Nechaev, A / Kirisits, A J / West, C R / Ryu, E K / MacCoss, M

Cancer drug delivery

1984 Volume 1, Issue 3, Page(s) 181–190

Abstract: The L-, D-, and D,L-isomers of 1-beta-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitin, new ... and i.c. implanted L1210 leukemia and the maximal ILS values found were greater than 543 and greater ... of 300 mg/kg and 125 mg/kg. The D- and D,L-isomers also displayed significant in vivo antitumor activity ...

Abstract	The L-, D-, and D,L-isomers of 1-beta-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitin, new prodrugs of ara-C5, have been evaluated for antitumor activity in L1210 lymphoid leukemic mice. The L-isomer produced significant increase in life span (ILS), and longterm survivors among mice bearing i.p. and i.c. implanted L1210 leukemia and the maximal ILS values found were greater than 543 and greater than 374% with five and four 45-day survivors out of six mice, respectively, at the optimal single doses of 300 mg/kg and 125 mg/kg. The D- and D,L-isomers also displayed significant in vivo antitumor activity against both i.p. and i.c. implanted L1210 leukemia in mice with ILS range of 144-293% at a total dose of 125-250 mg/kg. Significant schedule dependency was not observed when the conjugates were administered i.p. once daily for 5 days, once every 4 days, or as a single dose, but single doses typically produced the best effects. The L-isomer was found to be a more effective prodrug of ara-C than its isomers and other lipophilic prodrugs, 5'-O-palmitoyl-ara-C and N4-acyl-ara-C. Unlike the latter prodrugs, the new conjugates are water soluble by sonication method.
MeSH term(s)	Animals ; Cytarabine/analogs & derivatives ; Cytarabine/therapeutic use ; Drug Evaluation, Preclinical ; Isomerism ; Leukemia L1210/drug therapy ; Mice ; Mice, Inbred DBA ; Mice, Inbred Strains ; Structure-Activity Relationship
Chemical Substances	Cytarabine (04079A1RDZ)
Language	English
Publishing date	1984
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	605561-8
ISSN	0732-9482
ISSN	0732-9482
DOI	10.1089/cdd.1984.1.181
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Zs.A 1896: Show issues

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Book ; Online: Joint Programme Committee Onchocerciasis Control Programme in West Africa, sixteenth session, Washington, D.C., U.S.A., 6-8 December 1995

World Health Organization. Onchocerciasis Control Programme in West Africa. Joint Programme Committee. Session (16th: 1995: Washington, D.C.) / World Health Organization. Onchocerciasis Control Programme in West Africa

1995

Abstract: ONLINE ... JPC16. Unpublished ... 37 p. ...

Abstract	ONLINE JPC16. Unpublished 37 p.
Keywords	Onchocerciasis ; Africa ; Western ; Parasitic Diseases and their Control ; prevention and control
Language	English
Publisher	Geneva : World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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