LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 158

Search options

  1. Article: From Physiological Redox Signalling to Oxidant Stress.

    Ward, Jeremy P T

    Advances in experimental medicine and biology

    2017  Volume 967, Page(s) 335–342

    Abstract: Oxidant stress is strongly associated with cardiovascular disease, including pulmonary hypertension, but antioxidant therapies have so far proven ineffective. This is partly due to a lack of understanding of the key role played by reactive oxygen species ...

    Abstract Oxidant stress is strongly associated with cardiovascular disease, including pulmonary hypertension, but antioxidant therapies have so far proven ineffective. This is partly due to a lack of understanding of the key role played by reactive oxygen species (ROS) in physiological cell signalling, and partly to the complex interrelationships between generators of ROS (e.g. mitochondria and NADPH oxidases, NOX), cellular antioxidant systems and indeed Ca
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-63245-2_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Physiological redox signalling and regulation of ion channels: implications for pulmonary hypertension.

    Ward, Jeremy P T

    Experimental physiology

    2017  Volume 102, Issue 9, Page(s) 1078–1082

    Abstract: New findings: What is the topic of this review? The review concerns the role of reactive oxygen species as physiological second messengers in potentiating G-protein-coupled receptor-mediated vasoconstriction and its potential dysregulation by oxidant ... ...

    Abstract New findings: What is the topic of this review? The review concerns the role of reactive oxygen species as physiological second messengers in potentiating G-protein-coupled receptor-mediated vasoconstriction and its potential dysregulation by oxidant stress in pulmonary hypertension. What advances does it highlight? The review highlights the concept that physiological signalling by reactive oxygen species must normally be highly compartmentalized to prevent self-regenerating oxidant stress and promiscuous and uncontrolled signalling, which contribute to the aetiology. Pulmonary hypertension is associated with oxidant stress and increased generation of reactive oxygen species (ROS) by NADPH oxidases (NOX), mitochondria and other sources. There is considerable evidence that these contribute to the aetiology via promotion of pulmonary vascular remodelling, endothelial dysfunction and enhanced vasoreactivity. However, it is now recognized that ROS act as important signalling mediators and second messengers in normal physiological conditions. Many ion channels and protein kinases crucial to pulmonary vascular function are directly or indirectly affected by redox/ROS, including K
    MeSH term(s) Humans ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Ion Channels/metabolism ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology
    Chemical Substances Ion Channels ; Reactive Oxygen Species
    Language English
    Publishing date 2017-01-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP086040
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.102: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Society of Interventional Radiology-American College of Radiology Standardized Report-Based Data Registry: Early Observations and Reflections from 2017 to 2019 Biopsy Report Data of Select Sites.

    Charalel, Resmi A / Lewis, Paul B / Salei, Aliaksei / Cantos, Andrew / Dubel, Gregory / Baskin, Kevin M / Kassin, Michael T / Brook, Olga R / Al-Dulaimi, Ragheed / Kalva, Sanjeeva P / Ward, Thomas J / Durack, Jeremy C / Shah, Rajesh P

    Journal of vascular and interventional radiology : JVIR

    2023  Volume 34, Issue 7, Page(s) 1258–1260.e1

    MeSH term(s) Humans ; United States ; Radiology, Interventional ; Research Design
    Language English
    Publishing date 2023-03-25
    Publishing country United States
    Document type Letter
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2023.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?

    Riccardi, Daniela / Ward, Jeremy P T / Yarova, Polina L / Janssen, Luke J / Lee, Tak Hong / Ying, Sun / Corrigan, Chris J

    The European respiratory journal

    2022  Volume 60, Issue 2

    Abstract: In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative ... ...

    Abstract In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics.
    MeSH term(s) Asthma/drug therapy ; Calcium ; Humans ; Receptors, Calcium-Sensing
    Chemical Substances Receptors, Calcium-Sensing ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02103-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Development of a Highly Selective Ni(II) Chelator in Aqueous Solution.

    Gupta, Sayak / Ward, Cassandra L / Perera, S Sameera / Gowan, Conor T / Dittrich, Timothy M / Allen, Matthew J / McElmurry, Shawn P / Kodanko, Jeremy J

    Inorganic chemistry

    2022  Volume 61, Issue 48, Page(s) 19492–19501

    Abstract: The design, synthesis, and characterization of a novel Ni(II) ... ...

    Abstract The design, synthesis, and characterization of a novel Ni(II) chelator
    MeSH term(s) Chelating Agents ; Water ; Photoelectron Spectroscopy ; Spectrophotometry, Infrared ; Crystallography, X-Ray
    Chemical Substances Chelating Agents ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c03441
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: Physiology at a glance

    Ward, Jeremy P. T / Linden, R. W. A

    (At a glance series)

    2017  

    Author's details Jeremy P.T. Ward, Roger W.A. Linden
    Series title At a glance series
    MeSH term(s) Physiological Phenomena
    Language English
    Size p. ;, cm.
    Edition Fourth edition.
    Document type Book
    ISBN 9781119247272 ; 1119247276
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book: Physiology at a glance

    Ward, Jeremy P. T / Linden, R. W. A

    (At a glance)

    2013  

    Author's details Jeremy P.T. Ward, Roger W.A. Linden
    Series title At a glance
    MeSH term(s) Physiological Phenomena
    Language English
    Size 165 p. :, ill.
    Edition 3rd ed.
    Publisher John Wiley & Sons
    Publishing place Chichester, West Sussex, UK
    Document type Book
    ISBN 9780470659786 ; 0470659785
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: A twist in the tail: synergism between mitochondria and NADPH oxidase in the hypoxia-induced elevation of reactive oxygen species in pulmonary artery.

    Ward, Jeremy P T

    Free radical biology & medicine

    2008  Volume 45, Issue 9, Page(s) 1220–1222

    MeSH term(s) Animals ; Calcium/metabolism ; Gene Expression Regulation, Enzymologic ; Humans ; Hypoxia ; Kinetics ; Mitochondria/metabolism ; Models, Biological ; NADPH Oxidases/metabolism ; Papillomaviridae/metabolism ; Protein Kinase C/metabolism ; Pulmonary Artery/metabolism ; Reactive Oxygen Species
    Chemical Substances Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-) ; Protein Kinase C (EC 2.7.11.13) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2008-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2008.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Curiouser and curiouser: the perplexing conundrum of reactive oxygen species and hypoxic pulmonary vasoconstriction.

    Ward, Jeremy P T

    Experimental physiology

    2007  Volume 92, Issue 5, Page(s) 819–820

    MeSH term(s) Animals ; Humans ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Pulmonary Circulation/physiology ; Reactive Oxygen Species/metabolism ; Vasoconstriction/physiology
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Journal Article ; Review ; Comment
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/expphysiol.2007.038414
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.102: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Pilot Study on Dose-Dependent Effects of Transcranial Photobiomodulation on Brain Electrical Oscillations: A Potential Therapeutic Target in Alzheimer's Disease.

    Spera, Vincenza / Sitnikova, Tatiana / Ward, Meredith J / Farzam, Parya / Hughes, Jeremy / Gazecki, Samuel / Bui, Eric / Maiello, Marco / De Taboada, Luis / Hamblin, Michael R / Franceschini, Maria Angela / Cassano, Paolo

    Journal of Alzheimer's disease : JAD

    2021  Volume 83, Issue 4, Page(s) 1481–1498

    Abstract: ... Results: c-tPBM significantly boosted gamma (t = 3.02, df = 7, p < 0.02) and beta (t = 2.91, df = 7, p ... < 0.03) EEG spectral powers in eyes-open recordings and gamma power (t = 3.61, df = 6, p < 0.015 ... We conducted a single-blind, sham-controlled pilot study to test the effect of continuous (c-tPBM), pulse (p ...

    Abstract Background: Transcranial photobiomodulation (tPBM) has recently emerged as a potential cognitive enhancement technique and clinical treatment for various neuropsychiatric and neurodegenerative disorders by delivering invisible near-infrared light to the scalp and increasing energy metabolism in the brain.
    Objective: We assessed whether transcranial photobiomodulation with near-infrared light modulates cerebral electrical activity through electroencephalogram (EEG) and cerebral blood flow (CBF).
    Methods: We conducted a single-blind, sham-controlled pilot study to test the effect of continuous (c-tPBM), pulse (p-tPBM), and sham (s-tPBM) transcranial photobiomodulation on EEG oscillations and CBF using diffuse correlation spectroscopy (DCS) in a sample of ten healthy subjects [6F/4 M; mean age 28.6±12.9 years]. c-tPBM near-infrared radiation (NIR) (830 nm; 54.8 mW/cm2; 65.8 J/cm2; 2.3 kJ) and p-tPBM (830 nm; 10 Hz; 54.8 mW/cm2; 33%; 21.7 J/cm2; 0.8 kJ) were delivered concurrently to the frontal areas by four LED clusters. EEG and DCS recordings were performed weekly before, during, and after each tPBM session.
    Results: c-tPBM significantly boosted gamma (t = 3.02, df = 7, p < 0.02) and beta (t = 2.91, df = 7, p < 0.03) EEG spectral powers in eyes-open recordings and gamma power (t = 3.61, df = 6, p < 0.015) in eyes-closed recordings, with a widespread increase over frontal-central scalp regions. There was no significant effect of tPBM on CBF compared to sham.
    Conclusion: Our data suggest a dose-dependent effect of tPBM with NIR on cerebral gamma and beta neuronal activity. Altogether, our findings support the neuromodulatory effect of transcranial NIR.
    MeSH term(s) Adult ; Alzheimer Disease/therapy ; Brain/radiation effects ; Cerebrovascular Circulation ; Electroencephalography/radiation effects ; Female ; Healthy Volunteers ; Humans ; Male ; Neuropsychological Tests ; Pilot Projects ; Single-Blind Method ; Spectrum Analysis
    Language English
    Publishing date 2021-06-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-210058
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top