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  1. Article ; Online: Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model.

    Hawley, Laura E / Stringer, Megan / Deal, Abigail J / Folz, Andrew / Goodlett, Charles R / Roper, Randall J

    Neurobiology of disease

    2023  Volume 190, Page(s) 106359

    Abstract: Aberrant neurodevelopment in Down syndrome (DS)-caused by triplication of human chromosome 21-is commonly attributed to gene dosage imbalance, linking overexpression of trisomic genes with disrupted developmental processes, with DYRK1A particularly ... ...

    Abstract Aberrant neurodevelopment in Down syndrome (DS)-caused by triplication of human chromosome 21-is commonly attributed to gene dosage imbalance, linking overexpression of trisomic genes with disrupted developmental processes, with DYRK1A particularly implicated. We hypothesized that regional brain DYRK1A protein overexpression in trisomic mice varies over development in sex-specific patterns that may be distinct from Dyrk1a transcription, and reduction of Dyrk1a copy number from 3 to 2 in otherwise trisomic mice reduces DYRK1A, independent of other trisomic genes. DYRK1A overexpression varied with age, sex, and brain region, with peak overexpression on postnatal day (P) 6 in both sexes. Sex-dependent differences were also evident from P15-P24. Reducing Dyrk1a copy number confirmed that these differences depended on Dyrk1a gene dosage and not other trisomic genes. Trisomic Dyrk1a mRNA and protein expression were not highly correlated. Sex-specific patterns of DYRK1A overexpression during trisomic neurodevelopment may provide mechanistic targets for therapeutic intervention in DS.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Mice ; Brain/metabolism ; Disease Models, Animal ; Down Syndrome/genetics ; Down Syndrome/metabolism ; Mice, Transgenic ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Dyrk1a protein, mouse (EC 2.7.1.-)
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2023.106359
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4444: Show issues Location:
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  2. Article ; Online: CE: Environments & Health: Chemicals in the Home That Can Exacerbate Asthma.

    Polivka, Barbara J / Huntington-Moskos, Luz / Folz, Rodney / Barnett, Russel

    The American journal of nursing

    2022  Volume 122, Issue 5, Page(s) 34–39

    Abstract: Abstract: Although chemical exposures from cleaning and disinfectant products often go unnoticed or unrecognized, such exposures have been associated with asthma-related symptoms and exacerbations. The Environmental Working Group (EWG) website provides ... ...

    Abstract Abstract: Although chemical exposures from cleaning and disinfectant products often go unnoticed or unrecognized, such exposures have been associated with asthma-related symptoms and exacerbations. The Environmental Working Group (EWG) website provides consumer information on a wide range of issues and products related to human health and the environment, including the use of cleaning and disinfectant products, 2,500 of which it has rated in terms of their effects on respiratory function and asthma. In discussing how the use of cleaning and disinfectant products and the frequency of their use may affect asthma control, the authors use the EWG ratings as well as data collected for a study they conducted on older adults with asthma.
    MeSH term(s) Aged ; Asthma ; Disinfectants/adverse effects ; Humans ; Occupational Exposure
    Chemical Substances Disinfectants
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390780-6
    ISSN 1538-7488 ; 0002-936X
    ISSN (online) 1538-7488
    ISSN 0002-936X
    DOI 10.1097/01.NAJ.0000829776.73698.e0
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 948: Show issues Location:
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  3. Article ; Online: Photoacoustic Chemical Imaging Sodium Nano-Sensor Utilizing a Solvatochromic Dye Transducer for In Vivo Application.

    Folz, Jeff / Wasserman, Jacalyn H / Jo, Janggun / Wang, Xueding / Kopelman, Raoul

    Biosensors

    2023  Volume 13, Issue 10

    Abstract: Sodium has many vital and diverse roles in the human body, including maintaining the cellular pH, generating action potential, and regulating osmotic pressure. In cancer, sodium dysregulation has been correlated with tumor growth, metastasis, and immune ... ...

    Abstract Sodium has many vital and diverse roles in the human body, including maintaining the cellular pH, generating action potential, and regulating osmotic pressure. In cancer, sodium dysregulation has been correlated with tumor growth, metastasis, and immune cell inhibition. However, most in vivo sodium measurements are performed via Na
    MeSH term(s) Humans ; Sodium ; Hydrogen-Ion Concentration ; Ions ; Potassium ; Diagnostic Imaging
    Chemical Substances Sodium (9NEZ333N27) ; Ions ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13100923
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  4. Article ; Online: An optofluidic antenna for enhancing the sensitivity of single-emitter measurements.

    Morales-Inostroza, Luis / Folz, Julian / Kühnemuth, Ralf / Felekyan, Suren / Wieser, Franz-Ferdinand / Seidel, Claus A M / Götzinger, Stephan / Sandoghdar, Vahid

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2545

    Abstract: Many single-molecule investigations are performed in fluidic environments, for example, to avoid unwanted consequences of contact with surfaces. Diffusion of molecules in this arrangement limits the observation time and the number of collected photons, ... ...

    Abstract Many single-molecule investigations are performed in fluidic environments, for example, to avoid unwanted consequences of contact with surfaces. Diffusion of molecules in this arrangement limits the observation time and the number of collected photons, thus, compromising studies of processes with fast or slow dynamics. Here, we introduce a planar optofluidic antenna (OFA), which enhances the fluorescence signal from molecules by about 5 times per passage, leads to about 7-fold more frequent returns to the observation volume, and significantly lengthens the diffusion time within one passage. We use single-molecule multi-parameter fluorescence detection (sm-MFD), fluorescence correlation spectroscopy (FCS) and Förster resonance energy transfer (FRET) measurements to characterize our OFAs. The antenna advantages are showcased by examining both the slow (ms) and fast (50 μs) dynamics of DNA four-way (Holliday) junctions with real-time resolution. The FRET trajectories provide evidence for the absence of an intermediate conformational state and introduce an upper bound for its lifetime. The ease of implementation and compatibility with various microscopy modalities make OFAs broadly applicable to a diverse range of studies.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46730-w
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  5. Article ; Online: Facial mimicry and metacognitive judgments in emotion recognition are distinctly modulated by social anxiety and autistic traits.

    Folz, Julia / Akdağ, Rüya / Nikolić, Milica / van Steenbergen, Henk / Kret, Mariska E

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9730

    Abstract: Facial mimicry as well as the accurate assessment of one's performance when judging others' emotional expressions have been suggested to inform successful emotion recognition. Differences in the integration of these two information sources might explain ... ...

    Abstract Facial mimicry as well as the accurate assessment of one's performance when judging others' emotional expressions have been suggested to inform successful emotion recognition. Differences in the integration of these two information sources might explain alterations in the perception of others' emotions in individuals with Social Anxiety Disorder and individuals on the autism spectrum. Using a non-clinical sample (N = 57), we examined the role of social anxiety and autistic traits in the link between facial mimicry, or confidence in one's performance, and emotion recognition. While participants were presented with videos of spontaneous emotional facial expressions, we measured their facial muscle activity, asked them to label the expressions and indicate their confidence in accurately labelling the expressions. Our results showed that confidence in emotion recognition was lower with higher social anxiety traits even though actual recognition was not related to social anxiety traits. Higher autistic traits, in contrast, were associated with worse recognition, and a weakened link between facial mimicry and performance. Consequently, high social anxiety traits might not affect emotion recognition itself, but the top-down evaluation of own abilities in emotion recognition contexts. High autistic traits, in contrast, may be related to lower integration of sensorimotor simulations, which promote emotion recognition.
    MeSH term(s) Humans ; Autistic Disorder/psychology ; Judgment ; Emotions/physiology ; Fear ; Anxiety
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35773-6
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  6. Article ; Online: National survey of schools of pharmacy on prevalence and description of wellness initiatives.

    Folz, Heather N / Gauld, Andrea R / Ford, Bethany A / Thigpen, Jonathan

    Currents in pharmacy teaching & learning

    2021  Volume 13, Issue 10, Page(s) 1288–1292

    Abstract: Introduction: Although the importance of student wellness has been emphasized across health professions including pharmacy, there is a lack of information on the prevalence of such wellness programs in pharmacy schools. The objectives of this study were ...

    Abstract Introduction: Although the importance of student wellness has been emphasized across health professions including pharmacy, there is a lack of information on the prevalence of such wellness programs in pharmacy schools. The objectives of this study were to determine the prevalence of student wellness programs in United States (US) schools of pharmacy and to describe their basic structure.
    Methods: Deans from the 143 US schools of pharmacy were asked to participate in this study by completing an electronic survey. Institutions with wellness programs were prompted to answer questions related to their program, including who initiated the program, who participated, where wellness principles were taught and incorporated, and what dimensions of wellness were promoted.
    Results: Forty-six responses were collected for a response rate of 32.2%. Thirty-four (73.9%) of respondents answered that they had a school wellness program. Similar numbers of private and public schools completed the survey at 24 (52.3%) and 22 (47.8%), respectively. The majority of programs targeted students (97.1%), faculty (79.4%), and staff (76.5%), were initiated by either the office of the dean (73.5%) and/or faculty (58.8%), and were comprised of faculty (88.2%), staff (82.4%), and office of the dean (67.6%). Wellness principles were most often taught and practiced during extracurricular events and didactic courses.
    Conclusions: This descriptive, survey-based study provides a snapshot on the current incorporation of wellness initiatives across US schools of pharmacy. Further studies are needed to elucidate best wellness practices within pharmacy academia.
    MeSH term(s) Faculty ; Humans ; Pharmacy ; Prevalence ; Schools ; Schools, Pharmacy ; United States
    Language English
    Publishing date 2021-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2515217-8
    ISSN 1877-1300 ; 1877-1297
    ISSN (online) 1877-1300
    ISSN 1877-1297
    DOI 10.1016/j.cptl.2021.07.002
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  7. Article ; Online: Photoacoustic Spectral Analysis for Evaluating the Aggressiveness of Prostate Cancer Labeled by Methylene Blue Polyacrylamide Nanoparticles.

    Jo, Janggun / Salfi, Eamon / Folz, Jeff / Udager, Aaron M / Keller, Evan / Kopelman, Raoul / Kothapalli, Sri-Rajasekhar / Xu, Guan / Wang, Xueding

    Biosensors

    2023  Volume 13, Issue 3

    Abstract: Evaluating the aggressiveness of prostate cancer (PCa) is crucial for PCa diagnosis and prognosis. Previously, studies have shown that photoacoustic spectral analysis (PASA) can assess prostate tissue microarchitecture for evaluating the aggressiveness ... ...

    Abstract Evaluating the aggressiveness of prostate cancer (PCa) is crucial for PCa diagnosis and prognosis. Previously, studies have shown that photoacoustic spectral analysis (PASA) can assess prostate tissue microarchitecture for evaluating the aggressiveness of PCa. In this study, in a transgenic mouse (TRAMP) model of PCa, we utilized methylene blue polyacrylamide nanoparticles (MB PAA NPs) to label the cancer cells in prostate in vivo. MB PAA NPs can specifically target proliferating cancer cells as a contrast agent, allowing photoacoustic (PA) imaging to better detect PCa tumors, and also assessing prostate glandular architecture. With the PA signals from the prostates measured simultaneously by a needle hydrophone and a PA and ultrasound (US) dual-imaging system, we conducted PASA and correlated the quantified spectral parameter slopes with the cancer grading from histopathology. The PASA results from 18 mice showed significant differences between normal and cancer, and also between low-score cancer and high-score cancer. This study in the clinically relevant TRAMP model of PCa demonstrated that PA imaging and PASA, powered by MB PAA NPs that can label the PCa microarchitectures in vivo after systemic administration, can detect PCa and, more importantly, evaluate cancer aggressiveness.
    MeSH term(s) Male ; Humans ; Mice ; Animals ; Methylene Blue ; Prostatic Neoplasms/diagnostic imaging ; Prostate ; Nanoparticles ; Photoacoustic Techniques/methods
    Chemical Substances polyacrylamide (9003-05-8) ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13030403
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  8. Article ; Online: Phase 2, Double-Blind, Placebo-controlled Trial of a c-Jun N-Terminal Kinase Inhibitor in Idiopathic Pulmonary Fibrosis.

    Mattos, Waldo L L D / Khalil, Nasreen / Spencer, Lisa G / Bonella, Francesco / Folz, Rodney J / Rolf, J Douglass / Mogulkoc, Nesrin / Lancaster, Lisa H / Jenkins, R Gisli / Lynch, David A / Noble, Paul W / Maher, Toby M / Cottin, Vincent / Senger, Stefanie / Horan, Gerald S / Greenberg, Steven / Popmihajlov, Zoran

    American journal of respiratory and critical care medicine

    2024  

    Abstract: ... ...

    Abstract Rationale
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1907OC
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Fluoroacetate distribution, response to fluoridation, and synthesis in juvenile Gastrolobium bilobum plants.

    Leong, Bryan J / Folz, Jacob S / Bathe, Ulschan / Clark, David G / Fiehn, Oliver / Hanson, Andrew D

    Phytochemistry

    2022  Volume 202, Page(s) 113356

    Abstract: Like angiosperms from several other families, the leguminous shrub Gastrolobium bilobum R.Br ...

    Abstract Like angiosperms from several other families, the leguminous shrub Gastrolobium bilobum R.Br. produces and accumulates fluoroacetate, indicating that it performs the difficult chemistry needed to make a C-F bond. Bioinformatic analyses indicate that plants lack homologs of the only enzymes known to make a C-F bond, i.e., the Actinomycete flurorinases that form 5'-fluoro-5'-deoxyadenosine from S-adenosylmethionine and fluoride ion. To probe the origin of fluoroacetate in G. bilobum we first showed that fluoroacetate accumulates to millimolar levels in young leaves but not older leaves, stems or roots, that leaf fluoroacetate levels vary >20-fold between individual plants and are not markedly raised by sodium fluoride treatment. Young leaves were fed adenosine-
    MeSH term(s) Fluoridation ; Fluoroacetates/chemistry ; Fluoroacetates/metabolism ; Plants/metabolism ; Ribose ; S-Adenosylmethionine ; Serine
    Chemical Substances Fluoroacetates ; Serine (452VLY9402) ; Ribose (681HV46001) ; S-Adenosylmethionine (7LP2MPO46S)
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2022.113356
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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
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  10. Article: In vivo

    Tan, Joel W Y / Folz, Jeff / Kopelman, Raoul / Wang, Xueding

    Biomedical optics express

    2020  Volume 11, Issue 7, Page(s) 3507–3522

    Abstract: The accumulation of potassium ( ... ...

    Abstract The accumulation of potassium (K
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.393370
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