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  1. Book: Food allergy

    Metcalfe, Dean D.

    adverse reactions to foods and food additives

    2014  

    Title variant reaction
    Author's details ed. by Dean D. Metcalfe
    Keywords Food Hypersensitivity ; Food Aditives / adverse effects
    Language English
    Size XVI, 608 S. : Ill., graph. Darst.
    Edition 5. ed.
    Publisher Wiley-Blackwell
    Publishing place Chichester u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017746872
    ISBN 978-0-470-67255-6 ; 9781118744147 ; 9781118744161 ; 9781118744178 ; 9781118744185 ; 0-470-67255-2 ; 1118744144 ; 1118744160 ; 1118744179 ; 1118744187
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    134/592 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Targeted Therapy for the Predominant Form of Mastocytosis.

    Metcalfe, Dean D

    NEJM evidence

    2023  Volume 2, Issue 6, Page(s) EVIDe2300089

    Abstract: Mast cells are present in all vascularized tissues, often associated with blood vessels, glandular structures, and nerves, and they tend to be more numerous in tissues that interface with the external environment, including the skin and gastrointestinal ... ...

    Abstract Mast cells are present in all vascularized tissues, often associated with blood vessels, glandular structures, and nerves, and they tend to be more numerous in tissues that interface with the external environment, including the skin and gastrointestinal tract. These mast cells are involved in both innate and acquired immunity, as well as in other biologic processes, including wound healing. Mast cell numbers within tissues are remarkably consistent, although mast cell numbers somewhat increase in association with inflammation. Human mast cells have two principal receptors that when stimulated, lead to cellular activation.
    MeSH term(s) Humans ; Mastocytosis ; Mast Cells ; Inflammation ; Gastrointestinal Tract ; Adaptive Immunity
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Editorial
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDe2300089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Food allergy

    Metcalfe, Dean D.

    adverse reactions to foods and food additives

    2008  

    Author's details ed. by Dean D. Metcalfe
    Keywords Food Hypersensitivity ; Food Aditives / adverse effects
    Language English
    Size XV, 613 S. : Ill., graph. Darst.
    Edition 4. ed.
    Publisher Blackwell
    Publishing place Malden, Mass. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015292882
    ISBN 978-1-4051-5129-0 ; 1-4051-5129-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 2236 order for loan Magazin

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  4. Article ; Online: Research Advances in Mast Cell Biology and Their Translation Into Novel Therapies for Anaphylaxis.

    Dispenza, Melanie C / Metcalfe, Dean D / Olivera, Ana

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 7, Page(s) 2032–2042

    Abstract: Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction for which there are no known reliable preventative therapies. Its primary cell mediator, the mast cell, has several pathophysiologic roles and functions in IgE-mediated ... ...

    Abstract Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction for which there are no known reliable preventative therapies. Its primary cell mediator, the mast cell, has several pathophysiologic roles and functions in IgE-mediated reactions that continue to be poorly understood. Recent advances in the understanding of allergic mechanisms have identified novel targets for inhibiting mast cell function and activation. The prevention of anaphylaxis is within reach with new drugs that could modulate immune tolerance, mast cell proliferation and differentiation, and IgE regulation and production. Several US Food and Drug Administration-approved drugs for chronic urticaria, mastocytosis, and cancer are also being repurposed to prevent anaphylaxis. New therapeutics have not only shown promise in potential efficacy for preventing IgE-mediated reactions, but in some cases, they are able to inform us about mast cell mechanisms in vivo. This review summarizes the most recent advances in the treatment of anaphylaxis that have arisen from new pharmacologic tools and our current understanding of mast cell biology.
    MeSH term(s) Humans ; Anaphylaxis/prevention & control ; Mast Cells ; Mastocytosis/drug therapy ; Immunoglobulin E
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.03.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article ; Online: Reply to "MRGPRX2: A novel biomarker in mastocytosis?"

    Komarow, Hirsh D / Carter, Melody C / Metcalfe, Dean D / Ali, Hydar

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 2, Page(s) 671

    MeSH term(s) Humans ; Mastocytosis/diagnosis ; Mast Cells ; Biomarkers ; Nerve Tissue Proteins ; Receptors, Neuropeptide ; Receptors, G-Protein-Coupled
    Chemical Substances Biomarkers ; MRGPRX2 protein, human ; Nerve Tissue Proteins ; Receptors, Neuropeptide ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.10.054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  6. Article ; Online: A personal perspective on mentoring.

    Metcalfe, Dean D

    The Journal of allergy and clinical immunology

    2018  Volume 143, Issue 2, Page(s) 548–549

    MeSH term(s) Allergy and Immunology/education ; Biomedical Research ; Education ; Humans ; Hypersensitivity/immunology ; Mast Cells/immunology ; Mentoring/methods ; Mentors/psychology ; Publishing ; Vocational Guidance
    Language English
    Publishing date 2018-10-09
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
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  7. Book: Food allergy

    Metcalfe, Dean D.

    adverse reactions to foods and food additives

    2003  

    Author's details ed. by Dean D. Metcalfe
    Keywords Food Hypersensitivity ; Food Hypersensitivity / immunology ; Food Additives / adverse effects ; Lebensmittelallergie ; Zusatzstoff ; Allergie
    Subject Hypersensibilität ; Allergose ; Allergische Krankheit ; Allergische Reaktion ; Allergien ; Lebensmittel ; Fremdstoff ; Lebensmittelzusatzstoff ; Alimentäre Allergie ; Nahrungsmittelallergie
    Language English
    Size XV, 591 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Blackwell Science
    Publishing place Malden, Mass. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013806667
    ISBN 0-632-04601-5 ; 978-0-632-04601-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 3308 order for loan Magazin

    Order via subito

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  8. Book: Mast cell disorders

    Metcalfe, Dean D.

    (Hematology/oncology clinics of North America ; 14,3)

    2000  

    Author's details Dean D. Metcalfe ..., guest ed
    Series title Hematology/oncology clinics of North America ; 14,3
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size XIII S., S. 497 - 743 : Ill.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012782466
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1077 -14,3- verfügbar in Königswinter Königswinter

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  9. Article ; Online: Decoding the intricacies of the mast cell compartment.

    Carter, Melody C / Metcalfe, Dean D

    British journal of haematology

    2021  Volume 196, Issue 2, Page(s) 304–315

    Abstract: Historically, understanding of the human mast cell (MC) compartment has lagged behind the appreciation of other cell lineages. MCs exist in vascularised tissues but do not under normal circumstances circulate in blood, and there has been no ... ...

    Abstract Historically, understanding of the human mast cell (MC) compartment has lagged behind the appreciation of other cell lineages. MCs exist in vascularised tissues but do not under normal circumstances circulate in blood, and there has been no pharmacological agent identified that totally and selectively inhibits human MC function. There are no substantiated accounts of an apparently healthy individual who is severely lacking in MCs. Thus, some of the approaches employed to understand the function of a specific immune cell are not available to the MC biologist. The disease categories that have provided the greatest insight into MC biology have been monoclonal and IgE-mediated MC disorders. This has led to the categorisation of MC diseases as intrinsic or extrinsic to the MC compartment and to the recognition of the role of mediators in MC activation disorders. Mastocytosis as a clonal disorder not only impacts the MC compartment through changes intrinsic to the MC, but also by the effects of episodes of significant release of MC mediators. The availability of newer therapeutic approaches developed to treat monoclonal MC disorders offer insights into how to more selectively approach management of MC centric diseases.
    MeSH term(s) Age Factors ; Biomarkers ; Biopsy ; Combined Modality Therapy ; Diagnosis, Differential ; Disease Management ; Disease Susceptibility/immunology ; Genetic Predisposition to Disease ; Homeostasis ; Humans ; Immunophenotyping ; Mast Cells/cytology ; Mast Cells/immunology ; Mast Cells/metabolism ; Mastocytosis/diagnosis ; Mastocytosis/etiology ; Mastocytosis/metabolism ; Mastocytosis/therapy ; Molecular Diagnostic Techniques ; Phenotype ; Prognosis ; Treatment Outcome
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-08-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.182: Show issues Location:
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  10. Article ; Online: Reply to "Need to define a subgroup of patients with idiopathic mast cell activation syndrome".

    Gülen, Theo / Akin, Cem / Metcalfe, Dean D / Valent, Peter

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 4, Page(s) 1128

    Language English
    Publishing date 2022-04-10
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.01.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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