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  1. Article ; Online: Correction: OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases.

    Millet, Aurélie M C / Coustham, Corentin / Champigny, Camille / Merabet, Nadege / Botella, Marlène / Demeilliers, Christine / Devin, Anne / Galinier, Anne / Belenguer, Pascale / Bordeneuve-Guibé, Joel / Davezac, Noélie

    Disease models & mechanisms

    2024  Volume 17, Issue 4

    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The impact of host plant species on instar duration and body weight of nymphal

    Kreitman, Devin / Keena, Melody A / Nielsen, Anne L / Hamilton, George

    Frontiers in insect science

    2023  Volume 2, Page(s) 1110480

    Abstract: The spotted lanternfly, ...

    Abstract The spotted lanternfly,
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3123819-1
    ISSN 2673-8600 ; 2673-8600
    ISSN (online) 2673-8600
    ISSN 2673-8600
    DOI 10.3389/finsc.2022.1110480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mitochondrial Biogenesis and Mitochondrial Reactive Oxygen Species (ROS): A Complex Relationship Regulated by the cAMP/PKA Signaling Pathway.

    Bouchez, Cyrielle / Devin, Anne

    Cells

    2019  Volume 8, Issue 4

    Abstract: Mitochondrial biogenesis is a complex process. It requires the contribution of both the nuclear and the mitochondrial genomes and therefore cross talk between the nucleus and mitochondria. Cellular energy demand can vary by great length and it is now ... ...

    Abstract Mitochondrial biogenesis is a complex process. It requires the contribution of both the nuclear and the mitochondrial genomes and therefore cross talk between the nucleus and mitochondria. Cellular energy demand can vary by great length and it is now well known that one way to adjust adenosine triphosphate (ATP) synthesis to energy demand is through modulation of mitochondrial content in eukaryotes. The knowledge of actors and signals regulating mitochondrial biogenesis is thus of high importance. Here, we review the regulation of mitochondrial biogenesis both in yeast and in mammalian cells through mitochondrial reactive oxygen species.
    MeSH term(s) Animals ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Humans ; Mitochondria/metabolism ; Organelle Biogenesis ; Reactive Oxygen Species/metabolism ; Signal Transduction
    Chemical Substances Reactive Oxygen Species ; Cyclic AMP (E0399OZS9N) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
    Language English
    Publishing date 2019-03-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells8040287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Syncing to perform? A naturalistic uncontrolled prospective case study of emotional and physiological synchrony in a team of male volleyball athletes.

    Tamminen, Katherine Anne / Danyluck, Chad / Bonk, Devin / Chen, Ruochen

    Journal of sports sciences

    2023  Volume 41, Issue 11, Page(s) 1033–1046

    Abstract: Group processes are important for promoting relational and performance-related outcomes in sport; however, research exploring emotional and physiological synchrony and performance outcomes is rare. The objective of this study was to examine perceived ... ...

    Abstract Group processes are important for promoting relational and performance-related outcomes in sport; however, research exploring emotional and physiological synchrony and performance outcomes is rare. The objective of this study was to examine perceived emotional synchrony, physiological synchrony, and performance among male volleyball players using a naturalistic uncontrolled prospective case study approach over nine practices. Athletes participated in a coach-led pre-practice group visualization routine, while their heart rate and heart rate variability were continuously monitored. Athletes completed post-practice measures of emotional synchrony, and athletes and coaches completed ratings of individual and team performance. Emotional and physiological synchrony were not significantly correlated, but they were differentially related to performance outcomes, and there were significant interaction effects between physiological synchrony and time. Athletes' ratings of their own and their team's performance were associated with their perceived emotional synchrony. Coach performance ratings were associated with pre-practice team physiological synchrony but were unrelated to athletes' perceived emotional synchrony. Heart rate synchrony was associated with athlete and coach performance ratings and may be important for team dynamics and performance outcomes. The findings demonstrate evidence for emotional and physiological synchrony among athletes, providing a platform for future research examining processes and impacts of synchrony in sport.
    MeSH term(s) Humans ; Male ; Volleyball/psychology ; Athletes/psychology ; Group Processes ; Emotions ; Research Design
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 995528-8
    ISSN 1466-447X ; 0264-0414
    ISSN (online) 1466-447X
    ISSN 0264-0414
    DOI 10.1080/02640414.2023.2259205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2388: Show issues Location:
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  5. Article ; Online: OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases

    Aurélie M. C. Millet / Corentin Coustham / Camille Champigny / Marlène Botella / Christine Demeilliers / Anne Devin / Anne Galinier / Pascale Belenguer / Joel Bordeneuve-Guibé / Noélie Davezac

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 9

    Keywords mathematical model ; mitochondria ; neurodegenerative disease ; oxidative metabolism ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases.

    Millet, Aurélie M C / Coustham, Corentin / Champigny, Camille / Botella, Marlène / Demeilliers, Christine / Devin, Anne / Galinier, Anne / Belenguer, Pascale / Bordeneuve-Guibé, Joel / Davezac, Noélie / Merabet, Nadege

    Disease models & mechanisms

    2023  Volume 16, Issue 9

    Abstract: Dominant optic atrophy is an optic neuropathy with varying clinical symptoms and progression. A severe disorder is associated with certain OPA1 mutations and includes additional symptoms for >20% of patients. This underscores the consequences of OPA1 ... ...

    Abstract Dominant optic atrophy is an optic neuropathy with varying clinical symptoms and progression. A severe disorder is associated with certain OPA1 mutations and includes additional symptoms for >20% of patients. This underscores the consequences of OPA1 mutations in different cellular populations, not only retinal ganglionic cells. We assessed the effects of OPA1 loss of function on oxidative metabolism and antioxidant defences using an RNA-silencing strategy in a human epithelial cell line. We observed a decrease in the mitochondrial respiratory chain complexes, associated with a reduction in aconitase activity related to an increase in reactive oxygen species (ROS) production. In response, the NRF2 (also known as NFE2L2) transcription factor was translocated into the nucleus and upregulated SOD1 and GSTP1. This study highlights the effects of OPA1 deficiency on oxidative metabolism in replicative cells, as already shown in neurons. It underlines a translational process to use cycling cells to circumvent and describe oxidative metabolism. Moreover, it paves the way to predict the evolution of dominant optic atrophy using mathematical models that consider mitochondrial ROS production and their detoxifying pathways.
    MeSH term(s) Humans ; Optic Atrophy, Autosomal Dominant/genetics ; Optic Atrophy, Autosomal Dominant/metabolism ; Reactive Oxygen Species/metabolism ; Mitochondria/metabolism ; Cell Respiration ; Oxidative Stress ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism
    Chemical Substances Reactive Oxygen Species ; OPA1 protein, human (EC 3.6.1.-) ; GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modelling mitochondrial ROS production by the respiratory chain.

    Mazat, Jean-Pierre / Devin, Anne / Ransac, Stéphane

    Cellular and molecular life sciences : CMLS

    2019  Volume 77, Issue 3, Page(s) 455–465

    Abstract: ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling molecules and strong oxidizing agents leading to oxidative stress. Their production mainly occurs in mitochondria although they may have other locations (such as NADPH ... ...

    Abstract ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling molecules and strong oxidizing agents leading to oxidative stress. Their production mainly occurs in mitochondria although they may have other locations (such as NADPH oxidase in particular cell types). Mitochondrial ROS production depends in an interweaving way upon many factors such as the membrane potential, the cell type and the respiratory substrates. Moreover, it is experimentally difficult to quantitatively assess the contribution of each potential site in the respiratory chain. To overcome these difficulties, mathematical models have been developed with different degrees of complexity in order to analyse different physiological questions ranging from a simple reproduction/simulation of experimental results to a detailed model of the possible mechanisms leading to ROS production. Here, we analyse experimental results concerning ROS production including results still under discussion. We then critically review the three models of ROS production in the whole respiratory chain available in the literature and propose some direction for future modelling work.
    MeSH term(s) Animals ; Electron Transport/physiology ; Humans ; Mitochondria/metabolism ; Models, Theoretical ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2019-11-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-019-03381-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Recent advancements in the B7/CD28 immune checkpoint families: new biology and clinical therapeutic strategies.

    Pulanco, Marc C / Madsen, Anne T / Tanwar, Ankit / Corrigan, Devin T / Zang, Xingxing

    Cellular & molecular immunology

    2023  Volume 20, Issue 7, Page(s) 694–713

    Abstract: The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases. Recent basic and clinical studies have revealed novel biology of the B7/CD28 families and new ... ...

    Abstract The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases. Recent basic and clinical studies have revealed novel biology of the B7/CD28 families and new therapeutics for cancer therapy. In this review, we discuss the newly discovered KIR3DL3/TMIGD2/HHLA2 pathways, PD-1/PD-L1 and B7-H3 as metabolic regulators, the glycobiology of PD-1/PD-L1, B7x (B7-H4) and B7-H3, and the recently characterized PD-L1/B7-1 cis-interaction. We also cover the tumor-intrinsic and -extrinsic resistance mechanisms to current anti-PD-1/PD-L1 and anti-CTLA-4 immunotherapies in clinical settings. Finally, we review new immunotherapies targeting B7-H3, B7x, PD-1/PD-L1, and CTLA-4 in current clinical trials.
    MeSH term(s) Humans ; CD28 Antigens/metabolism ; B7-H1 Antigen/metabolism ; Neoplasms/therapy ; Immunotherapy ; Biology ; Immunoglobulins/metabolism
    Chemical Substances CD28 Antigens ; B7-H1 Antigen ; HHLA2 protein, human ; Immunoglobulins
    Language English
    Publishing date 2023-04-17
    Publishing country China
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-023-01019-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6681: Show issues Location:
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  9. Article ; Online: A Theoretical Model of Mitochondrial ATP Synthase Deficiencies. The Role of Mitochondrial Carriers

    Jean-Pierre Mazat / Anne Devin / Edgar Yoboue / Stéphane Ransac

    Processes, Vol 9, Iss 1424, p

    2021  Volume 1424

    Abstract: The m.8993T>G mutation of the mitochondrial MT-ATP6 gene is associated with NARP syndrome (neuropathy, ataxia and retinitis pigmentosa). The equivalent point mutation introduced in yeast Saccharomyces cerevisiae mitochondrial DNA considerably reduced the ...

    Abstract The m.8993T>G mutation of the mitochondrial MT-ATP6 gene is associated with NARP syndrome (neuropathy, ataxia and retinitis pigmentosa). The equivalent point mutation introduced in yeast Saccharomyces cerevisiae mitochondrial DNA considerably reduced the activity of ATP synthase and of cytochrome-c-oxidase, preventing yeast growth on oxidative substrates. The overexpression of the mitochondrial oxodicarboxylate carrier (Odc1p) was able to rescue the growth on the oxidative substrate by increasing the substrate-level phosphorylation of ADP coupled to the conversion of α -ketoglutarate (AKG) into succinate with an increase in Complex IV activity. Previous studies showed that equivalent point mutations in ATP synthase behave similarly and can be rescued by Odc1p overexpression and/or the uncoupling of OXPHOS from ATP synthesis. In order to better understand the mechanism of the ATP synthase mutation bypass, we developed a core model of mitochondrial metabolism based on AKG as a respiratory substrate. We describe the different possible metabolite outputs and the ATP/O ratio values as a function of ATP synthase inhibition.
    Keywords mitochondrial metabolism ; metabolic model ; ATP/O ; substrate-level phosphorylation ; Odc1 ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Entropy as the Driving Force of Pathogenesis

    Laurent Schwartz / Anne Devin / Frédéric Bouillaud / Marc Henry

    Substantia, Vol 4, Iss

    an Attempt of Diseases Classification Based on the Laws of Physics

    2020  Volume 2

    Abstract: In nature, every physical process involving matter is ruled by the second law of thermodynamics (the total entropy of an isolated system can never decrease over time, and is constant if and only if all processes are reversible). The living cell being a ... ...

    Abstract In nature, every physical process involving matter is ruled by the second law of thermodynamics (the total entropy of an isolated system can never decrease over time, and is constant if and only if all processes are reversible). The living cell being a material system should comply by releasing entropy either into the body or into the outside environment. In case of pathologies, entropy cannot be fully exported outside the body and stays inside the body either in the form of biomass, of extracellular waste products. We propose hereafter, a new way of classifying diseases by looking at the kind of entropy which cannot be easily excreted. In such a classification, inflammatory diseases play with entropy through increased heat, biomass synthesis (proliferation of lymphocytes and neutrophils) and secretion of pro-inflammatory proteins (waste products from the cell’s point of view). In the case of chronic inflammation, it induces mitochondrial impairment, owing to the increased oncotic pressure associated to hyper-osmolarity leading to cancer and degenerative diseases (DDs). In the special case of degenerative diseases, cellular entropy is mostly released in the form of wastes, such as amyloid plaques or Lewy’s bodies, and not as proliferating cells as in cancer. Consequently, despite quite different symptoms, these two diseases are proposed to be Janus-like twins, meaning that a remedy active against cancer, should also be active against various forms of DDs.
    Keywords entropy ; inflammation ; cancer ; extracellular pressure ; History (General) and history of Europe ; D ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Firenze University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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