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  1. AU=Talmage David A
  2. AU="Alessandro Achilli"
  3. AU="Julià Blanco"
  4. AU=Pardee Arthur B
  5. AU="Moossy, John J"
  6. AU="Ledger, Elizabeth V"
  7. AU="Abichandani, Deepa"
  8. AU="Piccinelli, Fabio"
  9. AU="Malinova, Tsveta S"
  10. AU="Harwood, Janet"
  11. AU=Buscombe John R
  12. AU=Meyer-Rusenberg Birthe
  13. AU="Jiang, Weiyan"
  14. AU="Mills, W"
  15. AU="Pintó, Rosa M."
  16. AU="Voisin, Tiphaine"
  17. AU="Takahashi, Hiromi"
  18. AU="Lin, Johnny"
  19. AU="Lee, Yu-Ru"
  20. AU="Safrankova, J."
  21. AU="Lanting, Linda L"
  22. AU=Koushik Nikhil S
  23. AU="Culhane, John"
  24. AU="Chippada, Appa Rao"
  25. AU="Hiroki Sato" AU="Hiroki Sato"
  26. AU="Al-Amer Eshraq"
  27. AU="Thanacoody, Ruben"
  28. AU="Lin, Chi-Wei"
  29. AU="Chidambaram, Vignesh"

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  1. Artikel ; Online: David (Propofol Wannabes) Versus Goliath (Propofol): AZD-3043 Goes Up Against the Giant!

    Sear, John W / Egan, Talmage D

    Anesthesia and analgesia

    2015  Band 121, Heft 4, Seite(n) 849–851

    Mesh-Begriff(e) Anesthesia/methods ; Anesthesia/trends ; Animals ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/pharmacokinetics ; Infusions, Intravenous ; Phenylacetates/administration & dosage ; Phenylacetates/pharmacokinetics ; Propofol/administration & dosage ; Propofol/pharmacokinetics
    Chemische Substanzen AZD-3043 ; Hypnotics and Sedatives ; Phenylacetates ; Propofol (YI7VU623SF)
    Sprache Englisch
    Erscheinungsdatum 2015-06-26
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Editorial
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000000904
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Seq'ing the origins of cells in the developing spinal cord.

    Rajebhosale, Prithviraj / Talmage, David A

    The Journal of biological chemistry

    2022  Band 298, Heft 11, Seite(n) 102602

    Abstract: In the developing central nervous system, neurogenesis precedes gliogenesis; however, when and how progenitors are specified for a neuronal versus glial fate and the temporal regulation of this process is unclear. Progenitors within the motor neuron ... ...

    Abstract In the developing central nervous system, neurogenesis precedes gliogenesis; however, when and how progenitors are specified for a neuronal versus glial fate and the temporal regulation of this process is unclear. Progenitors within the motor neuron progenitor domain in the developing spinal cord give rise to cholinergic motor neurons and cells of the oligodendroglial lineage sequentially. In a recent study, Xing et al. used single cell RNA-seq to identify previously unknown heterogeneity of these progenitors in zebrafish and to delineate the trajectories that distinct pools of these progenitors take. These data help integrate existing evidence and inform new hypotheses regarding how populations of neural progenitors in the same spatial domain commit to distinct fates.
    Mesh-Begriff(e) Animals ; Oligodendrocyte Transcription Factor 2 ; Zebrafish ; Basic Helix-Loop-Helix Transcription Factors ; Spinal Cord ; Oligodendroglia ; Motor Neurons ; Cell Differentiation
    Chemische Substanzen Oligodendrocyte Transcription Factor 2 ; Basic Helix-Loop-Helix Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2022-10-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102602
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  3. Artikel ; Online: Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.

    Kim, Ronald / Ananth, Mala R / Desai, Niraj S / Role, Lorna W / Talmage, David A

    Cell reports

    2024  Band 43, Heft 4, Seite(n) 114009

    Abstract: To better understand the function of cholinergic projection neurons in the ventral pallidum (VP), we examined behavioral responses to appetitive (APP) and aversive (AV) odors that elicited approach or avoidance, respectively. Exposure to each odor ... ...

    Abstract To better understand the function of cholinergic projection neurons in the ventral pallidum (VP), we examined behavioral responses to appetitive (APP) and aversive (AV) odors that elicited approach or avoidance, respectively. Exposure to each odor increased cFos expression and calcium signaling in VP cholinergic neurons. Activity and Cre-dependent viral vectors selectively labeled VP cholinergic neurons that were activated and reactivated in response to either APP or AV odors, but not both, identifying two non-overlapping populations of VP cholinergic neurons differentially activated by the valence of olfactory stimuli. These two subpopulations showed differences in electrophysiological properties, morphology, and projections to the basolateral amygdala. Although VP neurons are engaged in both approach and avoidance behavioral responses, cholinergic signaling is only required for approach behavior. Thus, two distinct subpopulations of VP cholinergic neurons differentially encode valence of olfactory stimuli and play distinct roles in approach and avoidance behaviors.
    Mesh-Begriff(e) Animals ; Cholinergic Neurons/physiology ; Basal Forebrain/physiology ; Odorants ; Mice ; Male ; Smell/physiology ; Mice, Inbred C57BL
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Basal forebrain cholinergic signalling: development, connectivity and roles in cognition.

    Ananth, Mala R / Rajebhosale, Prithviraj / Kim, Ronald / Talmage, David A / Role, Lorna W

    Nature reviews. Neuroscience

    2023  Band 24, Heft 4, Seite(n) 233–251

    Abstract: Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium ... ...

    Abstract Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium with far more topographical and functional organization than was historically appreciated. Together with the results of studies using new probes that allow release of acetylcholine to be detected with high spatial and temporal resolution, these findings have implicated cholinergic networks in 'binding' diverse behaviours that contribute to cognition. Here, we review recent findings on the developmental origins, connectivity and function of cholinergic neurons, and explore the participation of cholinergic signalling in the encoding of cognition-related behaviours.
    Mesh-Begriff(e) Humans ; Acetylcholine/physiology ; Basal Forebrain ; Cholinergic Agents/pharmacology ; Cognition ; Signal Transduction
    Chemische Substanzen Acetylcholine (N9YNS0M02X) ; Cholinergic Agents
    Sprache Englisch
    Erscheinungsdatum 2023-02-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-023-00677-x
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  5. Artikel: Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.

    Kim, Ronald / Ananth, Mala / Desai, Niraj S / Role, Lorna W / Talmage, David A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The ventral pallidum (VP) mediates motivated behaviors largely via the action of VP GABA and glutamatergic neurons. In addition to these neuronal subtypes, there is a population of cholinergic projection neurons in the VP, whose functional significance ... ...

    Abstract The ventral pallidum (VP) mediates motivated behaviors largely via the action of VP GABA and glutamatergic neurons. In addition to these neuronal subtypes, there is a population of cholinergic projection neurons in the VP, whose functional significance remains unclear. To understand the functional role of VP cholinergic neurons, we first examined behavioral responses to an appetitive (APP) odor that elicited approach, and an aversive (AV) odor that led to avoidance. To examine how VP cholinergic neurons were engaged in APP vs. AV responses, we used an immediate early gene marker and in-vivo fiber photometry, examining the activation profile of VP cholinergic neurons in response to each odor. Exposure to each odor led to an increase in the number of cFos counts and increased calcium signaling of VP cholinergic neurons. Activity and cre-dependent viral vectors were designed to label engaged VP cholinergic neurons in two distinct contexts: (1) exposure to the APP odor, (2) followed by subsequent exposure to the AV odor, and vice versa. These studies revealed two distinct, non-overlapping subpopulations of VP cholinergic neurons: one activated in response to the APP odor, and a second distinct population activated in response to the AV odor. These two subpopulations of VP cholinergic neurons are spatially intermingled within the VP, but show differences in electrophysiological properties, neuronal morphology, and projections to the basolateral amygdala. Although VP cholinergic neurons are engaged in behavioral responses to each odor, VP cholinergic signaling is only required for approach behavior. Indeed, inhibition of VP cholinergic neurons not only blocks approach to the APP odor, but reverses the behavior, leading to active avoidance. Our results highlight the functional heterogeneity of cholinergic projection neurons within the VP. These two subpopulations of VP cholinergic neurons differentially encode valence of olfactory stimuli and play unique roles in approach and avoidance behaviors.
    Sprache Englisch
    Erscheinungsdatum 2023-10-10
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.06.561261
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections.

    Zhong, Chongbo / Akmentin, Wendy / Role, Lorna W / Talmage, David A

    Frontiers in neural circuits

    2022  Band 16, Seite(n) 978837

    Abstract: Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of glutamatergic transmission in cortico-limbic circuits. By imaging gene ... ...

    Abstract Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of glutamatergic transmission in cortico-limbic circuits. By imaging gene chimeric co-cultures from mouse, we examined the role of α7* nAChRs mediated cholinergic modulation of glutamate release and synaptic vesicle organization in ventral hippocampal projections. We directly visualized exogenous and endogenous cholinergic facilitation of glutamate release in this specialized preparation of circuits in vitro. Disrupting α7* nAChRs mediated cholinergic signaling genetically or pharmacologically diminished cholinergic facilitation of glutamate release at presynaptic terminals. Alteration of α7* nAChRs mediated cholinergic signaling along glutamatergic axons also decreased functional synaptic vesicle clustering to presynaptic terminals. These findings suggest that presynaptic α7* nAChRs contribute to cholinergic modulation of glutamate release and synaptic vesicle organization.
    Mesh-Begriff(e) Animals ; Axons/metabolism ; Cholinergic Agents ; Glutamic Acid ; Hippocampus/metabolism ; Mice ; Receptors, Nicotinic/metabolism ; Synaptic Transmission/physiology ; Synaptic Vesicles/metabolism ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
    Chemische Substanzen Cholinergic Agents ; Receptors, Nicotinic ; alpha7 Nicotinic Acetylcholine Receptor ; Glutamic Acid (3KX376GY7L)
    Sprache Englisch
    Erscheinungsdatum 2022-09-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2452968-0
    ISSN 1662-5110 ; 1662-5110
    ISSN (online) 1662-5110
    ISSN 1662-5110
    DOI 10.3389/fncir.2022.978837
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and mice.

    Ananth, Mala R / Gardus, John D / Huang, Chuan / Palekar, Nikhil / Slifstein, Mark / Zaborszky, Laszlo / Parsey, Ramin V / Talmage, David A / DeLorenzo, Christine / Role, Lorna W

    Research square

    2024  

    Abstract: In a series of translational experiments using fully quantitative positron emission tomography (PET) imaging with a new tracer specific for the vesicular acetylcholine transporter ([ ...

    Abstract In a series of translational experiments using fully quantitative positron emission tomography (PET) imaging with a new tracer specific for the vesicular acetylcholine transporter ([
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-3851086/v2
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  8. Artikel: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.

    Rajebhosale, Prithviraj / Ananth, Mala R / Kim, Ronald / Crouse, Richard / Jiang, Li / López-Hernández, Gretchen / Zhong, Chongbo / Arty, Christian / Wang, Shaohua / Jone, Alice / Desai, Niraj S / Li, Yulong / Picciotto, Marina R / Role, Lorna W / Talmage, David A

    Research square

    2024  

    Abstract: Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/ ... ...

    Abstract Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-3938016/v1
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  9. Artikel ; Online: NeuRegenerate: A Framework for Visualizing Neurodegeneration.

    Boorboor, Saeed / Mathew, Shawn / Ananth, Mala / Talmage, David / Role, Lorna W / Kaufman, Arie E

    IEEE transactions on visualization and computer graphics

    2023  Band 29, Heft 3, Seite(n) 1625–1637

    Abstract: Recent advances in high-resolution microscopy have allowed scientists to better understand the underlying brain connectivity. However, due to the limitation that biological specimens can only be imaged at a single timepoint, studying changes to neural ... ...

    Abstract Recent advances in high-resolution microscopy have allowed scientists to better understand the underlying brain connectivity. However, due to the limitation that biological specimens can only be imaged at a single timepoint, studying changes to neural projections over time is limited to observations gathered using population analysis. In this article, we introduce NeuRegenerate, a novel end-to-end framework for the prediction and visualization of changes in neural fiber morphology within a subject across specified age-timepoints. To predict projections, we present neuReGANerator, a deep-learning network based on cycle-consistent generative adversarial network (GAN) that translates features of neuronal structures across age-timepoints for large brain microscopy volumes. We improve the reconstruction quality of the predicted neuronal structures by implementing a density multiplier and a new loss function, called the hallucination loss. Moreover, to alleviate artifacts that occur due to tiling of large input volumes, we introduce a spatial-consistency module in the training pipeline of neuReGANerator. Finally, to visualize the change in projections, predicted using neuReGANerator, NeuRegenerate offers two modes: (i) neuroCompare to simultaneously visualize the difference in the structures of the neuronal projections, from two age domains (using structural view and bounded view), and (ii) neuroMorph, a vesselness-based morphing technique to interactively visualize the transformation of the structures from one age-timepoint to the other. Our framework is designed specifically for volumes acquired using wide-field microscopy. We demonstrate our framework by visualizing the structural changes within the cholinergic system of the mouse brain between a young and old specimen.
    Mesh-Begriff(e) Animals ; Mice ; Image Processing, Computer-Assisted/methods ; Computer Graphics ; Brain/diagnostic imaging ; Head ; Microscopy
    Sprache Englisch
    Erscheinungsdatum 2023-01-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Intramural
    ISSN 1941-0506
    ISSN (online) 1941-0506
    DOI 10.1109/TVCG.2021.3127132
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  10. Artikel ; Online: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.

    Rajebhosale, Prithviraj / Ananth, Mala R / Kim, Ronald / Crouse, Richard / Jiang, Li / López-Hernández, Gretchen / Zhong, Chongbo / Arty, Christian / Wang, Shaohua / Jone, Alice / Desai, Niraj S / Li, Yulong / Picciotto, Marina R / Role, Lorna W / Talmage, David A

    eLife

    2024  Band 13

    Abstract: Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/ ... ...

    Abstract Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
    Mesh-Begriff(e) Mice ; Animals ; Basal Forebrain/physiology ; Cholinergic Neurons/physiology ; Memory/physiology ; Learning/physiology ; Acetylcholine/metabolism ; Cholinergic Agents
    Chemische Substanzen Acetylcholine (N9YNS0M02X) ; Cholinergic Agents
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86581
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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