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Article: [A 10-year-boy case showing refractory epilepsy and cognitive deterioration].

Hachiya, Yasuo

2013 Volume 45, Issue 5, Page(s) 347–348

MeSH term(s)	Brain Waves/physiology ; Child ; Cognition/physiology ; Cognition Disorders/physiopathology ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Epilepsy/psychology ; Humans ; Male ; Recurrence
Language	Japanese
Publishing date	2013-09
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	605615-5
ISSN	1884-7668 ; 0029-0831
ISSN (online)	1884-7668
ISSN	0029-0831
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Zs.A 1787: Show issues

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Article ; Online: The usefulness of a combination of age, body mass index, and blood urea nitrogen as prognostic factors in predicting oxygen requirements in patients with coronavirus disease 2019.

Goto, Norihiko / Wada, Yosuke / Ikuyama, Yuichi / Akahane, Jumpei / Kosaka, Makoto / Ushiki, Atsuhito / Kitaguchi, Yoshiaki / Yasuo, Masanori / Yamamoto, Hiroshi / Matsuo, Akemi / Hachiya, Tsutomu / Ideura, Gen / Yamazaki, Yoshitaka / Hanaoka, Masayuki

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2021 Volume 27, Issue 12, Page(s) 1706–1712

Abstract: Introduction: Risk factors for seriously ill coronavirus disease 19 (COVID-19) patients have been reported in several studies. However, to date, few studies have reported simple risk assessment tools for distinguishing patients becoming severely ill ... ...

Abstract	Introduction: Risk factors for seriously ill coronavirus disease 19 (COVID-19) patients have been reported in several studies. However, to date, few studies have reported simple risk assessment tools for distinguishing patients becoming severely ill after initial diagnosis. Hence, this study aimed to develop a simple clinical risk nomogram predicting oxygenation risk in patients with COVID-19 at the first triage. Methods: This retrospective study involved a chart review of the medical records of 84 patients diagnosed with COVID-19 between February 2020 and March 2021 at ten medical facilities. The patients were divided into requiring no oxygen therapy (non-severe group) and requiring oxygen therapy (severe group). Patient characteristics were compared between the two groups. We utilized univariate logistic regression analysis to confirm determinants of high risks of requiring oxygen therapy in patients with moderate COVID-19. Results: Thirty-five patients ware in severe group and forty-nine patients were in non-severe group. In comparison with patients in the non-severe group, patients in the severe group were significantly older with higher body mass index (BMI), and had a history of hypertension and diabetes. Serum blood urea nitrogen (BUN), lactic acid dehydrogenase (LDH), and C-reactive protein (CRP) levels were significantly higher in the severe group. Multivariate analysis showed that older age, higher BMI, and higher BUN levels were significantly associated with oxygen requirements. Conclusions: This study demonstrated that age, BMI, and BUN were independent risk factors in the moderate-to-severe COVID-19 group. Elderly patients with higher BMI and BUN require close monitoring and early treatment initiation.
MeSH term(s)	Aged ; Blood Urea Nitrogen ; Body Mass Index ; COVID-19 ; Humans ; Oxygen ; Prognosis ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-08-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2021.08.009
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Zs.A 5236: Show issues

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Article ; Online: Current status of first-line treatment with pembrolizumab for non-small-cell lung cancer with high PD-L1 expression.

Cancer science

2022 Volume 113, Issue 6, Page(s) 2109–2117

Abstract: It is not clear whether pembrolizumab monotherapy (MONO) or pembrolizumab plus platinum-based chemotherapy (COMB) should be selected for patients with advanced non-small-cell lung cancer (NSCLC) exhibiting high PD-L1 expression (tumor proportion score ≥ ... ...

Abstract	It is not clear whether pembrolizumab monotherapy (MONO) or pembrolizumab plus platinum-based chemotherapy (COMB) should be selected for patients with advanced non-small-cell lung cancer (NSCLC) exhibiting high PD-L1 expression (tumor proportion score ≥ 50%). We performed a retrospective, multicenter study of 300 patients with NSCLC exhibiting high PD-L1 expression who received MONO or COMB as first-line treatment between December 2018 and January 2020. We reviewed the medical records of all consecutive patients with no driver mutations, and assessed the patient characteristics, therapeutic regimens, treatment periods, and adverse events. In total, 166 (55%; median age: 74 years) and 134 (45%; median age: 68 years) patients received MONO and COMB, respectively. Patients were younger and had better performance status (0-1) in the COMB group (p < 0.01). With a median follow-up time of 10.6 (range: 0.1-20.6) months, the median progression-free survival was 7.1 months with MONO and 13.1 months with COMB. The objective response rate was 42.2% with MONO and 67.9% with COMB. With respect to treatment discontinuation, 36 out of 166 (21.7%) and 28 out of 134 (20.1%) patients discontinued MONO and COMB, respectively. In conclusion, COMB may be a promising option for first-line treatment for NSCLC with high PD-L1 expression and good performance status.
MeSH term(s)	Aged ; Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols ; B7-H1 Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Multicenter Studies as Topic ; Retrospective Studies
Chemical Substances	Antibodies, Monoclonal, Humanized ; B7-H1 Antigen ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15361
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Article ; Online: Poliovirus eradication.

Hachiya, Masahiko / Sakurada, Shinsaku / Mizuno, Tomomi / Sugiura, Yasuo

The Lancet. Infectious diseases

2012 Volume 12, Issue 6, Page(s) 433

MeSH term(s)	Humans ; Mass Vaccination ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Poliovirus Vaccine, Oral/administration & dosage ; Poliovirus Vaccine, Oral/economics
Chemical Substances	Poliovirus Vaccine, Oral
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(12)70103-2
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Zs.A 5743: Show issues

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Article ; Online: An 11-year-old boy showing rapid psychomotor regression and diffuse cerebral white matter lesions.

Hachiya, Yasuo / Hayashi, Masaharu

Neuropathology : official journal of the Japanese Society of Neuropathology

2009 Volume 29, Issue 4, Page(s) 517–519

MeSH term(s)	Brain/pathology ; Child ; Fatal Outcome ; Gangliosidosis, GM1/complications ; Gangliosidosis, GM1/pathology ; Humans ; Male ; Nerve Fibers, Myelinated/pathology ; Psychomotor Disorders/etiology ; Psychomotor Disorders/pathology
Language	English
Publishing date	2009-08
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1483794-8
ISSN	1440-1789 ; 0919-6544
ISSN (online)	1440-1789
ISSN	0919-6544
DOI	10.1111/j.1440-1789.2009.01025.x
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Zs.A 5086: Show issues

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Article: Bilirubin encephalopathy: a study of neuronal subpopulations and neurodegenerative mechanisms in 12 autopsy cases.

Hachiya, Yasuo / Hayashi, Masaharu

Brain & development

2008 Volume 30, Issue 4, Page(s) 269–278

Abstract: Bilirubin encephalopathy (BE), which includes acute (kernicterus) and chronic (postkernicteric) forms, results from severe neonatal jaundice. In order to investigate neurodegenerative mechanisms in autopsy cases of BE, we immunohistochemically examined ... ...

Abstract	Bilirubin encephalopathy (BE), which includes acute (kernicterus) and chronic (postkernicteric) forms, results from severe neonatal jaundice. In order to investigate neurodegenerative mechanisms in autopsy cases of BE, we immunohistochemically examined expressions of neurotransmitters, neuropeptides, and calcium-binding proteins in the basal ganglia; and deposition of oxidative products. Expression of tyrosine hydroxylase was reduced in the putamen in cases of acute BE, and in the globus pallidus in cases of acute and chronic postkernicteric BE. Methionine-enkephalin expression was reduced in the external segment of the globus pallidus in cases of acute and chronic postkernicteric BE, and immunoreactivity for substance P was severely altered in both internal and external segments in cases of chronic postkernicteric BE. A decrease in the number of parvalbumin-immunoreactive interneurons in the external segment of the globus pallidus was observed predominantly in cases of acute BE, whereas the number of interneurons immunoreactive for calbindin-D28K was reduced in the putamen in cases of chronic postkernicteric BE. Nuclear immunoreactivity for 8-hydroxy-2'-deoxyguanosine was seen in the putamen in half of the BE cases. These findings indicated that the putamen was impaired in BE and the pallidal external segment was also damaged in the acute form of BE, suggesting that oxidative damage to DNA is implicated in lesions of the basal ganglia.
MeSH term(s)	Adolescent ; Adult ; Calcium-Binding Proteins/metabolism ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Kernicterus/metabolism ; Kernicterus/pathology ; Male ; Nerve Degeneration/metabolism ; Nerve Degeneration/pathology ; Neuropeptides/metabolism ; Oxidative Stress ; Putamen/metabolism ; Putamen/pathology ; Substantia Nigra/metabolism ; Substantia Nigra/pathology ; Thalamus/metabolism ; Thalamus/pathology ; Tyrosine 3-Monooxygenase/metabolism
Chemical Substances	Calcium-Binding Proteins ; Neuropeptides ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
Language	English
Publishing date	2008-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604822-5
ISSN	0387-7604
ISSN	0387-7604
DOI	10.1016/j.braindev.2007.08.013
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Zs.A 1788: Show issues

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Article ; Online: Impact of Tumor Location on Postoperative Outcome of Intraductal Papillary Neoplasm of the Bile Duct.

Matsumoto, Takatsugu / Kubota, Keiichi / Hachiya, Hiroyuki / Sakuraoka, Yuhki / Shiraki, Takayuki / Shimizu, Takayuki / Mori, Shozo / Iso, Yukihiro / Kato, Masato / Yamagishi, Hidetsugu / Imai, Yasuo / Aoki, Taku

World journal of surgery

2019 Volume 43, Issue 5, Page(s) 1313–1322

Abstract: Background: The concept of intraductal papillary neoplasm of the bile duct (IPNB) has been proposed to be the biliary equivalent of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. While the classification of IPMNs is based on their ... ...

Abstract	Background: The concept of intraductal papillary neoplasm of the bile duct (IPNB) has been proposed to be the biliary equivalent of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. While the classification of IPMNs is based on their location of duct involvement, such classification has not been fully evaluated for IPNBs. The aim of this study is to investigate the value of IPNB classification based on its location. Methods: A total of 306 consecutive patients who underwent surgical resection with a diagnosis of bile duct tumor were enrolled. Among these patients, 21 were diagnosed as having IPNB. The IPNBs were classified into two groups as follows: extrahepatic IPNB, which located in the distal or perihilar bile duct, and intrahepatic IPNB, which located more peripherally than the hilar bile duct. The clinicopathological features of the two groups were then compared. Results: Extrahepatic IPNB tended to show more invasive characteristics than intrahepatic IPNB (presence of invasive component: 40.0 vs. 9.1%, p = 0.084). Moreover, patients with extrahepatic IPNB showed significantly poorer relapse-free survival (RFS) than those with intrahepatic IPNB [5-year RFS rate (%): 81.8 vs. 16.2, p = 0.014]. Conclusion: Patients with intrahepatic IPNB show more favorable pathological characteristics and postoperative survival outcomes than those with extrahepatic IPNB.
MeSH term(s)	Aged ; Aged, 80 and over ; Bile Duct Neoplasms/mortality ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/pathology ; Carcinoma, Papillary/mortality ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/surgery ; Female ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2019-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-019-04913-3
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Zs.A 1336: Show issues

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Article ; Online: An autopsy case presenting repetitive hypoglycemia and unique cortical dysplasia.

Hayashi, Masaharu / Hachiya, Yasuo / Arai, Nobutaka

Brain & development

2010 Volume 32, Issue 4, Page(s) 289–292

Abstract: In epileptic patients, focal cortical dysplasia (FCD) is pathologically characterized by irregular cortical lamination, blurring of the grey and white matter border and the occurrence of dysplastic cells in the cerebral cortex. Here, we report the case ... ...

Abstract	In epileptic patients, focal cortical dysplasia (FCD) is pathologically characterized by irregular cortical lamination, blurring of the grey and white matter border and the occurrence of dysplastic cells in the cerebral cortex. Here, we report the case of a 42-year-old male showing developmental delay, transient repetition of hypoglycemic attack and cortical dysplasia, partly mimicking FCD. He had no family history of neurological disorders. He had never been able to stand independently and had always been unable to speak. He developed generalized convulsion in infancy, and then, in the absence of predisposing factors, suffered from repetitive hypoglycemic attacks between the ages of 27 and 38. Various endocrine tests, abdominal CT and brain MRI failed to demonstrate abnormalities. He died of peritonitis. At autopsy, no changes were observed in the pancreas, liver, kidneys, endocrine organs or hypothalamus. In the insular and frontal cortices, many large bizarre cells in the deep layer were observed and perivascular oligodendrocyte satellitosis was present in the adjacent white matter. Unlike FCD, the cortical lamination and the grey-white matter interface were preserved. A well-demarcated pilocytic astrocytoma was present in the brainstem. The cortical dysplasia, consisting of the diffuse occurrence of bizarre cells and the preservation of cortical lamination, is unique and has not been previously reported. Repetition of hypoglycemic attacks within a certain period is also noteworthy, although the relationship of this with the cortical dysplasia is unknown.
MeSH term(s)	Adult ; Autopsy ; Epilepsy/complications ; Epilepsy/pathology ; Fatal Outcome ; Humans ; Hypoglycemia/etiology ; Hypoglycemia/physiopathology ; Magnetic Resonance Imaging ; Male ; Malformations of Cortical Development/complications ; Malformations of Cortical Development/etiology ; Malformations of Cortical Development/pathology
Language	English
Publishing date	2010-04
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	604822-5
ISSN	1872-7131 ; 0387-7604
ISSN (online)	1872-7131
ISSN	0387-7604
DOI	10.1016/j.braindev.2009.02.005
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Zs.A 1788: Show issues

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Article: [Immunohistochemical analysis of hepatic steatosis in autopsy cases of severe motor and intellectual disabilities].

Hachiya, Yasuo / Hayashi, Masaharu / Tanuma, Naoyuki

No to hattatsu. Brain and development

2008 Volume 40, Issue 5, Page(s) 381–385

Abstract: To explore the pathogenesis of hepatic steatosis in severe motor and intellectual disabilities (SMID), we immunohistochemically examined the accumulation of oxidative products in 8 autopsy cases of SMID, 5 of which pathologically showed hepatic steatosis. ...

Abstract	To explore the pathogenesis of hepatic steatosis in severe motor and intellectual disabilities (SMID), we immunohistochemically examined the accumulation of oxidative products in 8 autopsy cases of SMID, 5 of which pathologically showed hepatic steatosis. Three of the 8 cases also demonstrated fibrosis in Glisson's sheath. Serial sections of liver were treated with monoclonal antibodies to oxidative products to proteins, lipids and nucleosides. Immunoreactivity for 4-hydroxynonenal, a marker of oxidative damage to lipids, was increased in the cytoplasm of hepatocytes in 5 cases; 2 with steatosis plus fibrosis, one with only fibrosis, and 2 with only hepatic steatosis. One case showed immunoreactivity for advanced glycation endproduct, a marker of oxidative damage to protein, in hepatocytes. There was no immunoreactivity for 8-hydroxy-2'-deoxyguanosine and hexanoyl lysine, markers of oxidative damage to DNA and lipids, respectively. These findings partly mimic those observed in adult patients with nonalcoholic steatohepatitis. The results suggested the involvement of oxidative damage to lipids in the pathogenesis of hepatic steatosis and/or fibrosis in patients with SMID.
MeSH term(s)	Adult ; Disabled Persons ; Fatty Liver/metabolism ; Fatty Liver/pathology ; Female ; Humans ; Immunohistochemistry ; Male ; Oxidative Stress/physiology
Language	Japanese
Publishing date	2008-09
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	605615-5
ISSN	1884-7668 ; 0029-0831
ISSN (online)	1884-7668
ISSN	0029-0831
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Zs.A 1787: Show issues

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Article ; Online: First video report of static encephalopathy of childhood with neurodegeneration in adulthood.

Kasai-Yoshida, Emi / Kumada, Satoko / Yagishita, Akira / Shimoda, Konomi / Sato-Shirai, Ikuko / Hachiya, Yasuo / Kurihara, Eiji

Movement disorders : official journal of the Movement Disorder Society

2013 Volume 28, Issue 3, Page(s) 397–399

MeSH term(s)	Adult ; Brain Diseases/complications ; Brain Diseases/pathology ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Neurodegenerative Diseases/complications ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/pathology ; Tomography, X-Ray Computed ; Video Recording
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Case Reports ; Letter ; Video-Audio Media
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.25158
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