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  1. Article: Anesthetic Challenges in a Patient With an Expanding Recurrent Mycotic Pseudoaneurysm of the Right Brachiocephalic Artery: A Case Report and Literature Review.

    Jaffar Khan, Muhammad / Baykuziyev, Temur / Tageldin, Tarek / Albasha, Abdulatif

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55372

    Abstract: Airway obstruction requires urgent intervention. When dealing with the right brachiocephalic artery mycotic pseudoaneurysms, the risk of rupture and massive hemorrhage adds greater urgency to the management. Furthermore, tracheal compression presents ... ...

    Abstract Airway obstruction requires urgent intervention. When dealing with the right brachiocephalic artery mycotic pseudoaneurysms, the risk of rupture and massive hemorrhage adds greater urgency to the management. Furthermore, tracheal compression presents difficulties during airway management. This report highlights the airway and anesthetic challenges encountered during the procedure and emphasizes the importance of tailored intervention for optimal patient care. We describe the clinical case of a 38-year-old male patient who presented with a large recurrent right brachiocephalic artery pseudoaneurysm associated with tracheal compression. The patient required urgent surgical intervention due to the pseudoaneurysm's enlargement and progressive respiratory distress. Awake fiber-optic intubation was not feasible. A cardiopulmonary bypass was kept on standby in the event of failed intubation and ventilation, or circulatory collapse. Endotracheal intubation was performed successfully using a video-laryngoscopy. After successful surgical repair of the pseudoaneurysm, the patient was transferred to ICU where he was extubated 48 hours post-surgery, following treatment with methylprednisolone for edematous aryepiglottic folds identified during video-laryngoscopy. Overall, this case emphasizes the importance of early diagnosis, prompt surgical intervention, and effective teamwork in managing rare and potentially life-threatening conditions like mycotic pseudoaneurysms. It also highlights the critical role of anesthesiologists in providing optimal perioperative care, ensuring hemodynamic stability, managing airway challenges, and facilitating successful surgical outcomes. In our work, we also provide a summary of the reported similar cases.
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Emerging Robotic Innovations and Artificial Intelligence in Endotracheal Intubation and Airway Management: Current State of the Art.

    Khan, Muhammad Jaffar / Karmakar, Arunabha

    Cureus

    2023  Volume 15, Issue 7, Page(s) e42625

    Abstract: Robotic sciences have rapidly advanced and revolutionized various aspects of medicine, including the field of airway management. Robotic endotracheal intubation is an innovative method that utilizes robotic systems to aid in the accurate placement of an ... ...

    Abstract Robotic sciences have rapidly advanced and revolutionized various aspects of medicine, including the field of airway management. Robotic endotracheal intubation is an innovative method that utilizes robotic systems to aid in the accurate placement of an endotracheal tube within the trachea. This cutting-edge technique shows great promise in improving procedural precision and ensuring patient safety. In this comprehensive overview, we delve into the present status of robotic-assisted endotracheal intubation, examining its advantages, obstacles, and the potential implications it holds for the future. In addition, this review encompasses a comprehensive analysis of the existing literature and references on recent advances in robotic technology and artificial intelligence related to airway management.
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.42625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: BASILICA Works, But Are We Any Better at Predicting Who Needs It?

    Khan, Jaffar M / Lederman, Robert J

    JACC. Cardiovascular interventions

    2022  Volume 15, Issue 5, Page(s) 508–510

    MeSH term(s) Bioprosthesis ; Humans ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lessons From TAVR in the Gulf.

    Khan, Jaffar M / Bruce, Christopher G

    Cardiovascular revascularization medicine : including molecular interventions

    2022  Volume 41, Page(s) 27–28

    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Humans ; Transcatheter Aortic Valve Replacement/adverse effects
    Language English
    Publishing date 2022-05-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2022.05.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intraoperative tourniquet-induced hyperthermia in a pediatric patient: a forgotten association.

    Tageldin, Tarek / Khan, Muhammad Jaffar / Baykuziyev, Temur / Ahmed, Haitham

    Korean journal of anesthesiology

    2024  

    Abstract: Background: The intraoperative use of tourniquets is associated with several complications, including hyperthermia. We present the first documented case of tourniquet-induced hyperthermia in a pediatric patient at our institution.: Case: A 5-year-old ...

    Abstract Background: The intraoperative use of tourniquets is associated with several complications, including hyperthermia. We present the first documented case of tourniquet-induced hyperthermia in a pediatric patient at our institution.
    Case: A 5-year-old female with no past medical history underwent tendon release surgery for congenital talipes equinovarus under general anesthesia. Following inflation of a pneumatic tourniquet to a pressure of 250 mmHg on her left thigh, the patient experienced a gradual increase in body temperature. Despite the implementation of cooling measures, the temperature continued to increase until it plateaued. The hyperthermia gradually resolved upon deflation of the tourniquet.
    Conclusions: Tourniquet-induced hyperthermia should be considered as a potential cause of intraoperative hyperthermia, particularly in the absence of typical signs of malignant hyperthermia. Early recognition and appropriate management, including deflation of the tourniquet and implementation of cooling measures, are crucial for preventing potential complications associated with hyperthermia.
    Language English
    Publishing date 2024-01-04
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2557340-8
    ISSN 2005-7563 ; 2005-7563
    ISSN (online) 2005-7563
    ISSN 2005-7563
    DOI 10.4097/kja.23655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Practice and effect of pesticide use on farmers' health in Sindh, Pakistan.

    Khan, Amna / Jaffar, Nazish / Murad, Fatima

    JPMA. The Journal of the Pakistan Medical Association

    2022  Volume 72, Issue 3, Page(s) 587–592

    Abstract: Objective: To identify the frequency and mode of pesticide application, its adverse health effects, and to assess farmers' knowledge and practice of precautionary measures.: Methods: The cross-sectional study was conducted in Matli, Badin in the ... ...

    Abstract Objective: To identify the frequency and mode of pesticide application, its adverse health effects, and to assess farmers' knowledge and practice of precautionary measures.
    Methods: The cross-sectional study was conducted in Matli, Badin in the Sindh province of Pakistan from February to April 2020, and comprised farmers. Data was collected through face-to-face interview using a validated questionnaire. Data was analysed using SPSS 22.
    Results: Of the 332 farmers, 329(99.1%) were males. The overall mean age was 31.18±12.79 years (range: 21-30 years). Also, 269(81%) of them had not attended formal schooling, and the mean duration of farming practice was 1.64±0.859 years.` Further, 136(41%) participants did not follow the recommended frequency of pesticide application, accidental ingestion was reported by 208(62.7%) participants, and inhalation by 203(61.1%). Dumping of pesticide containers in open fields was a common practice for 247(74.4%) subjects, and 223(67.2%) showed interest in safety training sessions.
    Conclusions: Farmers of Sindh were found to be seriously exposed to pesticide risk because of inadequate knowledge.
    MeSH term(s) Adolescent ; Adult ; Cross-Sectional Studies ; Farmers ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Occupational Exposure/adverse effects ; Pakistan/epidemiology ; Pesticides/adverse effects ; Young Adult
    Chemical Substances Pesticides
    Language English
    Publishing date 2022-02-07
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The resurgence of Avian influenza and human infection: A brief outlook.

    Farahat, Ramadan Abdelmoez / Khan, Sheharyar Hassan / Rabaan, Ali A / Al-Tawfiq, Jaffar A

    New microbes and new infections

    2023  Volume 53, Page(s) 101122

    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2023.101122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: BASILICA to prevent coronary obstruction in transcatheter aortic valve replacement.

    Edelman, J James / Khan, Jaffar M

    Annals of cardiothoracic surgery

    2020  Volume 9, Issue 6, Page(s) 508–509

    Language English
    Publishing date 2020-11-25
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2020-av-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Metabolic Interplay in the Tumor Microenvironment

    Reem Youssef / Rohan Maniar / Jaffar Khan / Hector Mesa

    Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9753-

    Implications for Immune Function and Anticancer Response

    2023  Volume 9767

    Abstract: Malignant tumors exhibit rapid growth and high metabolic rates, similar to embryonic stem cells, and depend on aerobic glycolysis, known as the “Warburg effect”. This understanding has enabled the use of radiolabeled glucose analogs in tumor staging and ... ...

    Abstract Malignant tumors exhibit rapid growth and high metabolic rates, similar to embryonic stem cells, and depend on aerobic glycolysis, known as the “Warburg effect”. This understanding has enabled the use of radiolabeled glucose analogs in tumor staging and therapeutic response assessment via PET scans. Traditional treatments like chemotherapy and radiotherapy target rapidly dividing cells, causing significant toxicity. Despite immunotherapy’s impact on solid tumor treatment, gaps remain, leading to research on cancer cell evasion of immune response and immune tolerance induction via interactions with the tumor microenvironment (TME). The TME, consisting of immune cells, fibroblasts, vessels, and the extracellular matrix, regulates tumor progression and therapy responses. TME-targeted therapies aim to transform this environment from supporting tumor growth to impeding it and fostering an effective immune response. This review examines the metabolic disparities between immune cells and cancer cells, their impact on immune function and therapeutic targeting, the TME components, and the complex interplay between cancer cells and nontumoral cells. The success of TME-targeted therapies highlights their potential to achieve better cancer control or even a cure.
    Keywords tumor microenvironment ; immunotherapy ; oncometabolites ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Metabolic Interplay in the Tumor Microenvironment: Implications for Immune Function and Anticancer Response.

    Youssef, Reem / Maniar, Rohan / Khan, Jaffar / Mesa, Hector

    Current issues in molecular biology

    2023  Volume 45, Issue 12, Page(s) 9753–9767

    Abstract: Malignant tumors exhibit rapid growth and high metabolic rates, similar to embryonic stem cells, and depend on aerobic glycolysis, known as the "Warburg effect". This understanding has enabled the use of radiolabeled glucose analogs in tumor staging and ... ...

    Abstract Malignant tumors exhibit rapid growth and high metabolic rates, similar to embryonic stem cells, and depend on aerobic glycolysis, known as the "Warburg effect". This understanding has enabled the use of radiolabeled glucose analogs in tumor staging and therapeutic response assessment via PET scans. Traditional treatments like chemotherapy and radiotherapy target rapidly dividing cells, causing significant toxicity. Despite immunotherapy's impact on solid tumor treatment, gaps remain, leading to research on cancer cell evasion of immune response and immune tolerance induction via interactions with the tumor microenvironment (TME). The TME, consisting of immune cells, fibroblasts, vessels, and the extracellular matrix, regulates tumor progression and therapy responses. TME-targeted therapies aim to transform this environment from supporting tumor growth to impeding it and fostering an effective immune response. This review examines the metabolic disparities between immune cells and cancer cells, their impact on immune function and therapeutic targeting, the TME components, and the complex interplay between cancer cells and nontumoral cells. The success of TME-targeted therapies highlights their potential to achieve better cancer control or even a cure.
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45120609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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