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  1. Article: Secretogranin I/chromogranin B is a heparin-binding adhesive protein.

    Chen, M / Tempst, P / Yankner, B A

    Journal of neurochemistry

    1992  Volume 58, Issue 5, Page(s) 1691–1698

    Abstract: ... Amino-terminal sequencing of the purified protein identified it as secretogranin I/chromogranin B (SgI ...

    Abstract The major heparin-binding protein secreted by PC12 cells was purified from conditioned medium. Amino-terminal sequencing of the purified protein identified it as secretogranin I/chromogranin B (SgI/ChmB). The protein showed the same electrophoretic mobility and biochemical characteristics as previously reported for SgI/ChmB and could be purified in high yield using a simple procedure. In vitro experiments demonstrated that SgI/ChmB effectively promoted cell-substratum adhesion of NIH 3T3 and PC12 cells and supported neurite outgrowth in primary hippocampal neurons. Thus, SgI/ChmB may be a new member of the family of heparin-binding extracellular matrix proteins that mediate cell adhesion and support neurite outgrowth.
    MeSH term(s) Amino Acid Sequence ; Animals ; Cell Adhesion/physiology ; Chromogranins ; Heparin/metabolism ; Molecular Sequence Data ; Neurites/drug effects ; Neurites/physiology ; Proteins/isolation & purification ; Proteins/metabolism ; Proteins/physiology ; Tumor Cells, Cultured
    Chemical Substances Chromogranins ; Proteins ; Heparin (9005-49-6)
    Language English
    Publishing date 1992-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/j.1471-4159.1992.tb10042.x
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  2. Article ; Online: Physiology: Inflammation links ageing to the brain.

    Gabuzda, Dana / Yankner, Bruce A

    Nature

    2013  Volume 497, Issue 7448, Page(s) 197–198

    MeSH term(s) Aging/physiology ; Animals ; Female ; Gonadotropin-Releasing Hormone/metabolism ; Hypothalamus/physiology ; I-kappa B Kinase/metabolism ; Male ; NF-kappa B/metabolism
    Chemical Substances NF-kappa B ; Gonadotropin-Releasing Hormone (33515-09-2) ; I-kappa B Kinase (EC 2.7.11.10)
    Language English
    Publishing date 2013-05-01
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature12100
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  3. Article: A century of cognitive decline.

    Yankner, B A

    Nature

    2000  Volume 404, Issue 6774, Page(s) 125

    MeSH term(s) Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease/etiology ; Alzheimer Disease/pathology ; Cognition Disorders/etiology ; Cognition Disorders/pathology ; Humans ; Neurofibrillary Tangles ; Plaque, Amyloid
    Language English
    Publishing date 2000-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/35004673
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  4. Article: The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?

    Yankner, B A

    Annals of the New York Academy of Sciences

    2000  Volume 924, Page(s) 26–28

    Abstract: A central issue in Alzheimer's disease research is whether amyloid beta-protein (A beta) is a cause or effect of the pathogenic process. Several independent lines of evidence argue for causality, although human clinical trials may be required to finally ... ...

    Abstract A central issue in Alzheimer's disease research is whether amyloid beta-protein (A beta) is a cause or effect of the pathogenic process. Several independent lines of evidence argue for causality, although human clinical trials may be required to finally settle the issue.
    MeSH term(s) Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Brain/pathology ; Humans
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2000
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2000.tb05555.x
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  5. Article: Monster plaques: what they tell us about Alzheimer's disease.

    Yankner, B A

    Nature medicine

    1998  Volume 4, Issue 4, Page(s) 394–395

    MeSH term(s) Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Exons ; Humans ; Membrane Proteins/genetics ; Models, Neurological ; Nerve Degeneration/genetics ; Neurofibrillary Tangles/genetics ; Plaque, Amyloid/genetics ; Plaque, Amyloid/pathology ; Presenilin-1 ; Sequence Deletion ; Spastic Paraplegia, Hereditary/genetics ; Spastic Paraplegia, Hereditary/pathology
    Chemical Substances Amyloid beta-Peptides ; Membrane Proteins ; PSEN1 protein, human ; Presenilin-1
    Language English
    Publishing date 1998-04
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm0498-394
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  6. Article: Mechanisms of neuronal degeneration in Alzheimer's disease.

    Yankner, B A

    Neuron

    1996  Volume 16, Issue 5, Page(s) 921–932

    MeSH term(s) Alleles ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Apolipoproteins E/metabolism ; Dementia/etiology ; Disease Models, Animal ; Humans ; Membrane Proteins/metabolism ; Nerve Degeneration ; Oxidation-Reduction ; Presenilin-1 ; Presenilin-2
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Apolipoproteins E ; Membrane Proteins ; PSEN1 protein, human ; PSEN2 protein, human ; Presenilin-1 ; Presenilin-2 ; Psen2 protein, mouse
    Language English
    Publishing date 1996-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/s0896-6273(00)80115-4
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  7. Article: New clues to Alzheimer's disease: unraveling the roles of amyloid and tau.

    Yankner, B A

    Nature medicine

    1996  Volume 2, Issue 8, Page(s) 850–852

    MeSH term(s) Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/physiology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Humans ; Membrane Proteins/genetics ; Mutation ; Peptide Fragments/genetics ; Peptide Fragments/physiology ; Presenilin-1 ; Presenilin-2 ; tau Proteins/genetics ; tau Proteins/physiology
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Membrane Proteins ; PSEN1 protein, human ; PSEN2 protein, human ; Peptide Fragments ; Presenilin-1 ; Presenilin-2 ; amyloid beta-protein (1-40) ; amyloid beta-protein (1-42) ; tau Proteins
    Language English
    Publishing date 1996-08
    Publishing country United States
    Document type Comment ; Journal Article ; Review
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm0896-850
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  8. Article: Commentary and perspective on studies of beta amyloid neurotoxicity.

    Yankner, B A

    Neurobiology of aging

    1992  Volume 13, Issue 5, Page(s) 615–616

    MeSH term(s) Amyloid beta-Peptides/toxicity ; Animals ; Histocytochemistry ; Humans ; Nervous System Diseases/chemically induced ; Nervous System Diseases/pathology
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 1992-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/0197-4580(92)90067-8
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  9. Article: Inflammation and Alzheimer disease: the good, the bad, and the ugly.

    Weninger, S C / Yankner, B A

    Nature medicine

    2001  Volume 7, Issue 5, Page(s) 527–528

    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Brain/pathology ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Mice ; Mice, Transgenic
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2001-05
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
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    ISSN 1078-8956
    DOI 10.1038/87839
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  10. Article: Amyloid and Alzheimer's disease--cause or effect?

    Yankner, B A

    Neurobiology of aging

    1989  Volume 10, Issue 5, Page(s) 470–1; discussion 477–8

    Abstract: The design of a rational therapeutic approach to Alzheimer's disease ultimately depends on an understanding of its pathogenesis. Amyloid deposition is a well-established, but poorly understood concomitant of Alzheimer's disease. Advances in our knowledge ...

    Abstract The design of a rational therapeutic approach to Alzheimer's disease ultimately depends on an understanding of its pathogenesis. Amyloid deposition is a well-established, but poorly understood concomitant of Alzheimer's disease. Advances in our knowledge of the normal posttranslational processing of the amyloid precursor protein may help to elucidate the defect in Alzheimer's disease that leads to amyloid deposition. In addition, recent insights into the biological and pathological effects of amyloid on CNS neurons promise to help clarify the role of this protein in the disease mechanism.
    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid/metabolism ; Amyloid beta-Peptides ; Humans
    Chemical Substances Amyloid ; Amyloid beta-Peptides
    Language English
    Publishing date 1989-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/0197-4580(89)90101-2
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