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  1. Article ; Online: Treatment of hypertension: choosing the first‑line treatment. Dr. Franz H. Messerli in an interview with Dr. Roman Jaeschke: part 1.

    Messerli, Franz H / Jaeschke, Roman

    Polish archives of internal medicine

    2017  Volume 127, Issue 3, Page(s) 219–220

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Humans ; Hypertension/drug therapy
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2017-03-31
    Publishing country Poland
    Document type Interview
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.3992
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  2. Article ; Online: Treatment of hypertension: When to start? What is the target? Dr. Franz H. Messerli in an interview with Dr. Roman Jaeschke: part 2.

    Messerli, Franz H / Jaeschke, Roman

    Polish archives of internal medicine

    2017  Volume 127, Issue 3, Page(s) 221–222

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Humans ; Hypertension/drug therapy
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2017-03-31
    Publishing country Poland
    Document type Interview
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.3993
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  3. Article ; Online: 24 h-accelerometry in epidemiological studies: automated detection of non-wear time in comparison to diary information.

    Jaeschke, Lina / Luzak, Agnes / Steinbrecher, Astrid / Jeran, Stephanie / Ferland, Maike / Linkohr, Birgit / Schulz, Holger / Pischon, Tobias

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 2227

    Abstract: Estimation of physical activity using 24 h-accelerometry requires detection of accelerometer non ... accelerations, but this algorithm was originally developed for waking hours only and its applicability to 24 h ... in 24 h-accelerometry compared to diary in 47 ActivE and 559 KORA participants. NWT was determined ...

    Abstract Estimation of physical activity using 24 h-accelerometry requires detection of accelerometer non-wear time (NWT). It is common practice to define NWT as periods >60 minutes of consecutive zero-accelerations, but this algorithm was originally developed for waking hours only and its applicability to 24 h-accelerometry is unclear. We investigated sensitivity and specificity of different algorithms to detect NWT in 24 h-accelerometry compared to diary in 47 ActivE and 559 KORA participants. NWT was determined with algorithms >60, >90, >120, >150, or >180 minutes of consecutive zero-counts. Overall, 9.1% (ActivE) and 15.4% (KORA) of reported NWT was >60 minutes. Sensitivity and specificity were lowest for the 60-min algorithm in ActivE (0.72 and 0.00) and KORA (0.64 and 0.08), and highest for the 180-min algorithm in ActivE (0.88 and 0.92) and for the 120-min algorithm in KORA (0.76 and 0.74). Nevertheless, when applying these last two algorithms, the overlap of accelerometry with any diary based NWT minutes was around 20% only. In conclusion, only a small proportion of NWT is >60 minutes. The 60-min algorithm is less suitable for NWT detection in 24 h-accelerometry because of low sensitivity, specificity, and small overlap with reported NWT minutes. Longer algorithms perform better but detect lower proportions of reported NWT.
    MeSH term(s) Accelerometry ; Adult ; Aged ; Algorithms ; Cross-Sectional Studies ; Exercise ; Humans ; Middle Aged ; Public Health Surveillance ; Sensitivity and Specificity ; Young Adult
    Language English
    Publishing date 2017-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-01092-w
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  4. Article ; Online: 24 h-accelerometry in epidemiological studies

    Lina Jaeschke / Agnes Luzak / Astrid Steinbrecher / Stephanie Jeran / Maike Ferland / Birgit Linkohr / Holger Schulz / Tobias Pischon

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    automated detection of non-wear time in comparison to diary information

    2017  Volume 11

    Abstract: Abstract Estimation of physical activity using 24 h-accelerometry requires detection ... its applicability to 24 h-accelerometry is unclear. We investigated sensitivity and specificity of different ... algorithms to detect NWT in 24 h-accelerometry compared to diary in 47 ActivE and 559 KORA participants. NWT ...

    Abstract Abstract Estimation of physical activity using 24 h-accelerometry requires detection of accelerometer non-wear time (NWT). It is common practice to define NWT as periods >60 minutes of consecutive zero-accelerations, but this algorithm was originally developed for waking hours only and its applicability to 24 h-accelerometry is unclear. We investigated sensitivity and specificity of different algorithms to detect NWT in 24 h-accelerometry compared to diary in 47 ActivE and 559 KORA participants. NWT was determined with algorithms >60, >90, >120, >150, or >180 minutes of consecutive zero-counts. Overall, 9.1% (ActivE) and 15.4% (KORA) of reported NWT was >60 minutes. Sensitivity and specificity were lowest for the 60-min algorithm in ActivE (0.72 and 0.00) and KORA (0.64 and 0.08), and highest for the 180-min algorithm in ActivE (0.88 and 0.92) and for the 120-min algorithm in KORA (0.76 and 0.74). Nevertheless, when applying these last two algorithms, the overlap of accelerometry with any diary based NWT minutes was around 20% only. In conclusion, only a small proportion of NWT is >60 minutes. The 60-min algorithm is less suitable for NWT detection in 24 h-accelerometry because of low sensitivity, specificity, and small overlap with reported NWT minutes. Longer algorithms perform better but detect lower proportions of reported NWT.
    Keywords Medicine ; R ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Variability and reliability study of overall physical activity and activity intensity levels using 24 h-accelerometry-assessed data.

    Jaeschke, Lina / Steinbrecher, Astrid / Jeran, Stephanie / Konigorski, Stefan / Pischon, Tobias

    BMC public health

    2018  Volume 18, Issue 1, Page(s) 530

    Abstract: Background: 24 h-accelerometry is now used to objectively assess physical activity (PA ... to estimate habitual PA, and reliability are unclear.: Methods: We assessed 24 h-PA of 50 participants ... h-accelerometry, is highly variable between days, but the day of assessment or the day of the week ...

    Abstract Background: 24 h-accelerometry is now used to objectively assess physical activity (PA) in many observational studies like the German National Cohort; however, PA variability, observational time needed to estimate habitual PA, and reliability are unclear.
    Methods: We assessed 24 h-PA of 50 participants using triaxial accelerometers (ActiGraph GT3X+) over 2 weeks. Variability of overall PA and different PA intensities (time in inactivity and in low intensity, moderate, vigorous, and very vigorous PA) between days of assessment or days of the week was quantified using linear mixed-effects and random effects models. We calculated the required number of days to estimate PA, and calculated PA reliability using intraclass correlation coefficients.
    Results: Between- and within-person variance accounted for 34.4-45.5% and 54.5-65.6%, respectively, of total variance in overall PA and PA intensities over the 2 weeks. Overall PA and times in low intensity, moderate, and vigorous PA decreased slightly over the first 3 days of assessment. Overall PA (p = 0.03), time in inactivity (p = 0.003), in low intensity PA (p = 0.001), in moderate PA (p = 0.02), and in vigorous PA (p = 0.04) slightly differed between days of the week, being highest on Wednesday and Friday and lowest on Sunday and Monday, with apparent differences between Saturday and Sunday. In nested random models, the day of the week accounted for < 19% of total variance in the PA parameters. On average, the required number of days to estimate habitual PA was around 1 week, being 7 for overall PA and ranging from 6 to 9 for the PA intensities. Week-to-week reliability was good (intraclass correlation coefficients, range, 0.68-0.82).
    Conclusions: Individual PA, as assessed using 24 h-accelerometry, is highly variable between days, but the day of assessment or the day of the week explain only small parts of this variance. Our data indicate that 1 week of assessment is necessary for reliable estimation of habitual PA.
    MeSH term(s) Accelerometry ; Adult ; Exercise/physiology ; Exercise/psychology ; Female ; Habits ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Time Factors
    Language English
    Publishing date 2018-04-20
    Publishing country England
    Document type Journal Article ; Observational Study
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-018-5415-8
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  6. Article ; Online: Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue-

    Jaeschke, Hartmut

    Livers

    2022  Volume 2, Issue 3, Page(s) 105–107

    Language English
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-4389
    ISSN (online) 2673-4389
    DOI 10.3390/livers2030008
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  7. Article ; Online: Comments on "DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders."

    Jaeschke, Hartmut

    Chemico-biological interactions

    2021  Volume 351, Page(s) 109761

    Abstract: I read with interest the article "DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders" recently published in Chemico-Biological Interactions. The authors suggested that acetaminophen, one of the most ...

    Abstract I read with interest the article "DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders" recently published in Chemico-Biological Interactions. The authors suggested that acetaminophen, one of the most used drugs worldwide, alkylates DNA at therapeutic doses and is genotoxic. Given the implications of this statements for public health, it is important for the reader to hear a different perspective that is based on the entire literature on this subject. Everything considered, there is no credible evidence that acetaminophen is a genotoxic hazard or a carcinogen at therapeutic doses.
    MeSH term(s) Acetaminophen ; DNA ; DNA Damage ; Enzyme Inhibitors ; Ion Channels
    Chemical Substances Enzyme Inhibitors ; Ion Channels ; Acetaminophen (362O9ITL9D) ; DNA (9007-49-2)
    Language English
    Publishing date 2021-11-26
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2021.109761
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  8. Article ; Online: Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight.

    Umbaugh, David S / Jaeschke, Hartmut

    Expert review of clinical pharmacology

    2024  Volume 17, Issue 2, Page(s) 143–155

    Abstract: Introduction: Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury and can cause a rapid progression to acute liver failure (ALF). Therefore, the identification of prognostic biomarkers to determine which patients will require ...

    Abstract Introduction: Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury and can cause a rapid progression to acute liver failure (ALF). Therefore, the identification of prognostic biomarkers to determine which patients will require a liver transplant is critical for APAP-induced ALF.
    Areas covered: We begin by relating the mechanistic investigations in mouse models of APAP hepatotoxicity to the human APAP overdose pathophysiology. We draw insights from the established sequence of molecular events in mice to understand the progression of events in the APAP overdose patient. Through this mechanistic understanding, several new biomarkers, such as CXCL14, have recently been evaluated. We also explore how single-cell RNA sequencing, spatial transcriptomics, and other omics approaches have been leveraged for identifying novel biomarkers and how these approaches will continue to push the field of biomarker discovery forward.
    Expert opinion: Recent investigations have elucidated several new biomarkers or combination of markers such as CXCL14, a regenerative miRNA signature, a cell death miRNA signature, hepcidin, LDH, CPS1, and FABP1. While these biomarkers are promising, they all require further validation. Larger cohort studies analyzing these new biomarkers in the same patient samples, while adding these candidate biomarkers to prognostic models will further support their clinical utility.
    MeSH term(s) Humans ; Mice ; Animals ; Acetaminophen/adverse effects ; Liver Failure, Acute/chemically induced ; MicroRNAs/genetics ; Biomarkers ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/genetics ; Gene Expression Profiling
    Chemical Substances Acetaminophen (362O9ITL9D) ; MicroRNAs ; Biomarkers
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2024.2306219
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  9. Article ; Online: Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury.

    Jaeschke, Hartmut / Ramachandran, Anup

    Annual review of pathology

    2024  Volume 19, Page(s) 453–478

    Abstract: Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug. This review covers intracellular signaling ... ...

    Abstract Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug. This review covers intracellular signaling events starting with drug metabolism and the central role of mitochondrial dysfunction involving oxidant stress and peroxynitrite. Mitochondria-derived endonucleases trigger nuclear DNA fragmentation, the point of no return for cell death. In addition, adaptive mechanisms that limit cell death are discussed including autophagy, mitochondrial morphology changes, and biogenesis. Extensive evidence supports oncotic necrosis as the mode of cell death; however, a partial overlap with signaling events of apoptosis, ferroptosis, and pyroptosis is the basis for controversial discussions. Furthermore, an update on sterile inflammation in injury and repair with activation of Kupffer cells, monocyte-derived macrophages, and neutrophils is provided. Understanding these mechanisms of cell death led to discovery of
    MeSH term(s) Humans ; Animals ; Acetaminophen/adverse effects ; Chemical and Drug Induced Liver Injury/etiology ; Apoptosis ; Acetylcysteine/pharmacology ; Acetylcysteine/therapeutic use ; Autophagy
    Chemical Substances Acetaminophen (362O9ITL9D) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathmechdis-051122-094016
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  10. Article ; Online: Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects.

    Jaeschke, Hartmut / Ramachandran, Anup

    Phytotherapy research : PTR

    2024  Volume 38, Issue 4, Page(s) 1781–1782

    MeSH term(s) Humans ; Biological Products/therapeutic use ; Chemical and Drug Induced Liver Injury/drug therapy
    Chemical Substances Biological Products
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.8145
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