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  1. Article: Characterizing CD38 Expression and Enzymatic Activity in the Brain of Spontaneously Hypertensive Stroke-Prone Rats.

    Hannawi, Yousef / Ewees, Mohamed G / Moore, Jordan T / Zweier, Jay L

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 881708

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.881708
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  2. Article ; Online: Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin.

    Zweier, Jay L / Ilangovan, Govindasamy

    Antioxidants & redox signaling

    2020  Volume 32, Issue 16, Page(s) 1172–1187

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Animals ; Cytoglobin/deficiency ; Cytoglobin/metabolism ; Humans ; Nitric Oxide/metabolism ; Oxygenases/metabolism
    Chemical Substances Cytoglobin ; Nitric Oxide (31C4KY9ESH) ; Oxygenases (EC 1.13.-) ; nitric oxide dioxygenase (EC 1.14.13.-)
    Language English
    Publishing date 2020-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2019.7881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: In Situ EPR Spin Trapping and Competition Kinetics Demonstrate Temperature-Dependent Mechanisms of Synergistic Radical Production by Ultrasonically Activated Persulfate.

    Fagan, William P / Villamena, Frederick A / Zweier, Jay L / Weavers, Linda K

    Environmental science & technology

    2022  Volume 56, Issue 6, Page(s) 3729–3738

    Abstract: Ultrasound coupled with activated persulfate can synergistically degrade aqueous organic contaminants. Here, in situ electron paramagnetic resonance spin trapping was used to compare radicals produced by ultrasonically activated persulfate (US-PS) and ... ...

    Abstract Ultrasound coupled with activated persulfate can synergistically degrade aqueous organic contaminants. Here, in situ electron paramagnetic resonance spin trapping was used to compare radicals produced by ultrasonically activated persulfate (US-PS) and its individual technologies, ultrasound alone (US) and heat-activated persulfate (PS), with respect to temperature. Radicals were trapped using 5,5-dimethyl-1-pyrroline-
    MeSH term(s) Cyclic N-Oxides ; Electron Spin Resonance Spectroscopy/methods ; Free Radicals ; Kinetics ; Spin Labels ; Spin Trapping/methods ; Temperature
    Chemical Substances Cyclic N-Oxides ; Free Radicals ; Spin Labels
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.1c08562
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  4. Article ; Online: Trityl Quinodimethane Derivatives as Unimolecular Triple-Function Extracellular EPR Probes for Redox, pH, and Oxygen.

    Feng, Yalan / Tan, Xiaoli / Shi, Zhaojun / Villamena, Frederick A / Zweier, Jay L / Song, Yuguang / Liu, Yangping

    Analytical chemistry

    2023  Volume 95, Issue 2, Page(s) 1057–1064

    Abstract: Electron paramagnetic resonance (EPR) spectroscopy and imaging coupled with the use of suitable probes is a promising tool for assessment of the tumor microenvironment (TME). Measurement of multiple TME parameters by EPR is very desirable but challenging. ...

    Abstract Electron paramagnetic resonance (EPR) spectroscopy and imaging coupled with the use of suitable probes is a promising tool for assessment of the tumor microenvironment (TME). Measurement of multiple TME parameters by EPR is very desirable but challenging. Herein, we designed and synthesized a class of negative-charged trityl quinodimethane MTPs as unimolecular triple-function extracellular probes for redox, pH, and oxygen (O
    MeSH term(s) Electron Spin Resonance Spectroscopy/methods ; Oxygen/chemistry ; Oxidation-Reduction ; Reducing Agents ; Hydrogen-Ion Concentration
    Chemical Substances Oxygen (S88TT14065) ; Reducing Agents
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c03754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: High fidelity triangular sweep of the magnetic field for millisecond scan EPR imaging.

    Komarov, Denis A / Samouilov, Alexandre / Hirata, Hiroshi / Zweier, Jay L

    Journal of magnetic resonance (San Diego, Calif. : 1997)

    2021  Volume 329, Page(s) 107024

    Abstract: Linearity of the magnetic field sweep is important for high resolution continuous wave EPR imaging. Driving the field with triangular wave function is the most efficient way to scan EPR projections. However, the magnetic field sweep profile can be ... ...

    Abstract Linearity of the magnetic field sweep is important for high resolution continuous wave EPR imaging. Driving the field with triangular wave function is the most efficient way to scan EPR projections. However, the magnetic field sweep profile can be significantly distorted during fast millisecond projection scan. In this work, we introduce a method to generate highly linear and properly symmetrical triangular sweeps of the magnetic field using calibrated harmonics of the triangular wave function. First, the frequency response function of the EPR magnet and its power circuitry was obtained. For this, the field sweeping coil was driven with sinusoidal signals of different frequencies and the actual magnetic field inside the magnet was recorded. To cover wide range of frequencies, the measurements were carried out independently using gaussmeter, Hall-effect linear sensor integrated circuit, and an inductance coil. For each frequency, the system gain and the phase delay were determined. These data were used to adjust the amplitudes and the phases of individual harmonics of the triangular wave function. After the calibration, the maximum deviation of the magnetic field from the linear function was 0.05% of sweep width for 4 ms scan. The maximum discrepancy between the forward and the reverse scan was less than 0.04%. Sweep overhead time for changing the scan direction was 5%. The proposed approach allows generation of high fidelity triangular magnetic field sweeps with accuracy better than 0.1% for the range of the magnetic field sweep widths up to 48 G and scan duration from 10 s down to 1 ms.
    MeSH term(s) Diagnostic Imaging ; Electron Spin Resonance Spectroscopy ; Magnetic Fields
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1469665-4
    ISSN 1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
    ISSN (online) 1096-0856 ; 1557-8968
    ISSN 1090-7807 ; 0022-2364
    DOI 10.1016/j.jmr.2021.107024
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  6. Article ; Online: Serine mutations in overexpressed Hsp27 abrogate the protection against doxorubicin-induced p53-dependent cardiac apoptosis in mice.

    Kanagasabai, Ragu / Karthikeyan, Krishnamurthy / Zweier, Jay L / Ilangovan, Govindasamy

    American journal of physiology. Heart and circulatory physiology

    2021  Volume 321, Issue 5, Page(s) H963–H975

    Abstract: Small heat shock proteins (sHsps) protect the heart from chemotherapeutics-induced heart failure by inhibiting p53-dependent apoptosis. However, mechanism of such protection has not been elucidated yet. Here we test a hypothesis that serine ... ...

    Abstract Small heat shock proteins (sHsps) protect the heart from chemotherapeutics-induced heart failure by inhibiting p53-dependent apoptosis. However, mechanism of such protection has not been elucidated yet. Here we test a hypothesis that serine phosphorylation of sHsps is essential to inhibit the doxorubicin-induced and p53-dependent apoptotic pathway. Three transgenic mice (TG) lines with cardiomyocyte-specific overexpression of human heat shock protein 27 (hHsp27), namely, wild-type [myosin heavy chain (MHC)-hHsp27], S82A single mutant [MHC-mut-hHsp27(
    MeSH term(s) Animals ; Apoptosis ; Cardiomyopathy, Dilated/chemically induced ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Cardiotoxicity ; Cells, Cultured ; Disease Models, Animal ; Doxorubicin ; Female ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Male ; Mice, Transgenic ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Mutation ; Myocardium/metabolism ; Myocardium/pathology ; Myosin Heavy Chains/genetics ; Phosphorylation ; Serine ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances HSPB1 protein, human ; Heat-Shock Proteins ; Molecular Chaperones ; Trp53 protein, mouse ; Tumor Suppressor Protein p53 ; Serine (452VLY9402) ; Doxorubicin (80168379AG) ; Myosin Heavy Chains (EC 3.6.4.1)
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00027.2020
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Dioxygen Binding and Sensing Proteins.

    Estrín, Darío A / Luque, F Javier / Ilangovan, Govindasamy / Zweier, Jay L

    Antioxidants & redox signaling

    2020  Volume 32, Issue 16, Page(s) 1151–1154

    Abstract: Oxygen binding proteins ( ... ...

    Abstract Oxygen binding proteins (O
    MeSH term(s) Binding Sites ; Humans ; Oxygen/metabolism ; Proteins/metabolism
    Chemical Substances Proteins ; Oxygen (S88TT14065)
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2020.8034
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Algebraic reconstruction of 3D spatial EPR images from high numbers of noisy projections: An improved image reconstruction technique for high resolution fast scan EPR imaging.

    Komarov, Denis A / Samouilov, Alexandre / Ahmad, Rizwan / Zweier, Jay L

    Journal of magnetic resonance (San Diego, Calif. : 1997)

    2020  Volume 319, Page(s) 106812

    Abstract: A novel method for reconstructing 3D spatial EPR images from large numbers of noisy projections was developed that minimizes mean square error between the experimental projections and those from the reconstructed image. The method utilizes raw projection ...

    Abstract A novel method for reconstructing 3D spatial EPR images from large numbers of noisy projections was developed that minimizes mean square error between the experimental projections and those from the reconstructed image. The method utilizes raw projection data and zero gradient spectrum to account for EPR line shape and hyperfine structure of the paramagnetic probe without the need for deconvolution techniques that are poorly suited for processing of high noise projections. A numerical phantom was reconstructed for method validation. Reconstruction time for the matrix of 128
    MeSH term(s) Algorithms ; Electron Spin Resonance Spectroscopy ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional ; Phantoms, Imaging
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1469665-4
    ISSN 1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
    ISSN (online) 1096-0856 ; 1557-8968
    ISSN 1090-7807 ; 0022-2364
    DOI 10.1016/j.jmr.2020.106812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Trityl Quinodimethane Derivatives as Unimolecular Triple-Function Extracellular EPR Probes for Redox, pH, and Oxygen

    Feng, Yalan / Tan, Xiaoli / Shi, Zhaojun / Villamena, Frederick A. / Zweier, Jay L. / Song, Yuguang / Liu, Yangping

    Analytical Chemistry. 2023 Jan. 05, v. 95, no. 2 p.1057-1064

    2023  

    Abstract: Electron paramagnetic resonance (EPR) spectroscopy and imaging coupled with the use of suitable probes is a promising tool for assessment of the tumor microenvironment (TME). Measurement of multiple TME parameters by EPR is very desirable but challenging. ...

    Abstract Electron paramagnetic resonance (EPR) spectroscopy and imaging coupled with the use of suitable probes is a promising tool for assessment of the tumor microenvironment (TME). Measurement of multiple TME parameters by EPR is very desirable but challenging. Herein, we designed and synthesized a class of negative-charged trityl quinodimethane MTPs as unimolecular triple-function extracellular probes for redox, pH, and oxygen (O₂) levels. Using the deuterated analogue, dMTP₅, which has an optimal pK ₐ as well as high sensitivity to bioreduction and O₂, we reasonably evaluated pH effects on efflux of reducing agents from HepG2 cells and cellular O₂ consumption.
    Keywords analytical chemistry ; electron paramagnetic resonance spectroscopy ; neoplasms ; oxygen ; pH
    Language English
    Dates of publication 2023-0105
    Size p. 1057-1064.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c03754
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 52/94: Show issues
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  10. Article: Characterizing the Neuroimaging and Histopathological Correlates of Cerebral Small Vessel Disease in Spontaneously Hypertensive Stroke-Prone Rats.

    Hannawi, Yousef / Caceres, Eder / Ewees, Mohamed G / Powell, Kimerly A / Bratasz, Anna / Schwab, Jan M / Rink, Cameron L / Zweier, Jay L

    Frontiers in neurology

    2021  Volume 12, Page(s) 740298

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.740298
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