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  1. Article ; Online: The 2017 Garrod Lecture: Genes, guts and globalization.

    Hawkey, Peter M

    The Journal of antimicrobial chemotherapy

    2018  Volume 73, Issue 10, Page(s) 2589–2600

    Abstract: ... as illustrated by the emergence and rapid spread of CTX-M β-lactamases and the carbapenemases. The unique ...

    Abstract The widespread use of antibacterial drugs over the last 70 years has brought immense benefits to human health at the price of increasing drug inefficacy. Antibacterial agents have a strong selective effect in both favouring resistant strains and allowing particular species and families of bacteria to prosper, especially in the healthcare setting. Whilst important Gram-positive bacterial pathogens such as Staphylococcus aureus and Streptococcus pneumoniae caused concern over the last 20 years because of the spread of antibiotic-resistant strains, Enterobacteriaceae have become the biggest challenge. They have very efficient mechanisms for genetic exchange, as illustrated by the emergence and rapid spread of CTX-M β-lactamases and the carbapenemases. The unique epidemiology of Enterobacteriaceae, with substantial numbers colonizing the mammalian gut and subsequent release into and spread in the environment, presents a significant threat to human health because of the high levels of exposure for the whole community. The use of antimicrobials in agriculture combined with global movements of people, animals and food, arising from worldwide industrialization, generates a diversity and level of resistance not seen previously. Control will require globally coordinated interventions similar to those needed to ameliorate climate change.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Drug Resistance, Multiple, Bacterial/genetics ; Enterobacteriaceae/drug effects ; Enterobacteriaceae Infections/drug therapy ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/prevention & control ; Gram-Positive Bacteria/drug effects ; Humans ; Internationality ; Public Health ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2018-07-03
    Publishing country England
    Document type Journal Article ; Lecture
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dky277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  2. Book: Medical bacteriology

    Hawkey, Peter M.

    a practical approach

    (Practical approach series ; 263)

    2003  

    Author's details ed. by Peter Hawkey
    Series title Practical approach series ; 263
    The practical approach series
    Collection The practical approach series
    Keywords Bacteriology ; Medical bacteriology ; Diagnostic bacteriology ; Bakteriologie ; Methode
    Subject Methodik ; Verfahren ; Technik ; Methoden ; Bakterienkunde
    Subject code 616.014
    Language English
    Size XXVI, 409 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Bibliography. - Previous ed.: 1989
    HBZ-ID HT013734510
    ISBN 0-19-963778-4 ; 0-19-963779-2 ; 978-0-19-963778-2 ; 978-0-19-963779-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 20 order for loan Magazin

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  3. Book ; Conference proceedings: Sepsis

    Hawkey, Peter M.

    [September 1996 ... symposium held at St Andrews, Scotland]

    (The journal of antimicrobial chemotherapy ; 41, Suppl. A)

    1998  

    Author's details ed. by Peter M. Hawkey
    Series title The journal of antimicrobial chemotherapy ; 41, Suppl. A
    Collection
    Keywords Sepsis Syndrome / congresses
    Language English
    Size 112 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT008362382
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1197 -41,Suppl.A- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Revisiting the donor screening protocol of faecal microbiota transplantation (FMT): a systematic review.

    Ng, Rita Wy / Dharmaratne, Priyanga / Wong, Sunny / Hawkey, Peter / Chan, Paul / Ip, Margaret

    Gut

    2023  

    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-329515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Typing of Epidemiologically Associated Environmental and Clinical Strains of Listeria monocytogenes by Random Amplification of Polymorphic DNA.

    Kerr, Kevin G / Kite, Peter / Heritage, John / Hawkey, Peter M

    Journal of food protection

    2019  Volume 58, Issue 6, Page(s) 609–613

    Abstract: One hundred and three strains of Listeria monocytogenes (Lm), Listeria seeligeri and Listeria innocua of clinical, food, and environmental origin were examined by generating randomly amplified polymorphic DNA (RAPD). Using one 10 bp and two 13 bp random ... ...

    Abstract One hundred and three strains of Listeria monocytogenes (Lm), Listeria seeligeri and Listeria innocua of clinical, food, and environmental origin were examined by generating randomly amplified polymorphic DNA (RAPD). Using one 10 bp and two 13 bp random primers, epidemiologically related strains, previously shown to be indistinguishable by phage typing, yielded identical RAPD profiles. Strains isolated from the hands of three workers in a retail food establishment showed the presence of a single predominant Lm isolate. RAPD analysis is a rapid, reproducible, and relatively inexpensive method for the differentiation of epidemiologically linked isolates of Listeria spp.
    Language English
    Publishing date 2019-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243284-5
    ISSN 1944-9097 ; 0362-028X
    ISSN (online) 1944-9097
    ISSN 0362-028X
    DOI 10.4315/0362-028X-58.6.609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Economic evaluation of Faecal microbiota transplantation compared to antibiotics for the treatment of recurrent

    Abdali, Zainab I / Roberts, Tracy E / Barton, Pelham / Hawkey, Peter M

    EClinicalMedicine

    2020  Volume 24, Page(s) 100420

    Abstract: Background: Clostridioides difficile: Method: A cost utility analysis was conducted using a decision model representing the cost per additional Quality Adjusted Life Year (QALY) from a National Health Service (NHS) perspective. A Markov model was ... ...

    Abstract Background: Clostridioides difficile
    Method: A cost utility analysis was conducted using a decision model representing the cost per additional Quality Adjusted Life Year (QALY) from a National Health Service (NHS) perspective. A Markov model was constructed to compare FMT NGT and colonoscopy to antibiotic treatment (fidaxomicin or vancomycin). The model was informed by a literature review of clinical evidence, specifically focussing on hospitalised patients with rCDI over 65 years. Both deterministic and probabilistic sensitivity analyses were performed to assess uncertainties around the model inputs and assumptions.
    Findings: The base case analysis showed that FMT is a less costly and more effective treatment than either fidaxomicin or vancomycin. FMT colonoscopy was slightly more effective than FMT NGT leading to an additional 0.012 QALYs but more expensive and the incremental cost effectiveness ratio (ICER) was £242,514/QALY. The Probabilistic sensitivity analysis based on 10,000 simulations suggested the probability of FMT NGT being cost effective was almost 78% at £20,000/QALY Willingness-To-Pay (WTP) threshold.
    Interpretation: FMT is both more effective and less costly option than antimicrobial therapy. FMT NGT was the preferred route of administration and is likely to be considered the most cost-effective strategy by decision makers given current acceptable thresholds.
    Language English
    Publishing date 2020-06-27
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Medical bacteriology

    Hawkey, Peter M.

    a practical approach

    (The practical approach series ; [52])

    1989  

    Author's details ed. by P. M. Hawkey
    Series title The practical approach series ; [52]
    Collection
    Keywords Bacteriology / laboratory manuals ; Bakteriologie ; Methode
    Subject Methodik ; Verfahren ; Technik ; Methoden ; Bakterienkunde
    Language English
    Size XIX, 321 S. : Ill., graph. Darst.
    Publisher IRL Pr
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003499451
    ISBN 0-19-963008-9 ; 0-19-963009-7 ; 978-0-19-963008-0 ; 978-0-19-963009-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 2502 order for loan Magazin

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  8. Article ; Online: Incidence of Listeria spp. in Pre-cooked, Chilled Chicken Products as Determined by Culture and Enzyme-linked Immunoassay (ELISA).

    Kerr, Kevin G / Rotowa, Nathaniel A / Hawkey, Peter M / Lacey, Richard W

    Journal of food protection

    2019  Volume 53, Issue 7, Page(s) 606–607

    Abstract: One hundred and two samples of ready-to-eat, pre-cooked, chilled chicken were examined for Listeria spp. using culture and a commercially available enzyme linked immunoassay (ELISA). Overall, 29 (28%) samples contained Listeria spp. as determined by ... ...

    Abstract One hundred and two samples of ready-to-eat, pre-cooked, chilled chicken were examined for Listeria spp. using culture and a commercially available enzyme linked immunoassay (ELISA). Overall, 29 (28%) samples contained Listeria spp. as determined by culture, Listeria monocytogenes being present in 27 (26.5%) samples. In comparison with culture, the ELISA yielded no false positives. However, the technique detected Listeria spp. in only 24 of 29 culture-positive samples.
    Language English
    Publishing date 2019-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243284-5
    ISSN 1944-9097 ; 0362-028X
    ISSN (online) 1944-9097
    ISSN 0362-028X
    DOI 10.4315/0362-028X-53.7.606
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  9. Article ; Online: Mechanisms Involved in the Active Secretion of CTX-M-15 β-Lactamase by Pathogenic Escherichia coli ST131.

    Rangama, Severine / Lidbury, Ian D E A / Holden, Jennifer M / Borsetto, Chiara / Murphy, Andrew R J / Hawkey, Peter M / Wellington, Elizabeth M H

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 10, Page(s) e0066321

    Abstract: Infections caused by antimicrobial-resistant bacterial pathogens are fast becoming an important global health issue. Strains of Escherichia coli are common causal agents of urinary tract infection and can carry multiple resistance genes. This includes ... ...

    Abstract Infections caused by antimicrobial-resistant bacterial pathogens are fast becoming an important global health issue. Strains of Escherichia coli are common causal agents of urinary tract infection and can carry multiple resistance genes. This includes the gene
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Escherichia coli/genetics ; Escherichia coli Infections/drug therapy ; Genotype ; Humans ; Proteomics ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; beta-lactamase CTX-M-15 (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00663-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  10. Article ; Online: Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype.

    Bevan, Edward R / Jones, Annie M / Hawkey, Peter M

    The Journal of antimicrobial chemotherapy

    2017  Volume 72, Issue 8, Page(s) 2145–2155

    Abstract: ... and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 ... sanitation. We also provide explanations for the changing epidemiology of blaCTX-M-2 and blaCTX-M-27 ... of blaCTX-M and other antimicrobial resistance (AMR) genes, such as blaNDM, blaKPC and mcr-1. We provide ...

    Abstract Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world. Explanations for these changes can be attributed to: (i) horizontal gene transfer (HGT) of plasmids; (ii) successful Escherichia coli clones; (iii) ESBLs in food animals; (iv) the natural environment; and (v) human migration and access to basic sanitation. We also provide explanations for the changing epidemiology of blaCTX-M-2 and blaCTX-M-27. Modifiable anthropogenic factors, such as poor access to basic sanitary facilities, encourage the spread of blaCTX-M and other antimicrobial resistance (AMR) genes, such as blaNDM, blaKPC and mcr-1. We provide further justification for novel preventative and interventional strategies to reduce transmission of these AMR genes.
    MeSH term(s) Animals ; Disease Transmission, Infectious ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/isolation & purification ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Gene Transfer, Horizontal ; Genotype ; Global Health ; Humans ; Molecular Epidemiology ; Phylogeography ; Spatio-Temporal Analysis ; beta-Lactamases/genetics
    Chemical Substances beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2017--01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkx146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 124: Show issues

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