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  1. Article ; Online: Quinupristin-Dalfopristin A Viewpoint : A Viewpoint by Roland Leclercq.

    Leclercq, Roland

    Drugs

    1996  Volume 52, Issue 3, Page(s) 416

    Language English
    Publishing date 1996-09
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.2165/00003495-199652030-00007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 762: Show issues Location:
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  2. Article ; Online: Roland Lardinois, L’invention de l’Inde

    François Leclercq

    South Asia Multidisciplinary Academic Journal (2010)

    Entre ésotérisme et science

    2010  

    Keywords Social Sciences ; H
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Centre d’Etudes de l’Inde et de l’Asie du Sud
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Roland Lardinois, L’invention de l’Inde

    François Leclercq

    South Asia Multidisciplinary Academic Journal (2010)

    Entre ésotérisme et science

    2010  

    Keywords Social Sciences ; H
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Centre d’Etudes de l’Inde et de l’Asie du Sud
    Document type Article ; Online
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  4. Article ; Online: Roland Lardinois, L’invention de l’Inde

    François Leclercq

    South Asia Multidisciplinary Academic Journal (2010)

    Entre ésotérisme et science

    2010  

    Keywords Social Sciences ; H
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Centre d’Etudes de l’Inde et de l’Asie du Sud
    Document type Article ; Online
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  5. Article ; Online: Roland Lardinois, L’invention de l’Inde

    François Leclercq

    South Asia Multidisciplinary Academic Journal (2010)

    Entre ésotérisme et science

    2010  

    Abstract: L’Invention de l’Inde (‘The Invention of India’) provides a history of India studies in France in the 19th and 20th centuries, from the creation of modern scientific institutions in the decades following the French Revolution to the controversies raised ... ...

    Abstract L’Invention de l’Inde (‘The Invention of India’) provides a history of India studies in France in the 19th and 20th centuries, from the creation of modern scientific institutions in the decades following the French Revolution to the controversies raised by Louis Dumont’s magnum opus, Homo hierarchicus, first published in 1966. The author emphasises the life histories of the scholars who contributed to the field and their interactions with both academia and wider intellectual, literary and soc.
    Keywords Social Sciences ; H
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Centre d’Etudes de l’Inde et de l’Asie du Sud
    Document type Article ; Online
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  6. Book: Antibiogram

    Courvalin, Patrice / Leclercq, Roland / Rice, Louis B.

    2010  

    Author's details [ed.: Patrice Courvalin ; Roland Leclercq ; Louis B. Rice]
    Keywords Musculoskeletal Diseases / diagnosis ; Musculoskeletal System / injuries ; Diagnostic Imaging / methods
    Language English
    Size 705 S. : Ill., graph. Darst.
    Publisher ESKA Publ. u.a.
    Publishing place Portland, Or
    Publishing country United States
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016351924
    ISBN 978-1-5558-1496-0 ; 978-2-7472-1545-9 ; 1-5558-1496-4 ; 2-7472-1545-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 2432 order for loan Magazin

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  7. Article ; Online: Bipolar outflows out to 10 kpc for massive galaxies at redshift z ≈ 1.

    Guo, Yucheng / Bacon, Roland / Bouché, Nicolas F / Wisotzki, Lutz / Schaye, Joop / Blaizot, Jérémy / Verhamme, Anne / Cantalupo, Sebastiano / Boogaard, Leindert A / Brinchmann, Jarle / Cherrey, Maxime / Kusakabe, Haruka / Langan, Ivanna / Leclercq, Floriane / Matthee, Jorryt / Michel-Dansac, Léo / Schroetter, Ilane / Wendt, Martin

    Nature

    2023  Volume 624, Issue 7990, Page(s) 53–56

    Abstract: Galactic outflows are believed to play a critical role in the evolution of galaxies by regulating their mass build-up and star ... ...

    Abstract Galactic outflows are believed to play a critical role in the evolution of galaxies by regulating their mass build-up and star formation
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06718-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  8. Article ; Online: Twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce?

    Cattoir, Vincent / Leclercq, Roland

    The Journal of antimicrobial chemotherapy

    2013  Volume 68, Issue 4, Page(s) 731–742

    Abstract: Twenty-five years ago, isolation of vancomycin-resistant Enterococcus faecium (VREm) was reported both in the UK and in France. Since then, VREm has spread worldwide in hospitals. Hospital outbreaks appeared to be related to the evolution since the end ... ...

    Abstract Twenty-five years ago, isolation of vancomycin-resistant Enterococcus faecium (VREm) was reported both in the UK and in France. Since then, VREm has spread worldwide in hospitals. Hospital outbreaks appeared to be related to the evolution since the end of 1980s of a subpopulation of E. faecium highly resistant to ampicillin and fluoroquinolones (the so-called clonal complex CC17) that later acquired resistance to vancomycin. CC17 isolates are presumably better adapted than other E. faecium isolates to the constraints of the hospital environment and most contain mobile genetic elements, phage genes, genes encoding membrane proteins, regulatory genes, a putative pathogenicity island and megaplasmids. Colonization and persistence are major features of VREm. Inherent characteristics of E. faecium including a remarkable genome plasticity, in part due to acquisition of IS elements, in particular IS16, have facilitated niche adaptation of this distinct E. faecium subpopulation that is multiply resistant to antibiotics. Quinupristin/dalfopristin and linezolid are licensed for the treatment of VREm infections, with linezolid often used as a first-line treatment. However, the emergence of plasmid-mediated resistance to linezolid by production of a Cfr methyltransferase in Enterococcus faecalis is worrying. Daptomycin has not been extensively evaluated for the treatment of VREm infections and resistant mutants have been selected under daptomycin therapy. Although control of VRE is challenging, a laissez-faire policy would result in an increased number of infections and would create an irreversible situation. Although so far unsuccessful, dissemination of glycopeptide-resistant Staphylococcus aureus with van genes acquired from resistant enterococci cannot be ruled out.
    MeSH term(s) Carrier State/epidemiology ; Carrier State/microbiology ; Cross Infection/epidemiology ; Cross Infection/microbiology ; DNA, Bacterial/genetics ; Disease Outbreaks ; Enterococcus/classification ; Enterococcus/drug effects ; Enterococcus/genetics ; Enterococcus/isolation & purification ; Genotype ; Global Health ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Infection Control/methods ; Vancomycin Resistance
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2013-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dks469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  9. Article ; Online: Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications.

    Leclercq, Roland

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2002  Volume 34, Issue 4, Page(s) 482–492

    Abstract: Resistance to macrolides and lincosamides is increasingly reported in clinical isolates of gram-positive bacteria. The multiplicity of mechanisms of resistance, which include ribosomal modification, efflux of the antibiotic, and drug inactivation, ... ...

    Abstract Resistance to macrolides and lincosamides is increasingly reported in clinical isolates of gram-positive bacteria. The multiplicity of mechanisms of resistance, which include ribosomal modification, efflux of the antibiotic, and drug inactivation, results in a variety of phenotypes of resistance. There is controversy concerning the clinical relevance of in vitro macrolide resistance. Recent data, however, have shown that eradication of bacteria correlates with clinical outcome of acute otitis media in children and that macrolide therapy results in delayed eradication of macrolide-resistant pneumococci. These results support the need for in vitro detection of macrolide resistance and correct interpretation of susceptibility tests to guide therapy.
    MeSH term(s) Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Biological Transport ; Biotransformation ; DNA Methylation ; DNA, Ribosomal/metabolism ; Drug Resistance, Bacterial/genetics ; Drug Resistance, Bacterial/physiology ; Genetic Variation ; Humans ; Lincosamides ; Macrolides ; Mutation ; Outcome Assessment (Health Care)
    Chemical Substances Anti-Bacterial Agents ; DNA, Ribosomal ; Lincosamides ; Macrolides
    Language English
    Publishing date 2002-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1086/324626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  10. Article ; Online: Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.

    Liang, Kai Ling / Roels, Juliette / Lavaert, Marieke / Putteman, Tom / Boehme, Lena / Tilleman, Laurentijn / Velghe, Imke / Pegoretti, Valentina / Van de Walle, Inge / Sontag, Stephanie / Vandewalle, Jolien / Vandekerckhove, Bart / Leclercq, Georges / Van Vlierberghe, Pieter / Libert, Claude / Van Nieuwerburgh, Filip / Fischer, Roman / Kontermann, Roland E / Pfizenmaier, Klaus /
    Doody, Gina / Zenke, Martin / Taghon, Tom

    Nature immunology

    2023  Volume 24, Issue 3, Page(s) 474–486

    Abstract: The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cells (DCs) is evident but its physiological significance is unknown. Here we showed that DC-biased ... ...

    Abstract The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cells (DCs) is evident but its physiological significance is unknown. Here we showed that DC-biased precursors depended on the expression of the transcription factor IRF8 to express the membrane-bound precursor form of the cytokine TNF (tmTNF) to promote differentiation of thymus seeding hematopoietic progenitors into T-lineage specified precursors through activation of the TNF receptor (TNFR)-2 instead of TNFR1. In vitro recapitulation of TNFR2 signaling by providing low-density tmTNF or a selective TNFR2 agonist enhanced the generation of human T cell precursors. Our study shows that, in addition to mediating thymocyte selection and maturation, DCs function as hematopoietic stromal support for the early stages of human T cell development and provide proof of concept that selective targeting of TNFR2 can enhance the in vitro generation of T cell precursors for clinical application.
    MeSH term(s) Humans ; Cell Differentiation ; Cell Lineage ; Dendritic Cells ; Interferon Regulatory Factors/metabolism ; Receptors, Tumor Necrosis Factor, Type II/metabolism ; Thymus Gland/metabolism ; Tumor Necrosis Factors/metabolism
    Chemical Substances Interferon Regulatory Factors ; Receptors, Tumor Necrosis Factor, Type II ; Tumor Necrosis Factors
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01417-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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