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  1. Book ; Online ; Thesis: Comparison of splicing and nuclear envelope alterations in three muscular dystrophies

    Todorow, Vanessa Jimayma [Verfasser] / Grothe, Benedikt [Akademischer Betreuer]

    2024  

    Author's details Vanessa Jimayma Todorow ; Betreuer: Benedikt Grothe
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  2. Article ; Online: How the Barn Owl Computes Auditory Space.

    Grothe, Benedikt

    Trends in neurosciences

    2018  Volume 41, Issue 3, Page(s) 115–117

    Abstract: In a series of seminal behavioral and electrophysiological experiments, Knudsen and Konishi studied the mechanisms of hearing. Their 1979 article showed how the barn owl utilizes unique anatomical features for creating a systematic internal ... ...

    Abstract In a series of seminal behavioral and electrophysiological experiments, Knudsen and Konishi studied the mechanisms of hearing. Their 1979 article showed how the barn owl utilizes unique anatomical features for creating a systematic internal representation of auditory space. This established the barn owl as a prime model for studying sensory systems.
    MeSH term(s) Acoustic Stimulation/methods ; Animals ; Auditory Pathways/physiology ; Auditory Perception/physiology ; Hearing/physiology ; Humans ; Neurons/physiology ; Strigiformes/physiology
    Language English
    Publishing date 2018-03-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2018.01.004
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    Zs.A 1442: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 53: Show issues

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  3. Article ; Online: Ambient sound stimulation tunes axonal conduction velocity by regulating radial growth of myelin on an individual, axon-by-axon basis.

    Stancu, Mihai / Wohlfrom, Hilde / Heß, Martin / Grothe, Benedikt / Leibold, Christian / Kopp-Scheinpflug, Conny

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 11, Page(s) e2316439121

    Abstract: Adaptive myelination is the emerging concept of tuning axonal conduction velocity to the activity within specific neural circuits over time. Sound processing circuits exhibit structural and functional specifications to process signals with microsecond ... ...

    Abstract Adaptive myelination is the emerging concept of tuning axonal conduction velocity to the activity within specific neural circuits over time. Sound processing circuits exhibit structural and functional specifications to process signals with microsecond precision: a time scale that is amenable to adjustment in length and thickness of myelin. Increasing activity of auditory axons by introducing sound-evoked responses during postnatal development enhances myelin thickness, while sensory deprivation prevents such radial growth during development. When deprivation occurs during adulthood, myelin thickness was reduced. However, it is unclear whether sensory stimulation adjusts myelination in a global fashion (whole fiber bundles) or whether such adaptation occurs at the level of individual fibers. Using temporary monaural deprivation in mice provided an internal control for a) differentially tracing structural changes in active and deprived fibers and b) for monitoring neural activity in response to acoustic stimulation of the control and the deprived ear within the same animal. The data show that sound-evoked activity increased the number of myelin layers around individual active axons, even when located in mixed bundles of active and deprived fibers. Thicker myelination correlated with faster axonal conduction velocity and caused shorter auditory brainstem response wave VI-I delays, providing a physiologically relevant readout. The lack of global compensation emphasizes the importance of balanced sensory experience in both ears throughout the lifespan of an individual.
    MeSH term(s) Animals ; Mice ; Myelin Sheath ; Axons ; Sensory Deprivation ; Acoustic Stimulation ; Longevity
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2316439121
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    Zs.A 1148: Show issues Location:
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  4. Article ; Online: Development of myelination and axon diameter for fast and precise action potential conductance.

    Nabel, Alisha L / Teich, Laurin / Wohlfrom, Hilde / Alexandrova, Olga / Heß, Martin / Pecka, Michael / Grothe, Benedikt

    Glia

    2024  Volume 72, Issue 4, Page(s) 794–808

    Abstract: Axons of globular bushy cells in the cochlear nucleus convey hyper-accurate signals to the superior olivary complex, the initial site of binaural processing via comparably thick axons and the calyx of the Held synapse. Bushy cell fibers involved in hyper- ...

    Abstract Axons of globular bushy cells in the cochlear nucleus convey hyper-accurate signals to the superior olivary complex, the initial site of binaural processing via comparably thick axons and the calyx of the Held synapse. Bushy cell fibers involved in hyper-accurate binaural processing of low-frequency sounds are known to have an unusual internode length-to-axon caliber ratio (L/d) correlating with higher conduction velocity and superior temporal precision of action potentials. How the L/d-ratio develops and what determines this unusual myelination pattern is unclear. Here we describe a gradual developmental transition from very simple to complex, mature nodes of Ranvier on globular bushy cell axons during a 2-week period starting at postnatal day P6/7. The molecular composition of nodes matured successively along the axons from somata to synaptic terminals with morphologically and molecularly mature nodes appearing almost exclusively after hearing onset. Internodal distances are initially coherent with the canonical L/d-ratio of ~100. Several days after hearing onset, however, an over-proportional increase in axon caliber occurs in cells signaling low-frequency sounds which alters their L/d ratio to ~60. Hence, oligodendrocytes initially myelinating axons according to their transient axon caliber but a subsequent differential axon thickening after hearing onset results in the unusual myelination pattern.
    MeSH term(s) Action Potentials/physiology ; Axons/physiology ; Neurons ; Presynaptic Terminals ; Oligodendroglia ; Myelin Sheath/physiology
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639414-0
    ISSN 1098-1136 ; 0894-1491
    ISSN (online) 1098-1136
    ISSN 0894-1491
    DOI 10.1002/glia.24504
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    Zs.A 2345: Show issues Location:
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  5. Book ; Online ; Thesis: Conditionally cytotoxic and drug-controllable non-cytotoxic rabies viruses

    Pfaffinger, Verena [Verfasser] / Grothe, Benedikt [Akademischer Betreuer]

    2022  

    Author's details Verena Pfaffinger ; Betreuer: Benedikt Grothe
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  6. Book ; Online ; Thesis: The representation of auditory space in the auditory cortex of anesthetized and awake mice

    Gumbert, Matthias [Verfasser] / Grothe, Benedikt [Akademischer Betreuer]

    2022  

    Author's details Matthias Gumbert ; Betreuer: Benedikt Grothe
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  7. Article ; Online: Ketamine-xylazine anesthesia depth affects auditory neuronal responses in the lateral superior olive complex of the gerbil.

    Jing, Zhizi / Pecka, Michael / Grothe, Benedikt

    Journal of neurophysiology

    2021  Volume 126, Issue 5, Page(s) 1660–1669

    Abstract: Studies of in vivo neuronal responses to auditory inputs in the superior olive complex (SOC) are usually done under anesthesia. However, little attention has been paid to the effect of anesthesia itself on response properties. Here, we assessed the ... ...

    Abstract Studies of in vivo neuronal responses to auditory inputs in the superior olive complex (SOC) are usually done under anesthesia. However, little attention has been paid to the effect of anesthesia itself on response properties. Here, we assessed the effect of anesthesia depth under ketamine-xylazine anesthetics on auditory evoked response properties of lateral SOC neurons. Anesthesia depth was tracked by monitoring EEG spectral peak frequencies. An increase in anesthesia depth led to a decrease of spontaneous discharge activities and an elevated response threshold. The temporal responses to suprathreshold tones were also affected, with adapted responses reduced but peak responses unaffected. Deepening the anesthesia depth also increased first spike latency. However, spike jitter was not affected. Auditory brainstem responses to clicks confirmed that ketamine-xylazine anesthesia depth affects auditory neuronal activities and the effect on spike rate and spike timing persists through the auditory pathway. We concluded from those observations that ketamine-xylazine affects lateral SOC response properties depending on the anesthesia depth.
    MeSH term(s) Anesthesia ; Anesthetics, General/pharmacology ; Animals ; Auditory Perception/drug effects ; Electroencephalography/drug effects ; Evoked Potentials, Auditory, Brain Stem/drug effects ; Female ; Gerbillinae ; Ketamine/pharmacology ; Male ; Superior Olivary Complex/drug effects ; Xylazine/pharmacology
    Chemical Substances Anesthetics, General ; Xylazine (2KFG9TP5V8) ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00217.2021
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    Uc I Zs.224: Show issues Location:
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  8. Book ; Online ; Thesis: Myelination in the auditory brainstem

    Nabel, Alisha [Verfasser] / Grothe, Benedikt [Akademischer Betreuer]

    2021  

    Author's details Alisha Nabel ; Betreuer: Benedikt Grothe
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  9. Article ; Online: Source identity shapes spatial preference in primary auditory cortex during active navigation.

    Amaro, Diana / Ferreiro, Dardo N / Grothe, Benedikt / Pecka, Michael

    Current biology : CB

    2021  Volume 31, Issue 17, Page(s) 3875–3883.e5

    Abstract: Information about the position of sensory objects and identifying their concurrent behavioral relevance is vital to navigate the environment. In the auditory system, spatial information is computed in the brain based on the position of the sound source ... ...

    Abstract Information about the position of sensory objects and identifying their concurrent behavioral relevance is vital to navigate the environment. In the auditory system, spatial information is computed in the brain based on the position of the sound source relative to the observer and thus assumed to be egocentric throughout the auditory pathway. This assumption is largely based on studies conducted in either anesthetized or head-fixed and passively listening animals, thus lacking self-motion and selective listening. Yet these factors are fundamental components of natural sensing
    MeSH term(s) Acoustic Stimulation ; Animals ; Auditory Cortex/physiology ; Auditory Pathways ; Auditory Perception/physiology ; Sound Localization/physiology
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.06.025
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    Zs.A 3208: Show issues Location:
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  10. Book ; Online ; Thesis: Aspects of room acoustics, vision and motion in the human auditory perception of space

    Schutte, Michael [Verfasser] / Grothe, Benedikt [Akademischer Betreuer]

    2021  

    Author's details Michael Schutte ; Betreuer: Benedikt Grothe
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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