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Article ; Online: Ultrasound-guided thrombin injections for arterial pseudoaneurysms: a 14-year study conducted at King Khalid University Hospital Vascular Lab.

Altoijry, Abdulmajeed / Alghofili, Hesham / Al-Salman, Mussaad / Alsheikh, Sultan / Aljabri, Badr / Iqbal, Kaisor / Altuwaijri, Talal

Minerva cardioangiologica

2020 Volume 68, Issue 3, Page(s) 271–276

Abstract: ... to evaluate the safety and efficacy of UGTI for the treatment of arterial pseudoaneurysms at the King Khalid ...

Abstract	Background: Arterial pseudoaneurysms are a well-known complication resulting from procedures requiring arterial wall puncture. Previously, surgical repair was the definitive treatment option for arterial pseudoaneurysms despite being relatively invasive and time-consuming. Ultrasound-guided thrombin injection (UGTI) has become the standard of care since its initial description back in 1997. We aimed to evaluate the safety and efficacy of UGTI for the treatment of arterial pseudoaneurysms at the King Khalid University Hospital Vascular Lab. Methods: A retrospective analysis of prospectively maintained data was conducted on all patients diagnosed with arterial pseudoaneurysms by Doppler ultrasound between 2006 and 2019. Patients with large arterial pseudoaneurysms (>1.5 cm) qualified for thrombin injections. Individuals with a known hypersensitive to thrombin were excluded. All included patients were treated with UGTI until resolution and were followed at postoperative days 7 and 30. Results: In all, 35 patients qualified for thrombin injections. The mean age of the included patient population was 56.5 (range, 24-81) years. The majority of them were hypertensive (N.=26, 74.3%), and a quarter of them were on anticoagulant treatment (N.=9, 25%). The mean thrombin injection dose was 1000 U (range, 500-1500 U). In 34 of 35 (97.1%) patients, a thrombin injection resulted in complete thrombosis of the pseudoaneurysm lumen within a few seconds. There were no complications or recurrence of pseudoaneurysm after UGTI during the follow-up period. Conclusions: Throughout the study period of 14 years, we did not encounter any procedural complications or arterial pseudoaneurysm recurrence. This is attributed to a safe procedural technique and proper patient selection. UGTI for arterial pseudoaneurysms is a safe, successful, and convenient treatment for both patients and surgeons.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/drug therapy ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Hemostatics/administration & dosage ; Hemostatics/adverse effects ; Hospitals, University ; Humans ; Injections, Intra-Arterial ; Male ; Middle Aged ; Patient Selection ; Retrospective Studies ; Saudi Arabia ; Thrombin/administration & dosage ; Thrombin/adverse effects ; Ultrasonography, Doppler ; Ultrasonography, Interventional ; Young Adult
Chemical Substances	Hemostatics ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2020-02-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123583-7
ISSN	1827-1618 ; 0026-4725
ISSN (online)	1827-1618
ISSN	0026-4725
DOI	10.23736/S0026-4725.20.05112-9
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Article: Comparison of metabolite networks from four German population-based studies

Iqbal, Khalid

International journal of epidemiology, 47(6):2070-2081

2018

Abstract: BACKGROUND: Metabolite networks are suggested to reflect biological pathways in health and disease. However, it is unknown whether such metabolite networks are reproducible across different populations. Therefore, the current study aimed to investigate ... ...

Institution	Leibniz-Institut für Präventionsforschung und Epidemiologie Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Abstract	BACKGROUND: Metabolite networks are suggested to reflect biological pathways in health and disease. However, it is unknown whether such metabolite networks are reproducible across different populations. Therefore, the current study aimed to investigate similarity of metabolite networks in four German population-based studies. METHODS: One hundred serum metabolites were quantified in European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (n = 2458), EPIC-Heidelberg (n = 812), KORA (Cooperative Health Research in the Augsburg Region) (n = 3029) and CARLA (Cardiovascular Disease, Living and Ageing in Halle) (n = 1427) with targeted metabolomics. In a cross-sectional analysis, Gaussian graphical models were used to construct similar networks of 100 edges each, based on partial correlations of these metabolites. The four metabolite networks of the top 100 edges were compared based on (i) common features, i.e. number of common edges, Pearson correlation (r) and hamming distance (h); and (ii) meta-analysis of the four networks. RESULTS: Among the four networks, 57 common edges and 66 common nodes (metabolites) were identified. Pairwise network comparisons showed moderate to high similarity (r = 63–0.96, h = 7–72), among the networks. Meta-analysis of the networks showed that, among the 100 edges and 89 nodes of the meta-analytic network, 57 edges and 66 metabolites were present in all the four networks, 58–76 edges and 75–89 nodes were present in at least three networks, and 63–84 edges and 76–87 edges were present in at least two networks. The meta-analytic network showed clear grouping of 10 sphingolipids, 8 lyso-phosphatidylcholines, 31 acyl-alkyl-phosphatidylcholines, 30 diacyl-phosphatidylcholines, 8 amino acids and 2 acylcarnitines. CONCLUSIONS: We found structural similarity in metabolite networks from four large studies. Using a meta-analytic network, as a new approach for combining metabolite data from different studies, closely related metabolites could be identified, for some of which the biological relationships in metabolic pathways have been previously described. They are candidates for further investigation to explore their potential role in biological processes.
Keywords	Biological pathways ; Gaussian graphical models ; Meta-analysis ; Metabolomics ; Network analysis ; Reproducibility
Language	English
Document type	Article
Database	Repository for Life Sciences

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Book ; Online ; E-Book: Oral health and herbal medicine

Hakeem, Khalid Rehman / Abdul, Waseem Mohammed / Hussain, Mohd Muzzammil / Razvi, Syed Shoeb Iqbal

(SpringerBriefs in public health)

2019

Author's details	Khalid Rehman Hakeem, Waseem Mohammed Abdul, Mohd Muzzammil Hussain, Syed Shoeb Iqbal Razvi
Series title	SpringerBriefs in public health
Language	English
Size	1 Online-Ressource (x, 46 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019930228
ISBN	978-3-030-04336-0 ; 9783030043353 ; 3-030-04336-3 ; 3030043355
DOI	10.1007/978-3-030-04336-0
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Tau and Alzheimer's disease: Past, present and future.

Iqbal, Khalid

Cytoskeleton (Hoboken, N.J.)

2023 Volume 81, Issue 1, Page(s) 116–121

Abstract: My journey with tau started when in 1974 for the first time I isolated neurofibrillary tangles of paired helical filaments (PHFs) from autopsied Alzheimer's disease (AD) brains and discovered that they were made up of a ~50-70 KDa protein on SDS- ... ...

Abstract	My journey with tau started when in 1974 for the first time I isolated neurofibrillary tangles of paired helical filaments (PHFs) from autopsied Alzheimer's disease (AD) brains and discovered that they were made up of a ~50-70 KDa protein on SDS-polyacrylamide gels. Subsequently my team discovered that this PHF protein and the microtubule-associated factor called tau were one and the same protein. However, we found that tau in neurofibrillary tangles/PHFs in AD brain was abnormally hyperphosphorylated, and unlike normal tau, which promoted the assembly of tubulin into microtubules, the AD-hyperphosphorylated tau inhibited microtubule assembly. These discoveries of tau pathology in AD opened a new and a major area of research on tau and on the molecular pathology of this major cause of dementia in middle- and old-age individuals. Tau pathology, which without fail is made up of the aggregated hyperphosphorylated state of the protein, is also the hallmark lesion of a family of around 20 related neurodegenerative diseases, called tauopathies. Currently, tau pathology is a major drug target for the treatment of AD and related tauopathies. Both active and passive tau immunization human clinical trials at various stages are underway. Initial results range from negative to partially promising. Future studies will reveal whether tau therapy alone or in combination with drugs targeting Aβ and/or neurodegeneration will be required to achieve the most effective treatment for AD and related disorders.
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; tau Proteins ; Neurofibrillary Tangles/metabolism ; Neurofibrillary Tangles/pathology ; Tauopathies/metabolism ; Tauopathies/pathology ; Microtubules/metabolism
Chemical Substances	tau Proteins
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2534372-5
ISSN	1949-3592 ; 1949-3584
ISSN (online)	1949-3592
ISSN	1949-3584
DOI	10.1002/cm.21822
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Article ; Online: Thinking beyond the Aducanumab Controversy.

Iqbal, Khalid

Annals of neurology

2021 Volume 90, Issue 6, Page(s) 1003–1004

MeSH term(s)	Amyloid beta-Peptides ; Antibodies, Monoclonal, Humanized ; Humans
Chemical Substances	Amyloid beta-Peptides ; Antibodies, Monoclonal, Humanized ; aducanumab (105J35OE21)
Language	English
Publishing date	2021-11-05
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.26252
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Zs.A 1370: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 478: Show issues

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Article: Explaining decisions of a light-weight deep neural network for real-time coronary artery disease classification in magnetic resonance imaging.

Iqbal, Talha / Khalid, Aaleen / Ullah, Ihsan

Journal of real-time image processing

2024 Volume 21, Issue 2, Page(s) 31

Abstract: In certain healthcare settings, such as emergency or critical care units, where quick and accurate real-time analysis and decision-making are required, the healthcare system can leverage the power of artificial intelligence (AI) models to support ... ...

Abstract	In certain healthcare settings, such as emergency or critical care units, where quick and accurate real-time analysis and decision-making are required, the healthcare system can leverage the power of artificial intelligence (AI) models to support decision-making and prevent complications. This paper investigates the optimization of healthcare AI models based on time complexity, hyper-parameter tuning, and XAI for a classification task. The paper highlights the significance of a lightweight convolutional neural network (CNN) for analysing and classifying Magnetic Resonance Imaging (MRI) in real-time and is compared with CNN-RandomForest (CNN-RF). The role of hyper-parameter is also examined in finding optimal configurations that enhance the model's performance while efficiently utilizing the limited computational resources. Finally, the benefits of incorporating the XAI technique (e.g. GradCAM and Layer-wise Relevance Propagation) in providing transparency and interpretable explanations of AI model predictions, fostering trust, and error/bias detection are explored. Our inference time on a MacBook laptop for 323 test images of size 100x100 is only 2.6 sec, which is merely 8 milliseconds per image while providing comparable classification accuracy with the ensemble model of CNN-RF classifiers. Using the proposed model, clinicians/cardiologists can achieve accurate and reliable results while ensuring patients' safety and answering questions imposed by the General Data Protection Regulation (GDPR). The proposed investigative study will advance the understanding and acceptance of AI systems in connected healthcare settings.
Language	English
Publishing date	2024-02-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2280192-3
ISSN	1861-8219 ; 1861-8200
ISSN (online)	1861-8219
ISSN	1861-8200
DOI	10.1007/s11554-023-01411-7
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Book ; Conference proceedings: Alzheimer's disease

Iqbal, Khalid

new advances ; collection of selected articles of papers presented at the 10th International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain, July 15 - 20, 2006

2007

Title variant	Alzheimer's disease: new advances
Event/congress	International Conference on Alzheimer's Disease and Related Disorders (10, 2006, Madrid)
Author's details	ed. Khalid Iqbal
Subject code	616
Language	English
Size	XXVI, 698 S. : Ill., graph. Darst.
Publisher	Medimond
Publishing place	Bologna
Publishing country	Italy
Document type	Book ; Conference proceedings
Note	Contains bibliographies, summaries and authors index. - Proceedings
HBZ-ID	HT015118704
ISBN	978-88-7587-322-6 ; 88-7587-322-4
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2007 A 2855	order for loan	Magazin

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Book: Thyroid disorders

Imam, Syed Khalid / Ahmad, Shamim I.

basic science and clinical practice

2016

Author's details	Syed Khalid Imam, Shamim I. Ahmad editors
Keywords	Thyroid gland/Diseases
Subject code	616.44
Language	English
Size	xvi, 320 Seiten, Illustrationen, Diagramme, 26 cm
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book
Note	Includes bibliographical references
HBZ-ID	HT018941787
ISBN	978-3-319-25869-0 ; 978-3-319-25871-3 ; 3-319-25869-9 ; 3-319-25871-0
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2016 A 884	available for loan (reading room)	Lesesaal EG

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Article: Quality of life, depression and dietary intake in Obstructive Sleep Apnea patients

Boeing, Heiner / Iqbal, Khalid

Health and quality of life outcomes, 14:111

2016

Abstract: BACKGROUND The aim of this study was to analyze the association between depression, quality of life and dietary intake in newly diagnosed Obstructive Sleep Apnea (OSA) patients. METHODS From 153 eligible patients suffering from sleep disturbances, 64 met ...

Institution	Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Abstract	BACKGROUND The aim of this study was to analyze the association between depression, quality of life and dietary intake in newly diagnosed Obstructive Sleep Apnea (OSA) patients. METHODS From 153 eligible patients suffering from sleep disturbances, 64 met inclusion and exclusion criteria. The polysomnography was used for OSA diagnosis. The quality of life (QOL) was assessed by WHOQOL-BREF questionnaire, self-reported chronotype by morningness-eveningness questionnaire and level of depression by Beck’s Depression Inventory. Blood pressure and parameters of glucose and lipid metabolism were assessed by routine methods. The dietary intake was evaluated by 24-hr dietary recalls. RESULTS Significantly negative associations were found between depression inventory and QOL. Better QOL for physical health and social relationships was observed in the “definitely morning” chronotype. The “morning type” of patients was positively related to the intake of fat, monounsaturated fatty acids and vitamin B12. Correlations between QOL and diastolic blood pressure, HDL-cholesterol, TG, fasting glucose, as well as protein and vitamin B6 intake were found. CONCLUSIONS In conclusion, both chornotype and depression influence QOL in OSA patients where morning type is associated with better physical health and social relationships and increase in depression index deteriorate physical health, psychological and social relationship QOL domains. QOL as well as depression and chornotype are also influenced by selected cardio-metabolic factors and dietary intake.
Keywords	Chronotype ; Biomarkers ; Diet ; Sleep Apnea
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: Meal analysis for understanding eating behavior: meal- and participant-specific predictors for the variance in energy and macronutrient intake

Schwedhelm, Carolina / Iqbal, Khalid / Schwingshackl, Lukas / Boeing, Heiner / Knüppel, Sven

Nutrition journal, 18:15

2019

Abstract: BACKGROUND: Meals differ in their nutritional content. This variation has not been fully addressed despite its potential contribution in understanding eating behavior. The aim of this study was to investigate the between-meal and between-individual ... ...

Institution	Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Abstract	BACKGROUND: Meals differ in their nutritional content. This variation has not been fully addressed despite its potential contribution in understanding eating behavior. The aim of this study was to investigate the between-meal and between-individual variance in energy and macronutrient intake as a measure of variation in intake and the meal type-specific relative importance of predictors of these intake variations. METHODS: Energy and macronutrient intake were derived from three 24 h dietary recalls in an EPIC-Potsdam sub-cohort of 814 German adults. Intra-class correlation was calculated for participants and meal type. Predictors of intake were assessed using meal type-specific multilevel regression models in a structural equation modeling framework at intake and participant levels using the Pratt Index. The importance of the predictor energy misreporting was assessed in sensitivity analyses on 682 participants. 95% confidence intervals were calculated based on 1000 bootstrap samples. RESULTS: Differences between meal types explain a large proportion of the variation in intake (intra-class correlation: 39% for energy, 25% for carbohydrates, 47% for protein, and 33% for fat). Between-participant variation in intake was much lower, with a maximum of 3% for carbohydrate and fat. Place of meal was the most important intake-level predictor of energy and macronutrient intake (Pratt Index of up to 65%). Week/weekend day was important in the breakfast meal, and prior interval (hours passed since last meal) was important for the afternoon snack and dinner. On the participant level, sex was the most important predictor, with Pratt Index of up to 95 and 59% in the main and in the sensitivity analysis, respectively. Energy misreporting was especially important at the afternoon snack, accounting for up to 69% of the explained variance. CONCLUSIONS: The meal type explains the highest variation in energy and macronutrient intakes. We identified key predictors of variation in the intake and in the participant levels. These findings suggest that successful dietary modification efforts should focus on improving specific meals.
Keywords	Dietary intake ; EPIC Potsdam study ; Meal-based analysis ; Multilevel analysis ; Sources of variation
Language	English
Document type	Article
Database	Repository for Life Sciences

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