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  1. Book: Fluorescence-guided neurosurgery

    Hadjipanayis, Costas G. / Stummer, Walter

    neuro-oncology and cerebrovascular applications

    2019  

    Author's details [edited by] Constantinos G. Hadjipanayis, Walter Stummer
    Keywords Neurosurgical Procedures ; Fluorescent Dyes ; Brain Neoplasms ; Cerebrovascular Disorders ; Contrast Media ; Brain Mapping
    Language English
    Size xviii, 149 Seiten, Illustrationen
    Publisher Thieme
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code ; Includes bibliographical references
    HBZ-ID HT019869853
    ISBN 978-1-62623-714-8 ; 1-62623-714-X ; 9781626237155 ; 1626237158
    Database Catalogue ZB MED Medicine, Health

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    2018 A 1910 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies.

    Stummer, Walter / Müther, Michael / Spille, Dorothee

    Acta neurochirurgica

    2024  Volume 166, Issue 1, Page(s) 163

    Abstract: Glioblastoma is the most common primary malignant brain tumor. Despite advances in multimodal concepts over the last decades, prognosis remains poor. Treatment of patients with glioblastoma remains a considerable challenge due to the infiltrative nature ... ...

    Abstract Glioblastoma is the most common primary malignant brain tumor. Despite advances in multimodal concepts over the last decades, prognosis remains poor. Treatment of patients with glioblastoma remains a considerable challenge due to the infiltrative nature of the tumor, rapid growth rates, and tumor heterogeneity. Standard therapy consists of maximally safe microsurgical resection followed by adjuvant radio- and chemotherapy with temozolomide. In recent years, local therapies have been extensively investigated in experimental as well as translational levels. External stimuli-responsive therapies such as Photodynamic Therapy (PDT), Sonodynamic Therapy (SDT) and Radiodynamic Therapy (RDT) can induce cell death mechanisms via generation of reactive oxygen species (ROS) after administration of five-aminolevulinic acid (5-ALA), which induces the formation of sensitizing porphyrins within tumor tissue. Preliminary data from clinical trials are available. The aim of this review is to summarize the status of such therapeutic approaches as an adjunct to current standard therapy in glioblastoma.
    MeSH term(s) Humans ; Glioblastoma/surgery ; Aminolevulinic Acid/therapeutic use ; Fluorescence ; Temozolomide ; Reactive Oxygen Species
    Chemical Substances Aminolevulinic Acid (88755TAZ87) ; Temozolomide (YF1K15M17Y) ; Reactive Oxygen Species
    Language English
    Publishing date 2024-04-02
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-024-06049-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 5-ALA fluorescence in indeterminate grade gliomas.

    Müther, Michael / Stummer, Walter

    Neurosurgical focus: Video

    2022  Volume 6, Issue 1, Page(s) V6

    Abstract: 5-Aminolevulinic acid (5-ALA) is a useful and well-established adjunct for glioblastoma surgery. A growing body of evidence has revealed the potential utility of 5-ALA in grade II and grade III glioma patients as well. However, reliable means of ... ...

    Abstract 5-Aminolevulinic acid (5-ALA) is a useful and well-established adjunct for glioblastoma surgery. A growing body of evidence has revealed the potential utility of 5-ALA in grade II and grade III glioma patients as well. However, reliable means of identifying in whom fluorescence will occur have not been established. The authors report the case of such an indeterminate-grade glioma highlighting two pearls of 5-ALA fluorescence in this subgroup of patients. Firstly, 5-ALA-guided tissue sampling helps to ensure that the true grade of the lesion is not underestimated. Secondly, intraoperative fluorescence can serve as a prognostic marker. The video can be found here: https://stream.cadmore.media/r10.3171/2021.10.FOCVID21196.
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Journal Article
    ISSN 2643-5217
    ISSN (online) 2643-5217
    DOI 10.3171/2021.10.FOCVID21196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Normal Pressure Hydrocephalus and Comorbidities: A Quality Study of the University Hospital Münster.

    Nienhaus, Susanne / Stummer, Walter / Khaleghi Ghadiri, Maryam

    World neurosurgery

    2023  

    Abstract: Objective: Idiopathic normal pressure hydrocephalus (NPH) is commonly accompanied by diverse comorbidities that impact the postoperative course and result in a distinction between shunt responders and shunt non-responders. This study aimed to enhance ... ...

    Abstract Objective: Idiopathic normal pressure hydrocephalus (NPH) is commonly accompanied by diverse comorbidities that impact the postoperative course and result in a distinction between shunt responders and shunt non-responders. This study aimed to enhance diagnostics by identifying prognostic differences between NPH patients, individuals with comorbidities, and those with other complications.
    Methods: The data of 119 patients with NPH coding at the University Clinic Münster from January 2009 to June 2017 were examined. The study primarily concentrated on examining symptoms, comorbidities, and radiological measurements, including callosal angle (CA) and Evans index (EI). To evaluate the progression of symptoms, a novel scoring system was developed to quantitatively assess the course at specific time points: 5-7 weeks, 1-1.5 years, and 2.5 years after the operation. This scoring system aimed to provide a standardized approach for measuring and tracking the development of symptoms over time. Logistic regression analyses were employed to identify predictor associated with 3 key outcomes: shunt implantation, surgical success, and the development of complications.
    Results: Among the comorbidities observed, hypertension was the most prevalent. Gait disturbance, in the absence of polyneuropathy, was identified as a predictor of a favorable surgical outcome. Hygroma development was associated with a combination of vascular factors and cognitive disorders. The presence of spinal/skeletal changes, diabetes, and vascular constellations were found to increase the likelihood of developing complications.
    Conclusions: The evaluation of comorbidities accompanied by NPH holds significant importance and necessitates meticulous observation, expertise, and multidisciplinary care.
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Comment on Hosmann et al. 5-ALA Fluorescence Is a Powerful Prognostic Marker during Surgery of Low-Grade Gliomas (WHO Grade II)-Experience at Two Specialized Centers.

    Stummer, Walter / Thomas, Christian

    Cancers

    2021  Volume 13, Issue 22

    Abstract: With great interest, we have read the paper by Hosmann et al. [ ... ]. ...

    Abstract With great interest, we have read the paper by Hosmann et al. [...].
    Language English
    Publishing date 2021-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13225634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intra-operative tissue diagnosis: isn't it time for some reporting guidelines?

    Stummer, Walter

    Acta neurochirurgica

    2016  Volume 159, Issue 2, Page(s) 369–370

    Language English
    Publishing date 2016-12-23
    Publishing country Austria
    Document type Editorial ; Comment
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-016-3057-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Factors confounding fluorescein-guided malignant glioma resections: edema bulk flow, dose, timing, and now: imaging hardware?

    Stummer, Walter

    Acta neurochirurgica

    2016  Volume 158, Issue 2, Page(s) 327–328

    Language English
    Publishing date 2016-02
    Publishing country Austria
    Document type Letter
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-015-2655-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Commentary: Combining 5-Aminolevulinic Acid Fluorescence and Intraoperative Magnetic Resonance Imaging in Glioblastoma Surgery: A Histology-Based Evaluation.

    Stummer, Walter

    Neurosurgery

    2016  Volume 78, Issue 4, Page(s) 484–486

    MeSH term(s) Aminolevulinic Acid ; Brain Neoplasms/surgery ; Fluorescence ; Glioblastoma ; Humans ; Magnetic Resonance Imaging ; Photosensitizing Agents
    Chemical Substances Photosensitizing Agents ; Aminolevulinic Acid (88755TAZ87)
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 539: Show issues

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  9. Article ; Online: Poor man's fluorescence?

    Stummer, Walter

    Acta neurochirurgica

    2015  Volume 157, Issue 8, Page(s) 1379–1381

    Language English
    Publishing date 2015-09
    Publishing country Austria
    Document type Comment ; Letter
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-015-2471-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Thesis: Protektion des Gehirns durch spontane Lokomotion bei der zerebralen Ischämie

    Stummer, Walter

    experimentelle Untersuchungen mit Mongolischen Wüstenrenmäusen (Meriones Unguiculatus)

    1997  

    Author's details vorgelegt von Walter Stummer
    Keywords Brain Damage, Chronic / prevention & control ; Brain Ischemia ; Disease Models, Animal ; Gerbillinae
    Language German
    Size 62 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1997
    HBZ-ID HT008814395
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    98 D 1990 order for loan Magazin

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