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  1. Book ; Online: Features of Pathogenesis of Human Viral Infections and Antiviral Drugs

    Aquaro, Stefano

    2021  

    Keywords Medicine ; hRSV ; F gene ; G gene ; children ; respiratory diseases ; genotyping ; Saudi Arabia ; α chemokine receptor 4 ; β-chemokine receptor 5 ; human immunodeficiency virus ; monocyte-derived macrophages ; HPV ; sexually transmitted diseases (STDs) ; laboratory methods ; PCR ; genotypes ; surveillance ; epidemiology ; exopolysaccharides ; lactic acid bacteria ; human adenovirus type 5 ; antiviral activity ; cell cycle ; prevalence ; hepatitis B virus ; genotype ; bahrain ; sRAGE ; oxidative stress ; inflammation ; warts
    Size 1 electronic resource (84 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044071
    ISBN 9783039439188 ; 3039439189
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The Ongoing Impact of COVID-19 on Pediatric Obesity.

    Iacopetta, Domenico / Catalano, Alessia / Ceramella, Jessica / Pellegrino, Michele / Marra, Maria / Scali, Elisabetta / Sinicropi, Maria Stefania / Aquaro, Stefano

    Pediatric reports

    2024  Volume 16, Issue 1, Page(s) 135–150

    Abstract: In the developed world, pediatric obesity (PO) has been a major health concern since the last century, and this condition may lead to detrimental life-long physical and mental comorbidities. Currently, its prevalence has increased in low- and middle- ... ...

    Abstract In the developed world, pediatric obesity (PO) has been a major health concern since the last century, and this condition may lead to detrimental life-long physical and mental comorbidities. Currently, its prevalence has increased in low- and middle-income countries and in many high-income countries. Thus, the provision of effective and tailored care for children and their families has become vital. The social consequences of the COVID-19 pandemic are known everywhere, and among these, it has been argued that the COVID-19 pandemic has had a major impact on PO. Overall, the growth of PO over the last decade has been enhanced by the pandemic. During the COVID-19 pandemic, children, adolescents and young adults gained weight as the pediatric population dealt with sedentary lifestyles and changes in food habits. In this review, we want to highlight the impact that the COVID-19 pandemic had on PO.
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric16010013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Enhancing the Anticancer and Anti-Inflammatory Properties of Curcumin in Combination with Quercetin, for the Prevention and Treatment of Prostate Cancer.

    Pellegrino, Michele / Bevacqua, Emilia / Frattaruolo, Luca / Cappello, Anna Rita / Aquaro, Stefano / Tucci, Paola

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: Prostate cancer is the second most common cancer in men. Although epidemiologic studies show that a higher intake of polyphenols, curcumin (CUR), and quercetin (QRT), in particular, result in lower prostate cancer risk, the chemopreventive mechanisms ... ...

    Abstract Prostate cancer is the second most common cancer in men. Although epidemiologic studies show that a higher intake of polyphenols, curcumin (CUR), and quercetin (QRT), in particular, result in lower prostate cancer risk, the chemopreventive mechanisms underlying the effects of CUR and QRT have not been fully understood yet, and most investigations were conducted with individual compounds. Here, we investigated the anticancer and anti-inflammatory effects of CUR in combination with QRT, respectively, in a human prostate cancer cell line, PC-3, and in LPS-stimulated RAW 264.7 cells, and found that their combination significantly inhibited proliferation and arrested the cell cycle, inducing apoptosis, so exhibiting synergic activities stronger than single drug use. Moreover, via their antioxidant effects, the combination of CUR and QRT modulated several inflammation-mediated signaling pathways (ROS, nitric oxide, and pro-inflammatory cytokines) thus helping protect cells from undergoing molecular changes that trigger carcinogenesis. Although additional studies, including in vivo experiments and translational studies, are required, this study raises the possibility of their use as a safe, effective, and affordable therapeutic approach to prostate cancer.
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11072023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Specific synonymous mutations tightly correlate with HIV-1 co-receptor usage and differentially affect the secondary structure of HIV-1 Env RNA.

    Dimonte, Salvatore / Fabeni, Lavinia / Pellegrino, Michele / Aquaro, Stefano

    Acta virologica

    2021  Volume 65, Issue 2, Page(s) 173–180

    Abstract: Human immunodeficiency virus (HIV) is a pathogen that infects blood cells, using CD4 molecule and two cell receptors CCR5 and CXCR4. The other major actor is gp120/gp41 viral protein complex, which interacts with receptors. Here, the presence of ... ...

    Abstract Human immunodeficiency virus (HIV) is a pathogen that infects blood cells, using CD4 molecule and two cell receptors CCR5 and CXCR4. The other major actor is gp120/gp41 viral protein complex, which interacts with receptors. Here, the presence of synonymous mutations associated with HIV-1 tropism and the related RNA secondary-structure in HIV-1 infected patients was evaluated. The analysis includes gp120-sequences from 340 HIV-1 subtype-B infected patients, all retrieved from Los Alamos database and with phenotypic HIV tropism determination based on recombinant-virus entry-assay. Frequencies of all nucleotide substitutions were calculated. Mfold and RNAfold algorithms were used to predict RNA secondary-structure of HIV-1. Nineteen codons in V2/C2, V3 and C3 domains were found to be closely related to CCR5 and CXCR4. Additionally, in X4-sequences, gp120 gca303gcu and gua222guc synonymous mutations are positively related to the gp120 S11R and T8A/I codons in V3 protein domain. Furthermore, gua222guc increases stability of the viral RNA secondary-structure. Probably, it would not be surprising if a novel escape viral strategy therapy will be related to the gp120 synonymous mutations. Moreover, in relation to the pivotal role played by gp120 in polyvalent vaccine approaches, the impact of gp120 synonymous mutations may play an important role in HIV entry into the cell. Keywords: gp120; tropism; v3; s11r; evolution; vaccine.
    MeSH term(s) HIV Infections/genetics ; HIV-1/genetics ; Humans ; RNA ; Receptors, CCR5/genetics ; Silent Mutation
    Chemical Substances Receptors, CCR5 ; RNA (63231-63-0)
    Language English
    Publishing date 2021-06-15
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 210452-0
    ISSN 1336-2305 ; 0001-723X
    ISSN (online) 1336-2305
    ISSN 0001-723X
    DOI 10.4149/av_2021_211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 336: Show issues Location:
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  5. Article ; Online: Silver and Gold Complexes with NHC-Ligands Derived from Caffeine: Catalytic and Pharmacological Activity.

    Mariconda, Annaluisa / Iacopetta, Domenico / Sirignano, Marco / Ceramella, Jessica / D'Amato, Assunta / Marra, Maria / Pellegrino, Michele / Sinicropi, Maria Stefania / Aquaro, Stefano / Longo, Pasquale

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: ... ...

    Abstract N
    MeSH term(s) Humans ; Silver/chemistry ; Gold/chemistry ; Caffeine ; Anti-Bacterial Agents/pharmacology ; Methane/chemistry ; Methane/analogs & derivatives ; Neoplasms ; Heterocyclic Compounds/chemistry ; Coordination Complexes/chemistry
    Chemical Substances Silver (3M4G523W1G) ; Gold (7440-57-5) ; Caffeine (3G6A5W338E) ; carbene (2465-56-7) ; Anti-Bacterial Agents ; Methane (OP0UW79H66) ; Heterocyclic Compounds ; Coordination Complexes
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages.

    Aquaro, Stefano / Borrajo, Ana / Pellegrino, Michele / Svicher, Valentina

    Virulence

    2020  Volume 11, Issue 1, Page(s) 400–413

    Abstract: Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of ... ...

    Abstract Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellular reservoir, including monocyte-derived macrophages (MDM), that means the principal obstacle to HIV cure. MDM are widely distributed in all tissues and organs, including central system nervous (CNS) where they represent the most frequent HIV-infected cells that means the principal obstacle to HIV cure. Current FDA-approved antiretroviral drugs target viral reverse transcriptase, protease, integrase, and entry processes (coreceptor or fusion blockade). It is desirable to continue to develop new antiretrovirals directed against alternative targets in the virus lifecycle in order to further optimize therapeutic options, overcome resistance to existing medications, and potentially contribute to the elimination of viral reservoirs.This review provides a comprehensive overview of the activity of antiretroviral drugs (classical and upcoming) in monocytes-derived macrophages (MDM). Defining the antiviral activity of these drugs in this important cellular HIV-1 reservoir provides crucial hints about their efficacy in HIV-1 infected patients.
    MeSH term(s) Animals ; Anti-Retroviral Agents/pharmacology ; Central Nervous System/virology ; Clinical Trials as Topic ; Disease Reservoirs/virology ; HIV Infections/virology ; HIV-1/drug effects ; Humans ; Macrophages/chemistry ; Macrophages/drug effects ; Macrophages/virology ; Mice ; Virus Replication/drug effects
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2020.1760443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Crucial Role of Central Nervous System as a Viral Anatomical Compartment for HIV-1 Infection.

    Borrajo, Ana / Svicher, Valentina / Salpini, Romina / Pellegrino, Michele / Aquaro, Stefano

    Microorganisms

    2021  Volume 9, Issue 12

    Abstract: The chronic infection established by the human immunodeficiency virus 1 (HIV-1) produces serious CD4+ T cell immunodeficiency despite the decrease in HIV-1 ribonucleic acid (RNA) levels and the raised life expectancy of people living with HIV-1 (PLWH) ... ...

    Abstract The chronic infection established by the human immunodeficiency virus 1 (HIV-1) produces serious CD4+ T cell immunodeficiency despite the decrease in HIV-1 ribonucleic acid (RNA) levels and the raised life expectancy of people living with HIV-1 (PLWH) through treatment with combined antiretroviral therapies (cART). HIV-1 enters the central nervous system (CNS), where perivascular macrophages and microglia are infected. Serious neurodegenerative symptoms related to HIV-associated neurocognitive disorders (HAND) are produced by infection of the CNS. Despite advances in the treatment of this infection, HAND significantly contribute to morbidity and mortality globally. The pathogenesis and the role of inflammation in HAND are still incompletely understood. Principally, growing evidence shows that the CNS is an anatomical reservoir for viral infection and replication, and that its compartmentalization can trigger the evolution of neurological damage and thus make virus eradication more difficult. In this review, important concepts for understanding HAND and neuropathogenesis as well as the viral proteins involved in the CNS as an anatomical reservoir for HIV infection are discussed. In addition, an overview of the recent advancements towards therapeutic strategies for the treatment of HAND is presented. Further neurological research is needed to address neurodegenerative difficulties in people living with HIV, specifically regarding CNS viral reservoirs and their effects on eradication.
    Language English
    Publishing date 2021-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9122537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Associated effects of clinical characteristics, risk factors, and comorbidity on disease severity and mortality among patients with COVID-19 in Sulaimani City/ Kurdistan Region of Iraq.

    Aziz-Mawlood, Shakhawan / Ali, Salar Ibrahim / Babakir-Mina, Muhammed / Angeletti, Silvia / Dimonte, Salvatore / Pellegrino, Michele / Ciccozzi, Massimo / Aquaro, Stefano

    The new microbiologica

    2023  Volume 46, Issue 2, Page(s) 170–185

    Abstract: The effects of clinical symptoms, laboratory indicators, and comorbidity status of SARS-CoV-2-infected patients on the severity of disease and the risk of death were investigated. Questionnaires and electronic medical records of 371 hospitalized COVID-19 ...

    Abstract The effects of clinical symptoms, laboratory indicators, and comorbidity status of SARS-CoV-2-infected patients on the severity of disease and the risk of death were investigated. Questionnaires and electronic medical records of 371 hospitalized COVID-19 patients were used for data collection (demographics, clinical manifestation, comorbidities, laboratory data). Association among categorical variables was determined using Kolmogorov-Smirnov test (P-value ≤0.05). Median age of study population (249 males, 122 females) was 65 years. Roc curves analysis found that age ≥64 years and age ≥67 years are significant cut-offs identifying patients with more severe disease and mortality at 30 days. CRP values at cut-off ≥80.7 and ≥95.8 significantly identify patients with more severe disease and mortality. Patients with more severe disease and risk of death were significantly identified with platelet value at the cut-off ≤160,000, hemoglobin value at the cut-off ≤11.7, D-Dimer values ≥1383 and ≥1270, and with values of neutrophil granulocytes (≥8.2 and ≤2) and lymphocytes (≤2 and ≤2.4). Detailed clinical investigation suggests granulocytes together with lymphopenia may be a potential indicator for diagnosis. Older age, several comorbidities (cancer, cardiovascular diseases, hypertension) and more laboratory abnormalities (CRP, D-Dimer, platelets, hemoglobin) were associated with development of more severity and mortality among COVID-19 patients.
    MeSH term(s) Male ; Female ; Humans ; Aged ; Middle Aged ; COVID-19/epidemiology ; SARS-CoV-2 ; Iraq/epidemiology ; Retrospective Studies ; Comorbidity ; Risk Factors ; Patient Acuity
    Language English
    Publishing date 2023-05-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 756168-4
    ISSN 1121-7138 ; 0391-5352
    ISSN 1121-7138 ; 0391-5352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2267: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Cachrys

    Perri, Maria Rosaria / Pellegrino, Michele / Aquaro, Stefano / Cavaliere, Fabiola / Lupia, Carmine / Uzunov, Dimitar / Marrelli, Mariangela / Conforti, Filomena / Statti, Giancarlo

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 21

    Abstract: Different phytochemical compounds have been demonstrated to modulate the JAK/STAT signaling pathway. Here, ... ...

    Abstract Different phytochemical compounds have been demonstrated to modulate the JAK/STAT signaling pathway. Here, three
    Language English
    Publishing date 2022-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11212913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Synthesis of Novel

    Ceramella, Jessica / Troiano, Rubina / Iacopetta, Domenico / Mariconda, Annaluisa / Pellegrino, Michele / Catalano, Alessia / Saturnino, Carmela / Aquaro, Stefano / Sinicropi, Maria Stefania / Longo, Pasquale

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: ... ...

    Abstract Ruthenium
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12040693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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