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  1. Article ; Online: Assessment of the Impact of Cytokines on T

    Papillion, Amber / Jenkins, Meagan M / Ballesteros-Tato, André

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2380, Page(s) 189–199

    Abstract: Within the last several years, great strides have been made in understanding the molecular and cellular mechanisms that control the generation of T follicular helper ( ... ...

    Abstract Within the last several years, great strides have been made in understanding the molecular and cellular mechanisms that control the generation of T follicular helper (T
    MeSH term(s) Cytokines ; Humans ; Influenza, Human ; T-Lymphocytes, Helper-Inducer ; T-Lymphocytes, Regulatory
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-11-20
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1736-6_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mechanistic inferences from clinical reports of SARS-CoV-2.

    Jenkins, Meagan M / McCaw, Tyler R / Goepfert, Paul A

    Infectious diseases (London, England)

    2020  Volume 52, Issue 8, Page(s) 527–537

    Abstract: SARS-CoV-2 was identified as the causative pathogen in an outbreak of viral pneumonia cases originating in Wuhan, China, with an ensuing rapid global spread that led it to be declared a pandemic by the WHO on March 11, 2020. Given the threat to public ... ...

    Abstract SARS-CoV-2 was identified as the causative pathogen in an outbreak of viral pneumonia cases originating in Wuhan, China, with an ensuing rapid global spread that led it to be declared a pandemic by the WHO on March 11, 2020. Given the threat to public health posed by sequelae of SARS-CoV-2 infection, the literature surrounding patient presentation in severe and non-severe cases, transmission rates and routes, management strategies, and initial clinical trial results have become available at an unprecedented pace. In this review we collate current clinical and immunologic reports, comparing these to reports of previous coronaviruses to identify mechanisms driving progression to severe disease in some patients. In brief, we propose a model wherein dysregulated type I interferon signalling leads to aberrant recruitment and accumulation of innate immune lineages in the lung, impairing establishment of productive adaptive responses, and permitting a pathologic pro-inflammatory state. Finally, we extend these findings to suggest possible treatment options that may merit investigation in randomized clinical trials.
    MeSH term(s) Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Immunity, Innate ; Immunologic Memory ; Lung/immunology ; Lung/virology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2020.1769853
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 600: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Lung dendritic cells migrate to the spleen to prime long-lived TCF1

    Jenkins, Meagan M / Bachus, Holly / Botta, Davide / Schultz, Michael D / Rosenberg, Alexander F / León, Beatriz / Ballesteros-Tato, André

    Science immunology

    2021  Volume 6, Issue 63, Page(s) eabg6895

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Cell Movement/immunology ; Dendritic Cells/immunology ; Hepatocyte Nuclear Factor 1-alpha/immunology ; Humans ; Lung/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Orthomyxoviridae Infections/immunology ; Precursor Cells, T-Lymphoid/immunology ; Spleen/immunology
    Chemical Substances Hepatocyte Nuclear Factor 1-alpha ; Hnf1a protein, mouse
    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abg6895
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  4. Article ; Online: Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants.

    Jenkins, Meagan M / Phan Tran, Donna / Flores, Evelyn A / Kupferwasser, Deborah / Pickering, Harry / Zheng, Ying / Gjertson, David W / Ross, Ted M / Schaenman, Joanna M / Miller, Loren G / Yeaman, Michael R / Reed, Elaine F

    Frontiers in immunology

    2023  Volume 14, Page(s) 1139915

    Abstract: Introduction: SARS-CoV-2 is the etiologic agent of coronavirus disease 2019 (COVID-19). Questions remain regarding correlates of risk and immune protection against COVID-19.: Methods: We prospectively enrolled 200 participants with a high risk of ... ...

    Abstract Introduction: SARS-CoV-2 is the etiologic agent of coronavirus disease 2019 (COVID-19). Questions remain regarding correlates of risk and immune protection against COVID-19.
    Methods: We prospectively enrolled 200 participants with a high risk of SARS-CoV-2 occupational exposure at a U.S. medical center between December 2020 and April 2022. Participant exposure risks, vaccination/infection status, and symptoms were followed longitudinally at 3, 6, and 12 months, with blood and saliva collection. Serological response to the SARS-CoV-2 spike holoprotein (S), receptor binding domain (RBD) and nucleocapsid proteins (NP) were quantified by ELISA assay.
    Results: Based on serology, 40 of 200 (20%) participants were infected. Healthcare and non-healthcare occupations had equivalent infection incidence. Only 79.5% of infected participants seroconverted for NP following infection, and 11.5% were unaware they had been infected. The antibody response to S was greater than to RBD. Hispanic ethnicity was associated with 2-fold greater incidence of infection despite vaccination in this cohort.
    Discussion: Overall, our findings demonstrate: 1) variability in the antibody response to SARS-CoV-2 infection despite similar exposure risk; 2) the concentration of binding antibody to the SARS-CoV-2 S or RBD proteins is not directly correlated with protection against infection in vaccinated individuals; and 3) determinants of infection risk include Hispanic ethnicity despite vaccination and similar occupational exposure.
    MeSH term(s) Humans ; Antibodies ; COVID-19/epidemiology ; COVID-19/prevention & control ; Ethnicity ; Hispanic or Latino ; Nucleocapsid Proteins ; SARS-CoV-2 ; COVID-19 Vaccines ; Occupational Exposure ; Vaccination
    Chemical Substances Antibodies ; Nucleocapsid Proteins ; COVID-19 Vaccines
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1139915
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  5. Article ; Online: Mechanistic inferences from clinical reports of SARS-CoV-2

    Jenkins, Meagan M. / McCaw, Tyler R. / Goepfert, Paul A.

    Infectious Diseases

    2020  Volume 52, Issue 8, Page(s) 527–537

    Keywords Microbiology (medical) ; General Immunology and Microbiology ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2020.1769853
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Emerging harmful algal blooms caused by distinct seasonal assemblages of a toxic diatom.

    Sterling, Alexa R / Kirk, Riley D / Bertin, Matthew J / Rynearson, Tatiana A / Borkman, David G / Caponi, Marissa C / Carney, Jessica / Hubbard, Katherine A / King, Meagan A / Maranda, Lucie / McDermith, Emily J / Santos, Nina R / Strock, Jacob P / Tully, Erin M / Vaverka, Samantha B / Wilson, Patrick D / Jenkins, Bethany D

    Limnology and oceanography

    2022  Volume 67, Issue 11, Page(s) 2341–2359

    Abstract: Diatoms in ... ...

    Abstract Diatoms in the
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412737-7
    ISSN 0024-3590
    ISSN 0024-3590
    DOI 10.1002/lno.12189
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    In stock of ZB MED Bonn / Germany

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  7. Article: Mechanistic inferences from clinical reports of SARS-CoV-2

    Jenkins, Meagan M / McCaw, Tyler R / Goepfert, Paul A

    Infect Dis (Lond)

    Abstract: SARS-CoV-2 was identified as the causative pathogen in an outbreak of viral pneumonia cases originating in Wuhan, China, with an ensuing rapid global spread that led it to be declared a pandemic by the WHO on March 11, 2020. Given the threat to public ... ...

    Abstract SARS-CoV-2 was identified as the causative pathogen in an outbreak of viral pneumonia cases originating in Wuhan, China, with an ensuing rapid global spread that led it to be declared a pandemic by the WHO on March 11, 2020. Given the threat to public health posed by sequelae of SARS-CoV-2 infection, the literature surrounding patient presentation in severe and non-severe cases, transmission rates and routes, management strategies, and initial clinical trial results have become available at an unprecedented pace. In this review we collate current clinical and immunologic reports, comparing these to reports of previous coronaviruses to identify mechanisms driving progression to severe disease in some patients. In brief, we propose a model wherein dysregulated type I interferon signalling leads to aberrant recruitment and accumulation of innate immune lineages in the lung, impairing establishment of productive adaptive responses, and permitting a pathologic pro-inflammatory state. Finally, we extend these findings to suggest possible treatment options that may merit investigation in randomized clinical trials.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #382096
    Database COVID19

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  8. Book ; Online: Mechanistic Inferences from Clinical Reports of SARS-CoV-2

    Jenkins, Meagan M / McCaw, Tyler R / Goepfert, Paul A

    2020  

    Abstract: SARS-CoV-2 was identified as the causative pathogen in an outbreak of viral pneumonia cases originating in Wuhan, China, with an ensuing rapid global spread that led it to be declared a pandemic by the WHO on March 11, 2020. Given the threat to public ... ...

    Abstract SARS-CoV-2 was identified as the causative pathogen in an outbreak of viral pneumonia cases originating in Wuhan, China, with an ensuing rapid global spread that led it to be declared a pandemic by the WHO on March 11, 2020. Given the threat to public health posed by sequelae of SARS-CoV-2 infection, the literature surrounding patient presentation in severe and non-severe cases, transmission rates and routes, management strategies, and initial clinical trial results have become available at an unprecedented pace. In this review we collate current clinical and immunologic reports, comparing these to reports of previous coronaviruses to identify mechanisms driving progression to severe disease in some patients. In brief, we propose a model wherein dysregulated type I interferon signaling leads to aberrant recruitment and accumulation of innate immune lineages in the lung, impairing establishment of productive adaptive responses, and permitting a pathologic pro-inflammatory state. Finally, we extend these findings to suggest possible treatment options that may merit investigation in randomized clinical trials.
    Keywords covid19
    Publisher Center for Open Science
    Publishing country us
    Document type Book ; Online
    DOI 10.31219/osf.io/6q5bg
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates.

    Singh, Arun / Jenkins, Meagan A / Burke, Kenneth J / Beck, Goichi / Jenkins, Andrew / Scimemi, Annalisa / Traynelis, Stephen F / Papa, Stella M

    Cell reports

    2018  Volume 22, Issue 4, Page(s) 941–952

    Abstract: Dopamine (DA) loss in Parkinson's disease (PD) alters the function of striatal projection neurons (SPNs) and causes motor deficits, but DA replacement can induce further abnormalities. A key pathological change in animal models and patients is SPN ... ...

    Abstract Dopamine (DA) loss in Parkinson's disease (PD) alters the function of striatal projection neurons (SPNs) and causes motor deficits, but DA replacement can induce further abnormalities. A key pathological change in animal models and patients is SPN hyperactivity; however, the role of glutamate in altered DA responses remains elusive. We tested the effect of locally applied AMPAR or NMDAR antagonists on glutamatergic signaling in SPNs of parkinsonian primates. Following a reduction in basal hyperactivity by antagonists at either receptor, DA inputs induced SPN firing changes that were stable during the entire motor response, in clear contrast with the typically unstable effects. The SPN activity reduction over an extended putamenal area controlled the release of involuntary movements in the "on" state and therefore improved motor responses to DA replacement. These results demonstrate the pathophysiological role of upregulated SPN activity and support strategies to reduce striatal glutamate signaling for PD therapy.
    MeSH term(s) Animals ; Disease Models, Animal ; Dopamine/metabolism ; Neurons/metabolism ; Parkinson Disease/physiopathology ; Primates
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2018-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2017.12.095
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  10. Article: Dengue virus antibodies enhance Zika virus infection.

    Paul, Lauren M / Carlin, Eric R / Jenkins, Meagan M / Tan, Amanda L / Barcellona, Carolyn M / Nicholson, Cindo O / Michael, Scott F / Isern, Sharon

    Clinical & translational immunology

    2016  Volume 5, Issue 12, Page(s) e117

    Abstract: For decades, human infections with Zika virus (ZIKV), a mosquito-transmitted flavivirus, were sporadic, associated with mild disease, and went underreported since symptoms were similar to other acute febrile diseases. Recent reports of severe disease ... ...

    Abstract For decades, human infections with Zika virus (ZIKV), a mosquito-transmitted flavivirus, were sporadic, associated with mild disease, and went underreported since symptoms were similar to other acute febrile diseases. Recent reports of severe disease associated with ZIKV have greatly heightened awareness. It is anticipated that ZIKV will continue to spread in the Americas and globally where competent
    Language English
    Publishing date 2016-12-16
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1038/cti.2016.72
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