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  1. Article ; Online: Mechanistic insights into diuretic-induced insulin resistance.

    Dronavalli, Suma / Bakris, George L

    Hypertension (Dallas, Tex. : 1979)

    2008  Volume 52, Issue 6, Page(s) 1009–1011

    MeSH term(s) Antihypertensive Agents/adverse effects ; Diabetes Mellitus, Type 2/chemically induced ; Humans ; Hypertension/drug therapy ; Insulin Resistance ; Sodium Chloride Symporter Inhibitors/adverse effects
    Chemical Substances Antihypertensive Agents ; Sodium Chloride Symporter Inhibitors
    Language English
    Publishing date 2008-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.108.120923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Pharmacologic therapy of polycystic ovary syndrome.

    Dronavalli, Suma / Ehrmann, David A

    Clinical obstetrics and gynecology

    2007  Volume 50, Issue 1, Page(s) 244–254

    Abstract: Polycystic ovary syndrome (PCOS) is a multifaceted disorder that affects between 5% and 8% of women. As a syndrome, PCOS is comprised of reproductive, metabolic, and cardiovascular components. Hyperandrogenemia and hyperinsulinemia are central to the ... ...

    Abstract Polycystic ovary syndrome (PCOS) is a multifaceted disorder that affects between 5% and 8% of women. As a syndrome, PCOS is comprised of reproductive, metabolic, and cardiovascular components. Hyperandrogenemia and hyperinsulinemia are central to the pathogenesis of PCOS and thus typically serve as the targets for treatment. The spectrum of therapeutic options is broad and ranges from lifestyle intervention to specific pharmacologic agents. This chapter details current pharmacologic treatments for women with PCOS using a symptom-specific approach with a special focus on the metabolic effects of each treatment. Generally, oligomenorrhea mandates regulation of menstrual cyclicity and protection of the endometrium against the development of dysplasia and carcinoma. Progestins, either alone or in combination with estrogen (in the form of an oral contraceptive) are the mainstay of treatment of oligomenorrhea. Insulin lowering therapies also improve menstrual regularity. When androgen excess is the main target for therapy, an antiandrogen and/or oral contraceptives is typically chosen. Metabolic concerns of PCOS include excess body weight and insulin resistance. Metformin and thiazolidenediones both improve hyperinsulinemia but their differential effects on body weight must be considered.
    MeSH term(s) Amenorrhea/drug therapy ; Contraceptives, Oral, Hormonal/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Hyperandrogenism/drug therapy ; Metformin/therapeutic use ; Oligomenorrhea/drug therapy ; Polycystic Ovary Syndrome/drug therapy ; Thiazolidinediones/therapeutic use
    Chemical Substances Contraceptives, Oral, Hormonal ; Thiazolidinediones ; Metformin (9100L32L2N)
    Language English
    Publishing date 2007-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0b013e31802f35a0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The pathogenesis of diabetic nephropathy.

    Dronavalli, Suma / Duka, Irena / Bakris, George L

    Nature clinical practice. Endocrinology & metabolism

    2008  Volume 4, Issue 8, Page(s) 444–452

    Abstract: Between 20% and 40% of patients with diabetes ultimately develop diabetic nephropathy, which in the US is the most common cause of end-stage renal disease requiring dialysis. Diabetic nephropathy has several distinct phases of development and multiple ... ...

    Abstract Between 20% and 40% of patients with diabetes ultimately develop diabetic nephropathy, which in the US is the most common cause of end-stage renal disease requiring dialysis. Diabetic nephropathy has several distinct phases of development and multiple mechanisms contribute to the development of the disease and its outcomes. This Review provides a summary of the latest published data dealing with these mechanisms; it focuses not only on candidate genes associated with susceptibility to diabetic nephropathy but also on alterations in various cytokines and their interaction with products of advanced glycation and oxidant stress. Additionally, the interactions between fibrotic and hemodynamic cytokines, such as transforming growth factor beta1 and angiotensin II, respectively, are discussed in the context of new information concerning nephropathy development. We touch on the expanding clinical data regarding markers of nephropathy, such as microalbuminuria, and put them into context; microalbuminuria reflects cardiovascular and not renal risk. If albuminuria levels continue to increase over time then nephropathy is present. Lastly, we look at advances being made to enable identification of genetically predisposed individuals.
    MeSH term(s) Albuminuria/complications ; Albuminuria/metabolism ; Albuminuria/pathology ; Animals ; Cytokines/metabolism ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Genetic Predisposition to Disease ; Glycation End Products, Advanced/metabolism ; Humans ; Hyperglycemia/complications ; Hyperglycemia/metabolism ; Hyperglycemia/pathology
    Chemical Substances Cytokines ; Glycation End Products, Advanced
    Language English
    Publishing date 2008-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2228540-4
    ISSN 1745-8374 ; 1745-8366
    ISSN (online) 1745-8374
    ISSN 1745-8366
    DOI 10.1038/ncpendmet0894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Chronic kidney disease after nonrenal solid organ transplantation: a histological assessment and utility of chronic allograft damage index scoring.

    Kubal, Chandrashekhar / Cockwell, Paul / Gunson, Bridget / Jesky, Mark / Hanvesakul, Rajesh / Dronavalli, Vamsidhar / Bonser, Robert S / Neil, Desley

    Transplantation

    2012  Volume 93, Issue 4, Page(s) 406–411

    Abstract: ... for chronic allograft damage index parameters and for arteriolar hyalinosis. The sum of all chronic allograft ...

    Abstract Background: It is proposed that chronic calcineurin inhibitor (CNI) nephrotoxicity has a central role in chronic kidney disease after nonrenal solid organ transplantation (NRSOT), although there are little data on renal histology in this setting. The aim of this study was to assess the histological features and renal outcomes of a cohort of patients with chronic kidney disease after NRSOT.
    Methods: Renal biopsies of 62 NRSOT recipients were evaluated for histological diagnoses. Biopsies were graded for chronic allograft damage index parameters and for arteriolar hyalinosis. The sum of all chronic allograft damage index parameters and arteriolar hyalinosis scores was called chronic damage index.
    Results: The biopsies were performed at a median of 4 (range: 0.3-15.9) years after NRSOT and at serum creatinine of 318±17.7 μmol/L (mean±standard deviation). Twenty-two (35.5%) biopsies showed predominant features of chronic CNI nephrotoxicity, 27 (43.5%) predominant features of hypertensive nephropathy, and 12 (19.3%) an alternative primary renal pathology. Twenty-four (38.7%) patients had progression to end-stage renal disease, at a median of 1.5 (0-10.1) years after biopsy and 6.9 (0.3-19.2) years after NRSOT. The risk of renal progression was associated with in situ damage measured by chronic damage index.
    Conclusions: Although CNI nephrotoxicity is an important cause of renal failure after NRSOT, many patients do not have overt histological evidence of CNI toxicity. Quantitative parameters of chronic damage can stratify renal prognosis.
    MeSH term(s) Adult ; Aged ; Arterioles/metabolism ; Arterioles/pathology ; Biopsy ; Calcineurin Inhibitors ; Chronic Disease ; Cohort Studies ; Creatinine/blood ; Disease Progression ; Female ; Glomerular Filtration Rate/physiology ; Heart Transplantation ; Humans ; Hyalin/metabolism ; Kidney/metabolism ; Kidney/pathology ; Kidney/physiopathology ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/pathology ; Liver Transplantation ; Lung Transplantation ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Transplantation, Homologous
    Chemical Substances Calcineurin Inhibitors ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2012-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0b013e318240e984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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