Article ; Online: Imaging methods in mechanosensing: a historical perspective and visions for the future.
2021 Volume 32, Issue 9, Page(s) 842–854
Abstract: Over the past three decades, as mechanobiology has become a distinct area of study, researchers have developed novel imaging tools to discover the pathways of biomechanical signaling. Early work with substrate engineering and particle tracking ... ...
Abstract | Over the past three decades, as mechanobiology has become a distinct area of study, researchers have developed novel imaging tools to discover the pathways of biomechanical signaling. Early work with substrate engineering and particle tracking demonstrated the importance of cell-extracellular matrix interactions on the cell cycle as well as the mechanical flux of the intracellular environment. Most recently, tension sensor approaches allowed directly measuring tension in cell-cell and cell-substrate interactions. We retrospectively analyze how these various optical techniques progressed the field and suggest our vision forward for a unified theory of cell mechanics, mapping cellular mechanosensing, and novel biomedical applications for mechanobiology. |
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MeSH term(s) | Animals ; Biomechanical Phenomena/physiology ; Biophysics/methods ; Biophysics/trends ; Cell Differentiation ; Extracellular Matrix/metabolism ; Humans ; Mechanotransduction, Cellular/physiology ; Optical Imaging/methods ; Optical Imaging/trends ; Signal Transduction |
Language | English |
Publishing date | 2021-03-31 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review |
ZDB-ID | 1098979-1 |
ISSN | 1939-4586 ; 1059-1524 |
ISSN (online) | 1939-4586 |
ISSN | 1059-1524 |
DOI | 10.1091/mbc.E20-10-0671 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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