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Article: Mechanobiology predicts raft formations triggered by ligand-receptor activity across the cell membrane.

Carotenuto, Angelo R / Lunghi, Laura / Piccolo, Valentina / Babaei, Mahnoush / Dayal, Kaushik / Pugno, Nicola / Zingales, Massimiliano / Deseri, Luca / Fraldi, Massimiliano

Journal of the mechanics and physics of solids

2020 Volume 141, Page(s) 103974

Abstract: Clustering of ligand-binding receptors of different types on thickened isles of the cell membrane, namely lipid rafts, is an experimentally observed phenomenon. Although its influence on cell's response is deeply investigated, the role of the coupling ... ...

Abstract	Clustering of ligand-binding receptors of different types on thickened isles of the cell membrane, namely lipid rafts, is an experimentally observed phenomenon. Although its influence on cell's response is deeply investigated, the role of the coupling between mechanical processes and multiphysics involving the active receptors and the surrounding lipid membrane during ligand-binding has not yet been understood. Specifically, the focus of this work is on
Keywords	covid19
Language	English
Publishing date	2020-05-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2012341-3
ISSN	1873-4782 ; 0022-5096
ISSN (online)	1873-4782
ISSN	0022-5096
DOI	10.1016/j.jmps.2020.103974
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Brief Review: The Use of L-Ascorbic Acid as a Green Reducing Agent of Graphene Oxide.

Palomba, Mariano / Carotenuto, Gianfranco / Longo, Angela

Materials (Basel, Switzerland)

2022 Volume 15, Issue 18

Abstract: The reduced form of graphene oxide (r-GO) represents a versatile precursor to obtain graphene ... by different oxygen-containing groups, while r-GO is obtained by the almost complete removal of these oxygen ... containing functional groups. The r-GO has mechanical, electrical, and optical properties quite similar ...

Abstract	The reduced form of graphene oxide (r-GO) represents a versatile precursor to obtain graphene derivatives. Graphene oxide (GO) consists of a layered material based on a carbon skeleton functionalized by different oxygen-containing groups, while r-GO is obtained by the almost complete removal of these oxygen-containing functional groups. The r-GO has mechanical, electrical, and optical properties quite similar to graphene, thus, it proves to be a convenient 2D material useful for many technological applications. Nowadays, the most important aspects to consider in producing r-GO are: (i) the possibility of obtaining the highest reduction grade; (ii) the possibility of improving the dispersion stability of the resulting graphene using surfactants; (iii) the use of environmentally friendly and inexpensive reducing agents. Consequently, the availability of effective soft-chemistry approaches based on a green reducing agent for converting GO to r-GO are strongly needed. Among the green reductants, the most suitable is L-ascorbic acid (L-aa). Different studies have revealed that L-aa can achieve C/O ratio and conductivity values comparable to those obtained by hydrazine, a typical reducing agent. These aspects could promote an effective application strategy, and for this reason, this review summarizes and analyzes, in some detail, the up-to date literature on the reduction of GO by L-aa. The results are organized according to the two most important approaches, which are the reduction in liquid-phase, and the reduction in gel-phase. Reaction mechanisms and different experimental parameters affecting the processes were also compared.
Language	English
Publishing date	2022-09-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15186456
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Article ; Online: Burrowing below ground: interaction between soil mechanics and evolution of subterranean mammals.

Rosario Carotenuto, Angelo / Guarracino, Federico / Šumbera, Radim / Fraldi, Massimiliano

Journal of the Royal Society, Interface

2020 Volume 17, Issue 162, Page(s) 20190521

Abstract: The evolution of species is governed by complex phenomena in which biological and environmental features may interact dynamically. Subterranean mammals dig tunnels whose diameter minimizes energetic costs during excavations and display anatomical ... ...

Abstract	The evolution of species is governed by complex phenomena in which biological and environmental features may interact dynamically. Subterranean mammals dig tunnels whose diameter minimizes energetic costs during excavations and display anatomical adaptations in order to burrow structurally stable tunnels according to specific features of the soil. These animals weight from less than 50 g up to 1-2 kg, and dig tunnels with diameters from 3 to 15 cm. The use of allometric laws has enabled these data to be correlated. However, since tunnels need to be stable with respect to the geomechanical characteristics of the resident soils, a mathematical treatment linking the admissible dimensions of tunnels to the environment here suggests a mechanically grounded correlation between the body mass of subterranean mammals and the maximum dimensions of tunnels. Remarkably, such theoretical findings reflect very well the empirical allometric relationship and contribute to explain the wide differences observed in body sizes of subterranean mammals. In this respect, a far from ancillary role of environmental mechanics on the morphological evolution of subterranean mammals can be hypothesized.
MeSH term(s)	Acclimatization ; Animals ; Body Weight ; Mammals ; Soil
Chemical Substances	Soil
Language	English
Publishing date	2020-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2019.0521
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Article: Mechanobiology predicts raft formations triggered by ligand-receptor activity across the cell membrane

Carotenuto, Angelo R. / Lunghi, Laura / Piccolo, Valentina / Babaei, Mahnoush / Dayal, Kaushik / Pugno, Nicola / Zingales, Massimiliano / Deseri, Luca / Fraldi, Massimiliano

J Mech Phys Solids

Abstract	Clustering of ligand-binding receptors of different types on thickened isles of the cell membrane, namely lipid rafts, is an experimentally observed phenomenon. Although its influence on cell's response is deeply investigated, the role of the coupling between mechanical processes and multiphysics involving the active receptors and the surrounding lipid membrane during ligand-binding has not yet been understood. Specifically, the focus of this work is on G-protein-coupled receptors (GPCRs), the widest group of transmembrane proteins in animals, which regulate specific cell processes through chemical signalling pathways involving a synergistic balance between the cyclic Adenosine Monophosphate (cAMP) produced by active GPCRs in the intracellular environment and its efflux, mediated by the Multidrug Resistance Proteins (MRPs) transporters. This paper develops a multiphysics approach based on the interplay among energetics, multiscale geometrical changes and mass balance of species, i.e. active GPCRs and MRPs, including diffusion and kinetics of binding and unbinding. Because the obtained energy depends upon both the kinematics and the changes of species densities, balance of mass and of linear momentum are coupled and govern the space-time evolution of the cell membrane. The mechanobiology involving remodelling and change of lipid ordering of the cell membrane allows to predict dynamics of transporters and active receptors –in full agreement with experimentally observed cAMP levels– and how the latter trigger rafts formation and cluster on such sites. Within the current scientific debate on Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) and on the basis of the ascertained fact that lipid rafts often serve as an entry port for viruses, it is felt that approaches accounting for strong coupling among mechanobiological aspects could even turn helpful in better understanding membrane-mediated phenomena such as COVID-19 virus-cell interaction.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #420618
Database	COVID19

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Article: Association between cavernous angioma and cerebral glioma. Report of two cases and literature review of so-called angiogliomas.

Gazzeri, R / De Bonis, C / Carotenuto, V / Catapano, D / d'Angelo, V / Galarza, M

Neurocirugia (Asturias, Spain)

2011 Volume 22, Issue 6, Page(s) 562–566

Abstract: The association between vascular malformations and cerebral gliomas is unusual. While the association between cavernous angioma with gliomatous lesions is even more rare, it is considered by certain authors to be a particular pathological entity termed ... ...

Abstract	The association between vascular malformations and cerebral gliomas is unusual. While the association between cavernous angioma with gliomatous lesions is even more rare, it is considered by certain authors to be a particular pathological entity termed angioglioma. The authors report on two cases of association of a cavernous angioma with a ganglioglioma and an oligodendroglioma respectively. Subsequent review of the literature on the so-called angiogliomas was conducted. In the author's opinion, the entity of angiogliomas represents a general spectrum of angiomatous neoplasms that include gliomatous tumors, in the majority low-grade gliomas, associated with a major vascular component.
MeSH term(s)	Adolescent ; Adult ; Brain Neoplasms/classification ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Female ; Glioma/classification ; Glioma/pathology ; Glioma/surgery ; Hemangioma, Cavernous/classification ; Hemangioma, Cavernous/pathology ; Hemangioma, Cavernous/surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Treatment Outcome
Language	English
Publishing date	2011-12-14
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	2151282-6
ISSN	1130-1473
ISSN	1130-1473
DOI	10.1016/s1130-1473(11)70112-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of a Plastic-Free Lifestyle on Urinary Bisphenol A Levels in School-Aged Children of Southern Italy: A Pilot Study.

Sessa, Francesco / Polito, Rita / Monda, Vincenzo / Scarinci, Alessia / Salerno, Monica / Carotenuto, Marco / Cibelli, Giuseppe / Valenzano, Anna / Campanozzi, Angelo / Mollica, Maria Pina / Monda, Marcellino / Messina, Giovanni

Frontiers in public health

2021 Volume 9, Page(s) 626070

Abstract: Bisphenol A (BPA) is an endocrine disruptor (ED) frequently used in food packaging. BPA is used as a monomer in the manufacture of some food packaging. This study aimed to evaluate the urinary BPA concentration in an Italian pediatric cohort, testing the ...

Abstract	Bisphenol A (BPA) is an endocrine disruptor (ED) frequently used in food packaging. BPA is used as a monomer in the manufacture of some food packaging. This study aimed to evaluate the urinary BPA concentration in an Italian pediatric cohort, testing the levels of this ED over a period of 6 months, evaluating the effects of a diet regimen with a reduction of Plastic Food Packaging (PFP). One hundred thirty Italian children were enrolled and divided into two groups "School Canteen" and "No School Canteen." The first group consumed one meal at school using a plastic-free service for 5 days/weeks, while the other group did not modify their normal meal-time habits. The BPA levels were tested in urine samples at three time points: T0, is the time before the application of the plastic-free regimen diet; T3, 3 months later; and T6, 6 months later. A reduction of urine BPA levels was detected in the "School Canteen" group. In particular, the reduction was significant analyzing both the intra (among the three testing times) group and inter (between "School Canteen" and "No School Canteen") group variability. Our results show the effects of a diet regimen with a reduction of PFP, demonstrating a connection between urinary BPA levels and food packaging.
MeSH term(s)	Benzhydryl Compounds ; Child ; Humans ; Italy ; Life Style ; Phenols ; Pilot Projects ; Plastics ; Schools
Chemical Substances	Benzhydryl Compounds ; Phenols ; Plastics ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2021-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.626070
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Article ; Online: Ultrasound waves in tumors via needle irradiation for precise medicine

Antonello Cutolo / Angelo Rosario Carotenuto / Maria Alessandra Cutolo / Arsenio Cutolo / Martino Giaquinto / Stefania Palumbo / Andrea Cusano / Massimiliano Fraldi

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 14

Abstract: Abstract Grounded in the interdisciplinary crosstalk among physics and biological sciences, precision medicine-based diagnosis and treatment strategies have recently gained great attention for the actual applicability of new engineered approaches in many ...

Abstract	Abstract Grounded in the interdisciplinary crosstalk among physics and biological sciences, precision medicine-based diagnosis and treatment strategies have recently gained great attention for the actual applicability of new engineered approaches in many medical fields, particularly in oncology. Within this framework, the use of ultrasounds employed to attack cancer cells in tumors to induce possible mechanical damage at different scales has received growing attention from scholars and scientists worldwide. With these considerations in mind, on the basis of ad hoc elastodynamic solutions and numerical simulations, we propose a pilot study for in silico modeling of the propagation of ultrasound waves inside tissues, with the aim of selecting proper frequencies and powers to be irradiated locally through a new teragnostic platform based on Lab-on-Fiber technology, baptized as a hospital in the needle and already the object of a patent. It is felt that the outcomes and the related biophysical insights gained from the analyses could pave the way for envisaging new integrated diagnostic and therapeutic approaches that might play a central role in future applications of precise medicine, starting from the growing synergy among physics, engineering and biology.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long-Term Performance Assessment of Low-Cost Atmospheric Sensors in the Arctic Environment.

Carotenuto, Federico / Brilli, Lorenzo / Gioli, Beniamino / Gualtieri, Giovanni / Vagnoli, Carolina / Mazzola, Mauro / Viola, Angelo Pietro / Vitale, Vito / Severi, Mirko / Traversi, Rita / Zaldei, Alessandro

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 7

Abstract: The Arctic is an important natural laboratory that is extremely sensitive to climatic changes and its monitoring is, therefore, of great importance. Due to the environmental extremes it is often hard to deploy sensors and observations are limited to a ... ...

Abstract	The Arctic is an important natural laboratory that is extremely sensitive to climatic changes and its monitoring is, therefore, of great importance. Due to the environmental extremes it is often hard to deploy sensors and observations are limited to a few sparse observation points limiting the spatial and temporal coverage of the Arctic measurement. Given these constraints the possibility of deploying a rugged network of low-cost sensors remains an interesting and convenient option. The present work validates for the first time a low-cost sensor array (AIRQino) for monitoring basic meteorological parameters and atmospheric composition in the Arctic (air temperature, relative humidity, particulate matter, and CO
Language	English
Publishing date	2020-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20071919
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Article ; Online: Correction to: Normative values of the Rao's Brief Repeatable Battery in an Italian young adolescent population: the influence of age, gender, and education.

Falco, Fabrizia / Moccia, Marcello / Chiodi, Alessandro / Carotenuto, Antonio / D'Amelio, Angelo / Rosa, Laura / Piscopo, Kyrie / Falco, Andrea / Costabile, Teresa / Lauro, Francesca / Brescia Morra, Vincenzo / Lanzillo, Roberta

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2019 Volume 40, Issue 5, Page(s) 1099–1100

Abstract: The published version of this article unfortunately contained a mistake in Table 2. ...

Abstract	The published version of this article unfortunately contained a mistake in Table 2.
Language	English
Publishing date	2019-03-19
Publishing country	Italy
Document type	Published Erratum
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-019-03880-w
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Zs.A 1877: Show issues

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Article ; Online: Normative values of the Rao's Brief Repeatable Battery in an Italian young adolescent population: the influence of age, gender, and education.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2019 Volume 40, Issue 4, Page(s) 713–717

Abstract: Aim: The Brief Repeatable Battery of Neuropsychological Tests (BRB) is frequently used to estimate cognitive function in adults with multiple sclerosis (MS), while it has been included in few studies on young MS, also because of the absence of normative ...

Abstract	Aim: The Brief Repeatable Battery of Neuropsychological Tests (BRB) is frequently used to estimate cognitive function in adults with multiple sclerosis (MS), while it has been included in few studies on young MS, also because of the absence of normative values. We aim to evaluate the impact of age, gender, and education on BRB scores in a young adolescent population. Methods: We administered the BRB to 76, 14-to-17-year-old, healthy subjects. Linear regression models were used to assess the impact of age, gender, and education on sub-test scores. When statistically significant (p < 0.05), we used the regression coefficient to correct the raw scores. Results: Younger age was associated with better performance on SPART (β = - 2.54; p < 0.05) and SPART-D (β = - 1.06; p < 0.05). Male gender was associated with better performance on SPART (β = 3.40; p < 0.05), SPART-D (β = 1.41; p < 0.05), PASAT-3 (β = 5.58; p < 0.05), and PASAT-2 (β = 5.07; p < 0.05). Educational attainments were associated with better performance on SPART (β = 3.23; p < 0.05) and SPART-D (β = 1.28; p < 0.05). Cut-off points were suggested at the 5th lowest percentile. Interpretation: Age, gender, and education must be accounted for when applying the BRB to young population. Present results can prove useful for future clinical and research applications in adolescent MS patients.
MeSH term(s)	Adolescent ; Age Factors ; Educational Status ; Female ; Humans ; Italy ; Male ; Neuropsychological Tests/statistics & numerical data ; Sex Factors ; Task Performance and Analysis
Language	English
Publishing date	2019-01-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-019-3712-3
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