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Book ; Online ; E-Book: Modern mechanobiology

Lee, Juhyun / Gerecht, Sharon / Jo, Hanjoong / Hsiai, Tzung K.

convergence of biomechanics, development and genomics

2021

Abstract: Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to ... ...

Author's details	edited by Juhyun Lee, Sharon Gerecht, Hanjoong Jo, Tzung Hsiai
Abstract	Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.
Keywords	Biomechanics
Subject code	612.76
Language	English
Dates of publication	2021-2021
Size	1 online resource (x, 249 pages) :, illustrations
Publisher	Jenny Stanford Publishing
Publishing place	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-000-02092-4 ; 0-429-29483-2 ; 1-000-02126-2 ; 981-4800-58-9 ; 978-1-000-02092-2 ; 978-0-429-29483-9 ; 978-1-000-02126-4 ; 978-981-4800-58-7
DOI	10.1201/9780429294839
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Interfacing Bioelectronics and Biomedical Sensing

Cao, Hung / Coleman, Todd / Hsiai, Tzung K. / Khademhosseini, Ali

2020

Abstract: This book addresses the fundamental challenges underlying bioelectronics and tissue interface for clinical investigation. Appropriate for biomedical engineers and researchers, the authors cover topics ranging from retinal implants to restore vision, ... ...

Author's details	edited by Hung Cao, Todd Coleman, Tzung K. Hsiai, Ali Khademhosseini
Abstract	This book addresses the fundamental challenges underlying bioelectronics and tissue interface for clinical investigation. Appropriate for biomedical engineers and researchers, the authors cover topics ranging from retinal implants to restore vision, implantable circuits for neural implants, and intravascular electrochemical impedance to detect unstable plaques. In addition to these chapters, the authors also document the approaches and issues of multi-scale physiological assessment and monitoring in both humans and animal models for health monitoring and biological investigations; novel biomaterials such as conductive and biodegradable polymers to be used in biomedical devices; and the optimization of wireless power transfer via inductive coupling for batteryless and wireless implantable medical devices. In addition to engineers and researchers, this book is also an ideal supplementary or reference book for a number of courses in biomedical engineering programs, such as bioinstrumentation, MEMS/BioMEMS, bioelectronics and sensors, and more. Analyzes and discusses the electrode-tissue interfaces for optimization of biomedical devices. Introduces novel biomaterials to be used in next-generation biomedical devices. Discusses high-frequency transducers for biomedical applications.
Keywords	Biomedical engineering ; Biomedical materials ; Electronic circuits ; Nanotechnology ; Biomedical Engineering and Bioengineering ; Biomaterials ; Circuits and Systems ; Nanotechnology and Microengineering ; Biomedical Engineering/Biotechnology
Subject code	571.45
Language	English
Size	1 online resource (VIII, 234 p. 69 illus., 60 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-34467-3 ; 3-030-34466-5 ; 978-3-030-34467-2 ; 978-3-030-34466-5
DOI	10.1007/978-3-030-34467-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Hemodynamics and mechanobiology of endothelium

Hsiai, Tzung K.

2010

Author's details	ed. Tzung K. Hsiai
Keywords	Hemodynamics / physiology ; Endothelium, Vascular / cytology ; Blood Circulation / physiology ; Mechanotransduction, Cellular / physiology ; Oxidative Stress / physiology ; Models, Cardiovascular
Language	English
Size	VIII, 370 S. : Ill., graph. Darst.
Publisher	World Scientific
Publishing place	Hackensack, NJ u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT016144252
ISBN	978-981-4280-41-9 ; 981-4280-41-0 ; 9789814280426 ; 9814280429
Database	Catalogue ZB MED Medicine, Health

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Article: Augmented light field tomography through parallel spectral encoding.

Wang, Zhaoqiang / Hsiai, Tzung K / Gao, Liang

Optica

2023 Volume 10, Issue 1, Page(s) 62–65

Abstract: Snapshot recording of transient dynamics in three dimensions (3-D) is highly demanded in both fundamental and applied sciences. Yet it remains challenging for conventional high-speed cameras to address this need due to limited electronic bandwidth and ... ...

Abstract	Snapshot recording of transient dynamics in three dimensions (3-D) is highly demanded in both fundamental and applied sciences. Yet it remains challenging for conventional high-speed cameras to address this need due to limited electronic bandwidth and reliance on mechanical scanning. The emergence of light field tomography (LIFT) provides a new solution to these long-standing problems and enables 3-D imaging at an unprecedented frame rate. However, based on sparse-view computed tomography, LIFT can accommodate only a limited number of projections, degrading the resolution in the reconstructed image. To alleviate this problem, we herein present a spectral encoding scheme to significantly increase the number of allowable projections in LIFT while maintaining its snapshot advantage. The resultant system can record 3-D dynamics at a kilohertz volumetric frame rate. Moreover, by using a multichannel compressed sensing algorithm, we improve the image quality with an enhanced spatial resolution and suppressed aliasing artifacts.
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2779175-0
ISSN	2334-2536
ISSN	2334-2536
DOI	10.1364/optica.473848
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Article ; Online: Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells.

Hasani-Sadrabadi, Mohammad Mahdi / Majedi, Fatemeh S / Zarubova, Jana / Thauland, Timothy J / Arumugaswami, Vaithilingaraja / Hsiai, Tzung K / Bouchard, Louis-S / Butte, Manish J / Li, Song

ACS nano

2024 Volume 18, Issue 9, Page(s) 6908–6926

Abstract: The durability of a protective immune response generated by a vaccine depends on its ability to induce long-term T cell immunity, which tends to decline in aging populations. The longest protection appears to arise from T memory stem cells (TMSCs) that ... ...

Abstract	The durability of a protective immune response generated by a vaccine depends on its ability to induce long-term T cell immunity, which tends to decline in aging populations. The longest protection appears to arise from T memory stem cells (TMSCs) that confer high expandability and effector functions when challenged. Here we engineered artificial antigen presenting cells (aAPC) with optimized size, stiffness and activation signals to induce human and mouse CD8
MeSH term(s)	Mice ; Humans ; Animals ; CD8-Positive T-Lymphocytes ; Immunologic Memory ; Biocompatible Materials ; Vaccines ; Stem Cells
Chemical Substances	Biocompatible Materials ; Vaccines
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c08559
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Article ; Online: Microfluidic Organ-Chips and Stem Cell Models in the Fight Against COVID-19.

Satta, Sandro / Rockwood, Sarah J / Wang, Kaidong / Wang, Shaolei / Mozneb, Maedeh / Arzt, Madelyn / Hsiai, Tzung K / Sharma, Arun

Circulation research

2023 Volume 132, Issue 10, Page(s) 1405–1424

Abstract: SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 and the subsequent development of COVID-19, it is critical to detect, monitor, and model ... ...

Abstract	SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 and the subsequent development of COVID-19, it is critical to detect, monitor, and model viral pathogenesis. In this review, we discuss recent advancements in microfluidics, organ-on-a-chip, and human stem cell-derived models to study SARS-CoV-2 infection in the physiological organ microenvironment, together with their limitations. Microfluidic-based detection methods have greatly enhanced the rapidity, accessibility, and sensitivity of viral detection from patient samples. Engineered organ-on-a-chip models that recapitulate in vivo physiology have been developed for many organ systems to study viral pathology. Human stem cell-derived models have been utilized not only to model viral tropism and pathogenesis in a physiologically relevant context but also to screen for effective therapeutic compounds. The combination of all these platforms, along with future advancements, may aid to identify potential targets and develop novel strategies to counteract COVID-19 pathogenesis.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Microfluidics ; Microphysiological Systems
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.122.321877
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Article: Endothelial mechanotransduction in cardiovascular development and regeneration: emerging approaches and animal models.

Cavallero, Susana / Blázquez-Medela, Ana M / Satta, Sandro / Hsiai, Tzung K

Current topics in membranes

2021 Volume 87, Page(s) 131–151

Abstract: Living cells are exposed to multiple mechanical stimuli from the extracellular matrix or from surrounding cells. Mechanoreceptors are molecules that display status changes in response to mechanical stimulation, transforming physical cues into biological ... ...

Abstract	Living cells are exposed to multiple mechanical stimuli from the extracellular matrix or from surrounding cells. Mechanoreceptors are molecules that display status changes in response to mechanical stimulation, transforming physical cues into biological responses to help the cells adapt to dynamic changes of the microenvironment. Mechanical stimuli are responsible for shaping the tridimensional development and patterning of the organs in early embryonic stages. The development of the heart is one of the first morphogenetic events that occur in embryos. As the circulation is established, the vascular system is exposed to constant shear stress, which is the force created by the movement of blood. Both spatial and temporal variations in shear stress differentially modulate critical steps in heart development, such as trabeculation and compaction of the ventricular wall and the formation of the heart valves. Zebrafish embryos are small, transparent, have a short developmental period and allow for real-time visualization of a variety of fluorescently labeled proteins to recapitulate developmental dynamics. In this review, we will highlight the application of zebrafish models as a genetically tractable model for investigating cardiovascular development and regeneration. We will introduce our approaches to manipulate mechanical forces during critical stages of zebrafish heart development and in a model of vascular regeneration, as well as advances in imaging technologies to capture these processes at high resolution. Finally, we will discuss the role of molecules of the Plexin family and Piezo cation channels as major mechanosensors recently implicated in cardiac morphogenesis.
MeSH term(s)	Animals ; Mechanotransduction, Cellular ; Models, Animal ; Morphogenesis ; Stress, Mechanical ; Zebrafish
Language	English
Publishing date	2021-10-12
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1063-5823
ISSN	1063-5823
DOI	10.1016/bs.ctm.2021.07.002
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Article ; Online: An Ex Vivo Study of Outward Electrical Impedance Tomography (OEIT) for Intravascular Imaging.

Luo, Yuan / Huang, Dong / Huang, Zi-Yu / Hsiai, Tzung K / Tai, Yu-Chong

IEEE transactions on bio-medical engineering

2022 Volume 69, Issue 2, Page(s) 734–745

Abstract: Objective: Atherosclerosis is a chronic immuno-inflammatory condition emerging in arteries and considered the cause of a myriad of cardiovascular diseases. Atherosclerotic lesion characterization through invasive imaging modalities is essential in ... ...

Abstract	Objective: Atherosclerosis is a chronic immuno-inflammatory condition emerging in arteries and considered the cause of a myriad of cardiovascular diseases. Atherosclerotic lesion characterization through invasive imaging modalities is essential in disease evaluation and determining intervention strategy. Recently, electrical properties of the lesions have been utilized in assessing its vulnerability mainly owing to its capability to differentiate lipid content existing in the lesion, albeit with limited detection resolution. Electrical impedance tomography is the natural extension of conventional spectrometric measurement by incorporating larger number of interrogating electrodes and advanced algorithm to achieve imaging of target objects and thus provides significantly richer information. It is within this context that we develop Outward Electrical Impedance Tomography (OEIT), aimed at intravascular imaging for atherosclerotic lesion characterization. Methods: We utilized flexible electronics to establish the 32-electrode OEIT device with outward facing configuration suitable for imaging of vessels. We conducted comprehensive studies through simulation model and ex vivo setup to demonstrate the functionality of OEIT. Results: Quantitative characterization for OEIT regarding its proximity sensing and conductivity differentiation was achieved using well-controlled experimental conditions. Imaging capability for OEIT was further verified with phantom setup using porcine aorta to emulate in vivo environment. Conclusion: We have successfully demonstrated a novel tool for intravascular imaging, OEIT, with unique advantages for atherosclerosis detection. Significance: This study demonstrates for the first time a novel electrical tomography-based platform for intravascular imaging, and we believe it paves the way for further adaptation of OEIT for intravascular detection in more translational settings and offers great potential as an alternative imaging tool for medical diagnosis.
MeSH term(s)	Animals ; Atherosclerosis ; Electric Impedance ; Phantoms, Imaging ; Swine ; Tomography/methods ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2021.3104300
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Article ; Online: Non-invasive photoacoustic computed tomography of rat heart anatomy and function.

Lin, Li / Tong, Xin / Cavallero, Susana / Zhang, Yide / Na, Shuai / Cao, Rui / Hsiai, Tzung K / Wang, Lihong V

Light, science & applications

2023 Volume 12, Issue 1, Page(s) 12

Abstract: Complementary to mainstream cardiac imaging modalities for preclinical research, photoacoustic computed tomography (PACT) can provide functional optical contrast with high imaging speed and resolution. However, PACT has not been demonstrated to reveal ... ...

Abstract	Complementary to mainstream cardiac imaging modalities for preclinical research, photoacoustic computed tomography (PACT) can provide functional optical contrast with high imaging speed and resolution. However, PACT has not been demonstrated to reveal the dynamics of whole cardiac anatomy or vascular system without surgical procedure (thoracotomy) for tissue penetration. Here, we achieved non-invasive imaging of rat hearts using the recently developed three-dimensional PACT (3D-PACT) platform, demonstrating the regulated illumination and detection schemes to reduce the effects of optical attenuation and acoustic distortion through the chest wall; thereby, enabling unimpeded visualization of the cardiac anatomy and intracardiac hemodynamics following rapidly scanning the heart within 10 s. We further applied 3D-PACT to reveal distinct cardiac structural and functional changes among the healthy, hypertensive, and obese rats, with optical contrast to uncover differences in cardiac chamber size, wall thickness, and hemodynamics. Accordingly, 3D-PACT provides high imaging speed and nonionizing penetration to capture the whole heart for diagnosing the animal models, holding promises for clinical translation to cardiac imaging of human neonates.
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2662628-7
ISSN	2047-7538 ; 2047-7538
ISSN (online)	2047-7538
ISSN	2047-7538
DOI	10.1038/s41377-022-01053-7
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Article ; Online: A physicochemical-sensing electronic skin for stress response monitoring.

Xu, Changhao / Song, Yu / Sempionatto, Juliane R / Solomon, Samuel A / Yu, You / Nyein, Hnin Y Y / Tay, Roland Yingjie / Li, Jiahong / Heng, Wenzheng / Min, Jihong / Lao, Alison / Hsiai, Tzung K / Sumner, Jennifer A / Gao, Wei

Nature electronics

2024 Volume 7, Issue 2, Page(s) 168–179

Abstract: Approaches to quantify stress responses typically rely on subjective surveys and questionnaires. Wearable sensors can potentially be used to continuously monitor stress-relevant biomarkers. However, the biological stress response is spread across the ... ...

Abstract	Approaches to quantify stress responses typically rely on subjective surveys and questionnaires. Wearable sensors can potentially be used to continuously monitor stress-relevant biomarkers. However, the biological stress response is spread across the nervous, endocrine, and immune systems, and the capabilities of current sensors are not sufficient for condition-specific stress response evaluation. Here we report an electronic skin for stress response assessment that non-invasively monitors three vital signs (pulse waveform, galvanic skin response and skin temperature) and six molecular biomarkers in human sweat (glucose, lactate, uric acid, sodium ions, potassium ions and ammonium). We develop a general approach to prepare electrochemical sensors that relies on analogous composite materials for stabilizing and conserving sensor interfaces. The resulting sensors offer long-term sweat biomarker analysis of over 100 hours with high stability. We show that the electronic skin can provide continuous multimodal physicochemical monitoring over a 24-hour period and during different daily activities. With the help of a machine learning pipeline, we also show that the platform can differentiate three stressors with an accuracy of 98.0%, and quantify psychological stress responses with a confidence level of 98.7%.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ISSN	2520-1131
ISSN (online)	2520-1131
DOI	10.1038/s41928-023-01116-6
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