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  1. Book ; Online ; E-Book: Endothelial signalling in vascular dysfunction and disease

    Chatterjee, Shampa

    from bench to bedside

    2021  

    Author's details edited by Shampa Chatterjee
    Keywords Blood-vessels/Diseases
    Subject code 616.13
    Language English
    Size 1 online resource (279 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-816382-8 ; 0-12-816196-5 ; 978-0-12-816382-5 ; 978-0-12-816196-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Endothelial Mechanotransduction, Redox Signaling and the Regulation of Vascular Inflammatory Pathways.

    Chatterjee, Shampa

    Frontiers in physiology

    2018  Volume 9, Page(s) 524

    Abstract: The endothelium that lines the interior of blood vessels is directly exposed to blood flow. The shear stress arising from blood flow is "sensed" by the endothelium and is "transduced" into biochemical signals that eventually control vascular tone and ... ...

    Abstract The endothelium that lines the interior of blood vessels is directly exposed to blood flow. The shear stress arising from blood flow is "sensed" by the endothelium and is "transduced" into biochemical signals that eventually control vascular tone and homeostasis. Sensing and transduction of physical forces occur via signaling processes whereby the forces associated with blood flow are "
    Language English
    Publishing date 2018-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.00524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Vascular Health: The Endothelial Perspective in Regulation of Inflammation and Injury.

    Chatterjee, Shampa / Lacchini, Silvia / Jungraithmayr, Wolfgang / Wehrli, Felix W

    Frontiers in physiology

    2021  Volume 12, Page(s) 732234

    Language English
    Publishing date 2021-08-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.732234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Inflammation in Periodontal Disease: Possible Link to Vascular Disease.

    Paul, Oindrila / Arora, Payal / Mayer, Michael / Chatterjee, Shampa

    Frontiers in physiology

    2021  Volume 11, Page(s) 609614

    Abstract: Inflammation is a well-organized protective response to pathogens and consists of immune cell recruitment into areas of infection. Inflammation either clears pathogens and gets resolved leading to tissue healing or remains predominantly unresolved ... ...

    Abstract Inflammation is a well-organized protective response to pathogens and consists of immune cell recruitment into areas of infection. Inflammation either clears pathogens and gets resolved leading to tissue healing or remains predominantly unresolved triggering pathological processes in organs. Periodontal disease (PD) that is initiated by specific bacteria also triggers production of inflammatory mediators. These processes lead to loss of tissue structure and function. Reactive oxygen species and oxidative stress play a role in susceptibility to periodontal pathogenic bacterial infections. Periodontal inflammation is a risk factor for systemic inflammation and eventually cardiovascular disease (CVD). This review discusses the role of inflammation in PD and its two way association with other health conditions such as diabetes and CVD. Some of the mechanisms underpinning the links between inflammation, diabetes, CVD and PD are also discussed. Finally, we review available epidemiological data and other reports to assess possible links between oral health and CVD.
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.609614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Peroxiredoxin6 in Endothelial Signaling.

    Patel, Priyal / Chatterjee, Shampa

    Antioxidants (Basel, Switzerland)

    2019  Volume 8, Issue 3

    Abstract: Peroxiredoxins (Prdx) are a ubiquitous family of highly conserved antioxidant enzymes with a cysteine residue that participate in the reduction of peroxides. This family comprises members Prdx1⁻6, of which Peroxiredoxin 6 (Prdx6) is unique in that it is ... ...

    Abstract Peroxiredoxins (Prdx) are a ubiquitous family of highly conserved antioxidant enzymes with a cysteine residue that participate in the reduction of peroxides. This family comprises members Prdx1⁻6, of which Peroxiredoxin 6 (Prdx6) is unique in that it is multifunctional with the ability to neutralize peroxides (peroxidase activity) and to produce reactive oxygen species (ROS) via its phospholipase (PLA₂) activity that drives assembly of NADPH oxidase (NOX2). From the crystal structure, a C47 residue is responsible for peroxidase activity while a catalytic triad (S32, H26, and D140) has been identified as the active site for its PLA₂ activity. This paradox of being an antioxidant as well as an oxidant generator implies that Prdx6 is a regulator of cellular redox equilibrium (graphical abstract). It also indicates that a fine-tuned regulation of Prdx6 expression and activity is crucial to cellular homeostasis. This is specifically important in the endothelium, where ROS production and signaling are critical players in inflammation, injury, and repair, that collectively signal the onset of vascular diseases. Here we review the role of Prdx6 as a regulator of redox signaling, specifically in the endothelium and in mediating various pathologies.
    Language English
    Publishing date 2019-03-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox8030063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Peptide Inhibitor of Peroxiredoxin 6 Phospholipase A

    Fisher, Aron B / Dodia, Chandra / Chatterjee, Shampa

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: Ventilator induced lung injury (VILI) is a lung injury syndrome associated with mechanical ventilation, most frequently for treatment of Acute Lung Injury (ALI), and generally secondary to the use of greater than physiologic tidal volumes. To reproduce ... ...

    Abstract Ventilator induced lung injury (VILI) is a lung injury syndrome associated with mechanical ventilation, most frequently for treatment of Acute Lung Injury (ALI), and generally secondary to the use of greater than physiologic tidal volumes. To reproduce this syndrome experimentally, C57Bl/6 mice were intubated and ventilated with low (4 mL/Kg body weight) or high (12 mL/Kg) tidal volume for 6 h. Lung parameters with low volume ventilation were unchanged from non-ventilated (control) mice. High tidal volume ventilation resulted in marked lung injury with increased neutrophils in the bronchoalveolar lavage fluid (BALf) indicating lung inflammation, increase in both protein in BALf and lung dry/wet weight indicating lung edema, increased lung thiobarbituric acid reactive substances (TBARS) and 8-isoprostanes indicating lung lipid peroxidation, and increased lung protein carbonyls indicating protein oxidation. Either intratracheal or intravenous pretreatment of mice with a 9 amino acid peptide called peroxiredoxin 6 inhibitor peptide-2 (PIP-2) significantly reduced all parameters of lung injury by ~50-80%. PIP-2 inhibits NADPH oxidase type 2 (NOX2) activation. We propose that PIP-2 does not affect the mechanically induced lung damage component of VILI but does significantly reduce the secondary inflammatory component.
    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10060925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction: Fisher, Aron B., et al. A Peptide Inhibitor of NADPH Oxidase (NOX2) Activation Markedly Decreases Mouse Lung Injury and Mortality Following Administration of Lipopolysaccharide (LPS). Int. J. Mol. Sci. 2019, 20, 2395.

    Fisher, Aron B / Dodia, Chandra / Chatterjee, Shampa / Feinstein, Sheldon I

    International journal of molecular sciences

    2020  Volume 21, Issue 2

    Abstract: The authors wish to make the following corrections to our previously published paper [1] [ ... ]. ...

    Abstract The authors wish to make the following corrections to our previously published paper [1] [...].
    Language English
    Publishing date 2020-01-08
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21020398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Peptide Inhibitor of Peroxiredoxin 6 Phospholipase A2 Activity Significantly Protects against Lung Injury in a Mouse Model of Ventilator Induced Lung Injury (VILI)

    Fisher, Aron B. / Dodia, Chandra / Chatterjee, Shampa

    Antioxidants. 2021 June 07, v. 10, no. 6

    2021  

    Abstract: Ventilator induced lung injury (VILI) is a lung injury syndrome associated with mechanical ventilation, most frequently for treatment of Acute Lung Injury (ALI), and generally secondary to the use of greater than physiologic tidal volumes. To reproduce ... ...

    Abstract Ventilator induced lung injury (VILI) is a lung injury syndrome associated with mechanical ventilation, most frequently for treatment of Acute Lung Injury (ALI), and generally secondary to the use of greater than physiologic tidal volumes. To reproduce this syndrome experimentally, C57Bl/6 mice were intubated and ventilated with low (4 mL/Kg body weight) or high (12 mL/Kg) tidal volume for 6 h. Lung parameters with low volume ventilation were unchanged from non-ventilated (control) mice. High tidal volume ventilation resulted in marked lung injury with increased neutrophils in the bronchoalveolar lavage fluid (BALf) indicating lung inflammation, increase in both protein in BALf and lung dry/wet weight indicating lung edema, increased lung thiobarbituric acid reactive substances (TBARS) and 8-isoprostanes indicating lung lipid peroxidation, and increased lung protein carbonyls indicating protein oxidation. Either intratracheal or intravenous pretreatment of mice with a 9 amino acid peptide called peroxiredoxin 6 inhibitor peptide-2 (PIP-2) significantly reduced all parameters of lung injury by ~50–80%. PIP-2 inhibits NADPH oxidase type 2 (NOX2) activation. We propose that PIP-2 does not affect the mechanically induced lung damage component of VILI but does significantly reduce the secondary inflammatory component.
    Keywords NAD(P)H oxidase (H2O2-forming) ; amino acids ; body weight ; edema ; inflammation ; intravenous injection ; lipid peroxidation ; lungs ; mice ; neutrophils ; oxidation ; peptides ; peroxiredoxin ; phospholipase A2 ; tidal volume
    Language English
    Dates of publication 2021-0607
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10060925
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Vascular Inflammation in Lungs of Patients with Fatal Coronavirus Disease 2019 (COVID-19): Possible Role for the NLRP3 Inflammasome.

    Paul, Oindrila / Tao, Jian Qin / West, Eric / Litzky, Leslie / Feldman, Michael / Montone, Kathleen / Rajapakse, Chamith / Bermudez, Christian / Chatterjee, Shampa

    Research square

    2021  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-842167/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Correction

    Aron B. Fisher / Chandra Dodia / Shampa Chatterjee / Sheldon I. Feinstein

    International Journal of Molecular Sciences, Vol 21, Iss 2, p

    Fisher, Aron B., et al. A Peptide Inhibitor of NADPH Oxidase (NOX2) Activation Markedly Decreases Mouse Lung Injury and Mortality Following Administration of Lipopolysaccharide (LPS). Int. J. Mol. Sci. 2019, 20 , 2395

    2020  Volume 398

    Abstract: The authors wish to make the following corrections to our previously published paper [.] ...

    Abstract The authors wish to make the following corrections to our previously published paper [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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